New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice

Journal of Immunology

Volumn 161, Issue 4, 1998, Pages 1860-1867

  Butterfield, Russell J ^a   Sudweeks, Jayce D ^b   Blankenhorn, Elizabeth P ^c   Korngold, Robert ^d   Marini, Joseph C ^d   Todd, John A ^e   Roper, Randall J ^a   Teuscher, Cory ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b BRIGHAM YOUNG UNIVERSITY   (United States)

^c DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGIC ENCEPHALITIS; ANIMAL MODEL; ARTICLE; CHROMOSOME 11; CHROMOSOME 17; CHROMOSOME 3; CHROMOSOME 7; CHROMOSOME 9; FEMALE; GENE EXPRESSION; GENE LOCUS; GENOME; MALE; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CHROMOSOME MAPPING; CROSSES, GENETIC; DISEASE SUSCEPTIBILITY; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GENETIC MARKERS; HUMANS; INCIDENCE; LINEAR MODELS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MULTIPLE SCLEROSIS; QUANTITATIVE TRAIT, HERITABLE;

EID: 0032529630     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Ebers G. C., A. D. Sadovnick, N. J. Risch, and the Canadian Collaborative Study Group. 1995. A genetic basis for familial aggregation in multiple sclerosis. Nature 377:150.
2. Blankenhorn, E. P., and S. A. Stranford. 1992. Genetic factors in demyelinating diseases: genes that control demyelination due to experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalitis virus. Reg. Immunol. 4:331.
3. Wekerle, H., K. Kojima, J. Lannes-Vieira, H. Lassman, and C. Linington, C. 1994. Animal models. Ann. Neurol. 36:s47.
4. Lee, J. M., P. K. Olitsky, H. A. Schneider, and N. D. Zinder. 1954. Role of heredity in experimental disseminated encephalomyelitis in mice. Proc. Soc. Exp. Biol. Med. 85:430.
5. Lee, J. M., and P. K. Olitsky. 1955. Simple methods for enhancing development of acute disseminated encephalomyelitis in mice. Proc. Soc. Exp. Biol. Med. 89:263.
6. Levine, S., and R. Sowinski. 1973. Experimental allergic encephalomyelitis in inbred and outbred mice. J. Immunol. 110:139.
7. Levine, S., and R. Sowinski. 1974. Experimental allergic encephalomyelitis in congenic strains of mice. Immunogenetics 1:352.
8. Yasuda, T., T. Tsumita, Y. Nagai, E. Mitsuzawa, and S. Ohtani. 1975. Experimental allergic encephalomyeutis (EAE) in mice. I. Induction of EAE with mouse spinal cord homogenate and myelin basic protein. Jpn. J. Exp. Med. 45: 423.
9. Bernard, C. C. A. 1976. Experimental autoimmune encephalomyelitis in mice: genetic control of susceptibility. J. Immunogenet. 3:263.
10. Lando, Z., D. Teitelbaum, and R. Arnon. 1979. Genetic control of susceptibility to experimental allergic encephalomyelitis in mice. Immunogenetics 9:435.
11. Raine, C. S., L. B. Barnett, A. Brown, T. Behar, and D. E. McFarlin. 1980. Neuropathology of experimental allergic encephalomyelitis in inbred strains of mice. Lab. Invest. 43:150.
12. Montgomery, I. N., and H. C. Rauch. 1982. Experimental allergic encephalomelitis (EAE) in mice: primary control of EAE susceptibility is outside the H-2 complex. J. Immunol. 128:421.
13. Linthicum, D. S., and J. A. Frelinger. 1982. Acute automimune ecephalomyelitis in mice. II. Susceptibility is controlled by the combination of H-2 and histamine sensitization genes. J. Exp. Med. 155:31.
14. Fritz, R. B., L. L. Perry, and C-H. Jen Chou. 1984. Genetic control of myelin basic protein-induced experimental allergic encephalomyelitis in mice. Proc. Clin. Biol. Res. 146:235.
15. Fritz, R. B., M. J. Skenn, C.-H. Jen Chou, M. Garcia, and I. K. Egerov. 1985. Major histocompatibility complex-linked control of the murine immune response to myelin basic protein. J. Immunol. 134:2328.
16. r) mice. Eur. J. Immunol. 21:693.
17. Todd J. A., T. J. Aitman, R. J. Cornall, S. Ghosh, J. R. S. Hall, C. M. Hearne, A. M. Knight, J. M. Love, M. A. McAleer, J-B. Prin, N. Rodrigues, M. Lathrop, A. Pressey, N. H. DeLarato, L. B. Peterson, and L. S. Wicker. 1991. Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature 351:542.
18. Korngold, R., A. Feldman, L. B. Rorke, F. D. Lublin, and P. C. Doherty. 1986. Acute experimental allergic encephalomyelitis in radiation bone marrow chimeras between high and low susceptible strains of mice. Immunogenetics 24:309.
19. Binder, T. A., D. L. Greiner, M. Grunnet, and I. Goldschneider. 1993. Relative susceptibility of SJL/J and B10. S mice to experimental allergic encephalomyelitis (EAE) is determined by the ability of prethymic cells in bone marrow to develop into EAE effector T cells. J. Neuroimmunol. 42:23.
20. Klein, J., F. Figeroa, and C. S. David. 1983. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex. Immunogenetics 17:553.
21. Sawcer, S., Goodfellow, P.N., Compston, A. 1997. The genetic analysis of multiple sclerosis. Trends Genet. 13:234.
22. Teuscher, C., W. F. Hickey, and R. Korngold. 1990. An analysis of the role of TNF in the phenotypic expression of actively induced experimental allergic orchitis and experimental allergic encephalomyelitis. Clin. Immunol. Immunopathol. 54:442.
23. Sudweeks, J. D., J. A. Todd, E. P. Blankenhorn, B. B. Wardell, S. R. Woodward, N. D. Meeker, S. S. Estes, and C. Teuscher. 1993. Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene maps distal of T-cell receptor β-chain gene on mouse chromosome 6. Proc Natl. Acad. Sci. USA 90:3700.
24. Wardell, B. B., S. D. Michael, K. S. K. Tung, J. A. Todd, E. P. Blankenhorn, K. McEntee, J. D. Sudweeks, W. K. Hansen, N. D. Meeker, J. S. Griffith, K. D. Livingstone, and C. Teuscher. 1995. Aod1, the immunoregulatory locus controlling abrogation of tolerance in neonatal thymectomy-induced autoimmune ovarian dysgenesis, maps to chromosome 16. Proc. Natl. Acad. Sci. USA 92: 4758.
25. Meeker, N. D., W. F. Hickey, R. Korngold, W. K. Hansen, J. D. Sudweeks, B. B. Wardell, J. S. Griffith, and C. Teuscher. 1995. Multiple loci govern the bone marrow-derived immunoregulatory mechanism controlling dominant resistance to autoimmune orchitis. Proc. Natl. Acad. Sci. USA 92:5684.
26. Dietrich, W. F., J. C. Miller, R. G. Steen, M. Merchant, D. Damron-Boles, Z. Husain, R. Dredge, M. J. Daly, K. A. Ingalls, T. J. O'Connor, C. A. Evans, M. M. DeAngelis, D. M. Levinson, L. Kruglyak, N. Goodman, N. G. Copeland, N. A. Jenkins, T. L. Hawkins, L. Stein, D. C. Page, and E. S. Lander. 1996. A comprehensive genetic map of the mouse genome. Nature 380:149.
27. Lincoln, S., M. Daly, and E. Lander. 1992. Constructing genetic linkage maps with MAPMAKER/EXP 3.0. In Whitehead Institute Technical Report, 3rd bd. Whitehead Institute, Cambridge, MA.
28. Churchill, G.A., and R. W. Doerge. 1994. Empirical thresholds for quantitative trait mapping. Genetics 138:963.
29. SAS Institute. 1989. SST/STAT User's Guide, version 6, 4th Ed., Vol. 2. Cary, NC: SAS Institute.
30. Wendell D.L., and J. Gorski. 1997. Quantitative trait loci for estrogen-dependent pituitary tumor growth in the rat. Mamm. Genome 8:823.
31. Baker D., O. A. Rosenwasser, J. K. O'Neill, and J. L. Turk. 1995. Genetic analysis of experimental allergic encephalomyelitis in mice. J. Immunol. 155: 4046.
32. Sundvall, M., J. Jirholt, H.-T. Yang, L. Jansson, A. Engstrom, U. Petterson, and R. Holmdahl. 1995. Identification of munne loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis. Nat. Genet. 10:313.
33. Encinas, J. A., M. B. Lees, R. A. Sobel, C. Symonowicz, J. M. Greer, C. L. Shovlin, H. L. Weiner, C. E. Seidman, J. G. Seidman, and V. J. Kuchroo. 1996. Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice. J. Immunol. 157:2186.
34. Croxford J. L., J. K. O'Neil, and D. Baker, D. 1997. Polygenic control of experimental allergic encephalomyelitis in Biozzi ABH and BALB/c mice. J. Neuroimmunol. 74:205.
35. Vyse, T. J., and J. A. Todd. 1996. Genetic analysis of autoimmune disease. Cell 85:311.
36. Kuokkanen, S., M. Sundvall, J. D. Terwiliger, J. W. Tienari, R. Holmdahl, U. Pettersson, and L. Peltonen. 1996. A putative vulnerability locus to multiple sclerosis maps to 5p14-P12 in a region syntenic to the murine locus eae2. Nat. Genet. 13:477.
37. Lander, E., and L. Kruglyak. 1995. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat. Genet. 11:241.
38. Roper, R. J., R. W. Doerge, S. B. Call, K. S. K. Tung, W. F. Hickey, and C. Teuscher. 1998. Autoimmune orchitis, epididymitis, and vasitis are immunogenetically distinct lesions. Am. J. Pathol. 152:1337.
39. Segal, B. M., and E. M. Shevach. 1996. IL-12 unmasks latent autoimmune disease in resistant mice. J. Exp. Med. 184:771.
40. Gorham, J. D., M. L. Guler, R. G. Steen, A. J. Mackey, M. J. Daly, K. Frederick, W. F. Dietrich, and K. M. Murphy. 1996. Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses. Proc. Natl. Acad. Sci. USA 93:12467.
41. Rösener, M., P. A. Muraro, A. Riethmüller, M. Kalbus, G. Sappler, R. J. Thompson, R. Lichtenfels, N. Sommer, H. F. McFarland, and R. Martin. 1997. 2′,3′-cyclic nucleotide 3′-phosphodiesterase: a novel candidate autoantigen in demyelinating diseases. J. Neuroimmunol. 75:28.
42. Kolb, H., and V. Kolb-Bachofen. 1992. Nitric oxide: a pathogenic factor in autoimmunity. Immunol. Today 13:157.
43. Brenner, T., S. Brocke, F. Szafer, A. S. Sobel, J. F. Parkinson, D. H. Perez, and L. Steinman. 1997. Inhibition of nitric oxide synthase for treatment of experimental autoimmune encephalomyelitis. J. Immunol. 158:2940.
44. Prochazka, M., E. H. Leiter, D. V. Serreze, and D. Coleman. 1987. Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice. Science 237:286.
45. Risch, N., S. Ghosh, and J. A. Todd. 1993. Statistical evaluation of multiple locus linkage data in experimental species and relevance to human studies: application of murine and human IDDM. Am. J. Hum. Genet. 53:702.
46. Sawcer, S., H. B. Jones, R. Feakes, J. Gray, N. Smaldon, J. Chataway, N. Robertson, D. Clayton, P. N. Goodfellow, and A. Compston. 1996. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat. Genet. 13:464.
47. The Multiple Sclerosis Genetics Group. 1996. A complete genomic screen for multiple sclerosis underscores a role for the major hislocompatibility complex. Nat. Genet. 13:469.
48. Ebers, G. C., K. Kukay, D. E. Bulman, A. D. Sadonvick, G. Rice, C. Anderson, H. Armstrong, K. Cousin, R. B. Bell, W. Hader, D. W. Paty, S. Hashimoto, J. Oger, P. Duquette, S. Warren, T. Gray, P. O'Connor, A. Nath, A. Auty, L. Metz, G. Francis, J. E. Paulseth, T. J. Murray, W. Pryse-Phillips, R. Nelson, M. Freedman, D. Brunet, J. P. Bouchard, D. Hinds, and N. Risch. 1996. A full genome scan in multiple sclerosis. Nat. Genet. 13:472.
49. Kuokkanen, S., M. Gschwend, J. D. Rioux, M. J. Daly, J. D. Terwilliger, P. J. Tienari, J. Wikström, J. Palo, L. D. Stein, T. J. Hudson, E. S. Lander, and L. Peltonen. 1997. Genomewide scan of multiple sclerosis in Finnish Multiplex families. Am. J. Hum. Genet. 61:1379.