The recognition of DNA damage

Current Opinion in Genetics and Development

Volumn 6, Issue 1, 1996, Pages 19-25

  Jackson, Stephen P ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; DNA POLYMERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN;

CANCER; CELL CYCLE; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; DNA TRANSCRIPTION; ENZYME ACTIVATION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 0030021296     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(96)90005-2     Document Type: Article

References (15)

1. Lindahl T, Satoh MS, Poirier GG, Kungland A: Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. Trends Biochem Sci 1995, 20:407-412.
2. Kupper J-H, Muller M, Jacobson MK, Tatsumi-Miyajima J, Coyle DL, Jacobson EL, Burkle A: trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against γ-irradiation and N-methyl-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon. Mol Cell Biol 1995, 15:3154-3163.
3. Schreiber V, Hunting D, Trucco C, Gowans B, Grunwald D, De Murcia G, Menissier De Murcia J: A dominant-negative mutant of human poly(ADP-ribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage. Proc Natl Acad Sci USA 1995, 92:4753-4757. Together with [2*], this paper shows that overexpression of the PARP DNA-binding domain leads to elevated chromosomal instability and increased rates of spontaneous, and DNA-damage induced, sister chromatid exchanges. PARP DNA-binding domain overexpression also causes hypersensitivity to alkylating agents and γ-irradiation.
4. Wang Z-Q, Auer B, Sting L, Berghammer H, Haidacher D, Schweiger M, Wagner EF: Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev 1995, 9:509-520. This paper establishes that cells homozygous for null mutations in PARP lack PARP activity and are deviod of detectable poly(ADP-ribose). Other than being susceptible to epidermal hyperplasia and the development of skin lesions, PARP-deficient mice are reported to be healthy and fertile. Moreover, they are not hypersensitive to UV irradiation or DNA alkylating agents. These findings would argue against a simple role for PARP in DNA repair or checkpoint control mechanisms and have lead to a dramatic reappraisal of PARP function in vivo.
5. Zhou Z, Elledge SJ: DUN1 encodes a protein kinase that controls the DNA damage response in yeast Cell 1993, 75:1119-1127.
6. 2/M checkpoints. The checkpoint function of pol ε is shown to require the carboxy-terminal region, which is absent from other types of DNA polymerase.
7. Wei Y-F, Robbins P, Carter K, Caldecott K, Pappin DJC, Yu G-L, Wang R-P, Shell BK, Nash RA, Schar P, et al.: Molecular cloning and expression of human cDNAs encoding a novel ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination. Mol Cell Biol 1995, 15:3206-3216.
8. De Murcia G, Menissier de Murcia J: Poly(ADP-ribose) polymerase: a molecular nick-sensor. Trends Biochem Sci 1994, 19:172-176.
9. cdc2, this provides a link between DNA damage detection and the cell cycle machinery.
10. Gottlieb TM, Jackson SP: Protein kinases and DNA damage. Trends Biochem Sci 1994, 19:500-503.
11. Zdzienicka MZ: Mammalian mutants defective in the response to ionizing radiation-induced DNA damage. Mutat Res 1995, 336:203-213.
12. Jackson SP, Jeggo PA: DNA double-strand break repair and V(D)J recombination: Involvement of DNA-PK. Trends Biochem Sci 1995, 20:412-415.
13. Jeggo PA, Taccioli GE, Jackson SP: Menage a trois: double strand break repair, V(D)J recombination and DNA-PK. Bioessays 1995, 17:949-957.
14. Gottlieb TM, Jackson SP: The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 1993, 72:131-142.
15. Dvir A, Stein LY, Galore BL, Dynan WS: Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II. J Biol Chem 1993, 268:10440-10447.