The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization

Molecular and Cellular Biology

Volumn 17, Issue 4, 1997, Pages 2247-2256

  Vincent, Sylvie ^a   Settleman, Jeffrey ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; GUANOSINE TRIPHOSPHATASE; PROTEIN KINASE; RAS PROTEIN;

ACTIN FILAMENT; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME PURIFICATION; FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0030894714     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.4.2247     Document Type: Article

References (49)

1. Amano, M., H. Mukai, Y. Ono, K. Chihara, T. Matsui, Y. Hamajima, K. Okawa, A. Iwamatsu, and K. Kaibuchi. 1996. Identification of a putative target for Rho as the serine-threonine kinase protein kinase N. Science 271:648-650.
2. Bagrodia, S., B. Dérijard, R. J. Davis, and R. A. Cerione. 1995. Cdc42 and PAK-mediated signaling leads to jun kinase and p38 mitogen-activated protein kinase activation. J. Biol. Chem. 270:27995-27998.
3. Binétruy, B., T. Smeal, and M. Karin. 1991. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature 351:122-127.
4. Bourne, H. R., D. A. Sanders, and F. McCormick. 1990 The GTPase superfamily: a conserved switch for diverse cell functions. Nature 348:125-132.
5. Brill, S., S. Li, C. W. Lyman, D. M. Church, J. J. Wasmuth, L. Weissbach, A. Bernards, and A. J. Snijders. 1996. The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases. Mol. Cell. Biol. 16:4869-4878.
6. Burbelo, P. D., D. Dreschsel, and A. Hall. 1995. A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J. Biol. Chem. 270:29071-29074.
7. Chardin, P., P. Boquet, P. Madaule, M. R. Popoff, E. J. Rubin, and D. M. Gill. 1989. The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microhlaments in Vero cells. EMBO J. 8:1087-1092.
8. Coso, O. A., M. Chiariello, J.-C. Yu, H. Teramoto, P. Crespo, N. Xu, T. Miki, and J. S. Gutkind. 1995. The small GTP-binding proteins Rac1 and CDC42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137-1146.
9. Debant, A., C. Serra-Pages, K. Seipel, S. O'Brien, M. Tang, and S. H. Park. 1996. The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains. Proc. Natl. Acad. Sci. USA 93:5466-5471.
10. Hall, A. 1994. Small GTP-binding proteins and the regulation of the actin cytoskeleton. Annu. Rev. Cell Biol. 10:31-54.
11. Hill, C. S., J. Wynne, and R. Treisman. 1995. The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell 81:1159-1170.
12. Horii, Y., J. F. Beeler, K. Sakaguchi, M. Tachibana, and T. Miki. 1994. A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways. EMBO J. 13:4776-4786.
13. Howe, L. R., S. J. Leevers, N. Gomez, S. Nakielny, P. Cohen, and C. J. Marshall. 1992. Activation of the MAP kinase pathway by the protein kinase raf. Cell 71:335-342.
14. Ishizaki, T., M. Maekawa, K. Fujisawa, K. Okawa, A. Fugita, G. Watanabe, Y. Saito, A. Kakizuka, N. Morii, and S. Narumiya. 1996. The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr kinase homologous to the myotonic dystrophy kinase. EMBO J. 15:1885-1893.
15. Kitagawa, M., H. Mukai, H. Shibata, and Y. Ono. 1995. Purification and characterization of a fatty acid-activated protein kinase (PKN) from rat testis. Biochem. J. 310:657-664.
16. Kozma, R., S. Ahmed, A. Best, and L. Lim. 1995. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol. Cell. Biol. 15:1942-1952.
17. Lamarche, N., N. Tapon, P. D. Burbelo, P. Aspendröm, T. Bridges, J. Chant, and A. Hall. 1996. Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65pak and the JNK/SAPK MAP kinase cascade. Cell 87:519-529.
18. Lamaze, C., T.-H. Chuang, L. J. Terlecky, G. M. Bokoch, and S. Schmid. 1996. Regulation of receptor-mediated endocytosis by Rho and Rac. Nature 382:177-179.
19. Leberer, E., D. Dignard, D. Harcus, D. Y. Thomas, and M. Whiteway. 1992. The protein kinase homolog Ste20p is required to link the yeast pheromone response G-protein βγ subunits to downstream signalling components. EMBO J. 11:4815-4824.
20. Leung, T., X.-Q. Chen, E. Manser, and L. Lim. 1996. The p160 RhoA-binding kinase ROKα is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol. Cell. Biol. 16:5313-5327.
21. Leung, T., E. Manser, L. Tan, and L. Lim. 1995. A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes. J. Biol. Chem. 270:29051-29054.
22. Madaule, P., T. Furuyashiki, T. Reid, T. Ishizaki, G. Watanabe, N. Morii, and S. Narumiya. 1995. A novel partner for the GTP-bound forms of Rho and Rac. FEBS Lett. 377:243-248.
23. Manser, E., T. Leung, H. Salihuddin, Z. S. Zhao, and L. Lim. 1994. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367:40-46.
24. Marais, R., Y. Light, H. F. Paterson, and C. J. Marshall. 1995. Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation. EMBO J. 14:3136-3145.
25. Marshall, C. J. 1995. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179-185.
26. Martin, G. A., G. Bollag, F. McCormick, and A. Abo. 1995. A novel serine kinase activated by Rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO J. 14:1970-1978.
27. Matsui, T., M. Amano, T. Yamamoto, K. Chihara, M. Nakafuku, M. Ito, T. Nakano, K. Okawa, A. Iwamatsu, and K. Kaibuchi. 1996. Rho-associated kinase, a novel serine/threonine kinase, as a putative target for the small GTP binding protein Rho. EMBO J. 15:2208-2216.
28. Minden, A., A. Lin, F.-X. Claret, A. Abo, and M. Karin. 1995. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and CDC42Hs. Cell 81:1147-1157.
29. Nishiyama, T., T. Sasaki, K. Takaishi, M. Kato, H. Yaku, K. Araki, Y. Matsuura, and Y. Takai. 1994. rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells. Mol. Cell. Biol. 14:2447-2450.
30. Nobes, C., and A. Hall. 1994. Regulation and function of the Rho subfamily of small GTPases. Curr. Opin. Gen. Develop. 4:77-81.
31. Nobes, C. D., and A. Hall. 1995. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81:53-62.
32. Nonaka, H., K. Tanaka, H. Hirano, T. Fujiwara, H. Kohno, M. Umikawa, A. Mino, and Y. Takai. 1995. A downstream target of RHO1 small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae. EMBO J. 14:5931-5938.
33. Olson, M. F., A. Ashworth, and A. Hall. 1995. An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 269:1270-1272.
34. Palmer, R. H., L. V. Dekker, R. Woscholski, J. A. Le Good, R. Gigg, and P. J. Parker. 1995. Activation of PRK1 by phosphatidylinositol 4,5-bisphosphate and phosphatidyl 3,4,5-trisphosphate. J. Biol. Chem. 270:22412-22416.
35. Palmer, R. H., and P. J. Parker. 1995. Expression, purification and characterization of the ubiquitous protein kinase C-related kinase 1. Biochem. J. 309:315-320.
36. Palmer, R. H., J. Ridden, and P. J. Parker. 1995. Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase family. Eur. J. Biochem. 227:344-351.
37. 36a. Quilliam, L. A., Q. T. Lambert, L. A. Mickelson-Young, J. K. Westwick, A. B. Sparks, B. K. Kay, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, and C. J. Der. 1996. Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling. J. Biol. Chem. 271: 28772-28776.
38. Ramer, S. W., and R. W. Davis. 1993. A dominant truncation allele identifies a gene, Ste20, that encodes a putative protein kinase necessary for mating in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 90:452-456.
39. Reid, T., T. Furuyashiki, T. Ishizaki, G. Watanabe, N. Watanabe, K. Fujisawa, N. Morii, P. Madaule, and S. Narumiya. 1996. Rhotekin, a new putative target for rho bearing homology to a Ser/Thr kinase, PKN, and rhophilin in the Rho-binding domain. J. Biol. Chem. 271:13556-13560.
40. Ren, X.-D., G. M. Bokoch, A. Traynor-Kaplan, G. H. Jenkins, R. A. Anderson, and M. A. Schwartz. 1996. Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells. Mol. Biol. Cell 7:435-442.
41. Ridley, A. J., and A. Hall. 1992. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70:389-399.
42. Ridley, A. J., H. F. Paterson, C. L. Johnston, D. Diekmann, and A. Hall. 1992. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70:401-410.
43. Self, A. J., H. F. Paterson, and A. Hall. 1993. Different structural organization of Ras and Rho effector domains. Oncogene 8:655-661.
44. Settleman, J. Unpublished data.
45. Settleman, J., C. F. Albright, L. C. Foster, and R. A. Weinberg. 1992. Association between GTPase activators for rho and ras families. Nature 359:153-154.
46. Watanabe, G., Y. Saito, P. Madaule, T. Ischizaki, K. Fujisawa, N. Morii, H. Mukai, Y. Ono, S. Kakizuka, and S. Narumiya. 1996. Protein kinase N (PKN) and PKN-relaled protein rhophillin as targets of small GTPase Rho. Science 271:645-648.
47. Wessel, D., and U. I. Flugge. 1984. A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal. Biochem. 138:141-143.
48. Zhang, S., J. Han, M. A. Sells, J. Chernoff, U. G. Knaus, R. J. Ulevitch, and G. M. Bokoch. 1995. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J. Biol. Chem. 270: 23934-23936.
49. ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature 364:308-313.