Fas-mediated apoptosis in human prostatic carcinoma cell lines occurs via activation of caspase-8 and caspase-7

Cancer Research

Volumn 58, Issue 24, 1998, Pages 5870-5875

  Rokhlin, Oskar W ^a   Glover, Rebecca A ^a   Cohen, Michael B ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE INHIBITOR; CYCLOHEXIMIDE; DNA FRAGMENT; FAS ANTIGEN; MONOCLONAL ANTIBODY; PROTEIN; STAUROSPORINE;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; PROSTATE CARCINOMA;

ANTIGENS, CD95; APOPTOSIS; BLOTTING, WESTERN; CASPASE 7; CASPASE 8; CASPASE 9; CASPASES; ENZYME ACTIVATION; HUMANS; MALE; PROSTATIC NEOPLASMS; RETINOBLASTOMA PROTEIN; STAUROSPORINE; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032535018     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Alnemri, E. S. Mammalian cell death proteases: a family of highly conserved aspartate specific cysteine proteases. J. Cell. Biochem.,64: 33-42, 1997.
2. Cohen, G. M. Caspases: the executioners of apoptosis. Biochem. J.,326: 1-16, 1997.
3. Salvesen, G. S., and Dixit, V. M. Caspases: intracellular signalling by proteolysis. Cell, 91: 443-446, 1997.
4. Fraser, A., and Evan, G. A license to kill. Cell, 85: 781-784, 1996.
5. Srinivasula, S. M., Fernandes-Alnemri, T., Zangrilli, J., Robertson, N., Armstrong, C. R., Wang, L., Trapan, J., Tomaselli, K. J., Litwack, G., and Alnemri, E. S. The Ced- 3/interleukin 1β converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2α are substrates for the apoptotic mediator CPP32. J. Biol. Chem., 271: 27099-27106, 1996.
6. Muzio, M., Stockwell, B. R., Stennicke, H. R., Salvesen, G. S., and Dixit, V. M. An induced proximity model for caspase-8 activation. J. Biol. Chem., 273: 2926-2930, 1998.
7. Rokhlin, O. W., Bishop, G. A., Hostager, B. S., Waldschmidt, T. J., Sidorenko, S. P., Pavloff, N., Kiefer, M. C., Umansky, S. R., Glover, R. A., and Cohen, M. B. Fas-mediated apoptosis in human prostatic carcinoma cell lines. Cancer Res.,57: 1758-1768, 1997.
8. Rokhlin, O. W., Hostager, B. S., Bishop, G. A., Sidorenko, S. P., Glover, R. A., Gudkov, A. V., and Cohen, M. B. Dominant nature of the resistance to Fas- and tumor necrosis factor-α-mediated apoptosis in human prostatic carcinoma cell lines. Cancer Res.,57: 3941-3943, 1997.
9. Faleiro, L., Kobayashi, R., Fearnhead, H., and Lazebnik, Y. Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells. EMBO J., 16: 2271-2281, 1997.
10. Fernandes-Alnemri, T., Litwack, G., and Alnemri, E. S. Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. Cancer Res., 55: 2737-2742, 1995.
11. Talanian, R. V., Quinlan, C., Trautz, S., Hackett, M. C., Mankovich, J. A., Banach, D., Ghayur, T., Brady, K. D., and Wong, W. W. Substrate specificities of caspase family proteases. J. Biol. Chem.,272: 9677-9682, 1997.
12. Hirata, H., Takahashi, A., Kobayashi, S., Yonehara, S., Sawai, H., Okazaki, T., Yamamoto, K., and Sasada, M. Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis. J. Exp. Med.,187: 587-600, 1998.
13. Thornberry, N. A., Rano, T. A., Peterson, E. P., Rasper, D. M., Timkey, T., Garcia-Calvo, M., Houtzager, V. M., Nordstrom, P. A., Roy, S., Vaillancourt, J. P., Chapman, K. T., and Nicholson, D. W. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J. Biol. Chem.,272: 17907-17911, 1997.
14. Srinivasula, S. M., Ahmad, M., Fernandes-Alnemri, T., Litwack, G., and Alnemri, E. S. Molecular ordering of the Fas-apoptotic pathway: the Fas/Apo-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc. Natl. Acad. Sci. USA, 93: 14486-14491, 1996.
15. Bertrand, R., Solary, E., O'Connor, P., Kohn, K. W., and Pommier, Y. Induction of a common pathway of apoptosis by staurosporin. Exp. Cell Res.,211: 314-321, 1994.
16. Rokhlin, O. W., and Cohen, M. B. Differential sensitivity of human prostatic cancer cell lines to the effects of protein kinase and phosphatase inhibitors. Cancer Lett.,98: 103-110, 1995.
17. Boldin, M. P., Goncharov, T. M., Goltsev, Y. V., and Wallach, D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1 and TNF receptor-induced cell death. Cell, 85: 803-815, 1996.
18. Chinnaiyan, A. M., O'Rourke, K., Tewari, M., and Dixit, V. M. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell, 81: 505-512, 1995.
19. Kischkel, F. C., Hellbardt, S., Behrmann, I., Germer, M., Pawlita, M., Krammer, P. H., and Peter, M. E. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signalling complex (DISC) with the receptor EMBO J., 14: 5579-5588, 1995.
20. Chinnaiyan, A. M., Tepper, C. G., Seldin, M. F., O'Rourke, K., Kischkel, F. C., Hellbardt, S., Krammer, P. H., Peter, M. E., and Dixit, V. M. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J. Biol. Chem., 277: 4961-4965, 1996.
21. Medema, J. P., Scaffidi, C., Kischkel, F. C, Shevchenko, A., Mann, M., Krammer, P. H., and Peter, M. E. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J., 16: 2794-2804, 1997.
22. Marcelli, M., Cunningham, G. R., Haidacher, S. J., Padayatty, S. J., Sturgis, L., Kagan, C., and Denner, L. Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP. Cancer Res.,58: 76-83, 1998.
23. Fattman, C. L., An, B., and Dou, Q. P. Characterization of interior cleavage of retinoblastoma protein in apoptosis. J. Cell. Biochem.,67: 399-408, 1997.
24. Liu, X., Kim, C. N., Yang, J., Jemmerson, R., and Wang, X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome C. Cell, 86: 147-157, 1996.