Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: Evidence for genetic factors common to multiple autoimmune diseases

Journal of Immunology

Volumn 161, Issue 8, 1998, Pages 4411-4419

  Kawahito, Yutaka ^a,c   Cannon, Grant W ^b   Gulko, Pércío S ^a   Remmers, Elaine F ^a   Longman, Ryan E ^a   Reese, Van R ^b   Wang, Jianping ^a   Griffiths, Marie M ^b   Wilder, Ronald L ^a,d  

^a NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADJUVANT ARTHRITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CHROMOSOME 20; CHROMOSOME 4; DISEASE ASSOCIATION; ENTERITIS; FOLLOW UP; GENETIC LINKAGE; GENETIC REGULATION; GENOME; HEREDITY; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; RAT; SYSTEMIC LUPUS ERYTHEMATOSUS; THYROIDITIS;

ANIMALS; ARTHRITIS, EXPERIMENTAL; AUTOIMMUNITY; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN; GENOME; HUMANS; LINKAGE (GENETICS); MICE; QUANTITATIVE TRAIT, HERITABLE; RATS; RATS, INBRED F344;

EID: 0032532596     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (66)

1. Feldmann, M., F. M. Brennan, and R. N. Maini. 1996. Rheumatoid arthritis. Cell 85:307.
2. Aho, K., M. Koskenvuo, J. Tuominen, and J. Kaprio. 1986. Occurrence of rheumatoid arthritis in a nationwide series of twins. J. Rheumatol. 13:899.
3. Silman, A. J., A. J. MacGregor, W. Thomson, S. Holligan, D. Carthy, A. Farhan, and W. E. R. Ollier. 1993. Twin concordance rates for rheumatoid arthritis: results from a nationwide study. Br. J. Rheumatol. 32:903.
4. Worthington, J., W. E. R. Ollier, M. K. Leach, I. Smith, E. M. Hay, W. Thomson, L. Pepper, D. Carthy, A. Farhan, S. Martin, P. Dyer, J. Davison, S. Bamber, and A. J. Silman. 1994. The Arthritis and Rheumatism Council's national repository of family material: pedigrees from the first 100 rheumatoid arthritis families containing affected sibling pairs. Br. J. Rheumatol. 33:970.
5. Ollier, W., and W. Thomson. 1992. Population genetics of rheumatoid arthritis. Rheum. Dis. Clin. North Am. 18:741.
6. Ollier, W. E. R., and A. MacGregor. 1995. Genetic epidemiology of rheumatoid disease. Br. Med. Bull. 51:267.
7. Vyse, T. J., and J. A. Todd. 1996. Genetic analysis of autoimmune disease. Cell 85:311.
8. Theofilopoulos, A. N. 1995. The basis of autoimmunity. II. Genetic predisposition. Imunnol. Today 16:150.
9. Stoerk, H. C., T. C. Bielinski, and T. Budzilovich. 1954. Chronic polyarthritis in rats injected with spleen in adjuvants. Am. J. Pathol. 30:616 (Abstr.).
10. Pearson, C. M. 1956. Development of arthritis, periarthritis and periostitis in rats given adjuvant. Proc. Soc. Exp. Biol. Med. 91:95.
11. Cohen, I. R., J. Holoshitz, W. van Eden, and A. Frenkel. 1985. T lymphocyte clones illuminate pathogenesis and affect therapy of experimental arthritis. Arthritis Rheum. 28:841.
12. Whitehouse, M. W. 1988. Adjuvant induced polyarthritis in rats. In Handbook of Animal Models for Rheumatic Disease. R. A. Greenwald and H. S. Diamond, eds. CRC Press, Boca Raton, p. 3.
13. Van Eden, W., J. Holoshitz, Z. Nevo, A. Frenkel, A. Klajman, and I. R. Cohen. 1985. Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycan. Proc. Natl. Acad. Sci. USA 82:5117.
14. Johnson, W. J., K. A. Muirhead, P. C. Meunier, B. J. Votta, T. C. Schmitt, M. J. DiMartino, and N. Hanna. 1986. Macrophage activation in rat models of inflammation and arthritis: systemic activation precedes arthritis induction and progression. Arthritis Rheum. 29:1122.
15. Van Eden, W., J. E. R. Thole, R. van der Zee, A. Noordzij, J. D. A. van Embden, E. J. Henson, and I. R. Cohen. 1988. Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis. Nature 331:171.
16. Cannon, G. W., D. S. Harper, F. Clayton, and M. M. Griffiths. 1993. Passive transfer of adjuvant-induced arthritis into irradiated DA recipient rats. Autoimmunity 15:267.
17. Cannon, G. W., S. J. Openshaw, J. B. Hibbs Jr., J. R. Hoidal, T. P. Huecksteadt, and M. M. Griffiths. 1996. Nitric oxide production during adjuvant-induced and collagen-induced arthritis. Arthritis Rheum. 39:1677.
18. Trentham, D. E., A. S. Townes, and A. H. Kang. 1977. Autoimmunity to type II collagen: an experimental model of arthritis. J. Exp. Med. 146:857.
19. Griffiths, M. M. 1988. Immunogenetics of collagen-induced arthritis in rats. Int. Rev. Immunol. 4:1.
20. Crofford, L. J., and R. L. Wilder. 1997. Arthritis and autoimmunity in animals. In Arthritis and Allied Conditions, Vol. 13. W. J. Koopman, ed. Williams & Wilkins, Baltimore, p. 565.
21. Wooley, P. H., and J. M. Chapedelaine. 1987. Immunogenetics of collagen-induced arthritis. CRC Crit. Rev. Immunol. 8:1.
22. Wooley, P. H. 1991. Animal models of rheumatoid arthritis. Curr. Opin. Rheumatol. 3:407.
23. Griffiths, M. M., and C. W. DeWitt. 1984. Genetic control of collagen-induced arthritis in rats: the immune response to type II collagen among susceptible and resistant strains and evidence for multiple gene control. J. Immunol. 132:2830.
24. Battisto, J. R., R. N. Smith, K. Beckman, M. Sternlicht, and W. L. Welles. 1982. Susceptibility to adjuvant arthritis in DA and F344 rats. Arthritis Rheum. 25: 1194.
25. Lorentzen, J. C., and L. Klareskog. 1996. Susceptibility of DA rats to arthritis induced with adjuvant oil or rat collagen is determined by genes both within and outside the major histocompatibility complex. Scand. J. Immunol. 44:592.
26. Griffiths, M. M., and C. W. DeWitt. 1981. Immunogenetic control of experimental collagen-induced arthritis in rats. II. ECIA susceptibility and immune response to type II collagen (CALF) are linked to RT1. J. Immunogenet. 8:463.
27. Griffiths, M. M., M. A. Cremer, D. S. Harper, S. McCall, and G. W. Cannon. 1992. Immunogenetics of collagen-induced arthritis in rats: both MHC and non-MHC gene products determine the epitope specificity of immune response to bovine and chick type II collagens. J. Immunol. 149:309.
28. Griffiths, M. M., G. W. Cannon, P. A. Leonard, and V. R. Reese. 1993. Induction of autoimmune arthritis in rats by immunization with homologous rat type II collagen is restricted to the RT1av1 haplotype. Arthritis Rheum. 36:254.
29. Remmers, E. F., R. E. Longman, Y. Du, A. O'Hare, G. W. Cannon, M. M. Griffiths, and R. L. Wilder. 1996. A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. Nat. Genet. 14:82.
30. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl. 1994. Current Protocols in Molecular Biology. John Wiley and Sons, New York.
31. In The ARB Rat Genetic Database. Available at http://www.nih.gov/niams/scientific/ratgbase/index.htm.
32. In Wellcome Trust/Oxford University Rat Genetic Database. Available at http://www.well.ox.ac.uk/~bihoreau/key.html.
33. In The Whitehead Institute/MIT Rat Genetic Database. Available at http://ww-w.genome.wi.mit.edu/rat/public.
34. Lander, E. S., P. Green, J. Abrahamson, A. Barlow, M. J. Daly, S. E. Lincoln, and L. Newburg. 1987. MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1:174.
35. Lincoln, S. E., and E. S. Lander. 1992. Systematic detection of errors in genetic linkage data. Genomics 14:604.
36. Suzuki, D. T., A. J. F. Griffith, J. H. Miller, and R. C. Lewontin. 1986. An Introduction to Genetic Analysis, Vol. 4. W. H. Freeman and Company, New York.
37. Lander, E. S., and D. Botstein. 1989. Mapping mendelian factors underlying quantitative traits using RFLP maps. Genetics 121:185.
38. Fox, E., J. Kuo, L. Tilling, and C. Ulich. 1994. SigmaStat: User's Manual, Revision SSW 1.0. Jandel Scientific Software. San Rafael, p. 12.
39. Lander, E., and L. Kruglyak. 1995. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat. Genet. 11:241.
40. In The Mouse Genome Database. Available at http://www.informatics.jax.org/mgd.html.
41. In The Genome Database. Available at http://gdbwww.gdb.org/.
42. Daniels, S. E., S. Bhattacharrya, A. James, N. I. Leaves, A. Young, M. R. Hill, J. A. Faux, G. F. Ryan, P. N. leSouef, G. M. Lathrop, A. W. Musk, and W. O. C. M. Cookson. 1996. A genome-wide search for quantitative trait loci underlying asthma. Nature 383:247.
43. Sudweeks, J. D., J. A. Todd, E. P. Blankenhorn, B. B. Wardell, S. R. Woodward, N. D. Meeker, S. S. Estes, and C. Teuscher. 1993. Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T cell receptor β-chain gene on chromosome 6. Proc. Natl. Acad. Sci. USA 90:3700.
44. Satsangi, J., M. Parkes, E. Louis, L. Hashimoto, N. Kato, K. Welsh, J. D. Terwilliger, G. M. Lathrop, J. I. Bell, and D. P. Jewell. 1996. Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosome 3, 7 and 12. Nat. Genet. 14:199.
45. Sun, S. H., P. B. Silver, Y. Du, R. R. Caspi, R. L. Wilder, and E. F. Remmers. 1997. Identification of a locus on rat chromosome 4 associated with EAU susceptibility. Invest. Ophthalmol. Vis. Sci. 38:S436 (Abstr.).
46. Cornélis, F., S. Fauré, M. Martinez, J.-F. Purd'homme, P. Fritz, C. Dib, H. Alves, P. Barrera, N. de Vries, A. Balsa, et al. for the European Consortium on Rheumatoid Arthritis Families. 1997. Rheumatoid arthritis genome scan and putative autoimmunity locus. Arthritis Rheum. 40:S329 (Abstr.).
47. Jacob, H. J., A. Pettersson, D. D. Wilson, Y. Mao, Å. Lernmark, and E. S. Lander. 1992. Genetic dissection of autoimmune type 1 diabetes in the BB rat. Nat. Genet. 2:56.
48. De Gouyon, B., E. Melanitou, M. F. Richard, M. Requarth, I. H. Hahn, J. L. Guenet, F. Demenais, C. Julier, G. M. Lathrop, C. Boitard, and P. Avner. 1993. Genetic analysis of diabetes and insulitis in an interspecific cross of the nonobese diabetic mouse with Mus spretus. Proc. Natl. Acad. Sci. USA 90:1877.
49. McAleer, M. A., P. Reifsnyder, S. M. Palmer, M. Prochazka, J. M. Love, J. B. Copeman, E. E. Powell, N. R. Rodrigues, J.-B. Prins, D. V. Serreze et al. 1995. Crosses of NOD mice with the related NON strain: a polygenic model for IDDM. Diabetes 44:1186.
50. Sawcer, S., H. B. Jones, R. Feakes, J. Gray, N. Smaldon, J. Chataway, N. Robertson, D. Clayton, P. N. Goodfellow, and A. Compston. 1996. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 19q22. Nat. Genet. 13:464.
51. Haines, J., M. Pericak-Vance, E. Seboun, S. Hauser, and Multiple Sclerosis Genetics Group. 1996. A complete genome screen for multiple sclerosis underscores a role for the major histocompatibility complex. Nat. Genet. 13:469.
52. Ebers, G. C., K. Kukay, D. E. Bulman, A. D. Sadovnick, G. Rice, C. Anderson, H. Armstrong, K. Cousin, R. B. Bell, W. Hader et al. 1996. A full genome search in multiple sclerosis. Nat. Genet. 13:472.
53. Kono, D. H., R. W. Burlingame, D. G. Owens, A. Kuramochi, R. S. Balderas, D. Balomenos, and A. N. Theofilopoulos. 1994. Lupus susceptibility loci in New Zealand mice. Proc. Natl. Acad. Sci. USA 91:10168.
54. Gill, T. J. III, S. K. Salgar, X.-J. Yuan, and H. W. Kunz. 1997. Current status of the genetic and physical maps of the major histocompatibility complex in the rat. Transplant. Proc. 29:1657.
55. Stastny, P. 1978. Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N. Engl. J. Med. 298:869.
56. Gregersen, P. K., J. Silver, and R. J. Winchester. 1987. The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum. 30:1205.
57. Weyand, C. M., K. C. Hicok, D. L. Conn, and J. J. Goronzy. 1992. The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis. Ann. Intern. Med. 117:801.
58. Suarez-Almazor, M. E., S. Tao, F. Moustarah, A. S. Russell, and W. Maksymowych. 1995. HLA-DR1, DR4, and DRB1 disease related subtypes in rheumatoid arthritis: association with susceptibility but not severity in a city wide community based study. J. Rheumatol. 22:2027.
59. Wagner, U., S. Kaltenhauser, H. Sauer, S. Arnold, W. Seidel, H. Hantzschel, J. R. Kalden, and R. Wassmuth. 1997. HLA markers and prediction of clinical course and outcome in rheumatoid arthritis. Arthritis Rheum. 40:341.
60. Pettersson, A., D. Wilson, T. Daniels, S. Tobin, H. J. Jacob, E. S. Lander, and X. C. Lernmark. 1995. Thyroiditis in the BB rat is associated with lymphopenia but occurs independently of diabetes. J. Autoimmun. 8:493.
61. Thomas, D. J. B., A. Young, A. N. Gorsuch, G. F. Bottazzo, and A. G. Cudworth. 1983. Evidence for an association between rheumatoid arthritis and autoimmune endocrine disease. Ann. Rheum. Dis. 42:297.
62. Taneja, V., R. R. Singh, A. N. Malaviya, C. Anand, and N. K. Mehra. 1993. Occurrence of autoimmune diseases and relationship of autoantibody expression with HLA phenotpes in multicase rheumatoid arthritis families. Scand. J. Rheumatol. 22:152.
63. Puel, A., P. C. Groot, M. G. Lathrop, P. Demant, and D. Mouton. 1995. Mapping of genes controlling quantitative antibody production in Biozzi mice. J. Immunol. 154:5799.
64. Teuscher, C. 1985. Experimental allergic orchitis in mice. II. Association of disease susceptibility with the locus controlling Bordetella pertussis-induced sensitivity to histamine. Immunogenetics 22:417.
65. Ginn, L. R., J. P. Lin, P. H. Plotz, S. J. Bale, R. L. Wilder, A. Mbauya, and F. W. Miller. 1998. Familial autoimmunity in pedigrees of idiopathic inflammatory myopathy patients suggests common genetic risk factors for many autoimmune diseases. Arthritis Rheum. 41:400.
66. Becker, K. G., R. M. Simon, J. E. Bailey-Wilson, B. Friedlin, W. E. Biddison, H. F. McFarland, and J. M. Trent. 1998. Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases. Proc. Natl. Acad. Sci. USA 95:9979.