Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators

Journal of Medicinal Chemistry

Volumn 41, Issue 24, 1998, Pages 4800-4818

  Kalgutkar, Amit S ^a   Kozak, Kevin R ^a   Crews, Brenda C ^a   Hochgesang Jr , G Phillip ^a   Marnett, Lawrence J ^a  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ACETOXYPHENYLHEPT 2 YNYLSULFIDE; 2 ACETOXYPHENYLHEPTYLSULFIDE; 2 ACETOXYPHENYLMETHYLSULFIDE; ACETYLSALICYLIC ACID; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL CELL; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MACROPHAGE; MOUSE; NONHUMAN; PEPTIDE MAPPING; STRUCTURE ACTIVITY RELATION;

ACETYLATION; ACETYLENE; ALKYNES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS; COLONIC NEOPLASMS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; EXUDATES AND TRANSUDATES; HUMANS; INHIBITORY CONCENTRATION 50; ISOENZYMES; KINETICS; MACROPHAGES; MEMBRANE PROTEINS; MICE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; SHEEP; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES; THROMBOXANE B2; TUMOR CELLS, CULTURED;

EID: 0032548140     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980303s     Document Type: Article

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