The CD95/CD95 ligand system is not the major effector in anticancer drug-mediated apoptosis

Cell Death and Differentiation

Volumn 5, Issue 9, 1998, Pages 735-742

  Tolomeo, Manlio ^a   Dusonchet, Luisa ^a   Meli, Maria ^a   Grimaudo, Stefania ^a   D'Alessandro, Natale ^a   Papoff, Giuliana ^b   Ruberti, Giovina ^b   Rausa, Luciano ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b CNR   (Italy)

Author keywords

Anticancer drugs; Apoptosis; Caspases; CD95; CD95L

Indexed keywords

ANTINEOPLASTIC AGENT; BLOCKING ANTIBODY; CAMPTOTHECIN; DOXORUBICIN; ENZYME INHIBITOR; ETOPOSIDE; FAS ANTIGEN; FAS LIGAND; FLUOROURACIL; METHOTREXATE; PROTEIN P53; VINCRISTINE;

ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DRUG RESISTANCE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE INDUCTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LYMPHOMA CELL LINE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0031786658     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400406     Document Type: Article

References (43)

1. Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW and Yuan J (1996) Human ICE/CED-3 protease nomenclature. Cell 87: 171
2. Boldin MP, Varfolomeev EE, Pancer Z, Mett IL, Camonis JH and Wallach DJ (1995) A novel protein that interacts with death domain of Fas/APO-1 contains a sequence motif related to death domain. Biol Chem 270: 7795-7798
3. Boldin MP, Goncharov TM, Goltsev YV and Wallach D (1996) Involvement of Mach, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 85: 803-815
4. Bose R, Vermeij M, Haimovitz-Friedman A, Scotto K, Funks Zand Kolesnick R (1995) Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signal. Cell 82: 405-414
5. Cascino I, Papoff G, De Maria R, Testi R and Ruberti G (1996) Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis J Immunol 156: 13-17
6. Chinnaiyan AM, O'Rourke K, Tewan M and Dixit VM (1995) FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis, Cell 81. 505-512
7. Collins RJ, Harmon BV, Souvlis T, Pope JH and Kerr JFR (1991) Effects of cycloheximide on B-chronic lymphocytic leukaemic and normal lymphocytes in vitro: induction of apoptosis Br J Cancer 64: 518-522
8. Darziynkiewick Z, Bruno S, Del Bino G, Gorezyca W, Holz MA, Lassota P and Traganos F (1992) Features of apoptotic cells measured by flow cytometry Cytometry 13 795-798
9. Decaudin D, Geley S, Hirsch T, Castedo M, Marchetti P, Macho A, Kofler R and Kroemer G (1997) Bcl-2 and Bcl-xL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents. Cancer Res 57: 62-67
10. Del Bufalo D, Biroccio A, Soddu S, Laudonio N, D'Angelo C, Sacchi A and Zupi G (1996) Lonidamine induces apoptosis in drug-resistant cells independently of the p53 gene J Clin invest 98: 1165-1173
11. Duke RC and Cohen JJ (1992) Morphological and biochemical assays of apoptosis. In: Current Protocols in Immunology, Coligan JE, Kruisbeak AM, (eds) John Wiley & Sons: New York pp. 3. 17 1
12. Fan S, Smith M.L, Rivet DJ, Duba D, Zhan Q, Kohn KW, Fornace AJ Jr and O'Connor PM (1995) Distruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifyline. Cancer Res 55: 1649-1654
13. Fisher DE (1994) Apoptosis in cancer therapy: crossing the threshold. Cell 78: 539-542
14. Friesen C, Herr I, Krammer PH and Debatin K-M (1996) Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells Nature Med. 5: 574-577
15. Hahne M, Rimoldi D, Schroter M, Romero P, Schreier M, French LE, Schneider P, Bomand T, Fontana A, Lienard D, Cerottini J-C and Tschopp J (1996) Melanoma cell expression of Fas (Apo-1/CD95) ligand: implication in tumor immune escape. Science 274: 1363-1366
16. Hannun JA (1996) Functions of Ceramide in coordinating cellular responses to stress. Science 274: 1855-1859
17. Hughes DPM and Crispe IN (1995) A naturally occurring soluble isoform of murine Fas generated by alternative splicing. J Exp Med 182: 1395-1401
18. Ibrado AM, Huang Y, Fang G, Liu L and Bhalla KM (1996) Overexpression of Bcl-2 or Bcl-xL inhibits Ara-C-induced CPP32/Yama protease activity and apoptosis of human acute mielogenous leukemia HL-60 cells. Cancer Res 56. 4743-4748
19. Jung M, Notario V and Dritschilo A (1992) Mutation in the p53 gene in radiation-sensitive and -resistant human squamous carcinoma cells. Cancer Res 52 6390-6393
20. Kerr JFR, Wyllie AH and Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257
21. Kinzler KW and Vogelstein B (1994) Clinical implications of basic research: cancer therapy meets p53. New Eng J Med 331: 49-50
22. Kischkel FC, Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer PH and Peter ME (1995) Cytotoxicity-dependent APO-1 (FAS/CD95) associated protein form a death -inducing signaling complex (DISC) with the receptor. EMBO J 14: 5579-5588
23. Krammer PH, Dhein Y, Valczak H, Behrmann I, Mariani S, Matiba B, Fath M, Daniel PT, Knipping E, Westendorp MO, Stricker K, Baumler C, Hellbardt S, Germer M, Peter ME and Debatin K-M (1994) The role of APO-1-mediated apoptosis in the immune system, Immunol Rev 142. 175-191
24. Kumar Sand Lavin MF (1996) The ICE family of cysteine proteases as effectors of cell death. Cell Death Differ 3: 255-267
25. Lennon SV, Martin SJ and Cotter TG (1991) Dose-dependent induction of apoptosis in human tumor cell lines by widely diverging stimuli. Cell Prolif 24: 203-214
26. Lowe SW, Schmitt EM, Smith SW, Osborne BA and Jacks T (1993a) p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362: 847-849
27. Lowe SW, Ruley HE, Jacks T, and Housman DE (1993b) p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74 957-967
28. Martin SJ and Green DR (1995a) Apoptosts and cancer: the failure of controls on cell death and cell survival Critical Reviews in Oncology/Hematology 18: 137-153
29. Martin SJ and Green DR (1995b) Protease activation during apoptosis: death by a thousand units? Cell 82: 349-352
30. Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME and Dixit VM (1996) FLICE, a novel FADD-homologous ICE-CED-3-like protease is recruited to the CD95 (Fas-APO1) death-inducing signaling complex. Cell 85: 817-827
31. Nagata S (1997) Apoptosis by death factor. Cell 88: 355-365
32. Nagata S and Golstein P (1995) The Fas death factor. Science 267: 1449-1455
33. Niehans GA, Brunner T, Frizelle SP, Liston JC, Salerno CT, Knapp DJ, Green DR and Kratzke RA (1997) Human lung carcinomas express Fas ligand. Cancer Res 57: 1007-1012
34. 0'Connell J, O'Sullivan GC, Collins JK and Shanahan F (1996) The Fas conterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas Ligand J Exp Med 184: 1075-1082
35. Saas P, Walker P.R, Hahne M, Quiquerez AL, Schnuriger V, Perrin G, French L, Van Meir EG, de Tribolet N, Tschopp J and Dietrich PY (1997) Fas Ligand expression by astrocytoma in vivo: Maintaning Immune privilege in the brain. J Clin Invest 99: 1173-1178
36. Skowronski EW, Kolesnick RN and Green DR (1996) Fas-mediated apoptosis and sphingomyelinase signal transduction: the role of ceramide as a second messenger for apoptosis Cell Death Differ 3. 171-176
37. Slee EA, Zhu H, Chow SC, MacFarlane M, Nicholson DW and Cohen GM (1996) Benzyloxycarbonyl-Val-Ala-Asp (Ome) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem J 315: 21-24
38. Strand S, Hofman WJ, Hug H, Muller M, Otto G, Strand D, Mariani SM, Stremmel W, Krammer PH and Galle PR (1996) Lymphocyte apoptosis induced by CD95 (Apo1-/Fas) ligand-expressing tumor cells-a mechanism of immune evasion? Nature Medicine 2 1361-1366
39. Testi R (1996) Sphingomyelin breakdown and cell fate TIBS 21: 468-471
40. Walker PR, Smith C, Youdale T, Leblanc J, Whitfield JF and Sikorska M (1991) Topoisomerase II-reactive drugs induce apoptosis in thymocytes. Cancer Res 51: 1078-1098
41. Williams GT (1991) Programmed cell death: apoptosis and oncogenesis. Cell 65. 1097-1098
42. Williams GT and Smith CA (1993) Molecular regulation of apoptosis genetic controls on cell death. Cell 74 777-779
43. Xu C, Meikrantz W, Schlegel R and Sager R (1995) The human papilloma virus 16 E6 gene sensitizes human mammary epithelial cells to apoptosisinduced by DNA damage. Proc Natl Acad Sci 92: 7829-7833