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1
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0032168750
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New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study
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A genome-wide linkage study by the European Consortium on Rheumatoid Arthritis Families identified fourteen non-MHC candidate regions, several of which overlap IDDM loci. Extension to 261 nuclear families revealed significant association with a chromosome 3 locus (~16% of the genetic variability) housing genes for CD80 and CD86, molecules involved in antigen-specific T cell activation
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Cornelis F., Faure S., Martinez M., Prud'homme J.F., Fritz P., Dib C., Alves H., Barrera P., de Vries N., Balsa A. New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study. Proc Natl Acad Sci USA. 95:1998;10746-10750. A genome-wide linkage study by the European Consortium on Rheumatoid Arthritis Families identified fourteen non-MHC candidate regions, several of which overlap IDDM loci. Extension to 261 nuclear families revealed significant association with a chromosome 3 locus (~16% of the genetic variability) housing genes for CD80 and CD86, molecules involved in antigen-specific T cell activation.
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(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 10746-10750
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Cornelis, F.1
Faure, S.2
Martinez, M.3
Prud'Homme, J.F.4
Fritz, P.5
Dib, C.6
Alves, H.7
Barrera, P.8
De Vries, N.9
Balsa, A.10
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2
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0031723086
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Familial clustering of rheumatoid arthritis with other autoimmune diseases
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This is the first use of odds-ratio regression analysis and complex segregation analysis tools to test genetic models for familial aggregation of RA and other autoimmune diseases. A statistically significant occurrence of autoimmune thyroid disease, diabetes, ankylosing spondylitis, myasthenia gravis and rheumatic fever in first-degree relatives of RA patients was shown - suggesting a common, genetically influenced etiology
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Lin J.P., Cash J.M., Doyle S.Z., Peden S., Kanik K., Amos C.I., Bale S.J., Wilder R.L. Familial clustering of rheumatoid arthritis with other autoimmune diseases. Hum Genet. 103:1998;475-482. This is the first use of odds-ratio regression analysis and complex segregation analysis tools to test genetic models for familial aggregation of RA and other autoimmune diseases. A statistically significant occurrence of autoimmune thyroid disease, diabetes, ankylosing spondylitis, myasthenia gravis and rheumatic fever in first-degree relatives of RA patients was shown - suggesting a common, genetically influenced etiology.
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(1998)
Hum Genet
, vol.103
, pp. 475-482
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Lin, J.P.1
Cash, J.M.2
Doyle, S.Z.3
Peden, S.4
Kanik, K.5
Amos, C.I.6
Bale, S.J.7
Wilder, R.L.8
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3
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0033003164
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The genetics revolution and the assault on rheumatoid arthritis
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Seldin M.F., Amos C.I., Ward R., Gregersen P.K. The genetics revolution and the assault on rheumatoid arthritis. Arthritis Rheum. 42:1999;1071-1079.
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(1999)
Arthritis Rheum
, vol.42
, pp. 1071-1079
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Seldin, M.F.1
Amos, C.I.2
Ward, R.3
Gregersen, P.K.4
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4
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7344223861
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Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity
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This group reported a definitive linkage of familial MS to the HLA-DR2 allele within the MHC on chromosome 6. HLA-DR2 was estimated to contribute 17-63% of the genetic etiology of MS
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Haines J.L., Terwedow H.A., Burgess K., Pericak-Vance M.A., Rimmler J.B., Martin E.R., Oksenberg J.R., Lincoln R., Zhang D.Y., Banatao D.R.et al. Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. Hum Mol Genet. 7:1998;1229-1234. This group reported a definitive linkage of familial MS to the HLA-DR2 allele within the MHC on chromosome 6. HLA-DR2 was estimated to contribute 17-63% of the genetic etiology of MS.
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(1998)
Hum Mol Genet
, vol.7
, pp. 1229-1234
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Haines, J.L.1
Terwedow, H.A.2
Burgess, K.3
Pericak-Vance, M.A.4
Rimmler, J.B.5
Martin, E.R.6
Oksenberg, J.R.7
Lincoln, R.8
Zhang, D.Y.9
Banatao, D.R.10
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5
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0031795197
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Genetics of multiple sclerosis
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This review of current published data concludes that no one single locus contributes significantly to familial risk for MS with the exception of the HLA-DRB1-1501 DQA*0102 DQB1*0602 haplotype of the MHC
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Ebers G.C., Dyment D.A. Genetics of multiple sclerosis. Semin Neurol. 18:1998;295-299. This review of current published data concludes that no one single locus contributes significantly to familial risk for MS with the exception of the HLA-DRB1-1501 DQA*0102 DQB1*0602 haplotype of the MHC.
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(1998)
Semin Neurol
, vol.18
, pp. 295-299
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Ebers, G.C.1
Dyment, D.A.2
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6
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17444436401
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The genetics of multiple sclerosis: Principles, background and updated results of the United Kingdom systematic genome screen
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This study indicates that MS reflects the cumulative effects of multiple genes with small effects rather than a few genes of major importance. Also, some evidence of genetic subsets that segregate dependent on HLA-DR genotype was found
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Chataway J., Feakes R., Coraddu F., Gray J., Deans J., Fraser M., Robertson N., Broadley S., Jones H., Clayton D.et al. The genetics of multiple sclerosis: principles, background and updated results of the United Kingdom systematic genome screen. Brain. 121:1998;1869-1887. This study indicates that MS reflects the cumulative effects of multiple genes with small effects rather than a few genes of major importance. Also, some evidence of genetic subsets that segregate dependent on HLA-DR genotype was found.
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(1998)
Brain
, vol.121
, pp. 1869-1887
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Chataway, J.1
Feakes, R.2
Coraddu, F.3
Gray, J.4
Deans, J.5
Fraser, M.6
Robertson, N.7
Broadley, S.8
Jones, H.9
Clayton, D.10
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7
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0032404079
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Genetic susceptibility factors in type 1 diabetes: Linkage, disequilibrium and functional analyses
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She J.X., Marron M.P. Genetic susceptibility factors in type 1 diabetes: linkage, disequilibrium and functional analyses. Curr Opin Immunol. 10:1998;682-689.
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(1998)
Curr Opin Immunol
, vol.10
, pp. 682-689
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She, J.X.1
Marron, M.P.2
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8
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0033082240
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From genome to aetiology in a multifactorial disease, type 1 diabetes
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Thoughtful review of the genetics and possible causation of type 1 diabetes
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Todd J.A. From genome to aetiology in a multifactorial disease, type 1 diabetes. Bioessays. 21:1999;164-174. Thoughtful review of the genetics and possible causation of type 1 diabetes.
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(1999)
Bioessays
, vol.21
, pp. 164-174
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Todd, J.A.1
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9
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0033032379
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Comparative genetics of type 1 diabetes and autoimmune disease: Common loci, common pathways?
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Comparison of type 1 diabetes loci with candidate loci from other autoimmune/inflammatory disease shows overlap and supports the hypothesis of genetic sharing with SLE, MS and CD
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Becker K.G. Comparative genetics of type 1 diabetes and autoimmune disease: common loci, common pathways? Diabetes. 48:1999;1353-1358. Comparison of type 1 diabetes loci with candidate loci from other autoimmune/inflammatory disease shows overlap and supports the hypothesis of genetic sharing with SLE, MS and CD.
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(1999)
Diabetes
, vol.48
, pp. 1353-1358
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Becker, K.G.1
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10
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4243900858
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A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families
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Gaffney P.M., Kearns G.M., Shark K.B., Ortmann W.A., Selby S.A., Malmgren M.L., Rohlf K.E., Ockenden T.C., Messner R.P., King R.A.et al. A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families. Proc Natl Acad Sci USA. 95:1998;14875-14879.
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(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 14875-14879
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Gaffney, P.M.1
Kearns, G.M.2
Shark, K.B.3
Ortmann, W.A.4
Selby, S.A.5
Malmgren, M.L.6
Rohlf, K.E.7
Ockenden, T.C.8
Messner, R.P.9
King, R.A.10
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12
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0031893204
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Genetic susceptibility to systemic lupus erythematosus
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Comprehensive review of genetic linkage analysis data for both the New Zealand hybrid mouse model of lupus and human SLE
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Vyse T.J., Kotzin B.L. Genetic susceptibility to systemic lupus erythematosus. Annu Rev Immunol. 16:1998;261-292. Comprehensive review of genetic linkage analysis data for both the New Zealand hybrid mouse model of lupus and human SLE.
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(1998)
Annu Rev Immunol
, vol.16
, pp. 261-292
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Vyse, T.J.1
Kotzin, B.L.2
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13
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0032471612
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A new Graves disease-susceptibility locus maps to chromosome 20q11.2
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Tomer Y., Barbesino G., Greenberg D.A., Concepcion E., Davies T.F. A new Graves disease-susceptibility locus maps to chromosome 20q11.2. Am J Hum Genet. 63:1998;1749-1756.
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(1998)
Am J Hum Genet
, vol.63
, pp. 1749-1756
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Tomer, Y.1
Barbesino, G.2
Greenberg, D.A.3
Concepcion, E.4
Davies, T.F.5
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14
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0033563231
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A genome-wide search for linkage to asthma
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Genome-wide linkage study of affected sib-pairs in 97 families identified four regions (on chromosomes 2, 6, 9 and 12) that are linked to asthma
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Wjst M., Fischer G., Immervoll T., Jung M., Saar K., Rueschendorf F., Reis A., Ulbrecht M., Gomolka M., Weiss E.H.et al. A genome-wide search for linkage to asthma. Genomics. 58:1999;1-8. Genome-wide linkage study of affected sib-pairs in 97 families identified four regions (on chromosomes 2, 6, 9 and 12) that are linked to asthma.
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(1999)
Genomics
, vol.58
, pp. 1-8
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Wjst, M.1
Fischer, G.2
Immervoll, T.3
Jung, M.4
Saar, K.5
Rueschendorf, F.6
Reis, A.7
Ulbrecht, M.8
Gomolka, M.9
Weiss, E.H.10
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15
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0031726849
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: Genes in the spondyloarthropathies
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Wordsworth P. : Genes in the spondyloarthropathies. Rheum Dis Clin North Am. 24:1998;845-863.
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(1998)
Rheum Dis Clin North Am
, vol.24
, pp. 845-863
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Wordsworth, P.1
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16
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0032198308
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: Genetic epidemiology in inflammatory bowel disease
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Binder V. : Genetic epidemiology in inflammatory bowel disease. Dig Dis. 16:1998;351-355.
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(1998)
Dig Dis
, vol.16
, pp. 351-355
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Binder, V.1
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17
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0033358425
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A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort
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Hampe J., Schreiber S., Shaw S.H., Lau K.F., Bridger S., Macpherson A.J., Cardon L.R., Sakul H., Harris T.J., Buckler A.et al. A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort. Am J Hum Genet. 64:1999;808-816.
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(1999)
Am J Hum Genet
, vol.64
, pp. 808-816
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Hampe, J.1
Schreiber, S.2
Shaw, S.H.3
Lau, K.F.4
Bridger, S.5
MacPherson, A.J.6
Cardon, L.R.7
Sakul, H.8
Harris, T.J.9
Buckler, A.10
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18
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0031946030
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A genome-wide screen for susceptibility loci in ankylosing spondylitis
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Brown M.A., Pile K.D., Kennedy L.G., Campbell D., Andrew L., March R., Shatford J.L., Weeks D.E., Calin A., Wordsworth B.P. A genome-wide screen for susceptibility loci in ankylosing spondylitis. Arthritis Rheum. 41:1998;588-595.
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(1998)
Arthritis Rheum
, vol.41
, pp. 588-595
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Brown, M.A.1
Pile, K.D.2
Kennedy, L.G.3
Campbell, D.4
Andrew, L.5
March, R.6
Shatford, J.L.7
Weeks, D.E.8
Calin, A.9
Wordsworth, B.P.10
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19
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0033487663
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Genetic factors regulating experimental arthritis in mice and rats
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Basel: Karger AG. This intensive review of 287 published reports covering eight rat and mouse models of RA presents a lucid summary of the possible etiopathogenesis and underlying genetic basis for these models. Detailed tables show genetic intervals associating with disease in rats, mice and humans. The authors conclude that RA shares many genetic loci with several human autoimmune diseases and their surrogate animal models
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Wilder R.L., Remmers E.F., Kawahito Y., Gulko P.S., Cannon G.W., Griffiths M.M. Genetic factors regulating experimental arthritis in mice and rats. Current Directions in Autoimmunity, vol 1. 1999;121-165 Karger AG, Basel. This intensive review of 287 published reports covering eight rat and mouse models of RA presents a lucid summary of the possible etiopathogenesis and underlying genetic basis for these models. Detailed tables show genetic intervals associating with disease in rats, mice and humans. The authors conclude that RA shares many genetic loci with several human autoimmune diseases and their surrogate animal models.
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(1999)
Current Directions in Autoimmunity, Vol 1.
, pp. 121-165
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Wilder, R.L.1
Remmers, E.F.2
Kawahito, Y.3
Gulko, P.S.4
Cannon, G.W.5
Griffiths, M.M.6
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20
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0032544004
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Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases
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Possibly one of the most important publications of the year. This is a detailed review of linkage results from 23 genome-wide scans of the major human autoimmune/inflammatory diseases plus associated rodent models. Approximately 65% of QTLs associated with this category of disease map nonrandomly to one or more of 18 distinct gene clusters on the human genome. Of control data (from genome scans of nonautoimmune diseases), only 13% of the markers were clustered. The authors conclude that these clinically diverse autoimmune diseases may be regulated by a common set of susceptibility genes. Interestingly, five of the clusters are also associated with response to infectious agents
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Becker K.G., Simon R.M., Bailey-Wilson J.E., Freidlin B., Biddison W.E., McFarland H.F., Trent J.M. Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases. Proc Natl Acad Sci USA. 95:1998;9979-9984. Possibly one of the most important publications of the year. This is a detailed review of linkage results from 23 genome-wide scans of the major human autoimmune/inflammatory diseases plus associated rodent models. Approximately 65% of QTLs associated with this category of disease map nonrandomly to one or more of 18 distinct gene clusters on the human genome. Of control data (from genome scans of nonautoimmune diseases), only 13% of the markers were clustered. The authors conclude that these clinically diverse autoimmune diseases may be regulated by a common set of susceptibility genes. Interestingly, five of the clusters are also associated with response to infectious agents.
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(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 9979-9984
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Becker, K.G.1
Simon, R.M.2
Bailey-Wilson, J.E.3
Freidlin, B.4
Biddison, W.E.5
McFarland, H.F.6
Trent, J.M.7
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21
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0032402990
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Susceptibility to lupus nephritis in the NZB/W model system
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This review focuses on the autoimmune subphenotypes of this model and the use of QTL-congenic strains to dissect the associated genomic intervals
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Morel L., Wakeland E.K. Susceptibility to lupus nephritis in the NZB/W model system. Curr Opin Immunol. 10:1998;718-725. This review focuses on the autoimmune subphenotypes of this model and the use of QTL-congenic strains to dissect the associated genomic intervals.
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(1998)
Curr Opin Immunol
, vol.10
, pp. 718-725
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Morel, L.1
Wakeland, E.K.2
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22
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0033486824
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Localising quantitative trait loci in the NOD mouse model of type I diabetes
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Basel: Karger AG;
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Lyons, P.A., Wicker, P.A.: Localising quantitative trait loci in the NOD mouse model of type I diabetes. In Current Directions in Autoimmunity, vol 1. Basel: Karger AG; 1999:208-225.
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(1999)
In Current Directions in Autoimmunity
, vol.1
, pp. 208-225
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Lyons, P.A.1
Wicker, P.A.2
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23
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0033487172
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Genetics of experimental autoimmune encephalomyelitis
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Basel: Karger AG;
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Encinas, J.A., Kuchroo, V.K.: Genetics of experimental autoimmune encephalomyelitis. In Current Directions in Autoimmunity, vol 1. Basel: Karger AG; 1999:247-272.
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(1999)
In Current Directions in Autoimmunity
, vol.1
, pp. 247-272
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Encinas, J.A.1
Kuchroo, V.K.2
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25
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0032743793
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Genetic dissection of lupus pathogenesis: A recipe for nephrophilic autoantibodies
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Sle1 and Sle3 lupus nephritis loci in the NZM2410 strain were isolated on the C57BL/6 background and shown to regulate mild nephritis and mild polyclonal autoantibody. Bi-congenic mice, carrying both QTLs, developed highly penetrant glomerulonephritis. A two-step epistatic model is suggested
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Mohan C., Morel L., Yang P., Watanabe H., Croker B., Gilkeson G., Wakeland E.K. Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies. J Clin Invest. 103:1999;1685-1695. Sle1 and Sle3 lupus nephritis loci in the NZM2410 strain were isolated on the C57BL/6 background and shown to regulate mild nephritis and mild polyclonal autoantibody. Bi-congenic mice, carrying both QTLs, developed highly penetrant glomerulonephritis. A two-step epistatic model is suggested.
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(1999)
J Clin Invest
, vol.103
, pp. 1685-1695
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Mohan, C.1
Morel, L.2
Yang, P.3
Watanabe, H.4
Croker, B.5
Gilkeson, G.6
Wakeland, E.K.7
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26
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0032799722
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T-cell receptor Vbeta deletion and Valpha polymorphism are responsible for the resistance of SWR mouse to arthritis induction
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This report explains much of the long-standing debate over the role of TCRVβ genes compared with C5a deficiency in the resistance of SWR/J mice to CIA. It is shown that SWR/J mice lack both of the necessary Vβ and Vα genes needed for collagen-reactive cells
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Osman G.E., Hannibal M.C., Anderson J.P., Cheunsuk S., Lasky S.R., Liggitt H.D., Ladiges W.C., Hood L.E. T-cell receptor Vbeta deletion and Valpha polymorphism are responsible for the resistance of SWR mouse to arthritis induction. Immunogenetics. 49:1999;764-772. This report explains much of the long-standing debate over the role of TCRVβ genes compared with C5a deficiency in the resistance of SWR/J mice to CIA. It is shown that SWR/J mice lack both of the necessary Vβ and Vα genes needed for collagen-reactive cells.
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(1999)
Immunogenetics
, vol.49
, pp. 764-772
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Osman, G.E.1
Hannibal, M.C.2
Anderson, J.P.3
Cheunsuk, S.4
Lasky, S.R.5
Liggitt, H.D.6
Ladiges, W.C.7
Hood, L.E.8
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27
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0031765854
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Pristane-induced arthritis in mice. V. Susceptibility to pristane-induced arthritis is determined by the genetic regulation of the T cell repertoire
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Wooley P.H., Sud S., Whalen J.D., Nasser S. Pristane-induced arthritis in mice. V. Susceptibility to pristane-induced arthritis is determined by the genetic regulation of the T cell repertoire. Arthritis Rheum. 41:1998;2022-2031.
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(1998)
Arthritis Rheum
, vol.41
, pp. 2022-2031
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Wooley, P.H.1
Sud, S.2
Whalen, J.D.3
Nasser, S.4
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28
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0032776531
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Multiplex inheritance of component phenotypes in a murine model of lupus
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Detailed segregation analysis of eight genetic intervals associated with serological abnormalities in the NZB/W model indicates clustering of multiple susceptibility loci within these intervals. Each NZW2410 locus could be aligned with specific genetic pathways associated with SLE subphenotypes
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Morel L., Mohan C., Yu Y., Schiffenbauer J., Rudofsky U.H., Tian N., Longmate J.A., Wakeland E.K. Multiplex inheritance of component phenotypes in a murine model of lupus. Mamm Genome. 10:1999;176-181. Detailed segregation analysis of eight genetic intervals associated with serological abnormalities in the NZB/W model indicates clustering of multiple susceptibility loci within these intervals. Each NZW2410 locus could be aligned with specific genetic pathways associated with SLE subphenotypes.
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(1999)
Mamm Genome
, vol.10
, pp. 176-181
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Morel, L.1
Mohan, C.2
Yu, Y.3
Schiffenbauer, J.4
Rudofsky, U.H.5
Tian, N.6
Longmate, J.A.7
Wakeland, E.K.8
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29
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0344223322
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A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat
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Steen R.G., Kwitek-Black A.E., Glenn C., Gullings-Handley J., Van Etten W., Atkinson O.S., Appel D., Twigger S., Muir M., Mull T.et al. A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat. Genome Res. 9:1999;AP1-AP8.
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(1999)
Genome Res
, vol.9
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Steen, R.G.1
Kwitek-Black, A.E.2
Glenn, C.3
Gullings-Handley, J.4
Van Etten, W.5
Atkinson, O.S.6
Appel, D.7
Twigger, S.8
Muir, M.9
Mull, T.10
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30
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0033134912
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An integrated rat genetic map: Analysis of linkage conservation with the mouse and human maps
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Remmers E.F., Griffiths M.M., Longman R.E., Gulko P.S., Kawahito Y., Chen S., Chang L., Shepard J., Ge L., Dracheva S.et al. An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps. Transplant Proc. 31:1999;1549-1554.
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(1999)
Transplant Proc
, vol.31
, pp. 1549-1554
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Remmers, E.F.1
Griffiths, M.M.2
Longman, R.E.3
Gulko, P.S.4
Kawahito, Y.5
Chen, S.6
Chang, L.7
Shepard, J.8
Ge, L.9
Dracheva, S.10
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31
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0032854637
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A gene map of the rat derived from linkage analysis and related regions in the mouse and human genomes
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Gauguier D., Kaisaki P.J., Rouard M., Wallis R.H., Browne J., Rapp J.P., Bihoreau M.T. A gene map of the rat derived from linkage analysis and related regions in the mouse and human genomes. Mamm Genome. 10:1999;675-686.
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(1999)
Mamm Genome
, vol.10
, pp. 675-686
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Gauguier, D.1
Kaisaki, P.J.2
Rouard, M.3
Wallis, R.H.4
Browne, J.5
Rapp, J.P.6
Bihoreau, M.T.7
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32
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0033134911
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Rat genetic map and a rat/mouse/human comparative gene map
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Serikawa T., Kuramoto T., Yokoi N., Andoh Y., Cui Z., Kondo Y., Komeda K., Kitada K. Rat genetic map and a rat/mouse/human comparative gene map. Transplant Proc. 31:1999;1537-1540.
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(1999)
Transplant Proc
, vol.31
, pp. 1537-1540
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Serikawa, T.1
Kuramoto, T.2
Yokoi, N.3
Andoh, Y.4
Cui, Z.5
Kondo, Y.6
Komeda, K.7
Kitada, K.8
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33
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0032931687
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A radiation hybrid map of the rat genome containing 5,255 markers
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Watanabe T.K., Bihoreau M.T., McCarthy L.C., Kiguwa S.L., Hishigaki H., Tsuji A., Browne J., Yamasaki Y., Mizoguchi-Miyakita A., Oga K.et al. A radiation hybrid map of the rat genome containing 5,255 markers. Nat Genet. 22:1999;27-36.
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(1999)
Nat Genet
, vol.22
, pp. 27-36
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Watanabe, T.K.1
Bihoreau, M.T.2
McCarthy, L.C.3
Kiguwa, S.L.4
Hishigaki, H.5
Tsuji, A.6
Browne, J.7
Yamasaki, Y.8
Mizoguchi-Miyakita, A.9
Oga, K.10
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34
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0033297815
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Animal models of rheumatoid arthritis and related inflammation
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in press. This detailed review presents current concepts on the etiopathogenesis of the experimentally induced models of RA
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Joe B., Griffiths M.M., Remmers E.F., Wilder R.L. Animal models of rheumatoid arthritis and related inflammation. Curr Rheumatol Reports. 1999;. in press. This detailed review presents current concepts on the etiopathogenesis of the experimentally induced models of RA.
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(1999)
Curr Rheumatol Reports
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Joe, B.1
Griffiths, M.M.2
Remmers, E.F.3
Wilder, R.L.4
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35
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0032811531
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Identification of a new quantitative trait locus on chromosome 7 controlling disease severity of collagen-induced arthritis in rats
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Report of a second CIA-QTL on rat chromosome 7 and discussion of homologous regions of mouse and human genomes associated with arthritis
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Dracheva S.V., Remmers E.F., Gulko P.S., Kawahito Y., Longman R.E., Reese V.R., Cannon G.W., Griffiths M.M., Wilder R.L. Identification of a new quantitative trait locus on chromosome 7 controlling disease severity of collagen-induced arthritis in rats. Immunogenetics. 49:1999;787-791. Report of a second CIA-QTL on rat chromosome 7 and discussion of homologous regions of mouse and human genomes associated with arthritis.
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Dracheva, S.V.1
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36
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Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats
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Genome-wide scan for CIA severity QTLs in MHC-seroidentical (DA × ACI)F2 rats. Comparative mapping of this region to human and mouse chromosomes housing QTLs for IDDM, EAE, CD and MS. Reports gender association with severity of arthritis
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Gulko P.S., Kawahito Y., Remmers E.F., Reese V.R., Wang J., Dracheva S.V., Ge L., Longman R.E., Shepard J.S., Cannon G.W.et al. Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats. Arthritis Rheum. 41:1998;2122-2131. Genome-wide scan for CIA severity QTLs in MHC-seroidentical (DA × ACI)F2 rats. Comparative mapping of this region to human and mouse chromosomes housing QTLs for IDDM, EAE, CD and MS. Reports gender association with severity of arthritis.
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Gulko, P.S.1
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37
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0033134898
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Localization in rats of genetic loci regulating susceptibility to experimental erosive arthritis and related autoimmune diseases
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Concise summary of mapping data for experimental animal models of arthritis and autoimmune disease
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Wilder R.L., Griffiths M.M., Remmers E.F., Cannon G.W., Caspi R.R., Kawahito Y., Gulko P.S., Longman R.E., Dracheva S.V., Du Y.et al. Localization in rats of genetic loci regulating susceptibility to experimental erosive arthritis and related autoimmune diseases. Transplant Proc. 31:1999;1585-1588. Concise summary of mapping data for experimental animal models of arthritis and autoimmune disease.
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Wilder, R.L.1
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38
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Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: Evidence for genetic factors common to multiple autoimmune diseases
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First genome-wide scan for genetic intervals regulating the classic model of AIA in rats. Three QTLs are identified: Aia1 at the MHC and two proximally located QTLs on chromosome 4; Aia2 is independent; Aia3 overlaps Cia3
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Kawahito Y., Cannon G.W., Gulko P.S., Remmers E.F., Longman R.E., Reese V.R., Wang J., Griffiths M.M., Wilder R.L. Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases. J Immunol. 161:1998;4411-4419. First genome-wide scan for genetic intervals regulating the classic model of AIA in rats. Three QTLs are identified: Aia1 at the MHC and two proximally located QTLs on chromosome 4; Aia2 is independent; Aia3 overlaps Cia3.
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Kawahito, Y.1
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39
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Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat
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Kloting, I.1
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40
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Ida A., Hirose S., Hamano Y., Kodera S., Jiang Y., Abe M., Zhang D., Nishimura H., Shirai T. Multigenic control of lupus-associated antiphospholipid syndrome in a model of (NZW x BXSB) F1 mice. Eur J Immunol. 28:1998;2694-2703.
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Ida, A.1
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41
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0033515083
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Localization of non-MHC collagen-induced arthritis susceptibility loci in DBA/1j mice
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q. Non-MHC loci (mCia2, mCia3 and mCia4) were mapped to mouse chromosomes 2 and 6
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q. Non-MHC loci (mCia2, mCia3 and mCia4) were mapped to mouse chromosomes 2 and 6.
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(1999)
Proc Natl Acad Sci USA
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McIndoe, R.A.1
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42
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r strain (B10.RIII × RIIIS/j) mice. Two non-MHC loci, Mcia2 (co-localizing to Eae3 on chromosome 3) and a suggestive locus on chromosome 13, were mapped
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r strain (B10.RIII × RIIIS/j) mice. Two non-MHC loci, Mcia2 (co-localizing to Eae3 on chromosome 3) and a suggestive locus on chromosome 13, were mapped.
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(1998)
Eur J Immunol
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, pp. 3321-3328
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Jirholt, J.1
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Pettersson, U.7
Holmdahl, R.8
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43
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0032568616
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Identification of rat susceptibility loci for adjuvant-oil-induced arthritis
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First identification of non-MHC genetic loci regulating susceptibility to OIA
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Lorentzen J.C., Glaser A., Jacobsson L., Galli J., Fakhrai-Rad H., Klareskog L., Luthman H. Identification of rat susceptibility loci for adjuvant-oil-induced arthritis. Proc Natl Acad Sci USA. 95:1998;6383-6387. First identification of non-MHC genetic loci regulating susceptibility to OIA.
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, pp. 6383-6387
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Lorentzen, J.C.1
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Klareskog, L.6
Luthman, H.7
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44
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0031772326
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Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats
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First identification of non-MHC genetic loci regulating susceptibility to PIA in rats. Distinction is made for QTLs regulating clinical subphenotypes
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Vingsbo-Lundberg C., Nordquist N., Olofsson P., Sundvall M., Saxne T., Pettersson U., Holmdahl R. Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats. Nat Genet. 20:1998;401-404. First identification of non-MHC genetic loci regulating susceptibility to PIA in rats. Distinction is made for QTLs regulating clinical subphenotypes.
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(1998)
Nat Genet
, vol.20
, pp. 401-404
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Vingsbo-Lundberg, C.1
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Saxne, T.5
Pettersson, U.6
Holmdahl, R.7
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45
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0033555788
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Identification of quantitative trait loci governing arthritis severity and humoral responses in the murine model of Lyme disease
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First genome scan of an arthritis model induced by B. burgdorferi, the causative agent of human Lyme disease, identified multiple non-MHC loci associating individually with the various phenotypic manifestations of Lyme arthritis
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Weis J.J., McCracken B.A., Ma Y., Fairbairn D., Roper R.J., Morrison T.B., Weis J.H., Zachary J.F., Doerge R.W., Teuscher C. Identification of quantitative trait loci governing arthritis severity and humoral responses in the murine model of Lyme disease. J Immunol. 162:1999;948-956. First genome scan of an arthritis model induced by B. burgdorferi, the causative agent of human Lyme disease, identified multiple non-MHC loci associating individually with the various phenotypic manifestations of Lyme arthritis.
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(1999)
J Immunol
, vol.162
, pp. 948-956
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Weis, J.J.1
McCracken, B.A.2
Ma, Y.3
Fairbairn, D.4
Roper, R.J.5
Morrison, T.B.6
Weis, J.H.7
Zachary, J.F.8
Doerge, R.W.9
Teuscher, C.10
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46
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0032103047
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Theiler's virus infection of genetically susceptible mice induces central nervous system-infiltrating CTLs with no apparent viral or major myelin antigenic specificity
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+ cytotoxic T lymphocytes
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+ cytotoxic T lymphocytes.
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(1998)
J Immunol
, vol.160
, pp. 5661-5668
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Lin, X.1
Pease, L.R.2
Murray, P.D.3
Rodriguez, M.4
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47
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0031914643
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Subcongenic analysis of the Idd13 locus in NOD/Lt mice: Evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin
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Supports the concept that some of the QTLs now identified in genome-scan studies may in fact consist of multiple closely linked loci rather than a single locus affecting multiple models
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Serreze D.V., Bridgett M., Chapman H.D., Chen E., Richard S.D., Leiter E.H. Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin. J Immunol. 160:1998;1472-1478. Supports the concept that some of the QTLs now identified in genome-scan studies may in fact consist of multiple closely linked loci rather than a single locus affecting multiple models.
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(1998)
J Immunol
, vol.160
, pp. 1472-1478
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Serreze, D.V.1
Bridgett, M.2
Chapman, H.D.3
Chen, E.4
Richard, S.D.5
Leiter, E.H.6
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48
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0031945843
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Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis
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Strain analysis of an animal model of colitis
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Mahler M., Bristol I.J., Leiter E.H., Workman A.E., Birkenmeier E.H., Elson C.O., Sundberg J.P. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am J Physiol. 274:1998;G544-G551. Strain analysis of an animal model of colitis.
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(1998)
Am J Physiol
, vol.274
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Mahler, M.1
Bristol, I.J.2
Leiter, E.H.3
Workman, A.E.4
Birkenmeier, E.H.5
Elson, C.O.6
Sundberg, J.P.7
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49
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0033136734
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A major linkage region on distal chromosome 4 confers susceptibility to mouse autoimmune gastritis
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Genome-wide scan of mouse model of autoimmune gastritis shows unique and common QTLs. Clustering of genes regulating susceptibility to EAG and IDDM is shown and is consistent with inheritance of human gastritis and diabetes within families
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Silveira P.A., Baxter A.G., Cain W.E., van Driel I.R. A major linkage region on distal chromosome 4 confers susceptibility to mouse autoimmune gastritis. J Immunol. 162:1999;5106-5111. Genome-wide scan of mouse model of autoimmune gastritis shows unique and common QTLs. Clustering of genes regulating susceptibility to EAG and IDDM is shown and is consistent with inheritance of human gastritis and diabetes within families.
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(1999)
J Immunol
, vol.162
, pp. 5106-5111
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Silveira, P.A.1
Baxter, A.G.2
Cain, W.E.3
Van Driel, I.R.4
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50
-
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0032902739
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Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats
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First genome-wide scan for QTLs regulating this experimentally induced autoimmune disease of the eye locates two suggestive loci on rat chromosomes 4 and 12
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Sun S.H., Silver P.B., Caspi R.R., Du Y., Chan C.C., Wilder R.L., Remmers E.F. Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats. Int Immunol. 11:1999;529-534. First genome-wide scan for QTLs regulating this experimentally induced autoimmune disease of the eye locates two suggestive loci on rat chromosomes 4 and 12.
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(1999)
Int Immunol
, vol.11
, pp. 529-534
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Sun, S.H.1
Silver, P.B.2
Caspi, R.R.3
Du, Y.4
Chan, C.C.5
Wilder, R.L.6
Remmers, E.F.7
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51
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0032531157
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MHC haplotype-dependent regulation of MOG-induced EAE in rats
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Report demonstrates that the severity of MOG-induced EAE in rats is a result of interactions between specific MHC and non-MHC alleles
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Weissert R., Wallstrom E., Storch M.K., Stefferl A., Lorentzen J., Lassmann H., Linington C., Olsson T. MHC haplotype-dependent regulation of MOG-induced EAE in rats. J Clin Invest. 102:1998;1265-1273. Report demonstrates that the severity of MOG-induced EAE in rats is a result of interactions between specific MHC and non-MHC alleles.
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(1998)
J Clin Invest
, vol.102
, pp. 1265-1273
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Weissert, R.1
Wallstrom, E.2
Storch, M.K.3
Stefferl, A.4
Lorentzen, J.5
Lassmann, H.6
Linington, C.7
Olsson, T.8
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52
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0033168629
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Myelin oligodendrocyte glycoprotein induces experimental autoimmune encephalomyelitis in the 'resistant' Brown Norway rat: Disease susceptibility is determined by MHC and MHC-linked effects on the B cell response
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This study used reciprocal MHC-congenic strains to demonstrate a strong influence of MHC class I and class II genes, plus the RT1.M region encoding the MOG gene, on anti-MOG antibody titers and thus variable disease susceptibility in BN and LEW rats
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Stefferl A., Brehm U., Storch M., Lambracht-Washington D., Bourquin C., Wonigeit K., Lassmann H., Linington C. Myelin oligodendrocyte glycoprotein induces experimental autoimmune encephalomyelitis in the 'resistant' Brown Norway rat: disease susceptibility is determined by MHC and MHC-linked effects on the B cell response. J Immunol. 163:1999;40-49. This study used reciprocal MHC-congenic strains to demonstrate a strong influence of MHC class I and class II genes, plus the RT1.M region encoding the MOG gene, on anti-MOG antibody titers and thus variable disease susceptibility in BN and LEW rats.
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(1999)
J Immunol
, vol.163
, pp. 40-49
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-
Stefferl, A.1
Brehm, U.2
Storch, M.3
Lambracht-Washington, D.4
Bourquin, C.5
Wonigeit, K.6
Lassmann, H.7
Linington, C.8
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53
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0032209673
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B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization
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Hjelmstrom P., Juedes A.E., Fjell J., Ruddle N.H. B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization. J Immunol. 161:1998;4480-4483.
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J Immunol
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Hjelmstrom, P.1
Juedes, A.E.2
Fjell, J.3
Ruddle, N.H.4
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54
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0031874025
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Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; Impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern
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Dahlman I., Lorentzen J.C., de Graaf K.L., Stefferl A., Linington C., Luthman H., Olsson T. Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern. Eur J Immunol. 28:1998;2188-2196.
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Eur J Immunol
, vol.28
, pp. 2188-2196
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Dahlman, I.1
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De Graaf, K.L.3
Stefferl, A.4
Linington, C.5
Luthman, H.6
Olsson, T.7
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55
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0033105381
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Genome-wide linkage analysis of chronic relapsing experimental autoimmune encephalomyelitis in the rat identifies a major susceptibility locus on chromosome 9
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New severity QTLs identified in (DA × BN)F2 rats with EAE
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Dahlman I., Jacobsson L., Glaser A., Lorentzen J.C., Andersson M., Luthman H., Olsson T. Genome-wide linkage analysis of chronic relapsing experimental autoimmune encephalomyelitis in the rat identifies a major susceptibility locus on chromosome 9. J Immunol. 162:1999;2581-2588. New severity QTLs identified in (DA × BN)F2 rats with EAE.
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(1999)
J Immunol
, vol.162
, pp. 2581-2588
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Dahlman, I.1
Jacobsson, L.2
Glaser, A.3
Lorentzen, J.C.4
Andersson, M.5
Luthman, H.6
Olsson, T.7
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56
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0033557725
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A genome-wide search identifies two susceptibility loci for experimental autoimmune encephalomyelitis on rat chromosomes 4 and 10
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Identification of QTLs regulating EAE in (LEW × BN)F2 rats that are different from those identified by others in (DA × BN)F2 rats
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Roth M.P., Viratelle C., Dolbois L., Delverdier M., Borot N., Pelletier L., Druet P., Clanet M., Coppin H. A genome-wide search identifies two susceptibility loci for experimental autoimmune encephalomyelitis on rat chromosomes 4 and 10. J Immunol. 162:1999;1917-1922. Identification of QTLs regulating EAE in (LEW × BN)F2 rats that are different from those identified by others in (DA × BN)F2 rats.
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(1999)
J Immunol
, vol.162
, pp. 1917-1922
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Roth, M.P.1
Viratelle, C.2
Dolbois, L.3
Delverdier, M.4
Borot, N.5
Pelletier, L.6
Druet, P.7
Clanet, M.8
Coppin, H.9
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57
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0032529630
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New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice
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Butterfield R.J., Sudweeks J.D., Blankenhorn E.P., Korngold R., Marini J.C., Todd J.A., Roper R.J., Teuscher C. New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice. J Immunol. 161:1998;1860-1867.
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J Immunol
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Butterfield, R.J.1
Sudweeks, J.D.2
Blankenhorn, E.P.3
Korngold, R.4
Marini, J.C.5
Todd, J.A.6
Roper, R.J.7
Teuscher, C.8
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58
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0033104698
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Genetic analysis of disease subtypes and sexual dimorphisms in mouse experimental allergic encephalomyelitis (EAE): Relapsing/remitting and monophasic remitting/nonrelapsing EAE are immunogenetically distinct
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EAE clinical subphenotypes of chronic relapsing/remitting, benign and acute, monophasic forms of EAE subtypes were associated with novel and distinct QTLs
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Butterfield R.J., Blankenhorn E.P., Roper R.J., Zachary J.F., Doerge R.W., Sudweeks J., Rose J., Teuscher C. Genetic analysis of disease subtypes and sexual dimorphisms in mouse experimental allergic encephalomyelitis (EAE): relapsing/remitting and monophasic remitting/nonrelapsing EAE are immunogenetically distinct. J Immunol. 162:1999;3096-3102. EAE clinical subphenotypes of chronic relapsing/remitting, benign and acute, monophasic forms of EAE subtypes were associated with novel and distinct QTLs.
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(1999)
J Immunol
, vol.162
, pp. 3096-3102
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-
Butterfield, R.J.1
Blankenhorn, E.P.2
Roper, R.J.3
Zachary, J.F.4
Doerge, R.W.5
Sudweeks, J.6
Rose, J.7
Teuscher, C.8
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59
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0032947236
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QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15 cM region containing Il2
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This study fine-maps the regulatory element for two autoimmune disease models (EAE and IDDM) and shows convincing data that one locus, Il2, contributes to both models. This finding supports the concept that some alleles will contribute to autoimmune diseases of different clinical presentation
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Encinas J.A., Wicker L.S., Peterson L.B., Mukasa A., Teuscher C., Sobel R., Weiner H.L., Seidman C.E., Seidman J.G., Kuchroo V.K. QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15 cM region containing Il2. Nat Genet. 21:1999;158-160. This study fine-maps the regulatory element for two autoimmune disease models (EAE and IDDM) and shows convincing data that one locus, Il2, contributes to both models. This finding supports the concept that some alleles will contribute to autoimmune diseases of different clinical presentation.
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(1999)
Nat Genet
, vol.21
, pp. 158-160
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-
Encinas, J.A.1
Wicker, L.S.2
Peterson, L.B.3
Mukasa, A.4
Teuscher, C.5
Sobel, R.6
Weiner, H.L.7
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Seidman, J.G.9
Kuchroo, V.K.10
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60
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0032401779
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Reviews the major QTLs in NOD mice and BB(DP) rats identified throughout 1998. Focus is on functional studies of candidate genes and pathways of transgenic and gene-knockout mice
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McDuffie M. Genetics of autoimmune diabetes in animal models. Curr Opin Immunol. 10:1998;704-709. Reviews the major QTLs in NOD mice and BB(DP) rats identified throughout 1998. Focus is on functional studies of candidate genes and pathways of transgenic and gene-knockout mice.
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Curr Opin Immunol
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McDuffie, M.1
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61
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0032939329
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Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat
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A new disease model incorporating distinct loci for disease susceptibility (chromosome 20), initiation as measured by insulitis (chromosome 4), disease progression (chromosome 13) and lyp providing spontaneous disease expression
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Martin A.M., Blankenhorn E.P., Maxson M.N., Zhao M., Leif J., Mordes J.P., Greiner D.L. Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat. Diabetes. 48:1999;50-58. A new disease model incorporating distinct loci for disease susceptibility (chromosome 20), initiation as measured by insulitis (chromosome 4), disease progression (chromosome 13) and lyp providing spontaneous disease expression.
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Diabetes
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, pp. 50-58
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Martin, A.M.1
Blankenhorn, E.P.2
Maxson, M.N.3
Zhao, M.4
Leif, J.5
Mordes, J.P.6
Greiner, D.L.7
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62
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0031771012
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Linkage of a major quantitative trait locus to Yaa gene-induced lupus-like nephritis in (NZW × C57BL/6)F1 mice
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Santiago M.L., Mary C., Parzy D., Jacquet C., Montagutelli X., Parkhouse R.M., Lemoine R., Izui S., Reininger L. Linkage of a major quantitative trait locus to Yaa gene-induced lupus-like nephritis in (NZW × C57BL/6)F1 mice. Eur J Immunol. 28:1998;4257-4267.
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Eur J Immunol
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Santiago, M.L.1
Mary, C.2
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Lemoine, R.7
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Reininger, L.9
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63
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0033104610
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Analysis of MHC class II genes in the susceptibility to lupus in New Zealand mice
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Rozzo S.J., Vyse T.J., David C.S., Palmer E., Izui S., Kotzin B.L. Analysis of MHC class II genes in the susceptibility to lupus in New Zealand mice. J Immunol. 162:1999;2623-2630.
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J Immunol
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Rozzo, S.J.1
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Kotzin, B.L.6
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64
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0032521036
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Contributions of Ea(z) and Eb(z) MHC genes to lupus susceptibility in New Zealand mice
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