Genetic dissection of lupus pathogenesis: A recipe for nephrophilic autoantibodies

Journal of Clinical Investigation

Volumn 103, Issue 12, 1999, Pages 1685-1695

  Mohan, Chandra ^a,d   Morel, Laurence ^b   Yang, Ping ^b   Watanabe, Hiroshi ^c   Croker, Byron ^b   Gilkeson, Gary ^c   Wakeland, Edward K ^a,d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY;

ANIMAL CELL; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; FLOW CYTOMETRY; GLOMERULONEPHRITIS; LUPUS ERYTHEMATOSUS NEPHRITIS; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SPLENOMEGALY; T LYMPHOCYTE ACTIVATION;

EID: 0032743793     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI5827     Document Type: Article

References (55)

1. Mohan, C., and Datta, S.K. 1995. Lupus: key pathogenic mechanisms and contributing factors. Clin. Immunol. Immunopathol. 77:209-220.
2. Theofilopoulos, A.N. 1995. The basis of auroimmunity. I. Mechanisms of aberrant self-recognition. Immunol. Today. 16:90-98.
3. Kotzin, B.L. 1996. Systemic lupus erythematosus. Cell. 85:303-306.
4. Wakeland, E.K., Morel, L., Mohan, C., and Yui, M. 1997. Genetic dissection of lupus nephritis in murine models of SLE [review]. J. Clin. Immunol. 17:272-281.
5. Vyse, T.J., and Todd, J.A. 1996. Genetic analysis of autoimmune disease [review]. Cell. 85:311-318.
6. Kono, D.H., and Theofilopoulos, A.N. 1996. Genetic contributions to SLE [review]. J. Autoimmun. 9:437-452.
7. Rudofsky, U.H., Evans, B.D., Balaban, S.L., Mottironi, V.D., and Gabrielsen, A.E. 1993. Differences in expression of lupus nephritis in New Zealand mixed H-2z homozygous inbred strains of mice derived from New Zealand black and New Zealand white mice. Origins and initial characterization. Lab. Invest. 68:419-426.
8. Mohan, C., Morel, L., Yang, P., and Wakeland, E.K. 1997. Splenic B1a cell expansion in NZM2410 lupus strain, with strong antigen presenting capability. Arthritts Rheum. 41:1652-1662.
9. Morel, L., Rudofsky, U.H., Longmate, J.A., Schiffenbauer, J., and Wakeland, E.K. 1994. Polygenic control of susceptibility to murine systemic lupus erythematosus. Immunity. 1:219-229.
10. Wakeland, E.K., Morel, L., Achey, K., Yui, M.E., and Longmate, J.A. 1998. Speed congenic: a classic technique moves into the fast lane (relatively speaking). Immunol. Today. 18:473-477.
11. Morel, L., Yu, Y., Blenman, K.R., Caldwell, R.A., and Wakeland, E.K. 1996. Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. Mamm. Genome. 7:335-339.
12. Morel, L., et al. 1997. Functional dissection of SLE pathogenesis using congenic mouse strains. J. Immunol. 158:6019-6028.
13. Mohan, C., Morel, L., Croker, B., Yang, P., and Wakeland, E.K. 1997. Genetic dissection of SLE pathogenesis: Sle2 on murine chromosome 4 leads to B-cell hyperactivity. J. Immunol. 159:454-465.
14. Mohan, C., Alas, E., Morel, L., Yang, P., and Wakeland, E.K. 1997. Genetic dissection of SLE pathogenesis: Sle1 on murine chromosome 1 leads to loss of tolerance to H2A/H2B/DNA subnucleosomes. J. Clin. Invest. 101:1362-1372.
15. Mohan, C., Yu, Y., Morel, L., and Wakeland, E.K. 1999. Genetic dissection of SLE pathogenesis: Sle3 on murine chromosome 7 impacts T cell activation, differentiation and cell death. J. Immunol. In press.
16. Mohan, C., Adams, S., Stanik, V., and Dana, S.K. 1993. Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus. J. Exp. Med. 177:1367-1381.
17. Burlingame, R.W., and Rubin, R.L. 1990. Subnucleosome structures as substrates in enzyme-linked immunosorbent assays. J. Immunol. Methods. 134:187-199.
18. Losman, M.J., Fasy, T.M., Novick, K.E., and Monestier, M. 1992. Monoclonal autoantibodies to subnucleosomes from a MRL/Mp(-)+/+ mouse. Oligoclonality of the antibody response and recognition of a determinant composed of histones H2A, H2B, and DNA. J. Immunol. 148:1561-1569.
19. Van-Bruggen, M.C., et al. 1997. Antigen specificity of anti-nuclear antibodies complexed to nucleosomes determines glomerular basement membrane binding in vivo. Eur. J. Immunol. 27:1564-1569.
20. Bernstein, K.A., Valerio, R.D., and Lefkowith, J.B. 1995. Glomerular binding activity in MRL lpr serum consists of antibodies that bind to a DNA/histone/type IV collagen complex. J. Immunol. 154:2424-2433.
21. Bernstein, K., Bolshoun, D., Gilkeson, G., Munns, T., and Lefkowith, J.B. 1993. Detection of glomerular binding immune elements in murine lupus using a tissue-based ELISA. Clin. Exp. Immunol. 91:449-455.
22. Pirani, C.L., and Croker, B. 1994. Handling and processing of renal biopsy and nephrectomy specimens. In Renal pathology: with clinical and functional correlations. C.C. Tisher and B.M. Brenner, editors. J.B. Lippincott. Philadelphia, PA. 1683-1694.
23. Pirani, C.L., Pollack, V.E., and Schwartz, R.S. 1964. The reproducibility of semiquantitative analyses of renal histology. Nephron. 1:230-237.
24. Theofilopoulos, A.N., and Dixon, F.J. 1985. Murine models of systemic lupus erythematosus. Adv. Immunol. 37:269-390.
25. Izui, S., Berney, T., Shibata, T., and Fulpius, T. 1993. IgG3 cryoglobulins in autoimmune MRL-lpr/lpr mice: immunopathogenesis, therapeutic approaches and relevance to similar human diseases. Ann. Rheum. Dis. 52:48S-54S.
26. Lefkowith, J.B., et al. 1996. Heterogeneity and clinical significance of glomerular-bindingantibodies in systemic lupus erythematosus. J. Clin. Invest. 98:1373-1380.
27. Budhai, L., Oh, K., and Davidson, A. 1996. An in vitro assay for detection of glomerular binding IgG autoantibodies in patients with systemic lupus erythematosus. J. Clin. Invest 98:1585-1593.
28. Lefkowith, J.B., and Gilkeson, G.S. 1996. Nephritogenic autoantibodies in lupus. Current concepts and continuing controversies. Arthritis Rheum. 39:894-903.
29. Kleinman, H.K., et al. 1982. Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma. Biochemistry. 21:6188-6193.
30. East, J. 1970. Immunopathology and neoplasms in New Zealand black (NZB) and SJL/J mice. Progr. Exp. Tumor Res. 13:84-134.
31. Burlingame, R.W., Boey, M.L., Starkebaum, G., and Rubin, R.L. 1994. The central role of chromatin in autoimmune responses to histones and DNA in systemic lupus erythematosus. J. Clin. Invest. 94:184-192.
32. Burlingame, R.W., Rubin, R.L., Balderas, R.S., and Theofilopoulos, A.N. 1993. Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen. J. Clin. Invest. 91:1687-1696.
33. Amoura, Z., et al. 1994. Nucleosome-restricted antibodies are detected before anti-dsDNA and/or antihistone antibodies in serum of MRL-Mp lpr/lpr and +/+ mice, and are present in kidney eluates of lupus mice with proteinuria. Arthritis Rheum. 37:1684-1688.
34. Vlahakos, D.V., et al. 1992. Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites. Kidney Int. 41:1690-1700.
35. Rubin, R.L., Bell, S.A., and Burlingame, R.W. 1992. Autoantibodies associated with lupus induced by diverse drugs target a similar epitope in the (H2A-H2B)-DNA complex. J. Clin. Invest. 90:165-173.
36. Totoritis, M.C., Tan, E.M., McNally, E.M., and Rubin, R.L. 1988. Association of antibody to histone complex H2A-H2B with symptomatic procainamide-induced lupus. N. Engl. J. Med. 318:1431-1436.
37. Tsao, B.P., et al. 1997. Evidence for linkage of a candidate chromosome 1 region to systemic lupus erythematosus (SLE). J. Clin. Invest. 99:725-731.
38. Moser, K.L., et al. 1998. Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees. Proc. Natl. Acad. Sci. USA. 95:14869-14874.
39. Cohen, P.L., and Eisenberg, R.A. 1991. Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9:243-269.
40. Izui, S., et al. 1984. Induction of various autoantibodies by mutant gene lpr in several strains of mice. J. Immunol. 133:227-233.
41. Gilkeson, G.S., et al. 1995. The influence of variable-region somatic mutations on the specificity and pathogenicity of murine monoclonal anti-DNA antibodies. Clin. Immunol. Immunopathol. 76:59-67.
42. Wloch, M.K., Alexander, A.L., Pippen, A.M., Pisetsky, D.S., and Gilkeson, G.S. 1996. Differences in V kappa gene utilization and VH CDR3 sequence among anti-DNA from C3H-lpr mice and lupus mice with nephritis. Eur. J. Immunol. 26:2225-2233.
43. Lefkowith, J.B., et al. 1996. Murine glomerulotrophic monoclonal antibodies are highly oligoclonal and exhibit distinctive molecular features. J. Immunol. 157:1297-1305.
44. Foster, M.H., et al. 1993. Molecular analysis of spontaneous nephrotropic anti-laminin antibodies in an autoimmune MRL-lpr/lpr mouse. J. Immunol. 151:814-824.
45. Ben, Y.A., et al. 1995. The urine of SLE patients contains antibodies that bind to the laminin component of the extracellular matrix. J. Autoimmun. 8:279-291.
46. Termaat, R.M., et al. 1993. Antigen-specificity of antibodies bound to glomeruli of mice with systemic lupus erythematosus syndromes. Lab. Invest. 68:164-173.
47. Fillit, H., and Lahita, R. 1991. Antibodies to vascular heparan sulfate proteoglycan in patients with systemic lupus erythematosus. Autoimmunity. 9:159-164.
48. Moreland, L.W., Gay, R.E., and Gay, S. 1991. Collagen autoantibodies in patients with vasculitis and systemic lupus erythematosus. Clin. Immunol. Immunopathol. 60:412-418.
49. Ratkay, L.G., Tonzetich, J., and Waterfield, J.D. 1991. Antibodies to extracellular matrix proteins in the sera of MRL-lpr mice. Clin. Immunol. Immunopathol. 59:236-245.
50. Termaat, R.M., et al. 1992. Anti-DNA antibodies can bind to the glomerulus via two distinct mechanisms. Kidney Int. 42:1363-1371.
51. Steinberg, A.D., et al. 1979. Approach to the study of the role of sex hormones in autoimmunity. Arthritis Rheum. 22:1170-1189.
52. Ansar, A.S., Penhale, W.J., and Talal, N. 1985. Sex hormones, immune responses, and autoimmune diseases. Mechanisms of sex hormone action. Am. J. Pathol. 121:531-551.
53. Sobel, E.S., Mohan, C., Morel, L., Schiffenbauer, J., and Wakeland, E.K. 1999. Genetic dissection of SLE pathogenesis: adoptive transfer of Sle1 mediates the loss of tolerance by bone marrow derived B cells. J. Immunol. 162:2415-2421.
54. Kretz-Rommel, A., Duncan, S.R., and Rubin, R.L. 1997. Autoimmunity caused by disruption of central T cell tolerance. A murine model of drug-induced lupus. J. Clin. Invest. 99:1888-1896.
55. Yung, R., et al. 1996. Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function associated antigen 1 become autoreactive and causes a lupus-like disease in syngeneic mice. J. Clin. Invest. 97:2866-2871.