The use of dominant-negative mutations to elucidate signal transduction pathways in lymphocytes

Current Opinion in Immunology

Volumn 8, Issue 2, 1996, Pages 285-290

  Perlmutter, Roger M ^a,b   Alberola Ila, José ^b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOMINANT GENE; GENE MUTATION; GENE TARGETING; IMMUNOGENETICS; LYMPHOCYTE; MUTATION; NONHUMAN; SHORT SURVEY; SIGNAL TRANSDUCTION; TRANSGENIC ANIMAL;

EID: 0029976805     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(96)80069-0     Document Type: Article

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46. ••].
47. •].
48. •] illustrate the fact that, in some cases, dominant-negative mutants can be created without knowing much about the structure or function of a protein, and may provide important information for the elucidation of signal transduction cascades.