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Volumn 10, Issue 6, 1998, Pages 552-559

The role of ceramide in the cellular response to cytotoxic agents

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CERAMIDE; CYTARABINE; CYTOTOXIC AGENT; DAUNORUBICIN; SPHINGOLIPID;

EID: 0031756497     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001622-199811000-00013     Document Type: Review
Times cited : (40)

References (108)
  • 1
    • 0031919157 scopus 로고    scopus 로고
    • Regulation of ceramide production and apoptosis
    • Kolesnick RN: Regulation of ceramide production and apoptosis. Annu Rev Physiol 1998, 60:643-668.
    • (1998) Annu Rev Physiol , vol.60 , pp. 643-668
    • Kolesnick, R.N.1
  • 2
    • 0031905956 scopus 로고    scopus 로고
    • The role of sphingolipid-mediated cell death in neurodegenerative disease
    • Ariga T, Jarvis WD, Yu RK: The role of sphingolipid-mediated cell death in neurodegenerative disease. J Lipid Res 1998, 39:1-16.
    • (1998) J Lipid Res , vol.39 , pp. 1-16
    • Ariga, T.1    Jarvis, W.D.2    Yu, R.K.3
  • 3
    • 0030925375 scopus 로고    scopus 로고
    • Sphingolipids as differential regulators of cellular signalling processes
    • Pyne S, Tolan DG, Conway AM, Pyne N: Sphingolipids as differential regulators of cellular signalling processes. Biochem Soc Trans 1997, 25:549-556.
    • (1997) Biochem Soc Trans , vol.25 , pp. 549-556
    • Pyne, S.1    Tolan, D.G.2    Conway, A.M.3    Pyne, N.4
  • 4
    • 0030634437 scopus 로고    scopus 로고
    • Ceramide: A novel mediator of apoptosis
    • Smyth MJ, Obeid L, Hannun YA: Ceramide: a novel mediator of apoptosis. Adv Pharmacol 1997, 41:133-154.
    • (1997) Adv Pharmacol , vol.41 , pp. 133-154
    • Smyth, M.J.1    Obeid, L.2    Hannun, Y.A.3
  • 7
    • 0005065275 scopus 로고
    • Sphingolipids and their metabolites in cell regulation
    • Merrill AH, Hannun YA, Bell RM: Sphingolipids and their metabolites in cell regulation. Adv Lipid Res 1993, 23:1-26.
    • (1993) Adv Lipid Res , vol.23 , pp. 1-26
    • Merrill, A.H.1    Hannun, Y.A.2    Bell, R.M.3
  • 8
    • 0029148660 scopus 로고
    • Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
    • Bose R, Verheij M, Haimovitz-Friedman A, Scotto K, Kolesnick RN: Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 1995, 82:405-414. The initial report implicating the ceramide synthase pathway in drug-induced cell death.
    • (1995) Cell , vol.82 , pp. 405-414
    • Bose, R.1    Verheij, M.2    Haimovitz-Friedman, A.3    Scotto, K.4    Kolesnick, R.N.5
  • 10
    • 0030712182 scopus 로고    scopus 로고
    • The protein kinase C activators phorbol diesters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin
    • Mansat V, Laurent G, Levade T, Bettaib A, Jaffrezou J-P: The protein kinase C activators phorbol diesters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin. Cancer Res 1997, 57:5300-5304.
    • (1997) Cancer Res , vol.57 , pp. 5300-5304
    • Mansat, V.1    Laurent, G.2    Levade, T.3    Bettaib, A.4    Jaffrezou, J.-P.5
  • 11
    • 0027197994 scopus 로고
    • Substrate recognition by ceramide-activated protein kinase: Evidence that kinase activity is proline-directed
    • Joseph CK, Byun HS, Bittman R, Kolesnick RN: Substrate recognition by ceramide-activated protein kinase: evidence that kinase activity is proline-directed. J Biol Chem 1993, 268:20002-20006.
    • (1993) J Biol Chem , vol.268 , pp. 20002-20006
    • Joseph, C.K.1    Byun, H.S.2    Bittman, R.3    Kolesnick, R.N.4
  • 12
    • 0027968517 scopus 로고
    • Renaturation and TNFα stimulation of a 97-KDa ceramide-activated protein kinase
    • Liu J, Mathias S, Yang Z, Kolesnick RN: Renaturation and TNFα stimulation of a 97-KDa ceramide-activated protein kinase. J Biol Chem 1994, 269:3047-3052.
    • (1994) J Biol Chem , vol.269 , pp. 3047-3052
    • Liu, J.1    Mathias, S.2    Yang, Z.3    Kolesnick, R.N.4
  • 13
    • 0027461121 scopus 로고
    • Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1β
    • Mathias S, Younes A, Kan C-C, Orlow I, Joseph C, and Kolesnick RN: Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1β. Science 1993, 259:519-522.
    • (1993) Science , vol.259 , pp. 519-522
    • Mathias, S.1    Younes, A.2    Kan, C.-C.3    Orlow, I.4    Joseph, C.5    Kolesnick, R.N.6
  • 14
    • 0343742670 scopus 로고    scopus 로고
    • Kinase suppressor of ras is ceramide-activated protein kinase
    • Zhang Y, Yao B, Delikat S, Bayoumy S, Lin X-H, Basu S, et al.: Kinase suppressor of ras is ceramide-activated protein kinase. Cell 89:63-72, 1997.
    • (1997) Cell , vol.89 , pp. 63-72
    • Zhang, Y.1    Yao, B.2    Delikat, S.3    Bayoumy, S.4    Lin, X.-H.5    Basu, S.6
  • 15
    • 0026723048 scopus 로고
    • Ceramide stimulates a cytosolic protein phosphatase
    • Dobrowsky RT, Hannun YA: Ceramide stimulates a cytosolic protein phosphatase. J Biol Chem 1992, 267:5048-5051.
    • (1992) J Biol Chem , vol.267 , pp. 5048-5051
    • Dobrowsky, R.T.1    Hannun, Y.A.2
  • 17
    • 0028122397 scopus 로고
    • Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction
    • Wolff RA, Dobrowsky TR, Bielawska A, Hannun YA: Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J Biol Chem 1994, 269:19605-19609.
    • (1994) J Biol Chem , vol.269 , pp. 19605-19609
    • Wolff, R.A.1    Dobrowsky, T.R.2    Bielawska, A.3    Hannun, Y.A.4
  • 20
    • 0029003788 scopus 로고
    • Protein kinase C-ζ is a molecular switch in signal transduction of TNFα, bifunctionally regulated by ceramide and arachidonic acid
    • Muller G, Ayoub M, Storz P, Rennecke J, Fabbro P, Pfizenmaier K: Protein kinase C-ζ is a molecular switch in signal transduction of TNFα, bifunctionally regulated by ceramide and arachidonic acid. EMBO J 1995, 14:1961-1969.
    • (1995) EMBO J , vol.14 , pp. 1961-1969
    • Muller, G.1    Ayoub, M.2    Storz, P.3    Rennecke, J.4    Fabbro, P.5    Pfizenmaier, K.6
  • 21
    • 0028277981 scopus 로고
    • Direct stimulation of vav guanine nucleotide exchange activity for ras by phorbol diesters and diglyceride
    • Gulbins E, Coggeshall M, Baier G, Telford D, Langtet C, Baier-Bitterlich G, et al.: Direct stimulation of vav guanine nucleotide exchange activity for ras by phorbol diesters and diglyceride. Mol Cell Biol 1994, 14:4749-4758.
    • (1994) Mol Cell Biol , vol.14 , pp. 4749-4758
    • Gulbins, E.1    Coggeshall, M.2    Baier, G.3    Telford, D.4    Langtet, C.5    Baier-Bitterlich, G.6
  • 23
    • 0347537940 scopus 로고    scopus 로고
    • Requirement for ceramide-initiated stress-activated protein kinase/c-Jun aminoterminal kinase (SAPK/JNK) signalling in stress-induced apoptosis
    • Verheij M, Bose R, Lin X-H, Yao B, Jarvis WD, Grant S, et al.: Requirement for ceramide-initiated stress-activated protein kinase/c-Jun aminoterminal kinase (SAPK/JNK) signalling in stress-induced apoptosis. Nature 1996, 380:75-79. This study demonstrates the essential involvement of SAPK-AP1 signaling in the cytotoxicity of ceramide and ceramide-dependent lethal stimuli.
    • (1996) Nature , vol.380 , pp. 75-79
    • Verheij, M.1    Bose, R.2    Lin, X.-H.3    Yao, B.4    Jarvis, W.D.5    Grant, S.6
  • 24
    • 0028846952 scopus 로고
    • Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells
    • Sawai H, Okazaki T, Yamamoto H, Okano H, Takeda Y, Tashima M. et al.: Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells. J Biol Chem 1995, 270:27326-27331.
    • (1995) J Biol Chem , vol.270 , pp. 27326-27331
    • Sawai, H.1    Okazaki, T.2    Yamamoto, H.3    Okano, H.4    Takeda, Y.5    Tashima, M.6
  • 25
    • 0031439924 scopus 로고    scopus 로고
    • Coordinate regulation of stress-activated protein kinase (SAPK) and mitogen-activated protein kinase (MAPK) cascades in the apoptotic actions of ceramide and sphingosine in human myeloid leukemia cells
    • Jarvis WD, Fornari FA, Auer KL, Freemerman AJ, Szabo E, Birrer MJ, et al.: Coordinate regulation of stress-activated protein kinase (SAPK) and mitogen-activated protein kinase (MAPK) cascades in the apoptotic actions of ceramide and sphingosine in human myeloid leukemia cells. Mol Pharmacol 1997, 52:935-947.
    • (1997) Mol Pharmacol , vol.52 , pp. 935-947
    • Jarvis, W.D.1    Fornari, F.A.2    Auer, K.L.3    Freemerman, A.J.4    Szabo, E.5    Birrer, M.J.6
  • 27
    • 0029922118 scopus 로고    scopus 로고
    • Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells
    • Jarvis WD, Fornari FA, Traylor RS, Martin HA, Kramer LB, Erukulla RK, et al.: Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells. J Biol Chem 1996, 271:8275-8284.
    • (1996) J Biol Chem , vol.271 , pp. 8275-8284
    • Jarvis, W.D.1    Fornari, F.A.2    Traylor, R.S.3    Martin, H.A.4    Kramer, L.B.5    Erukulla, R.K.6
  • 28
    • 0028880006 scopus 로고
    • Opposing effects of ERK, JNK, and RK kinases on apoptosis
    • Xia Z, Dickens M, Raingeaud J, David RJ, Greenberg ME. Opposing effects of ERK, JNK, and RK kinases on apoptosis. Science 1995, 270:1326-1331. This paper demonstrates that cell survival is determined by changes in the balance between MAPK and SAPK signaling.
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    David, R.J.4    Greenberg, M.E.5
  • 29
    • 0030011128 scopus 로고    scopus 로고
    • Uncoupling of S-phase and mitosis induced by anticancer agents lacking p21
    • Waldman T, Langauer C, Keazler KW, Vogelstein B: Uncoupling of S-phase and mitosis induced by anticancer agents lacking p21. Nature 1996, 381:713-716.
    • (1996) Nature , vol.381 , pp. 713-716
    • Waldman, T.1    Langauer, C.2    Keazler, K.W.3    Vogelstein, B.4
  • 30
    • 0032054738 scopus 로고    scopus 로고
    • Overexpressed WAF1/Cip1 renders glioblastoma cells resistant to chemotherapy agents 1,3-bis(2-chloroethyl)-1-nitroso-urea and cisplatin
    • Ruan S, Fatih M, Ren J-P, Chiao P, Andreef M, Levin V, Zhang W: Overexpressed WAF1/Cip1 renders glioblastoma cells resistant to chemotherapy agents 1,3-bis(2-chloroethyl)-1-nitroso-urea and cisplatin. Cancer Res 1998, 58:1538-1543.
    • (1998) Cancer Res , vol.58 , pp. 1538-1543
    • Ruan, S.1    Fatih, M.2    Ren, J.-P.3    Chiao, P.4    Andreef, M.5    Levin, V.6    Zhang, W.7
  • 31
    • 0029858387 scopus 로고    scopus 로고
    • TNF and cancer therapy-induced apoptosis: Potentiation by inhibition of NFκB
    • Wang C-Y, Mayo MW, Baldwin AS: TNF and cancer therapy-induced apoptosis: potentiation by inhibition of NFκB. Science 1996, 274:784-787.
    • (1996) Science , vol.274 , pp. 784-787
    • Wang, C.-Y.1    Mayo, M.W.2    Baldwin, A.S.3
  • 33
    • 1842330849 scopus 로고    scopus 로고
    • Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species: Role of mitochondrial glutathione
    • Garcia-Ruiz C, Collel A, Mari M, Morales A, Fernandez-Checa JC: Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species: role of mitochondrial glutathione. J Biol Chem 1997, 272:11369-11377.
    • (1997) J Biol Chem , vol.272 , pp. 11369-11377
    • Garcia-Ruiz, C.1    Collel, A.2    Mari, M.3    Morales, A.4    Fernandez-Checa, J.C.5
  • 34
    • 0031005956 scopus 로고    scopus 로고
    • Ceramide induces hepatocyte cell death through disruption of mitochondrial function in the rat
    • Arora AS, Jones BJ, Patel TC, Bronk SF, Goreo GS: Ceramide induces hepatocyte cell death through disruption of mitochondrial function in the rat. Hepatology 1997, 25:958-963.
    • (1997) Hepatology , vol.25 , pp. 958-963
    • Arora, A.S.1    Jones, B.J.2    Patel, T.C.3    Bronk, S.F.4    Goreo, G.S.5
  • 36
  • 37
    • 0030696598 scopus 로고    scopus 로고
    • Differential inhibition of radiation-induced apoptosis
    • Haimovitz-Friedman A, Kolesnick RN, Fuks Z: Differential inhibition of radiation-induced apoptosis. Stem Cells 1997, 15:43-47.
    • (1997) Stem Cells , vol.15 , pp. 43-47
    • Haimovitz-Friedman, A.1    Kolesnick, R.N.2    Fuks, Z.3
  • 39
    • 0030041536 scopus 로고    scopus 로고
    • Persistent activation of Jun N-terminal kinase (JNK) in γ-irradiation-induced apoptosis
    • Chen YR, Meyer CF, Tan TH: Persistent activation of Jun N-terminal kinase (JNK) in γ-irradiation-induced apoptosis. J Biol Chem 1996, 271:631-634.
    • (1996) J Biol Chem , vol.271 , pp. 631-634
    • Chen, Y.R.1    Meyer, C.F.2    Tan, T.H.3
  • 41
    • 0028793693 scopus 로고
    • Effects of ionizing radiation on AP1-binding activity by drug-sensitive and multidrug-resistant cells
    • Lee YJ, Galoforo SS, Berns CM, Erdos G, Gupta AK, Ways DK, Lorry PM: Effects of ionizing radiation on AP1-binding activity by drug-sensitive and multidrug-resistant cells. J Biol Chem 1995, 270:28790-28796.
    • (1995) J Biol Chem , vol.270 , pp. 28790-28796
    • Lee, Y.J.1    Galoforo, S.S.2    Berns, C.M.3    Erdos, G.4    Gupta, A.K.5    Ways, D.K.6    Lorry, P.M.7
  • 42
    • 0028238298 scopus 로고
    • Basic fibroblastic growth factor protects endothelial cells from programmed cell death in vitro and in vivo
    • Fuks Z, Persaud RS, Alfieri A, McLoughlin M, Ehleiter D, Schwartz HL, et al.: Basic fibroblastic growth factor protects endothelial cells from programmed cell death in vitro and in vivo. Cancer Res 1994, 54:2582-2590.
    • (1994) Cancer Res , vol.54 , pp. 2582-2590
    • Fuks, Z.1    Persaud, R.S.2    Alfieri, A.3    McLoughlin, M.4    Ehleiter, D.5    Schwartz, H.L.6
  • 44
    • 0030815108 scopus 로고    scopus 로고
    • Decreasing the apoptotic threshold of tumor cells through protein kinase C and sphingomyelinase activation increases tumor killing by ionizing radiation
    • Chmura SJ, Mauceri HJ, Advani S, Heimann R, Beckett MA, Nodzenski E, et al.: Decreasing the apoptotic threshold of tumor cells through protein kinase C and sphingomyelinase activation increases tumor killing by ionizing radiation. Cancer Res 1997, 57:4340-4347.
    • (1997) Cancer Res , vol.57 , pp. 4340-4347
    • Chmura, S.J.1    Mauceri, H.J.2    Advani, S.3    Heimann, R.4    Beckett, M.A.5    Nodzenski, E.6
  • 45
    • 0030769389 scopus 로고    scopus 로고
    • Resistance to radiation-induced apoptosis in Burkitt's lymphoma is associated with defective ceramide signaling
    • Michael JM, Lavin MF, Watters DJ: Resistance to radiation-induced apoptosis in Burkitt's lymphoma is associated with defective ceramide signaling. Cancer Res 1997, 57:3600-3605.
    • (1997) Cancer Res , vol.57 , pp. 3600-3605
    • Michael, J.M.1    Lavin, M.F.2    Watters, D.J.3
  • 46
    • 0031851003 scopus 로고    scopus 로고
    • Lack of ceramide generation in TF-1 human myeloid leukemia cells resistant to ionizing radiation
    • Bruno AP, Laurent G, Averbeck D, Demur C, Bonnet J, Bettaib A, et al.: Lack of ceramide generation in TF-1 human myeloid leukemia cells resistant to ionizing radiation. Cell Death Differ 1998, 5:173-182.
    • (1998) Cell Death Differ , vol.5 , pp. 173-182
    • Bruno, A.P.1    Laurent, G.2    Averbeck, D.3    Demur, C.4    Bonnet, J.5    Bettaib, A.6
  • 47
    • 16044364385 scopus 로고    scopus 로고
    • Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
    • Santana P, Pena LA, Haimovitz-Friedman A, Martin S, Green D, McLoughlin M, et al.: Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell 1996, 86:189-199. This report provides direct evidence of a functional involvement of acidic sphingomyelinase in radiation-related cell death.
    • (1996) Cell , vol.86 , pp. 189-199
    • Santana, P.1    Pena, L.A.2    Haimovitz-Friedman, A.3    Martin, S.4    Green, D.5    McLoughlin, M.6
  • 48
    • 0031468368 scopus 로고    scopus 로고
    • Anthracyclines in hematology: Preclinical studies, toxicity, and delivery systems
    • Richardson DS, Johnson SA: Anthracyclines in hematology: preclinical studies, toxicity, and delivery systems. Blood Rev 1997, 11:201-223.
    • (1997) Blood Rev , vol.11 , pp. 201-223
    • Richardson, D.S.1    Johnson, S.A.2
  • 49
    • 1842376234 scopus 로고    scopus 로고
    • Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin
    • Mansat V, Bettaib A, Levade T, Laurent G, Jaffrezou JP: Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin. FASEB J 1997, 11:695-702.
    • (1997) FASEB J , vol.11 , pp. 695-702
    • Mansat, V.1    Bettaib, A.2    Levade, T.3    Laurent, G.4    Jaffrezou, J.P.5
  • 50
    • 0030983329 scopus 로고    scopus 로고
    • Influence of Bcl-2 overexpression on the ceramide pathway in daunorubicin-induced apoptosis of leukemic cells
    • Allouche M, Bettaieb A, Vindis C, Rousse A, Gringon C, Laurent G: Influence of Bcl-2 overexpression on the ceramide pathway in daunorubicin-induced apoptosis of leukemic cells. Oncogene 1997, 14:1837-1845.
    • (1997) Oncogene , vol.14 , pp. 1837-1845
    • Allouche, M.1    Bettaieb, A.2    Vindis, C.3    Rousse, A.4    Gringon, C.5    Laurent, G.6
  • 51
    • 0030445804 scopus 로고    scopus 로고
    • Induction of apoptotic cell death in hen granulosa cells by ceramide
    • Witty JP, Bridgham JT, Johnson AL: Induction of apoptotic cell death in hen granulosa cells by ceramide. Endocrinology 1996, 137:5269-5272.
    • (1996) Endocrinology , vol.137 , pp. 5269-5272
    • Witty, J.P.1    Bridgham, J.T.2    Johnson, A.L.3
  • 53
    • 0026498122 scopus 로고
    • Modulation of subcellular distribution of doxorubicin in multidrug-resistant p388 leukemia cells by the chemosensitizer ((2-isopropyl-1-(4-[3-N-methyl-N-(3,4-dimethoxyphenyl)amino]propyloxy)- benzenesulfonyl))indolizine
    • Jaffrezou J-P, Levade T, Chatelain P, Laurent G: Modulation of subcellular distribution of doxorubicin in multidrug-resistant p388 leukemia cells by the chemosensitizer ((2-isopropyl-1-(4-[3-N-methyl-N-(3,4-dimethoxyphenyl)amino]propyloxy)- benzenesulfonyl))indolizine. Cancer Res 1992, 52:6440-6446.
    • (1992) Cancer Res , vol.52 , pp. 6440-6446
    • Jaffrezou, J.-P.1    Levade, T.2    Chatelain, P.3    Laurent, G.4
  • 55
    • 0031872523 scopus 로고    scopus 로고
    • Commitment to cell death measured by loss of clonogenicity is separable from the appearance of apoptotic markers
    • Brunet CL, Gunby RH, Benson RSP, Hickman JA, Watson AJM, Brady C: Commitment to cell death measured by loss of clonogenicity is separable from the appearance of apoptotic markers. Cell Death Differ 1998, 5:107-115.
    • (1998) Cell Death Differ , vol.5 , pp. 107-115
    • Brunet, C.L.1    Gunby, R.H.2    Benson, R.S.P.3    Hickman, J.A.4    Watson, A.J.M.5    Brady, C.6
  • 56
    • 0031972535 scopus 로고    scopus 로고
    • 1-[β-D-arabinofuranosyl]cytosine: Molecular and cellular pharmacology
    • Grant S: 1-[β-D-arabinofuranosyl]cytosine: molecular and cellular pharmacology. Adv Cancer Res 1997, 72:197-233.
    • (1997) Adv Cancer Res , vol.72 , pp. 197-233
    • Grant, S.1
  • 57
    • 0026638006 scopus 로고
    • 1-[β-D-arabinofuranosyl]cytosine-diphosphate is formed by reversal of cholinephosphotransferase and not via cytidylyltransferase
    • Kucera GL, Capizzi RL: 1-[β-D-arabinofuranosyl]cytosine-diphosphate is formed by reversal of cholinephosphotransferase and not via cytidylyltransferase. Cancer Res 1992, 52:3886-3891. This paper illustrates the first direct evidence of diglyceride formation in response to ara-C, providing a possible mechanism for ara C-induced cPKC/nPKC activation.
    • (1992) Cancer Res , vol.52 , pp. 3886-3891
    • Kucera, G.L.1    Capizzi, R.L.2
  • 58
    • 0028176730 scopus 로고
    • 1-[β-D-arabinofuranosyl]cytosine stimulates ceramide and diglyceride formation in HL-60 cells
    • Strum, JL, Small GW, Pauig SB, Daniel LW: 1-[β-D-arabinofuranosyl]cytosine stimulates ceramide and diglyceride formation in HL-60 cells. J Biol Chem 1994, 269:15493-15497. This study demonstrates that ara-C-lethality is associated with generation of both ceramide and diglyceride.
    • (1994) J Biol Chem , vol.269 , pp. 15493-15497
    • Strum, J.L.1    Small, G.W.2    Pauig, S.B.3    Daniel, L.W.4
  • 59
    • 0025867205 scopus 로고
    • Regulation of c-jun expression in HL-60 leukemia cells by 1-[β-D-arabinofuranosyl]cytosine; potential involvement of a protein kinase C mechanism
    • Kharbanda SM, Datta R, Kufe DW: Regulation of c-jun expression in HL-60 leukemia cells by 1-[β-D-arabinofuranosyl]cytosine; potential involvement of a protein kinase C mechanism. Biochemistry 1991, 30:7747-7752.
    • (1991) Biochemistry , vol.30 , pp. 7747-7752
    • Kharbanda, S.M.1    Datta, R.2    Kufe, D.W.3
  • 60
    • 0027943488 scopus 로고
    • Deoxycytidine kinase in phosphorylated in vitro and in vivo by protein kinase C
    • Wang LM, Kucera GL: Deoxycytidine kinase in phosphorylated in vitro and in vivo by protein kinase C. Biochim Biophys Acta 1994, 1224:161-167.
    • (1994) Biochim Biophys Acta , vol.1224 , pp. 161-167
    • Wang, L.M.1    Kucera, G.L.2
  • 61
    • 0030612643 scopus 로고    scopus 로고
    • 11 activation by 1-[β-D-arabinofuranosyl]-cytosine is antagonistic to stimulation of apoptosis and Bcl-2 down-regulation
    • 11 activation by 1-[β-D-arabinofuranosyl]-cytosine is antagonistic to stimulation of apoptosis and Bcl-2 down-regulation. J Biol Chem 1997, 272:23481-23484.
    • (1997) J Biol Chem , vol.272 , pp. 23481-23484
    • Whitman, S.P.1    Civoli, F.2    Daniel, L.W.3
  • 62
    • 0028167697 scopus 로고
    • 1-[β-D-arabinofuranosyl]cytosine activates serine/threonine protein kinases and c-jun gene expression in phorbol diester-resistant myeloid leukemia cells
    • Kharbanda SM, Emoto Y, Kiasaki H, Saleem A, Kufe DW: 1-[β-D-arabinofuranosyl]cytosine activates serine/threonine protein kinases and c-jun gene expression in phorbol diester-resistant myeloid leukemia cells. Mol Pharmacol 1994, 46:67-72.
    • (1994) Mol Pharmacol , vol.46 , pp. 67-72
    • Kharbanda, S.M.1    Emoto, Y.2    Kiasaki, H.3    Saleem, A.4    Kufe, D.W.5
  • 63
    • 0028865539 scopus 로고
    • Involvement of stress-activated protein kinase in the cellular response to 1-[β-D-arabinofuranosyl]cytosine and other DNA-damaging agents
    • Saleem A, Datta R, Yuan Z-M, Kharbanda SM, Kufe DW: Involvement of stress-activated protein kinase in the cellular response to 1-[β-D-arabinofuranosyl]cytosine and other DNA-damaging agents. Cell Growth Differ 1995, 6:1651-1658.
    • (1995) Cell Growth Differ , vol.6 , pp. 1651-1658
    • Saleem, A.1    Datta, R.2    Yuan, Z.-M.3    Kharbanda, S.M.4    Kufe, D.W.5
  • 64
    • 0025000649 scopus 로고
    • Transcriptional regulation of c-jun gene expression by 1-[β-D-arabinofuranosyl]cytosine in human myeloid leukemia cells
    • Kharbanda SM, Sherman MC, Kufe DW: Transcriptional regulation of c-jun gene expression by 1-[β-D-arabinofuranosyl]cytosine in human myeloid leukemia cells. J Clin Invest 1990, 86:1517-1523.
    • (1990) J Clin Invest , vol.86 , pp. 1517-1523
    • Kharbanda, S.M.1    Sherman, M.C.2    Kufe, D.W.3
  • 65
    • 0026593111 scopus 로고
    • Activation of the AP-1 transcription factor by 1-[β-D-arabinofuranosyl]cytosine in myeloid leukemia cells
    • Brach, MA, Herrmann F, Kufe DW: Activation of the AP-1 transcription factor by 1-[β-D-arabinofuranosyl]cytosine in myeloid leukemia cells. Blood 1992, 79:728-734.
    • (1992) Blood , vol.79 , pp. 728-734
    • Brach, M.A.1    Herrmann, F.2    Kufe, D.W.3
  • 66
    • 0028928295 scopus 로고
    • Suppression of bcl2 mRNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor-α, and ceramide
    • Chen M, Quintans J, Fuks Z, Thompson Z, Kufe DW, Weichselbaum RR: Suppression of bcl2 mRNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor-α, and ceramide. Cancer Res 1995, 55:991-994.
    • (1995) Cancer Res , vol.55 , pp. 991-994
    • Chen, M.1    Quintans, J.2    Fuks, Z.3    Thompson, Z.4    Kufe, D.W.5    Weichselbaum, R.R.6
  • 68
    • 0029802369 scopus 로고    scopus 로고
    • Effect of 1-[β-D-arabinofuranosyl]cytosine on apoptosis and differentiation n human monoblastic leukemia cells (U937) expressing a c-Jun dominant-negative mutant protein (TAM-67)
    • Grant S, Freemerman AJ, Birrer MJ, Martin HA, Turner AJ, Szabo E, et al.: Effect of 1-[β-D-arabinofuranosyl]cytosine on apoptosis and differentiation n human monoblastic leukemia cells (U937) expressing a c-Jun dominant-negative mutant protein (TAM-67). Cell Growth Differ 1996, 7:603-613.
    • (1996) Cell Growth Differ , vol.7 , pp. 603-613
    • Grant, S.1    Freemerman, A.J.2    Birrer, M.J.3    Martin, H.A.4    Turner, A.J.5    Szabo, E.6
  • 69
    • 0026773819 scopus 로고
    • Modulation of cell growth and differentiation by ceramide
    • Bielawska A, Linardic CM, Hannun YA: Modulation of cell growth and differentiation by ceramide. FEBS Lett 1992, 307:211-214.
    • (1992) FEBS Lett , vol.307 , pp. 211-214
    • Bielawska, A.1    Linardic, C.M.2    Hannun, Y.A.3
  • 71
    • 0032081313 scopus 로고    scopus 로고
    • 2+-independent sphingomyelinase activities precede commitment to apoptosis and are not a consequence of caspase-3-like activity in Molt-4 cells in response to the thymidylate synthase inhibitor GW1843
    • 2+-independent sphingomyelinase activities precede commitment to apoptosis and are not a consequence of caspase-3-like activity in Molt-4 cells in response to the thymidylate synthase inhibitor GW1843. Blood 1998, 91:4350-4360.
    • (1998) Blood , vol.91 , pp. 4350-4360
    • Laethem, R.M.1    Hannun, Y.A.2    Jayadev, S.3    Sexton, C.J.4    Strum, J.C.5    Sundseth, R.6    Smith, G.K.7
  • 72
    • 0030948694 scopus 로고    scopus 로고
    • Ceramide generation in response to photodynamic treatment of L5178Y mouse lymphoma cells
    • Separovic D, He J, Oleinick NL: Ceramide generation in response to photodynamic treatment of L5178Y mouse lymphoma cells. Cancer Res 1997, 57:1717-1721.
    • (1997) Cancer Res , vol.57 , pp. 1717-1721
    • Separovic, D.1    He, J.2    Oleinick, N.L.3
  • 73
    • 0030715241 scopus 로고    scopus 로고
    • Role of ceramide in suramin-induced cancer cell death
    • Gill JS, Windebank AJ: Role of ceramide in suramin-induced cancer cell death. Cancer Lett 1997, 119:169-176.
    • (1997) Cancer Lett , vol.119 , pp. 169-176
    • Gill, J.S.1    Windebank, A.J.2
  • 74
    • 17544402409 scopus 로고    scopus 로고
    • Sequential operation of ceramide synthesis and ICE cascade in CPT-11-initiated apoptotic death signaling
    • Suzuki A, Iwasaki M, Kato M, Wagai N: Sequential operation of ceramide synthesis and ICE cascade in CPT-11-initiated apoptotic death signaling. Exp Cell Res 1997, 233:41-47.
    • (1997) Exp Cell Res , vol.233 , pp. 41-47
    • Suzuki, A.1    Iwasaki, M.2    Kato, M.3    Wagai, N.4
  • 75
    • 0028537064 scopus 로고
    • The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation
    • Kolesnick RN, Haimovitz-Friedman A, Fuks Z: The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation. Biochem Cell Biol 1994, 72:471-474.
    • (1994) Biochem Cell Biol , vol.72 , pp. 471-474
    • Kolesnick, R.N.1    Haimovitz-Friedman, A.2    Fuks, Z.3
  • 76
    • 0028670374 scopus 로고
    • Fas antigen and sphingomyelin/ceramide turnover-mediated signaling: Role in life and death of lymphocytes
    • Gill BM, Nishikata H, Chan G, Delovitch TL, Ochi A: Fas antigen and sphingomyelin/ceramide turnover-mediated signaling: role in life and death of lymphocytes. Immunol Rev 1994, 142:113-125.
    • (1994) Immunol Rev , vol.142 , pp. 113-125
    • Gill, B.M.1    Nishikata, H.2    Chan, G.3    Delovitch, T.L.4    Ochi, A.5
  • 79
    • 0028095477 scopus 로고
    • Apoptotic signaling through (CD95) Fas/APO1 activates an acidic sphingomyelinase
    • Cifone MG, De Maria R, Roncaioli P, Rippo MR, Azuma M, Lanier LL, et al.: Apoptotic signaling through (CD95) Fas/APO1 activates an acidic sphingomyelinase. J Exp Med 1994, 180:1547-1552.
    • (1994) J Exp Med , vol.180 , pp. 1547-1552
    • Cifone, M.G.1    De Maria, R.2    Roncaioli, P.3    Rippo, M.R.4    Azuma, M.5    Lanier, L.L.6
  • 80
    • 0028790239 scopus 로고
    • Multiple pathways originate at the Fas/APO1 (CD95) receptor: Sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal
    • Cifone MG, Roncaioli P, De Maria R, Camarda G, Santoni A, Ruberti G, Testi R: Multiple pathways originate at the Fas/APO1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal. EMBO J 1995, 14:5859-5868.
    • (1995) EMBO J , vol.14 , pp. 5859-5868
    • Cifone, M.G.1    Roncaioli, P.2    De Maria, R.3    Camarda, G.4    Santoni, A.5    Ruberti, G.6    Testi, R.7
  • 81
    • 0030948224 scopus 로고    scopus 로고
    • Influence of I-carnitine on CD95 crosslinking-induced apoptosis and ceramide generation in human cell lines: Correlation with effects on purified acidic and neutral sphingomyelinases in vitro
    • Di Marzio L, Alesse F, Roncaioli P, Muzi P, Moretti S, Marcellini S, et al.: Influence of I-carnitine on CD95 crosslinking-induced apoptosis and ceramide generation in human cell lines: correlation with effects on purified acidic and neutral sphingomyelinases in vitro. Proc Assoc Am Physicians 1997, 109:154-163.
    • (1997) Proc Assoc Am Physicians , vol.109 , pp. 154-163
    • Di Marzio, L.1    Alesse, F.2    Roncaioli, P.3    Muzi, P.4    Moretti, S.5    Marcellini, S.6
  • 82
    • 0032536876 scopus 로고    scopus 로고
    • Acidic sphingomyelinase is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells
    • De Maria R, Rippo MR, Schuchman EH, Testi R: Acidic sphingomyelinase is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells. J Exp Med 1998, 187:897-902.
    • (1998) J Exp Med , vol.187 , pp. 897-902
    • De Maria, R.1    Rippo, M.R.2    Schuchman, E.H.3    Testi, R.4
  • 83
    • 0029965928 scopus 로고    scopus 로고
    • Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24-kDa apoptotic protease AP24
    • Wright SC, Zhend H, Zhong J: Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24-kDa apoptotic protease AP24. FASEB J 1996, 10:325-332.
    • (1996) FASEB J , vol.10 , pp. 325-332
    • Wright, S.C.1    Zhend, H.2    Zhong, J.3
  • 84
    • 0031779350 scopus 로고    scopus 로고
    • Distinct adaptor proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor
    • Adam-Klages S, Schwander R, Adam D, Kreder D, Bernado K, Kronke M: Distinct adaptor proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor. J Leukoc Biol 1998, 63:678-682.
    • (1998) J Leukoc Biol , vol.63 , pp. 678-682
    • Adam-Klages, S.1    Schwander, R.2    Adam, D.3    Kreder, D.4    Bernado, K.5    Kronke, M.6
  • 86
  • 87
    • 10244219861 scopus 로고    scopus 로고
    • Fas-induced apoptosis is mediated by activation of a ras and rac protein-regulated signaling pathway
    • Gulbins E, Coggeshall KM, Brenner B, Schlottman K, Linderkamp O, Lang F: Fas-induced apoptosis is mediated by activation of a ras and rac protein-regulated signaling pathway. J Biol Chem 1996, 271:26389-26394.
    • (1996) J Biol Chem , vol.271 , pp. 26389-26394
    • Gulbins, E.1    Coggeshall, K.M.2    Brenner, B.3    Schlottman, K.4    Linderkamp, O.5    Lang, F.6
  • 88
    • 0030803278 scopus 로고    scopus 로고
    • Fas- or ceramide-induced apoptosis is mediated by rac1-regulated activation of Jun N-terminal kinase/p38 kinases and CADD153
    • Brenner B, Koppenhoefer U, Weinstock C, Linderkamp O, Land F, Gulbins E: Fas-or ceramide-induced apoptosis is mediated by rac1-regulated activation of Jun N-terminal kinase/p38 kinases and CADD153. J Biol Chem 1997, 272:22173-22181.
    • (1997) J Biol Chem , vol.272 , pp. 22173-22181
    • Brenner, B.1    Koppenhoefer, U.2    Weinstock, C.3    Linderkamp, O.4    Land, F.5    Gulbins, E.6
  • 90
    • 0030785790 scopus 로고    scopus 로고
    • The central executioner of apoptosis: Multiple connections between protease activation and mitochondria in Fas/APO1/CD95- and ceramide-induced apoptosis
    • Susin SA, Zamzami N, Castedo M, Daugas E, Wang HG, Geley S, et al.: The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO1/CD95- and ceramide-induced apoptosis. J Exp Med 1997, 186:25-37.
    • (1997) J Exp Med , vol.186 , pp. 25-37
    • Susin, S.A.1    Zamzami, N.2    Castedo, M.3    Daugas, E.4    Wang, H.G.5    Geley, S.6
  • 91
    • 0030774818 scopus 로고    scopus 로고
    • CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3/CPP32β inhibition
    • Tepper AD, Cock JG, de Vries E, Borst J, van Blitterswijk WJ: CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3/CPP32β inhibition. J Biol Chem 1997, 272:24308-24312.
    • (1997) J Biol Chem , vol.272 , pp. 24308-24312
    • Tepper, A.D.1    Cock, J.G.2    De Vries, E.3    Borst, J.4    Van Blitterswijk, W.J.5
  • 92
    • 0032571251 scopus 로고
    • CD95 (Fas/APO1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase
    • Cock JG, Tepper AD, de Vries E, van Blitterswijk WJ, Borst J: CD95 (Fas/APO1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase. J Biol Chem 1988, 273:7560-7565.
    • (1988) J Biol Chem , vol.273 , pp. 7560-7565
    • Cock, J.G.1    Tepper, A.D.2    De Vries, E.3    Van Blitterswijk, W.J.4    Borst, J.5
  • 93
    • 0031007242 scopus 로고    scopus 로고
    • Evidence against an early signaling role for ceramide in Fas-mediated apoptosis
    • Sillence DJ, Allan D: Evidence against an early signaling role for ceramide in Fas-mediated apoptosis. Biochem J 1997, 324:29-32.
    • (1997) Biochem J , vol.324 , pp. 29-32
    • Sillence, D.J.1    Allan, D.2
  • 96
    • 0030038488 scopus 로고    scopus 로고
    • Fas ligation induces apoptosis and Jnu kinase activation independently of CD45 and Lck in human T cells
    • Latinis KM, Koretzky GA: Fas ligation induces apoptosis and Jnu kinase activation independently of CD45 and Lck in human T cells. Blood 1996, 87:781-875.
    • (1996) Blood , vol.87 , pp. 781-875
    • Latinis, K.M.1    Koretzky, G.A.2
  • 97
    • 0029026548 scopus 로고
    • FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
    • Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM: FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 1995, 81:505-512.
    • (1995) Cell , vol.81 , pp. 505-512
    • Chinnaiyan, A.M.1    O'Rourke, K.2    Tewari, M.3    Dixit, V.M.4
  • 98
    • 15844412409 scopus 로고    scopus 로고
    • FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO1) death-inducing signaling complex
    • Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, et al.: FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO1) death-inducing signaling complex. Cell 1996, 85:817-827.
    • (1996) Cell , vol.85 , pp. 817-827
    • Muzio, M.1    Chinnaiyan, A.M.2    Kischkel, F.C.3    O'Rourke, K.4    Shevchenko, A.5    Ni, J.6
  • 100
    • 15144349717 scopus 로고    scopus 로고
    • Cytochrome c-dependent and -independent induction of apoptosis of apoptosis in multiple myeloma cells
    • Chauhan D, Pandey P, Ogata A, Teoh G, Krett N, Halgren R, et al.: Cytochrome c-dependent and -independent induction of apoptosis of apoptosis in multiple myeloma cells. J Biol Chem 1997, 272:29995-29997.
    • (1997) J Biol Chem , vol.272 , pp. 29995-29997
    • Chauhan, D.1    Pandey, P.2    Ogata, A.3    Teoh, G.4    Krett, N.5    Halgren, R.6
  • 101
    • 0030597935 scopus 로고    scopus 로고
    • CPP-32β inhibition prevents Fas-induced ceramide generation and apoptosis in human cells
    • Gamen S, Marzo I, Anel A, Pineiro A, Naval J: CPP-32β inhibition prevents Fas-induced ceramide generation and apoptosis in human cells. FEBS Lett 1996, 390:232-237.
    • (1996) FEBS Lett , vol.390 , pp. 232-237
    • Gamen, S.1    Marzo, I.2    Anel, A.3    Pineiro, A.4    Naval, J.5
  • 102
    • 0032570595 scopus 로고    scopus 로고
    • Caspase-dependent ceramide production in Fas- and HLA class I-mediated peripheral T cell apoptosis
    • Genestier L, Prigent AF, Paillot R, Quemeneur L, Durand J, Banchereau J, et al.: Caspase-dependent ceramide production in Fas- and HLA class I-mediated peripheral T cell apoptosis. J Biol Chem 1998, 273:5060-5066.
    • (1998) J Biol Chem , vol.273 , pp. 5060-5066
    • Genestier, L.1    Prigent, A.F.2    Paillot, R.3    Quemeneur, L.4    Durand, J.5    Banchereau, J.6
  • 103
    • 0029935682 scopus 로고    scopus 로고
    • Involvement of the CD95 (APO-1/Fas) receptor ligand system in drug-induced apoptosis in leukemia cells
    • Friesen C, Herr I, Krammer PH, Debatin KM: Involvement of the CD95 (APO-1/Fas) receptor ligand system in drug-induced apoptosis in leukemia cells. Nature Med 1996, 2:574-577.
    • (1996) Nature Med , vol.2 , pp. 574-577
    • Friesen, C.1    Herr, I.2    Krammer, P.H.3    Debatin, K.M.4
  • 104
    • 0030656234 scopus 로고    scopus 로고
    • Deficient activation of the CD95 (APO-1/Fas) system in drug-resistant cells
    • Friesen C, Fulda S, Debatin K-M: Deficient activation of the CD95 (APO-1/Fas) system in drug-resistant cells. Leukemia 1997, 11:1833-1841.
    • (1997) Leukemia , vol.11 , pp. 1833-1841
    • Friesen, C.1    Fulda, S.2    Debatin, K.-M.3
  • 105
    • 0030897001 scopus 로고    scopus 로고
    • Selection of drug-resistance results in resistance to Fas-mediated apoptosis
    • Landowski TH, Geason-Guzman MC, Dalton WS: Selection of drug-resistance results in resistance to Fas-mediated apoptosis. Blood 1997, 89:1854-1861.
    • (1997) Blood , vol.89 , pp. 1854-1861
    • Landowski, T.H.1    Geason-Guzman, M.C.2    Dalton, W.S.3
  • 106
    • 0030744833 scopus 로고    scopus 로고
    • Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells
    • Villunger A, Egle A, Kos M, Hartmann BL, Geley S, Kofler R, Greil, R: Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells. Cancer Res 1997, 57:3331-3334.
    • (1997) Cancer Res , vol.57 , pp. 3331-3334
    • Villunger, A.1    Egle, A.2    Kos, M.3    Hartmann, B.L.4    Geley, S.5    Kofler, R.6    Greil, R.7
  • 107
    • 0030806351 scopus 로고    scopus 로고
    • Comparison of apoptosis in wild-type and Fas-resistant cells: Chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions
    • Eischen CM, Kottke TJ, Martins LM, Basi GS, Tung JS, Earnshaw WC, et al.: Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions. Blood 1997, 90:935-943.
    • (1997) Blood , vol.90 , pp. 935-943
    • Eischen, C.M.1    Kottke, T.J.2    Martins, L.M.3    Basi, G.S.4    Tung, J.S.5    Earnshaw, W.C.6
  • 108
    • 0030670626 scopus 로고    scopus 로고
    • Activation of CD95 (APO1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis
    • Herr I, Wilhelm D, Bohler T, Angel P, Debatin K-M: Activation of CD95 (APO1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J 1997, 16:6200-6208. This study proposes the participation of FasR/FasL in cell-killing by antineoplastic agents.
    • (1997) EMBO J , vol.16 , pp. 6200-6208
    • Herr, I.1    Wilhelm, D.2    Bohler, T.3    Angel, P.4    Debatin, K.-M.5


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