1,2-Diarylpyrroles as potent and selective inhibitors of cyclooxygenase- 2

Journal of Medicinal Chemistry

Volumn 40, Issue 11, 1997, Pages 1619-1633

  Khanna, Ish K ^a   Weier, Richard M ^a   Yu, Yi ^a   Collins, Paul W ^a   Miyashiro, Julie M ^a   Koboldt, Carol M ^a   Veenhuizen, Amy W ^a   Currie, Jerry L ^a   Seibert, Karen ^a   Isakson, Peter C ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 FLUOROPHENYL) 2 METHYL 5 [4 (METHYLSULFONYL)PHENYL] 1H PYRROLE; 2 (4 FLUOROPHENYL) 1 [4 (METHYLSULFONYL)PHENYL] 1H PYRROLE; 2 (4 FLUOROPHENYL) 5 METHYL 1 [4 (METHYLSULFONYL)PHENYL] 1H PYRROLE; 4 [2 (4 FLUOROPHENYL) 1H PYRROL 1 YL]BENZENESULFONAMIDE; CYCLOOXYGENASE 2 INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DOSE RESPONSE; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; EDEMA; INFLAMMATION; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; EDEMA; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; MOLECULAR STRUCTURE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRROLES; RATS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0030968683     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970036a     Document Type: Article

References (48)

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