Signalling to p53: Where does it all start?

BioEssays

Volumn 18, Issue 8, 1996, Pages 617-619

  Kastan, Michael B ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0030219646     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.950180804     Document Type: Review

References (28)

1. 1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev. 10, 934-947.
2. Donehower, L. A. et al. (1992). Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215-221.
3. Hollstein, M. et al. (1996). Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation. Nucleic Acids Res. 24, 141-146.
4. Eliyahu, D., Raz, A., Gruss, P., Givol, D. and Oren, M. (1984). Participation of p53 cellular tumor antigen in transformation of normal embryonic cells. Nature 312, 646-649.
5. Hinds, P. W., Finlay, C. A. and Levine, A. J. (1989). Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation. J. Virol. 63, 739-746.
6. Symonds, H. et al. (1994). p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell78, 703-711.
7. Williams, B. O., Remington, L., Albert, D. M., Mukai, S., Bronson, R. T. and Jacks, T. (1994). Cooperative tumorigenic effects of germline mutations in Rb and p53. Nature Genetics 7, 480-484.
8. Baker, S. J., Markowitz, S., Fearon, E. R., Willson, J. K. V. and Vogelstein, B. (1990). Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 249, 912-915.
9. Diller, L. et al. (1990). p53 functions as a cell cycle control protein in osteosarcomas. Mol. Cell. Biol. 10, 5772-5781.
10. Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B. and Craig, R. W. (1991). Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51, 6304-6311.
11. Kuerbitz, S. J., Plunkett, B. S., Walsh, W. V. and Kastan, M. B. (1992). Wildtype p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl Acad. Sci. USA 89, 7491-7495.
12. Kastan, M. B. et al. (1992). A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell71, 587-597.
13. Lowe, S. W., Schmitt, S. W., Smith, S. W., Osborne, B. A. and Jacks, T. (1993). p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-849.
14. Lowe, S. W., Ruley, H. E., Jacks, T. and Housman, D. E. (1993). p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74, 957-967.
15. Clarke, A. R. et al. (1993). Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362, 849-852.
16. Graeber, T. G. et al. (1996). Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379, 88-91.
17. Kemp, C. J., Wheldon, T. and Balmain, A. (1994). p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis. Nature Genetics 8, 66-69.
18. Lee, J. M., Abrahamson, J. L. A., Kandel, R., Donehower, L. A. and Bernstein, A. (1994). Susceptibility to radiationcarcinogenesis and accumulation of chromosomal breakage in p53 deficient mice. Oncogene 9, 3731-3736.
19. Donehower, L. A. et al. (1995). Deficiency of p53 accelerates mammary tumorigenesis in Vnt-l transgenic mice and promotes chromosomal instability. Genes Dev. 9, 882-895.
20. Tishler, R. B., Calderwood, S. K., Coleman, C. N. and Price, B. D. (1993). Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents. Cancer Res 53, 2212-2216.
21. Nelson, W. G. and Kastan, M. B. (1994). DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol. Cell. Biol. 14, 1815-1823.
22. Lu, X. and Lane, D. P. (1993). Differential induction of transcriptionally active p53 following UV or ionizing radiation: Defects in chromosome instability syndromes? Cell 75, 765-778.
23. 1 arrest. Proc. Natl Acad. Sci. USA 93, 4827-4832.
24. Bakalkin, G. et al. (1994). p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer. Proc. Natl Acad. Sci. USA 91, 413-417.
25. Bakalkin, G. et al. (1995). p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain. Nucleic Acids Res. 23, 362-369.
26. Jayaraman, L. and Prives, C. (1995). Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus. Cell 81, 1021-1029.
27. Lee, S., Elenbaas, B., Levine, A. and Griffith, J. (1995). p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches. Cell 81, 1013-1020.
28. 1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol. Cell. Biol. 14, 6264-6277.