메뉴 건너뛰기




Volumn 11, Issue 6, 1999, Pages 689-700

Mapping autoimmunity genes

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN;

EID: 0032725389     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(99)00038-2     Document Type: Review
Times cited : (74)

References (78)
  • 1
    • 0032168750 scopus 로고    scopus 로고
    • New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study
    • A genome-wide linkage study by the European Consortium on Rheumatoid Arthritis Families identified fourteen non-MHC candidate regions, several of which overlap IDDM loci. Extension to 261 nuclear families revealed significant association with a chromosome 3 locus (~16% of the genetic variability) housing genes for CD80 and CD86, molecules involved in antigen-specific T cell activation
    • Cornelis F., Faure S., Martinez M., Prud'homme J.F., Fritz P., Dib C., Alves H., Barrera P., de Vries N., Balsa A. New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study. Proc Natl Acad Sci USA. 95:1998;10746-10750. A genome-wide linkage study by the European Consortium on Rheumatoid Arthritis Families identified fourteen non-MHC candidate regions, several of which overlap IDDM loci. Extension to 261 nuclear families revealed significant association with a chromosome 3 locus (~16% of the genetic variability) housing genes for CD80 and CD86, molecules involved in antigen-specific T cell activation.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 10746-10750
    • Cornelis, F.1    Faure, S.2    Martinez, M.3    Prud'Homme, J.F.4    Fritz, P.5    Dib, C.6    Alves, H.7    Barrera, P.8    De Vries, N.9    Balsa, A.10
  • 2
    • 0031723086 scopus 로고    scopus 로고
    • Familial clustering of rheumatoid arthritis with other autoimmune diseases
    • This is the first use of odds-ratio regression analysis and complex segregation analysis tools to test genetic models for familial aggregation of RA and other autoimmune diseases. A statistically significant occurrence of autoimmune thyroid disease, diabetes, ankylosing spondylitis, myasthenia gravis and rheumatic fever in first-degree relatives of RA patients was shown - suggesting a common, genetically influenced etiology
    • Lin J.P., Cash J.M., Doyle S.Z., Peden S., Kanik K., Amos C.I., Bale S.J., Wilder R.L. Familial clustering of rheumatoid arthritis with other autoimmune diseases. Hum Genet. 103:1998;475-482. This is the first use of odds-ratio regression analysis and complex segregation analysis tools to test genetic models for familial aggregation of RA and other autoimmune diseases. A statistically significant occurrence of autoimmune thyroid disease, diabetes, ankylosing spondylitis, myasthenia gravis and rheumatic fever in first-degree relatives of RA patients was shown - suggesting a common, genetically influenced etiology.
    • (1998) Hum Genet , vol.103 , pp. 475-482
    • Lin, J.P.1    Cash, J.M.2    Doyle, S.Z.3    Peden, S.4    Kanik, K.5    Amos, C.I.6    Bale, S.J.7    Wilder, R.L.8
  • 3
    • 0033003164 scopus 로고    scopus 로고
    • The genetics revolution and the assault on rheumatoid arthritis
    • Seldin M.F., Amos C.I., Ward R., Gregersen P.K. The genetics revolution and the assault on rheumatoid arthritis. Arthritis Rheum. 42:1999;1071-1079.
    • (1999) Arthritis Rheum , vol.42 , pp. 1071-1079
    • Seldin, M.F.1    Amos, C.I.2    Ward, R.3    Gregersen, P.K.4
  • 4
    • 7344223861 scopus 로고    scopus 로고
    • Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity
    • This group reported a definitive linkage of familial MS to the HLA-DR2 allele within the MHC on chromosome 6. HLA-DR2 was estimated to contribute 17-63% of the genetic etiology of MS
    • Haines J.L., Terwedow H.A., Burgess K., Pericak-Vance M.A., Rimmler J.B., Martin E.R., Oksenberg J.R., Lincoln R., Zhang D.Y., Banatao D.R.et al. Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. Hum Mol Genet. 7:1998;1229-1234. This group reported a definitive linkage of familial MS to the HLA-DR2 allele within the MHC on chromosome 6. HLA-DR2 was estimated to contribute 17-63% of the genetic etiology of MS.
    • (1998) Hum Mol Genet , vol.7 , pp. 1229-1234
    • Haines, J.L.1    Terwedow, H.A.2    Burgess, K.3    Pericak-Vance, M.A.4    Rimmler, J.B.5    Martin, E.R.6    Oksenberg, J.R.7    Lincoln, R.8    Zhang, D.Y.9    Banatao, D.R.10
  • 5
    • 0031795197 scopus 로고    scopus 로고
    • Genetics of multiple sclerosis
    • This review of current published data concludes that no one single locus contributes significantly to familial risk for MS with the exception of the HLA-DRB1-1501 DQA*0102 DQB1*0602 haplotype of the MHC
    • Ebers G.C., Dyment D.A. Genetics of multiple sclerosis. Semin Neurol. 18:1998;295-299. This review of current published data concludes that no one single locus contributes significantly to familial risk for MS with the exception of the HLA-DRB1-1501 DQA*0102 DQB1*0602 haplotype of the MHC.
    • (1998) Semin Neurol , vol.18 , pp. 295-299
    • Ebers, G.C.1    Dyment, D.A.2
  • 6
    • 17444436401 scopus 로고    scopus 로고
    • The genetics of multiple sclerosis: Principles, background and updated results of the United Kingdom systematic genome screen
    • This study indicates that MS reflects the cumulative effects of multiple genes with small effects rather than a few genes of major importance. Also, some evidence of genetic subsets that segregate dependent on HLA-DR genotype was found
    • Chataway J., Feakes R., Coraddu F., Gray J., Deans J., Fraser M., Robertson N., Broadley S., Jones H., Clayton D.et al. The genetics of multiple sclerosis: principles, background and updated results of the United Kingdom systematic genome screen. Brain. 121:1998;1869-1887. This study indicates that MS reflects the cumulative effects of multiple genes with small effects rather than a few genes of major importance. Also, some evidence of genetic subsets that segregate dependent on HLA-DR genotype was found.
    • (1998) Brain , vol.121 , pp. 1869-1887
    • Chataway, J.1    Feakes, R.2    Coraddu, F.3    Gray, J.4    Deans, J.5    Fraser, M.6    Robertson, N.7    Broadley, S.8    Jones, H.9    Clayton, D.10
  • 7
    • 0032404079 scopus 로고    scopus 로고
    • Genetic susceptibility factors in type 1 diabetes: Linkage, disequilibrium and functional analyses
    • She J.X., Marron M.P. Genetic susceptibility factors in type 1 diabetes: linkage, disequilibrium and functional analyses. Curr Opin Immunol. 10:1998;682-689.
    • (1998) Curr Opin Immunol , vol.10 , pp. 682-689
    • She, J.X.1    Marron, M.P.2
  • 8
    • 0033082240 scopus 로고    scopus 로고
    • From genome to aetiology in a multifactorial disease, type 1 diabetes
    • Thoughtful review of the genetics and possible causation of type 1 diabetes
    • Todd J.A. From genome to aetiology in a multifactorial disease, type 1 diabetes. Bioessays. 21:1999;164-174. Thoughtful review of the genetics and possible causation of type 1 diabetes.
    • (1999) Bioessays , vol.21 , pp. 164-174
    • Todd, J.A.1
  • 9
    • 0033032379 scopus 로고    scopus 로고
    • Comparative genetics of type 1 diabetes and autoimmune disease: Common loci, common pathways?
    • Comparison of type 1 diabetes loci with candidate loci from other autoimmune/inflammatory disease shows overlap and supports the hypothesis of genetic sharing with SLE, MS and CD
    • Becker K.G. Comparative genetics of type 1 diabetes and autoimmune disease: common loci, common pathways? Diabetes. 48:1999;1353-1358. Comparison of type 1 diabetes loci with candidate loci from other autoimmune/inflammatory disease shows overlap and supports the hypothesis of genetic sharing with SLE, MS and CD.
    • (1999) Diabetes , vol.48 , pp. 1353-1358
    • Becker, K.G.1
  • 12
    • 0031893204 scopus 로고    scopus 로고
    • Genetic susceptibility to systemic lupus erythematosus
    • Comprehensive review of genetic linkage analysis data for both the New Zealand hybrid mouse model of lupus and human SLE
    • Vyse T.J., Kotzin B.L. Genetic susceptibility to systemic lupus erythematosus. Annu Rev Immunol. 16:1998;261-292. Comprehensive review of genetic linkage analysis data for both the New Zealand hybrid mouse model of lupus and human SLE.
    • (1998) Annu Rev Immunol , vol.16 , pp. 261-292
    • Vyse, T.J.1    Kotzin, B.L.2
  • 14
    • 0033563231 scopus 로고    scopus 로고
    • A genome-wide search for linkage to asthma
    • Genome-wide linkage study of affected sib-pairs in 97 families identified four regions (on chromosomes 2, 6, 9 and 12) that are linked to asthma
    • Wjst M., Fischer G., Immervoll T., Jung M., Saar K., Rueschendorf F., Reis A., Ulbrecht M., Gomolka M., Weiss E.H.et al. A genome-wide search for linkage to asthma. Genomics. 58:1999;1-8. Genome-wide linkage study of affected sib-pairs in 97 families identified four regions (on chromosomes 2, 6, 9 and 12) that are linked to asthma.
    • (1999) Genomics , vol.58 , pp. 1-8
    • Wjst, M.1    Fischer, G.2    Immervoll, T.3    Jung, M.4    Saar, K.5    Rueschendorf, F.6    Reis, A.7    Ulbrecht, M.8    Gomolka, M.9    Weiss, E.H.10
  • 15
    • 0031726849 scopus 로고    scopus 로고
    • : Genes in the spondyloarthropathies
    • Wordsworth P. : Genes in the spondyloarthropathies. Rheum Dis Clin North Am. 24:1998;845-863.
    • (1998) Rheum Dis Clin North Am , vol.24 , pp. 845-863
    • Wordsworth, P.1
  • 16
    • 0032198308 scopus 로고    scopus 로고
    • : Genetic epidemiology in inflammatory bowel disease
    • Binder V. : Genetic epidemiology in inflammatory bowel disease. Dig Dis. 16:1998;351-355.
    • (1998) Dig Dis , vol.16 , pp. 351-355
    • Binder, V.1
  • 19
    • 0033487663 scopus 로고    scopus 로고
    • Genetic factors regulating experimental arthritis in mice and rats
    • Basel: Karger AG. This intensive review of 287 published reports covering eight rat and mouse models of RA presents a lucid summary of the possible etiopathogenesis and underlying genetic basis for these models. Detailed tables show genetic intervals associating with disease in rats, mice and humans. The authors conclude that RA shares many genetic loci with several human autoimmune diseases and their surrogate animal models
    • Wilder R.L., Remmers E.F., Kawahito Y., Gulko P.S., Cannon G.W., Griffiths M.M. Genetic factors regulating experimental arthritis in mice and rats. Current Directions in Autoimmunity, vol 1. 1999;121-165 Karger AG, Basel. This intensive review of 287 published reports covering eight rat and mouse models of RA presents a lucid summary of the possible etiopathogenesis and underlying genetic basis for these models. Detailed tables show genetic intervals associating with disease in rats, mice and humans. The authors conclude that RA shares many genetic loci with several human autoimmune diseases and their surrogate animal models.
    • (1999) Current Directions in Autoimmunity, Vol 1. , pp. 121-165
    • Wilder, R.L.1    Remmers, E.F.2    Kawahito, Y.3    Gulko, P.S.4    Cannon, G.W.5    Griffiths, M.M.6
  • 20
    • 0032544004 scopus 로고    scopus 로고
    • Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases
    • Possibly one of the most important publications of the year. This is a detailed review of linkage results from 23 genome-wide scans of the major human autoimmune/inflammatory diseases plus associated rodent models. Approximately 65% of QTLs associated with this category of disease map nonrandomly to one or more of 18 distinct gene clusters on the human genome. Of control data (from genome scans of nonautoimmune diseases), only 13% of the markers were clustered. The authors conclude that these clinically diverse autoimmune diseases may be regulated by a common set of susceptibility genes. Interestingly, five of the clusters are also associated with response to infectious agents
    • Becker K.G., Simon R.M., Bailey-Wilson J.E., Freidlin B., Biddison W.E., McFarland H.F., Trent J.M. Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases. Proc Natl Acad Sci USA. 95:1998;9979-9984. Possibly one of the most important publications of the year. This is a detailed review of linkage results from 23 genome-wide scans of the major human autoimmune/inflammatory diseases plus associated rodent models. Approximately 65% of QTLs associated with this category of disease map nonrandomly to one or more of 18 distinct gene clusters on the human genome. Of control data (from genome scans of nonautoimmune diseases), only 13% of the markers were clustered. The authors conclude that these clinically diverse autoimmune diseases may be regulated by a common set of susceptibility genes. Interestingly, five of the clusters are also associated with response to infectious agents.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9979-9984
    • Becker, K.G.1    Simon, R.M.2    Bailey-Wilson, J.E.3    Freidlin, B.4    Biddison, W.E.5    McFarland, H.F.6    Trent, J.M.7
  • 21
    • 0032402990 scopus 로고    scopus 로고
    • Susceptibility to lupus nephritis in the NZB/W model system
    • This review focuses on the autoimmune subphenotypes of this model and the use of QTL-congenic strains to dissect the associated genomic intervals
    • Morel L., Wakeland E.K. Susceptibility to lupus nephritis in the NZB/W model system. Curr Opin Immunol. 10:1998;718-725. This review focuses on the autoimmune subphenotypes of this model and the use of QTL-congenic strains to dissect the associated genomic intervals.
    • (1998) Curr Opin Immunol , vol.10 , pp. 718-725
    • Morel, L.1    Wakeland, E.K.2
  • 22
    • 0033486824 scopus 로고    scopus 로고
    • Localising quantitative trait loci in the NOD mouse model of type I diabetes
    • Basel: Karger AG;
    • Lyons, P.A., Wicker, P.A.: Localising quantitative trait loci in the NOD mouse model of type I diabetes. In Current Directions in Autoimmunity, vol 1. Basel: Karger AG; 1999:208-225.
    • (1999) In Current Directions in Autoimmunity , vol.1 , pp. 208-225
    • Lyons, P.A.1    Wicker, P.A.2
  • 23
    • 0033487172 scopus 로고    scopus 로고
    • Genetics of experimental autoimmune encephalomyelitis
    • Basel: Karger AG;
    • Encinas, J.A., Kuchroo, V.K.: Genetics of experimental autoimmune encephalomyelitis. In Current Directions in Autoimmunity, vol 1. Basel: Karger AG; 1999:247-272.
    • (1999) In Current Directions in Autoimmunity , vol.1 , pp. 247-272
    • Encinas, J.A.1    Kuchroo, V.K.2
  • 25
    • 0032743793 scopus 로고    scopus 로고
    • Genetic dissection of lupus pathogenesis: A recipe for nephrophilic autoantibodies
    • Sle1 and Sle3 lupus nephritis loci in the NZM2410 strain were isolated on the C57BL/6 background and shown to regulate mild nephritis and mild polyclonal autoantibody. Bi-congenic mice, carrying both QTLs, developed highly penetrant glomerulonephritis. A two-step epistatic model is suggested
    • Mohan C., Morel L., Yang P., Watanabe H., Croker B., Gilkeson G., Wakeland E.K. Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies. J Clin Invest. 103:1999;1685-1695. Sle1 and Sle3 lupus nephritis loci in the NZM2410 strain were isolated on the C57BL/6 background and shown to regulate mild nephritis and mild polyclonal autoantibody. Bi-congenic mice, carrying both QTLs, developed highly penetrant glomerulonephritis. A two-step epistatic model is suggested.
    • (1999) J Clin Invest , vol.103 , pp. 1685-1695
    • Mohan, C.1    Morel, L.2    Yang, P.3    Watanabe, H.4    Croker, B.5    Gilkeson, G.6    Wakeland, E.K.7
  • 26
    • 0032799722 scopus 로고    scopus 로고
    • T-cell receptor Vbeta deletion and Valpha polymorphism are responsible for the resistance of SWR mouse to arthritis induction
    • This report explains much of the long-standing debate over the role of TCRVβ genes compared with C5a deficiency in the resistance of SWR/J mice to CIA. It is shown that SWR/J mice lack both of the necessary Vβ and Vα genes needed for collagen-reactive cells
    • Osman G.E., Hannibal M.C., Anderson J.P., Cheunsuk S., Lasky S.R., Liggitt H.D., Ladiges W.C., Hood L.E. T-cell receptor Vbeta deletion and Valpha polymorphism are responsible for the resistance of SWR mouse to arthritis induction. Immunogenetics. 49:1999;764-772. This report explains much of the long-standing debate over the role of TCRVβ genes compared with C5a deficiency in the resistance of SWR/J mice to CIA. It is shown that SWR/J mice lack both of the necessary Vβ and Vα genes needed for collagen-reactive cells.
    • (1999) Immunogenetics , vol.49 , pp. 764-772
    • Osman, G.E.1    Hannibal, M.C.2    Anderson, J.P.3    Cheunsuk, S.4    Lasky, S.R.5    Liggitt, H.D.6    Ladiges, W.C.7    Hood, L.E.8
  • 27
    • 0031765854 scopus 로고    scopus 로고
    • Pristane-induced arthritis in mice. V. Susceptibility to pristane-induced arthritis is determined by the genetic regulation of the T cell repertoire
    • Wooley P.H., Sud S., Whalen J.D., Nasser S. Pristane-induced arthritis in mice. V. Susceptibility to pristane-induced arthritis is determined by the genetic regulation of the T cell repertoire. Arthritis Rheum. 41:1998;2022-2031.
    • (1998) Arthritis Rheum , vol.41 , pp. 2022-2031
    • Wooley, P.H.1    Sud, S.2    Whalen, J.D.3    Nasser, S.4
  • 28
    • 0032776531 scopus 로고    scopus 로고
    • Multiplex inheritance of component phenotypes in a murine model of lupus
    • Detailed segregation analysis of eight genetic intervals associated with serological abnormalities in the NZB/W model indicates clustering of multiple susceptibility loci within these intervals. Each NZW2410 locus could be aligned with specific genetic pathways associated with SLE subphenotypes
    • Morel L., Mohan C., Yu Y., Schiffenbauer J., Rudofsky U.H., Tian N., Longmate J.A., Wakeland E.K. Multiplex inheritance of component phenotypes in a murine model of lupus. Mamm Genome. 10:1999;176-181. Detailed segregation analysis of eight genetic intervals associated with serological abnormalities in the NZB/W model indicates clustering of multiple susceptibility loci within these intervals. Each NZW2410 locus could be aligned with specific genetic pathways associated with SLE subphenotypes.
    • (1999) Mamm Genome , vol.10 , pp. 176-181
    • Morel, L.1    Mohan, C.2    Yu, Y.3    Schiffenbauer, J.4    Rudofsky, U.H.5    Tian, N.6    Longmate, J.A.7    Wakeland, E.K.8
  • 31
    • 0032854637 scopus 로고    scopus 로고
    • A gene map of the rat derived from linkage analysis and related regions in the mouse and human genomes
    • Gauguier D., Kaisaki P.J., Rouard M., Wallis R.H., Browne J., Rapp J.P., Bihoreau M.T. A gene map of the rat derived from linkage analysis and related regions in the mouse and human genomes. Mamm Genome. 10:1999;675-686.
    • (1999) Mamm Genome , vol.10 , pp. 675-686
    • Gauguier, D.1    Kaisaki, P.J.2    Rouard, M.3    Wallis, R.H.4    Browne, J.5    Rapp, J.P.6    Bihoreau, M.T.7
  • 34
    • 0033297815 scopus 로고    scopus 로고
    • Animal models of rheumatoid arthritis and related inflammation
    • in press. This detailed review presents current concepts on the etiopathogenesis of the experimentally induced models of RA
    • Joe B., Griffiths M.M., Remmers E.F., Wilder R.L. Animal models of rheumatoid arthritis and related inflammation. Curr Rheumatol Reports. 1999;. in press. This detailed review presents current concepts on the etiopathogenesis of the experimentally induced models of RA.
    • (1999) Curr Rheumatol Reports
    • Joe, B.1    Griffiths, M.M.2    Remmers, E.F.3    Wilder, R.L.4
  • 35
    • 0032811531 scopus 로고    scopus 로고
    • Identification of a new quantitative trait locus on chromosome 7 controlling disease severity of collagen-induced arthritis in rats
    • Report of a second CIA-QTL on rat chromosome 7 and discussion of homologous regions of mouse and human genomes associated with arthritis
    • Dracheva S.V., Remmers E.F., Gulko P.S., Kawahito Y., Longman R.E., Reese V.R., Cannon G.W., Griffiths M.M., Wilder R.L. Identification of a new quantitative trait locus on chromosome 7 controlling disease severity of collagen-induced arthritis in rats. Immunogenetics. 49:1999;787-791. Report of a second CIA-QTL on rat chromosome 7 and discussion of homologous regions of mouse and human genomes associated with arthritis.
    • (1999) Immunogenetics , vol.49 , pp. 787-791
    • Dracheva, S.V.1    Remmers, E.F.2    Gulko, P.S.3    Kawahito, Y.4    Longman, R.E.5    Reese, V.R.6    Cannon, G.W.7    Griffiths, M.M.8    Wilder, R.L.9
  • 36
    • 17444377878 scopus 로고    scopus 로고
    • Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats
    • Genome-wide scan for CIA severity QTLs in MHC-seroidentical (DA × ACI)F2 rats. Comparative mapping of this region to human and mouse chromosomes housing QTLs for IDDM, EAE, CD and MS. Reports gender association with severity of arthritis
    • Gulko P.S., Kawahito Y., Remmers E.F., Reese V.R., Wang J., Dracheva S.V., Ge L., Longman R.E., Shepard J.S., Cannon G.W.et al. Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats. Arthritis Rheum. 41:1998;2122-2131. Genome-wide scan for CIA severity QTLs in MHC-seroidentical (DA × ACI)F2 rats. Comparative mapping of this region to human and mouse chromosomes housing QTLs for IDDM, EAE, CD and MS. Reports gender association with severity of arthritis.
    • (1998) Arthritis Rheum , vol.41 , pp. 2122-2131
    • Gulko, P.S.1    Kawahito, Y.2    Remmers, E.F.3    Reese, V.R.4    Wang, J.5    Dracheva, S.V.6    Ge, L.7    Longman, R.E.8    Shepard, J.S.9    Cannon, G.W.10
  • 37
    • 0033134898 scopus 로고    scopus 로고
    • Localization in rats of genetic loci regulating susceptibility to experimental erosive arthritis and related autoimmune diseases
    • Concise summary of mapping data for experimental animal models of arthritis and autoimmune disease
    • Wilder R.L., Griffiths M.M., Remmers E.F., Cannon G.W., Caspi R.R., Kawahito Y., Gulko P.S., Longman R.E., Dracheva S.V., Du Y.et al. Localization in rats of genetic loci regulating susceptibility to experimental erosive arthritis and related autoimmune diseases. Transplant Proc. 31:1999;1585-1588. Concise summary of mapping data for experimental animal models of arthritis and autoimmune disease.
    • (1999) Transplant Proc , vol.31 , pp. 1585-1588
    • Wilder, R.L.1    Griffiths, M.M.2    Remmers, E.F.3    Cannon, G.W.4    Caspi, R.R.5    Kawahito, Y.6    Gulko, P.S.7    Longman, R.E.8    Dracheva, S.V.9    Du, Y.10
  • 38
    • 0032532596 scopus 로고    scopus 로고
    • Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: Evidence for genetic factors common to multiple autoimmune diseases
    • First genome-wide scan for genetic intervals regulating the classic model of AIA in rats. Three QTLs are identified: Aia1 at the MHC and two proximally located QTLs on chromosome 4; Aia2 is independent; Aia3 overlaps Cia3
    • Kawahito Y., Cannon G.W., Gulko P.S., Remmers E.F., Longman R.E., Reese V.R., Wang J., Griffiths M.M., Wilder R.L. Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases. J Immunol. 161:1998;4411-4419. First genome-wide scan for genetic intervals regulating the classic model of AIA in rats. Three QTLs are identified: Aia1 at the MHC and two proximally located QTLs on chromosome 4; Aia2 is independent; Aia3 overlaps Cia3.
    • (1998) J Immunol , vol.161 , pp. 4411-4419
    • Kawahito, Y.1    Cannon, G.W.2    Gulko, P.S.3    Remmers, E.F.4    Longman, R.E.5    Reese, V.R.6    Wang, J.7    Griffiths, M.M.8    Wilder, R.L.9
  • 39
    • 0037896004 scopus 로고    scopus 로고
    • Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat
    • Kloting I., Schmidt S., Kovacs P. Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat. Biochem Biophys Res Commun. 245:1998;483-486.
    • (1998) Biochem Biophys Res Commun , vol.245 , pp. 483-486
    • Kloting, I.1    Schmidt, S.2    Kovacs, P.3
  • 42
    • 0031689094 scopus 로고    scopus 로고
    • Genetic linkage analysis of collagen-induced arthritis in the mouse
    • r strain (B10.RIII × RIIIS/j) mice. Two non-MHC loci, Mcia2 (co-localizing to Eae3 on chromosome 3) and a suggestive locus on chromosome 13, were mapped
    • r strain (B10.RIII × RIIIS/j) mice. Two non-MHC loci, Mcia2 (co-localizing to Eae3 on chromosome 3) and a suggestive locus on chromosome 13, were mapped.
    • (1998) Eur J Immunol , vol.28 , pp. 3321-3328
    • Jirholt, J.1    Cook, A.2    Emahazion, T.3    Sundvall, M.4    Jansson, L.5    Nordquist, N.6    Pettersson, U.7    Holmdahl, R.8
  • 43
    • 0032568616 scopus 로고    scopus 로고
    • Identification of rat susceptibility loci for adjuvant-oil-induced arthritis
    • First identification of non-MHC genetic loci regulating susceptibility to OIA
    • Lorentzen J.C., Glaser A., Jacobsson L., Galli J., Fakhrai-Rad H., Klareskog L., Luthman H. Identification of rat susceptibility loci for adjuvant-oil-induced arthritis. Proc Natl Acad Sci USA. 95:1998;6383-6387. First identification of non-MHC genetic loci regulating susceptibility to OIA.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6383-6387
    • Lorentzen, J.C.1    Glaser, A.2    Jacobsson, L.3    Galli, J.4    Fakhrai-Rad, H.5    Klareskog, L.6    Luthman, H.7
  • 44
    • 0031772326 scopus 로고    scopus 로고
    • Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats
    • First identification of non-MHC genetic loci regulating susceptibility to PIA in rats. Distinction is made for QTLs regulating clinical subphenotypes
    • Vingsbo-Lundberg C., Nordquist N., Olofsson P., Sundvall M., Saxne T., Pettersson U., Holmdahl R. Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats. Nat Genet. 20:1998;401-404. First identification of non-MHC genetic loci regulating susceptibility to PIA in rats. Distinction is made for QTLs regulating clinical subphenotypes.
    • (1998) Nat Genet , vol.20 , pp. 401-404
    • Vingsbo-Lundberg, C.1    Nordquist, N.2    Olofsson, P.3    Sundvall, M.4    Saxne, T.5    Pettersson, U.6    Holmdahl, R.7
  • 45
    • 0033555788 scopus 로고    scopus 로고
    • Identification of quantitative trait loci governing arthritis severity and humoral responses in the murine model of Lyme disease
    • First genome scan of an arthritis model induced by B. burgdorferi, the causative agent of human Lyme disease, identified multiple non-MHC loci associating individually with the various phenotypic manifestations of Lyme arthritis
    • Weis J.J., McCracken B.A., Ma Y., Fairbairn D., Roper R.J., Morrison T.B., Weis J.H., Zachary J.F., Doerge R.W., Teuscher C. Identification of quantitative trait loci governing arthritis severity and humoral responses in the murine model of Lyme disease. J Immunol. 162:1999;948-956. First genome scan of an arthritis model induced by B. burgdorferi, the causative agent of human Lyme disease, identified multiple non-MHC loci associating individually with the various phenotypic manifestations of Lyme arthritis.
    • (1999) J Immunol , vol.162 , pp. 948-956
    • Weis, J.J.1    McCracken, B.A.2    Ma, Y.3    Fairbairn, D.4    Roper, R.J.5    Morrison, T.B.6    Weis, J.H.7    Zachary, J.F.8    Doerge, R.W.9    Teuscher, C.10
  • 46
    • 0032103047 scopus 로고    scopus 로고
    • Theiler's virus infection of genetically susceptible mice induces central nervous system-infiltrating CTLs with no apparent viral or major myelin antigenic specificity
    • + cytotoxic T lymphocytes
    • + cytotoxic T lymphocytes.
    • (1998) J Immunol , vol.160 , pp. 5661-5668
    • Lin, X.1    Pease, L.R.2    Murray, P.D.3    Rodriguez, M.4
  • 47
    • 0031914643 scopus 로고    scopus 로고
    • Subcongenic analysis of the Idd13 locus in NOD/Lt mice: Evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin
    • Supports the concept that some of the QTLs now identified in genome-scan studies may in fact consist of multiple closely linked loci rather than a single locus affecting multiple models
    • Serreze D.V., Bridgett M., Chapman H.D., Chen E., Richard S.D., Leiter E.H. Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin. J Immunol. 160:1998;1472-1478. Supports the concept that some of the QTLs now identified in genome-scan studies may in fact consist of multiple closely linked loci rather than a single locus affecting multiple models.
    • (1998) J Immunol , vol.160 , pp. 1472-1478
    • Serreze, D.V.1    Bridgett, M.2    Chapman, H.D.3    Chen, E.4    Richard, S.D.5    Leiter, E.H.6
  • 48
    • 0031945843 scopus 로고    scopus 로고
    • Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis
    • Strain analysis of an animal model of colitis
    • Mahler M., Bristol I.J., Leiter E.H., Workman A.E., Birkenmeier E.H., Elson C.O., Sundberg J.P. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am J Physiol. 274:1998;G544-G551. Strain analysis of an animal model of colitis.
    • (1998) Am J Physiol , vol.274
    • Mahler, M.1    Bristol, I.J.2    Leiter, E.H.3    Workman, A.E.4    Birkenmeier, E.H.5    Elson, C.O.6    Sundberg, J.P.7
  • 49
    • 0033136734 scopus 로고    scopus 로고
    • A major linkage region on distal chromosome 4 confers susceptibility to mouse autoimmune gastritis
    • Genome-wide scan of mouse model of autoimmune gastritis shows unique and common QTLs. Clustering of genes regulating susceptibility to EAG and IDDM is shown and is consistent with inheritance of human gastritis and diabetes within families
    • Silveira P.A., Baxter A.G., Cain W.E., van Driel I.R. A major linkage region on distal chromosome 4 confers susceptibility to mouse autoimmune gastritis. J Immunol. 162:1999;5106-5111. Genome-wide scan of mouse model of autoimmune gastritis shows unique and common QTLs. Clustering of genes regulating susceptibility to EAG and IDDM is shown and is consistent with inheritance of human gastritis and diabetes within families.
    • (1999) J Immunol , vol.162 , pp. 5106-5111
    • Silveira, P.A.1    Baxter, A.G.2    Cain, W.E.3    Van Driel, I.R.4
  • 50
    • 0032902739 scopus 로고    scopus 로고
    • Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats
    • First genome-wide scan for QTLs regulating this experimentally induced autoimmune disease of the eye locates two suggestive loci on rat chromosomes 4 and 12
    • Sun S.H., Silver P.B., Caspi R.R., Du Y., Chan C.C., Wilder R.L., Remmers E.F. Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats. Int Immunol. 11:1999;529-534. First genome-wide scan for QTLs regulating this experimentally induced autoimmune disease of the eye locates two suggestive loci on rat chromosomes 4 and 12.
    • (1999) Int Immunol , vol.11 , pp. 529-534
    • Sun, S.H.1    Silver, P.B.2    Caspi, R.R.3    Du, Y.4    Chan, C.C.5    Wilder, R.L.6    Remmers, E.F.7
  • 51
    • 0032531157 scopus 로고    scopus 로고
    • MHC haplotype-dependent regulation of MOG-induced EAE in rats
    • Report demonstrates that the severity of MOG-induced EAE in rats is a result of interactions between specific MHC and non-MHC alleles
    • Weissert R., Wallstrom E., Storch M.K., Stefferl A., Lorentzen J., Lassmann H., Linington C., Olsson T. MHC haplotype-dependent regulation of MOG-induced EAE in rats. J Clin Invest. 102:1998;1265-1273. Report demonstrates that the severity of MOG-induced EAE in rats is a result of interactions between specific MHC and non-MHC alleles.
    • (1998) J Clin Invest , vol.102 , pp. 1265-1273
    • Weissert, R.1    Wallstrom, E.2    Storch, M.K.3    Stefferl, A.4    Lorentzen, J.5    Lassmann, H.6    Linington, C.7    Olsson, T.8
  • 52
    • 0033168629 scopus 로고    scopus 로고
    • Myelin oligodendrocyte glycoprotein induces experimental autoimmune encephalomyelitis in the 'resistant' Brown Norway rat: Disease susceptibility is determined by MHC and MHC-linked effects on the B cell response
    • This study used reciprocal MHC-congenic strains to demonstrate a strong influence of MHC class I and class II genes, plus the RT1.M region encoding the MOG gene, on anti-MOG antibody titers and thus variable disease susceptibility in BN and LEW rats
    • Stefferl A., Brehm U., Storch M., Lambracht-Washington D., Bourquin C., Wonigeit K., Lassmann H., Linington C. Myelin oligodendrocyte glycoprotein induces experimental autoimmune encephalomyelitis in the 'resistant' Brown Norway rat: disease susceptibility is determined by MHC and MHC-linked effects on the B cell response. J Immunol. 163:1999;40-49. This study used reciprocal MHC-congenic strains to demonstrate a strong influence of MHC class I and class II genes, plus the RT1.M region encoding the MOG gene, on anti-MOG antibody titers and thus variable disease susceptibility in BN and LEW rats.
    • (1999) J Immunol , vol.163 , pp. 40-49
    • Stefferl, A.1    Brehm, U.2    Storch, M.3    Lambracht-Washington, D.4    Bourquin, C.5    Wonigeit, K.6    Lassmann, H.7    Linington, C.8
  • 53
    • 0032209673 scopus 로고    scopus 로고
    • B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization
    • Hjelmstrom P., Juedes A.E., Fjell J., Ruddle N.H. B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization. J Immunol. 161:1998;4480-4483.
    • (1998) J Immunol , vol.161 , pp. 4480-4483
    • Hjelmstrom, P.1    Juedes, A.E.2    Fjell, J.3    Ruddle, N.H.4
  • 54
    • 0031874025 scopus 로고    scopus 로고
    • Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; Impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern
    • Dahlman I., Lorentzen J.C., de Graaf K.L., Stefferl A., Linington C., Luthman H., Olsson T. Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern. Eur J Immunol. 28:1998;2188-2196.
    • (1998) Eur J Immunol , vol.28 , pp. 2188-2196
    • Dahlman, I.1    Lorentzen, J.C.2    De Graaf, K.L.3    Stefferl, A.4    Linington, C.5    Luthman, H.6    Olsson, T.7
  • 55
    • 0033105381 scopus 로고    scopus 로고
    • Genome-wide linkage analysis of chronic relapsing experimental autoimmune encephalomyelitis in the rat identifies a major susceptibility locus on chromosome 9
    • New severity QTLs identified in (DA × BN)F2 rats with EAE
    • Dahlman I., Jacobsson L., Glaser A., Lorentzen J.C., Andersson M., Luthman H., Olsson T. Genome-wide linkage analysis of chronic relapsing experimental autoimmune encephalomyelitis in the rat identifies a major susceptibility locus on chromosome 9. J Immunol. 162:1999;2581-2588. New severity QTLs identified in (DA × BN)F2 rats with EAE.
    • (1999) J Immunol , vol.162 , pp. 2581-2588
    • Dahlman, I.1    Jacobsson, L.2    Glaser, A.3    Lorentzen, J.C.4    Andersson, M.5    Luthman, H.6    Olsson, T.7
  • 56
    • 0033557725 scopus 로고    scopus 로고
    • A genome-wide search identifies two susceptibility loci for experimental autoimmune encephalomyelitis on rat chromosomes 4 and 10
    • Identification of QTLs regulating EAE in (LEW × BN)F2 rats that are different from those identified by others in (DA × BN)F2 rats
    • Roth M.P., Viratelle C., Dolbois L., Delverdier M., Borot N., Pelletier L., Druet P., Clanet M., Coppin H. A genome-wide search identifies two susceptibility loci for experimental autoimmune encephalomyelitis on rat chromosomes 4 and 10. J Immunol. 162:1999;1917-1922. Identification of QTLs regulating EAE in (LEW × BN)F2 rats that are different from those identified by others in (DA × BN)F2 rats.
    • (1999) J Immunol , vol.162 , pp. 1917-1922
    • Roth, M.P.1    Viratelle, C.2    Dolbois, L.3    Delverdier, M.4    Borot, N.5    Pelletier, L.6    Druet, P.7    Clanet, M.8    Coppin, H.9
  • 58
    • 0033104698 scopus 로고    scopus 로고
    • Genetic analysis of disease subtypes and sexual dimorphisms in mouse experimental allergic encephalomyelitis (EAE): Relapsing/remitting and monophasic remitting/nonrelapsing EAE are immunogenetically distinct
    • EAE clinical subphenotypes of chronic relapsing/remitting, benign and acute, monophasic forms of EAE subtypes were associated with novel and distinct QTLs
    • Butterfield R.J., Blankenhorn E.P., Roper R.J., Zachary J.F., Doerge R.W., Sudweeks J., Rose J., Teuscher C. Genetic analysis of disease subtypes and sexual dimorphisms in mouse experimental allergic encephalomyelitis (EAE): relapsing/remitting and monophasic remitting/nonrelapsing EAE are immunogenetically distinct. J Immunol. 162:1999;3096-3102. EAE clinical subphenotypes of chronic relapsing/remitting, benign and acute, monophasic forms of EAE subtypes were associated with novel and distinct QTLs.
    • (1999) J Immunol , vol.162 , pp. 3096-3102
    • Butterfield, R.J.1    Blankenhorn, E.P.2    Roper, R.J.3    Zachary, J.F.4    Doerge, R.W.5    Sudweeks, J.6    Rose, J.7    Teuscher, C.8
  • 59
    • 0032947236 scopus 로고    scopus 로고
    • QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15 cM region containing Il2
    • This study fine-maps the regulatory element for two autoimmune disease models (EAE and IDDM) and shows convincing data that one locus, Il2, contributes to both models. This finding supports the concept that some alleles will contribute to autoimmune diseases of different clinical presentation
    • Encinas J.A., Wicker L.S., Peterson L.B., Mukasa A., Teuscher C., Sobel R., Weiner H.L., Seidman C.E., Seidman J.G., Kuchroo V.K. QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15 cM region containing Il2. Nat Genet. 21:1999;158-160. This study fine-maps the regulatory element for two autoimmune disease models (EAE and IDDM) and shows convincing data that one locus, Il2, contributes to both models. This finding supports the concept that some alleles will contribute to autoimmune diseases of different clinical presentation.
    • (1999) Nat Genet , vol.21 , pp. 158-160
    • Encinas, J.A.1    Wicker, L.S.2    Peterson, L.B.3    Mukasa, A.4    Teuscher, C.5    Sobel, R.6    Weiner, H.L.7    Seidman, C.E.8    Seidman, J.G.9    Kuchroo, V.K.10
  • 60
    • 0032401779 scopus 로고    scopus 로고
    • Genetics of autoimmune diabetes in animal models
    • Reviews the major QTLs in NOD mice and BB(DP) rats identified throughout 1998. Focus is on functional studies of candidate genes and pathways of transgenic and gene-knockout mice
    • McDuffie M. Genetics of autoimmune diabetes in animal models. Curr Opin Immunol. 10:1998;704-709. Reviews the major QTLs in NOD mice and BB(DP) rats identified throughout 1998. Focus is on functional studies of candidate genes and pathways of transgenic and gene-knockout mice.
    • (1998) Curr Opin Immunol , vol.10 , pp. 704-709
    • McDuffie, M.1
  • 61
    • 0032939329 scopus 로고    scopus 로고
    • Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat
    • A new disease model incorporating distinct loci for disease susceptibility (chromosome 20), initiation as measured by insulitis (chromosome 4), disease progression (chromosome 13) and lyp providing spontaneous disease expression
    • Martin A.M., Blankenhorn E.P., Maxson M.N., Zhao M., Leif J., Mordes J.P., Greiner D.L. Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat. Diabetes. 48:1999;50-58. A new disease model incorporating distinct loci for disease susceptibility (chromosome 20), initiation as measured by insulitis (chromosome 4), disease progression (chromosome 13) and lyp providing spontaneous disease expression.
    • (1999) Diabetes , vol.48 , pp. 50-58
    • Martin, A.M.1    Blankenhorn, E.P.2    Maxson, M.N.3    Zhao, M.4    Leif, J.5    Mordes, J.P.6    Greiner, D.L.7
  • 63
    • 0033104610 scopus 로고    scopus 로고
    • Analysis of MHC class II genes in the susceptibility to lupus in New Zealand mice
    • Rozzo S.J., Vyse T.J., David C.S., Palmer E., Izui S., Kotzin B.L. Analysis of MHC class II genes in the susceptibility to lupus in New Zealand mice. J Immunol. 162:1999;2623-2630.
    • (1999) J Immunol , vol.162 , pp. 2623-2630
    • Rozzo, S.J.1    Vyse, T.J.2    David, C.S.3    Palmer, E.4    Izui, S.5    Kotzin, B.L.6
  • 66
    • 0032006599 scopus 로고    scopus 로고
    • Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Fas lpr mice
    • Four QTLs associated with lymphadenopathy and/or splenomegaly, independent of the Fas/lpr mutation, were identified
    • Vidal S., Kono D.H., Theofilopoulos A.N. Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Fas lpr mice. J Clin Invest. 101:1998;696-702. Four QTLs associated with lymphadenopathy and/or splenomegaly, independent of the Fas/lpr mutation, were identified.
    • (1998) J Clin Invest , vol.101 , pp. 696-702
    • Vidal, S.1    Kono, D.H.2    Theofilopoulos, A.N.3
  • 67
    • 0032534737 scopus 로고    scopus 로고
    • Genetic determinants of autoimmune disease and coronary vasculitis in the MRL-lpr/lpr mouse model of systemic lupus erythematosus
    • Gu L., Weinreb A., Wang X.P., Zack D.J., Qiao J.H., Weisbart R., Lusis A.J. Genetic determinants of autoimmune disease and coronary vasculitis in the MRL-lpr/lpr mouse model of systemic lupus erythematosus. J Immunol. 161:1998;6999-7006.
    • (1998) J Immunol , vol.161 , pp. 6999-7006
    • Gu, L.1    Weinreb, A.2    Wang, X.P.3    Zack, D.J.4    Qiao, J.H.5    Weisbart, R.6    Lusis, A.J.7
  • 69
    • 0033515520 scopus 로고    scopus 로고
    • Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes
    • Demonstrates a human disease syndrome (TRAPS) in association with a mutation within the gene for the TNFR1 molecule, a candidate gene for several of the autoimmune disease models
    • McDermott M.F., Aksentijevich I., Galon J., McDermott E.M., Ogunkolade B.W., Centola M., Mansfield E., Gadina M., Karenko L., Pettersson T.et al. Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. Cell. 97:1999;133-144. Demonstrates a human disease syndrome (TRAPS) in association with a mutation within the gene for the TNFR1 molecule, a candidate gene for several of the autoimmune disease models.
    • (1999) Cell , vol.97 , pp. 133-144
    • McDermott, M.F.1    Aksentijevich, I.2    Galon, J.3    McDermott, E.M.4    Ogunkolade, B.W.5    Centola, M.6    Mansfield, E.7    Gadina, M.8    Karenko, L.9    Pettersson, T.10
  • 70
    • 0031909921 scopus 로고    scopus 로고
    • Genetic control of susceptibility to collagen-induced arthritis in T cell receptor beta-chain transgenic mice
    • Mori L., de Libero G. Genetic control of susceptibility to collagen-induced arthritis in T cell receptor beta-chain transgenic mice. Arthritis Rheum. 41:1998;256-262.
    • (1998) Arthritis Rheum , vol.41 , pp. 256-262
    • Mori, L.1    De Libero, G.2
  • 71
    • 0029761370 scopus 로고    scopus 로고
    • A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats
    • First genome-wide scan for genetic intervals regulating autoimmune arthritis in an animal model
    • Remmers E.F., Longman R.E., Du Y., O'Hare A., Cannon G.W., Griffiths M.M., Wilder R.L. A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. Nat Genet. 14:1996;82-85. First genome-wide scan for genetic intervals regulating autoimmune arthritis in an animal model.
    • (1996) Nat Genet , vol.14 , pp. 82-85
    • Remmers, E.F.1    Longman, R.E.2    Du, Y.3    O'Hare, A.4    Cannon, G.W.5    Griffiths, M.M.6    Wilder, R.L.7
  • 72
    • 0032212253 scopus 로고    scopus 로고
    • HLA-DQ6/8 double transgenic mice develop auricular chondritis following type II collagen immunization: A model for human relapsing polychondritis
    • A new model of autoimmune polychondritis is described using HLA-transgenic mice immunized with type II collagen
    • Bradley D.S., Das P., Griffiths M.M., Luthra H.S., David C.S. HLA-DQ6/8 double transgenic mice develop auricular chondritis following type II collagen immunization: a model for human relapsing polychondritis. J Immunol. 161:1998;5046-5053. A new model of autoimmune polychondritis is described using HLA-transgenic mice immunized with type II collagen.
    • (1998) J Immunol , vol.161 , pp. 5046-5053
    • Bradley, D.S.1    Das, P.2    Griffiths, M.M.3    Luthra, H.S.4    David, C.S.5
  • 73
    • 0032586666 scopus 로고    scopus 로고
    • An HLA-DRB1*0402 derived peptide (HV3 65-79) prevents collagen-induced arthritis in HLA-DQ8 transgenic mice
    • Das P., Bradley D.S., Geluk A., Griffiths M.M., Luthra H.S., David C.S. An HLA-DRB1*0402 derived peptide (HV3 65-79) prevents collagen-induced arthritis in HLA-DQ8 transgenic mice. Hum Immunol. 60:1999;575-582.
    • (1999) Hum Immunol , vol.60 , pp. 575-582
    • Das, P.1    Bradley, D.S.2    Geluk, A.3    Griffiths, M.M.4    Luthra, H.S.5    David, C.S.6
  • 74
    • 0032990261 scopus 로고    scopus 로고
    • Genes in two major histocompatibility complex class I regions control selection, phenotype, and function of a rat Ly-49 natural killer cell subset
    • An important mechanism of interaction between MHC alleles and the NK cell region of rat chromosome 4, which houses Cia13, and genetic loci for IDDM and EAE is demonstrated. The results suggest alternative, non-antigen-specific, modes of MHC-non-MHC interaction that could regulate autoimmune disease in an allele-specific fashion
    • Naper C., Ryan J.C., Kirsch R., Butcher G.W., Rolstad B., Vaage J.T. Genes in two major histocompatibility complex class I regions control selection, phenotype, and function of a rat Ly-49 natural killer cell subset. Eur J Immunol. 29:1999;2046-2053. An important mechanism of interaction between MHC alleles and the NK cell region of rat chromosome 4, which houses Cia13, and genetic loci for IDDM and EAE is demonstrated. The results suggest alternative, non-antigen-specific, modes of MHC-non-MHC interaction that could regulate autoimmune disease in an allele-specific fashion.
    • (1999) Eur J Immunol , vol.29 , pp. 2046-2053
    • Naper, C.1    Ryan, J.C.2    Kirsch, R.3    Butcher, G.W.4    Rolstad, B.5    Vaage, J.T.6
  • 75
    • 0032401760 scopus 로고    scopus 로고
    • Peripheral-antigen-expressing cells in thymic medulla: Factors in self- tolerance and autoimmunity
    • Review of data supporting the concept that many self-antigens previously thought to be sequestered from the immune system are in fact found in the young thymus and thus probably help shape the peripheral T cell repertoire. Variable expression of individual self-antigens within thymic tissues could be a common feature of autoimmune disease
    • Hanahan D. Peripheral-antigen-expressing cells in thymic medulla: factors in self- tolerance and autoimmunity. Curr Opin Immunol. 10:1998;656-662. Review of data supporting the concept that many self-antigens previously thought to be sequestered from the immune system are in fact found in the young thymus and thus probably help shape the peripheral T cell repertoire. Variable expression of individual self-antigens within thymic tissues could be a common feature of autoimmune disease.
    • (1998) Curr Opin Immunol , vol.10 , pp. 656-662
    • Hanahan, D.1
  • 76
  • 77
    • 0032401766 scopus 로고    scopus 로고
    • Genetics of susceptibility to chronic experimental encephalomyelitis and arthritis
    • Holmdahl R. Genetics of susceptibility to chronic experimental encephalomyelitis and arthritis. Curr Opin Immunol. 10:1998;710-717.
    • (1998) Curr Opin Immunol , vol.10 , pp. 710-717
    • Holmdahl, R.1
  • 78
    • 0033487444 scopus 로고    scopus 로고
    • Genetic susceptibility to spontaneous lupus in mice
    • Basel: Karger AG; Detailed and comprehensive review of this topic
    • Kono, D., Theofilopoulos, A. Genetic susceptibility to spontaneous lupus in mice. In Current Directions in Autoimmunity, vol 1. Basel: Karger AG; 1999:72-98. Detailed and comprehensive review of this topic.
    • (1999) In Current Directions in Autoimmunity , vol.1 , pp. 72-98
    • Kono, D.1    Theofilopoulos, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.