메뉴 건너뛰기




Volumn 26, Issue 6 SUPPL. 1, 1997, Pages 2-10

Mechanism of action of aspirin-like drugs

Author keywords

Cyclooxygenase; NSAIDs; Prostaglandins

Indexed keywords

ACETYLSALICYLIC ACID; ANTIINFLAMMATORY AGENT; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; IBUPROFEN; INDOMETACIN; MELOXICAM; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; PROSTAGLANDIN DERIVATIVE; PROSTAGLANDIN SYNTHASE INHIBITOR; ROFECOXIB; SULINDAC; UNCLASSIFIED DRUG;

EID: 0030982146     PISSN: 00490172     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-0172(97)80046-7     Document Type: Article
Times cited : (157)

References (78)
  • 1
    • 0015237292 scopus 로고
    • Inhibition of prostaglandin synthesis as a mechanism of action for the aspirin-like drugs
    • Vane J.R. Inhibition of prostaglandin synthesis as a mechanism of action for the aspirin-like drugs Nature 231 1971 232 235
    • (1971) Nature , vol.231 , pp. 232-235
    • Vane, J.R.1
  • 2
    • 0011168516 scopus 로고
    • Effects of anti-inflammatory drugs on prostaglandins in rheumatoid arthritis
    • Higgs G.A. Vane J.R. Hart F.D. Wojtulewski J.A. Effects of anti-inflammatory drugs on prostaglandins in rheumatoid arthritis Robinson H.I. Vane J.R. Prostaglandin Synthase Inhibitors 1974 Raven 165 173
    • (1974) , pp. 165-173
    • Higgs, G.A.1    Vane, J.R.2    Hart, F.D.3    Wojtulewski, J.A.4
  • 3
    • 0017094438 scopus 로고
    • Purification of the cyclooxygenase that forms prostaglandins: Demonstration of two forms of iron in the holoenzyme
    • Hemler M. Lands W.E.M. Smith W.L. Purification of the cyclooxygenase that forms prostaglandins: Demonstration of two forms of iron in the holoenzyme J Biol Chem 251 1976 5575 5579
    • (1976) J Biol Chem , vol.251 , pp. 5575-5579
    • Hemler, M.1    Lands, W.E.M.2    Smith, W.L.3
  • 4
    • 0028009093 scopus 로고
    • The x-ray crystal structure of the membrane protein prostaglandin H2 synthase-1
    • 2 synthase-1 Nature 367 1994 243 249
    • (1994) Nature , vol.367 , pp. 243-249
    • Picot, D.1    Loll, P.J.2    Garavito, R.M.3
  • 6
    • 0029899186 scopus 로고    scopus 로고
    • A single amino acid difference between cyclooxygenase-1 (COX-1) and −2 (COX-2) reverses the selectivity of COX-2 specific inhibitors
    • Gierse J.K. McDonald J.J. Hauser S.D. Rangwala S.H. Koboldt C.M. Seibert K. A single amino acid difference between cyclooxygenase-1 (COX-1) and −2 (COX-2) reverses the selectivity of COX-2 specific inhibitors J Biol Chem 271 1996 15810 15814
    • (1996) J Biol Chem , vol.271 , pp. 15810-15814
    • Gierse, J.K.1    McDonald, J.J.2    Hauser, S.D.3    Rangwala, S.H.4    Koboldt, C.M.5    Seibert, K.6
  • 7
    • 0017094798 scopus 로고
    • An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
    • Moncada S. Gryglewski R. Bunting S. Vane J.R. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation Nature 263 1976 663 665
    • (1976) Nature , vol.263 , pp. 663-665
    • Moncada, S.1    Gryglewski, R.2    Bunting, S.3    Vane, J.R.4
  • 8
    • 0018904225 scopus 로고
    • Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa
    • Whittle B.J.R. Higgs G.A. Eakins K.E. Moncada S. Vane J.R. Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa Nature 284 1980 271 273
    • (1980) Nature , vol.284 , pp. 271-273
    • Whittle, B.J.R.1    Higgs, G.A.2    Eakins, K.E.3    Moncada, S.4    Vane, J.R.5
  • 9
    • 0025909387 scopus 로고
    • Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment
    • Funk C.D. Funk L.B. Kennedy M.E. Pong A.S. Fitzgerald G.A. Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment FASEB J 5 1991 2304 2312
    • (1991) FASEB J , vol.5 , pp. 2304-2312
    • Funk, C.D.1    Funk, L.B.2    Kennedy, M.E.3    Pong, A.S.4    Fitzgerald, G.A.5
  • 10
    • 0001208476 scopus 로고
    • Temporal and pharmacological division of fibroblast cyclooxygenase expression into transcriptional and translational phases
    • Raz A. Wyche A. Needleman P. Temporal and pharmacological division of fibroblast cyclooxygenase expression into transcriptional and translational phases Proc Natl Acad Sci U S A 86 1989 1657 1661
    • (1989) , pp. 1657-1661
    • Raz, A.1    Wyche, A.2    Needleman, P.3
  • 11
    • 0025005862 scopus 로고
    • The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes
    • Fu J.Y. Masferrer J.L. Seibert K. Raz A. Needleman P. The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes J Biol Chem 265 1990 16737 16740
    • (1990) J Biol Chem , vol.265 , pp. 16737-16740
    • Fu, J.Y.1    Masferrer, J.L.2    Seibert, K.3    Raz, A.4    Needleman, P.5
  • 12
    • 0025187588 scopus 로고
    • Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice
    • Masferrer J.L. Zweifel B.S. Seibert K. Needleman P. Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice J Clin Invest 86 1990 1375 1379
    • (1990) J Clin Invest , vol.86 , pp. 1375-1379
    • Masferrer, J.L.1    Zweifel, B.S.2    Seibert, K.3    Needleman, P.4
  • 13
    • 0025754779 scopus 로고
    • Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing
    • Xie W. Chipman J.G. Robertson D.L. Erikson R.L. Simmons D.L. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing Proc Natl Acad Sci U S A 88 1991 2692 2696
    • (1991) , pp. 2692-2696
    • Xie, W.1    Chipman, J.G.2    Robertson, D.L.3    Erikson, R.L.4    Simmons, D.L.5
  • 14
    • 0026588961 scopus 로고
    • Mitogen-inducible prostaglandin G/H synthase: a new target for nonsteroidal antiinflammatory drugs
    • Xie W. Robertson D.L. Simmons D.L. Mitogen-inducible prostaglandin G/H synthase: a new target for nonsteroidal antiinflammatory drugs Drug Devel Res 25 1992 249 265
    • (1992) Drug Devel Res , vol.25 , pp. 249-265
    • Xie, W.1    Robertson, D.L.2    Simmons, D.L.3
  • 15
    • 0026322957 scopus 로고
    • A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein
    • O'Banion M.K. Sadowski H.B. Winn V. Young D.A. A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein J Biol Chem 266 1991 23261 23267
    • (1991) J Biol Chem , vol.266 , pp. 23261-23267
    • O'Banion, M.K.1    Sadowski, H.B.2    Winn, V.3    Young, D.A.4
  • 16
    • 0000698133 scopus 로고
    • TIS 10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue
    • Kujubu D.A. Fletcher B.S. Varnum B.C. Lim R.W. Herschman H.R. TIS 10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue J Biol Chem 26 1991 12866 12872
    • (1991) J Biol Chem , vol.26 , pp. 12866-12872
    • Kujubu, D.A.1    Fletcher, B.S.2    Varnum, B.C.3    Lim, R.W.4    Herschman, H.R.5
  • 17
    • 0026744831 scopus 로고
    • Purification and characterization of a novel, distinct, isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin ingranulosa cells of rat preovulatory follicles
    • Sirois J. Richards I.S. Purification and characterization of a novel, distinct, isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin ingranulosa cells of rat preovulatory follicles J Biol Chem 267 1992 6382 6388
    • (1992) J Biol Chem , vol.267 , pp. 6382-6388
    • Sirois, J.1    Richards, I.S.2
  • 18
    • 0028044609 scopus 로고
    • Towards a better aspirin
    • Vane J. Towards a better aspirin Nature 367 1994 215 216
    • (1994) Nature , vol.367 , pp. 215-216
    • Vane, J.1
  • 19
    • 0025857560 scopus 로고
    • Prostaglandin endoperoxide synthase: Regulation of enzyme expression
    • DeWitt D.L. Prostaglandin endoperoxide synthase: Regulation of enzyme expression Biochim Biophys Acta 1083 1991 121 134
    • (1991) Biochim Biophys Acta , vol.1083 , pp. 121-134
    • DeWitt, D.L.1
  • 20
    • 0026034248 scopus 로고
    • Aspirin inhibits interleukin 1-induced prostaglandin H synthase expression in cultured endothelial cells
    • Wu K.K. Sanduja R. Tsai A.L. Ferhanoglu B. Loose-Mitchell D.S. Aspirin inhibits interleukin 1-induced prostaglandin H synthase expression in cultured endothelial cells Proc Natl Acad Sci U S A 88 1991 2384 2387
    • (1991) , pp. 2384-2387
    • Wu, K.K.1    Sanduja, R.2    Tsai, A.L.3    Ferhanoglu, B.4    Loose-Mitchell, D.S.5
  • 21
    • 0000551783 scopus 로고
    • Prostanoids as regulators of gastrointestinal function
    • Whittle B.J.R. Vane J.R. Prostanoids as regulators of gastrointestinal function Johnston L.R. ed 2 Physiology of the Gastrointestinal Tract Vol I 1987 Raven New York 143 180
    • (1987) , pp. 143-180
    • Whittle, B.J.R.1    Vane, J.R.2
  • 22
    • 0030017042 scopus 로고    scopus 로고
    • Characterization of prostaglandin G/H synthase 1 and 2 in rat, dog, monkey and human gastrointestinal tracts
    • Kargman S. Charleson S. Cartwright M. Characterization of prostaglandin G/H synthase 1 and 2 in rat, dog, monkey and human gastrointestinal tracts Gastroenterology 111 1996 445 454
    • (1996) Gastroenterology , vol.111 , pp. 445-454
    • Kargman, S.1    Charleson, S.2    Cartwright, M.3
  • 23
    • 0028843881 scopus 로고
    • Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
    • Langenbach R. Morham S.G. Tiano H.E. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration Cell 83 1995 483 492
    • (1995) Cell , vol.83 , pp. 483-492
    • Langenbach, R.1    Morham, S.G.2    Tiano, H.E.3
  • 24
    • 0029899153 scopus 로고    scopus 로고
    • Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: Evidence for a transcriptional effect
    • Kutchera W. Jones D.A. Matsunami N. Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: Evidence for a transcriptional effect Proc Natl Acad Sci U S A 93 1996 4816 4820
    • (1996) , pp. 4816-4820
    • Kutchera, W.1    Jones, D.A.2    Matsunami, N.3
  • 25
    • 0030071213 scopus 로고    scopus 로고
    • Cyclooxygenase-1 and cyclooxygenase-2 gene expression in human colorectal adenocarcinomas and in azoxymethane induced colonic tumours in rats
    • Gustafson-Svard C. Lilja I. Hallbook O. Sjodahl R. Cyclooxygenase-1 and cyclooxygenase-2 gene expression in human colorectal adenocarcinomas and in azoxymethane induced colonic tumours in rats Gut 38 1996 79 84
    • (1996) Gut , vol.38 , pp. 79-84
    • Gustafson-Svard, C.1    Lilja, I.2    Hallbook, O.3    Sjodahl, R.4
  • 26
    • 0025998557 scopus 로고
    • Aspirin use and reduced risk of fatal colon cancer
    • Thun M.J. Namboodiri M.M. Heath C.W.J. Aspirin use and reduced risk of fatal colon cancer New Engl J Med 325 1991 1593 1596
    • (1991) New Engl J Med , vol.325 , pp. 1593-1596
    • Thun, M.J.1    Namboodiri, M.M.2    Heath, C.W.J.3
  • 27
    • 0030013660 scopus 로고    scopus 로고
    • Prevention of gastrointestinal cancer-the potential role of NSAIDs in colorectal cancer
    • Luk G.D. Prevention of gastrointestinal cancer-the potential role of NSAIDs in colorectal cancer Schweiz Med Wochenschr 126 1996 801 812
    • (1996) Schweiz Med Wochenschr , vol.126 , pp. 801-812
    • Luk, G.D.1
  • 28
    • 0029954663 scopus 로고    scopus 로고
    • Tissue prostaglandin levels in familial adenomatous polyposis patients treated with sulindac
    • Nugent K.P. Spigelman A.D. Phillips R.K.S. Tissue prostaglandin levels in familial adenomatous polyposis patients treated with sulindac Dis Colon Rectum 39 1996 659 662
    • (1996) Dis Colon Rectum , vol.39 , pp. 659-662
    • Nugent, K.P.1    Spigelman, A.D.2    Phillips, R.K.S.3
  • 29
    • 0018656916 scopus 로고
    • Effect of prostaglandin E2 on chloride transport across the rabbit thick ascending limb of Henle. Selective inhibitions of the medullary portion
    • Stokes J.B. Effect of prostaglandin E2 on chloride transport across the rabbit thick ascending limb of Henle. Selective inhibitions of the medullary portion J Clin Invest 64 1979 495 502
    • (1979) J Clin Invest , vol.64 , pp. 495-502
    • Stokes, J.B.1
  • 30
    • 0018080134 scopus 로고
    • Role of prostaglandin E (PGE) in the modulation of action of vasopressin on water flow in the urinary bladder of the toad and mammalian kidney
    • Orloff J. Zusman R. Role of prostaglandin E (PGE) in the modulation of action of vasopressin on water flow in the urinary bladder of the toad and mammalian kidney J Membr Biol 40 1978 297 304
    • (1978) J Membr Biol , vol.40 , pp. 297-304
    • Orloff, J.1    Zusman, R.2
  • 31
    • 0028034970 scopus 로고
    • Cyclooxygenase-2 is associated with the macula dense of rat kidney and increases with salt restriction
    • Harris R.C. McKanna J.A. Akai Y. Jacobson H.R. Dubois R.N. Greyer M.D. Cyclooxygenase-2 is associated with the macula dense of rat kidney and increases with salt restriction J Clin Invest 94 1994 2504 2510
    • (1994) J Clin Invest , vol.94 , pp. 2504-2510
    • Harris, R.C.1    McKanna, J.A.2    Akai, Y.3    Jacobson, H.R.4    Dubois, R.N.5    Greyer, M.D.6
  • 32
    • 0030061641 scopus 로고    scopus 로고
    • Effect of cyclic AMP and prostaglandin E2 on the induction of nitric oxide- and prostanoid-forming pathways in cultured rat mesangial cells
    • Nusing R.M. Klein T. Pfeilschifter J. Ullrich V. Effect of cyclic AMP and prostaglandin E2 on the induction of nitric oxide- and prostanoid-forming pathways in cultured rat mesangial cells Biochem J 313 1996 617 623
    • (1996) Biochem J , vol.313 , pp. 617-623
    • Nusing, R.M.1    Klein, T.2    Pfeilschifter, J.3    Ullrich, V.4
  • 33
    • 0028807498 scopus 로고
    • Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
    • Morham S.G. Langenbach R. Loftin C.D. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse Cell 83 1995 473 482
    • (1995) Cell , vol.83 , pp. 473-482
    • Morham, S.G.1    Langenbach, R.2    Loftin, C.D.3
  • 34
    • 0025936564 scopus 로고
    • Molecular mechanisms of sleep-wake regulation: roles of prostaglandin D2 and E2
    • Hayaishi O. Molecular mechanisms of sleep-wake regulation: roles of prostaglandin D2 and E2 FASEB J 5 1991 2575 2581
    • (1991) FASEB J , vol.5 , pp. 2575-2581
    • Hayaishi, O.1
  • 36
    • 0028822708 scopus 로고
    • Prostaglandin G/H synthase-2 is a major contributor of brain Prostaglandins in the newborn
    • Peri K.G. Hardy P. Li D.Y. Varma D.R. Chemtob S. Prostaglandin G/H synthase-2 is a major contributor of brain Prostaglandins in the newborn J Biol Chem 270 1995 2461 2520
    • (1995) J Biol Chem , vol.270 , pp. 2461-2520
    • Peri, K.G.1    Hardy, P.2    Li, D.Y.3    Varma, D.R.4    Chemtob, S.5
  • 37
    • 0025301756 scopus 로고
    • Prostanoids determine the range of cerebral blood flow autoreguiation of newborn piglets
    • Chemtob S. Beharry K. Rex J. Varma D.R. Aranda J.V. Prostanoids determine the range of cerebral blood flow autoreguiation of newborn piglets Stroke 21 1990 777 784
    • (1990) Stroke , vol.21 , pp. 777-784
    • Chemtob, S.1    Beharry, K.2    Rex, J.3    Varma, D.R.4    Aranda, J.V.5
  • 38
    • 0027290813 scopus 로고
    • Expression of a mitogen-inducible cyclooxygenase in brain neurons; regulation by synaptic activity and glucocorticoids
    • Yamagata K. Andreassson K.I. Kaufman W.E. Barnes C.A. Worley P.F. Expression of a mitogen-inducible cyclooxygenase in brain neurons; regulation by synaptic activity and glucocorticoids Neuron 11 1993 371 386
    • (1993) Neuron , vol.11 , pp. 371-386
    • Yamagata, K.1    Andreassson, K.I.2    Kaufman, W.E.3    Barnes, C.A.4    Worley, P.F.5
  • 39
    • 0028902109 scopus 로고
    • Characterization of inducible cyclooxygenase in rat brain
    • Breder C.D. Dewitt D. Kraig R.P. Characterization of inducible cyclooxygenase in rat brain J Comp Neurol 355 1995 296 315
    • (1995) J Comp Neurol , vol.355 , pp. 296-315
    • Breder, C.D.1    Dewitt, D.2    Kraig, R.P.3
  • 40
    • 0029866955 scopus 로고    scopus 로고
    • Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide
    • Breder C.D. Saper C.B. Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide Brain Res 713 1996 64 69
    • (1996) Brain Res , vol.713 , pp. 64-69
    • Breder, C.D.1    Saper, C.B.2
  • 41
    • 0030590429 scopus 로고    scopus 로고
    • Endothelial cells of the brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1,B: a possible site of prostaglandin synthesis responsible for fever
    • Cao C. Matsumura K. Yamagata K. Watanabe Y. Endothelial cells of the brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1,B: a possible site of prostaglandin synthesis responsible for fever Brain Res 733 1996 263 272
    • (1996) Brain Res , vol.733 , pp. 263-272
    • Cao, C.1    Matsumura, K.2    Yamagata, K.3    Watanabe, Y.4
  • 42
    • 0028846219 scopus 로고
    • Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response
    • Cao C. Matsumura K. Yamagata K. Watanabe Y. Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response Brain Res 697 1995 187 196
    • (1995) Brain Res , vol.697 , pp. 187-196
    • Cao, C.1    Matsumura, K.2    Yamagata, K.3    Watanabe, Y.4
  • 43
    • 0029748545 scopus 로고    scopus 로고
    • Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus
    • Marcheselli V.L. Bazan N.G. Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus J Biol Chem 271 1996 24794 24799
    • (1996) J Biol Chem , vol.271 , pp. 24794-24799
    • Marcheselli, V.L.1    Bazan, N.G.2
  • 44
    • 0030597962 scopus 로고    scopus 로고
    • Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation
    • Beiche F. Scheuerer S. Brune K. Geisslinger G. Goppelt-Struebe M. Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation FEBS Lett 390 1996 165 169
    • (1996) FEBS Lett , vol.390 , pp. 165-169
    • Beiche, F.1    Scheuerer, S.2    Brune, K.3    Geisslinger, G.4    Goppelt-Struebe, M.5
  • 45
    • 0141474263 scopus 로고
    • Antipyretic actions of aspirin
    • Milton A.S. Antipyretic actions of aspirin Vane J.R. Botting R.M. Aspirin and Other Salicylates 1992 Chapman & Hall London 213 244
    • (1992) , pp. 213-244
    • Milton, A.S.1
  • 46
    • 0027516402 scopus 로고
    • NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects which causes minimal stomach lesions
    • Futaki N. Yoshikawa K. Hamasaka Y. NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects which causes minimal stomach lesions Gen Pharmacol 24 1993 105 110
    • (1993) Gen Pharmacol , vol.24 , pp. 105-110
    • Futaki, N.1    Yoshikawa, K.2    Hamasaka, Y.3
  • 47
    • 0000029302 scopus 로고    scopus 로고
    • COX-2 expression in labour
    • and London: William Harvey Press Bennett P. Slater D. COX-2 expression in labour Vane J. Botting J. Botting R. Improved Non-steroid Antiinflammatory Drugs. COX-2 Enzyme Inhibitors 1996 Kluwer Academic Publishers Lancaster UK 167 188
    • (1996) , pp. 167-188
    • Bennett, P.1    Slater, D.2
  • 48
    • 0028843881 scopus 로고
    • Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
    • Langenbach R. Morham S.G. Tiano H.F. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration Cell 83 1995 483 492
    • (1995) Cell , vol.83 , pp. 483-492
    • Langenbach, R.1    Morham, S.G.2    Tiano, H.F.3
  • 49
    • 0029740064 scopus 로고    scopus 로고
    • Localization of prostaglandin H synthase type 2 protein and mRNA in term human fetal membranes and decidua
    • Gibb W. Sun M. Localization of prostaglandin H synthase type 2 protein and mRNA in term human fetal membranes and decidua J Endocrinol 150 1996 497 503
    • (1996) J Endocrinol , vol.150 , pp. 497-503
    • Gibb, W.1    Sun, M.2
  • 51
    • 0029917190 scopus 로고    scopus 로고
    • Expression of human chorionic gonadotropin (hCG)/iuteinizing hormone receptors and regulation of the cyclooxygenase-1 gene by exogenous hCG in human fetal membranes
    • Toth P. Li X. Lei Z.M. Rao C.V. Expression of human chorionic gonadotropin (hCG)/iuteinizing hormone receptors and regulation of the cyclooxygenase-1 gene by exogenous hCG in human fetal membranes J Clin Endocrinol Metab 81 1996 1283 1288
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1283-1288
    • Toth, P.1    Li, X.2    Lei, Z.M.3    Rao, C.V.4
  • 52
    • 0028818913 scopus 로고
    • Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II.
    • Dinchuk J.E. Car B.D. Focht R.J. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature 378 1995 406 409
    • (1995) Nature , vol.378 , pp. 406-409
    • Dinchuk, J.E.1    Car, B.D.2    Focht, R.J.3
  • 53
    • 0029949756 scopus 로고    scopus 로고
    • Developmental expression of the cyclo-oxygenase-1 and cyclo-oxygenase-2 genes in the pert-implantation mouse uterus and their differential regulation by the blastocyst and ovarian steroids
    • Chakraborty I. Das S.K. Wang J. Dey S.K. Developmental expression of the cyclo-oxygenase-1 and cyclo-oxygenase-2 genes in the pert-implantation mouse uterus and their differential regulation by the blastocyst and ovarian steroids J Mol Endocrinol 16 1996 107 122
    • (1996) J Mol Endocrinol , vol.16 , pp. 107-122
    • Chakraborty, I.1    Das, S.K.2    Wang, J.3    Dey, S.K.4
  • 54
    • 0028922530 scopus 로고
    • Glucocorticoids stimulate the expression of prostaglandin endoperoxide H synthase-2 in amnion cells
    • Zakar T. Hirst J.J. Milovic J.E. Olson D.M. Glucocorticoids stimulate the expression of prostaglandin endoperoxide H synthase-2 in amnion cells Endocrinology 136 1995 1610 1619
    • (1995) Endocrinology , vol.136 , pp. 1610-1619
    • Zakar, T.1    Hirst, J.J.2    Milovic, J.E.3    Olson, D.M.4
  • 55
    • 0042540024 scopus 로고    scopus 로고
    • The induction of cyclooxygenase-2 (COX-2) in intact human amnion tissue by interleukin-4
    • Spaziani E.P. Lantz M.E. Benoit R.R. O'Brien W.E. The induction of cyclooxygenase-2 (COX-2) in intact human amnion tissue by interleukin-4 Prostaglandins 51 1996 215 223
    • (1996) Prostaglandins , vol.51 , pp. 215-223
    • Spaziani, E.P.1    Lantz, M.E.2    Benoit, R.R.3    O'Brien, W.E.4
  • 56
    • 0029824156 scopus 로고    scopus 로고
    • Expression of prostaglandin G/H synthase-1 and -2 in ovine amnion and placenta following glucocorticoid-induced labour onset
    • McLaren W.J. Young I.R. Wong M.I.T. Rice G.E. Expression of prostaglandin G/H synthase-1 and -2 in ovine amnion and placenta following glucocorticoid-induced labour onset J Endocrinol 151 1996 125 135
    • (1996) J Endocrinol , vol.151 , pp. 125-135
    • McLaren, W.J.1    Young, I.R.2    Wong, M.I.T.3    Rice, G.E.4
  • 57
    • 0028327671 scopus 로고
    • Risk of upper gastrointestinal bleeding and perforation associated with individual nonsteroidal anti-inflammatory drugs
    • García Rodríguez L.A. Jick H. Risk of upper gastrointestinal bleeding and perforation associated with individual nonsteroidal anti-inflammatory drugs Lancet 343 1994 769 772
    • (1994) Lancet , vol.343 , pp. 769-772
    • García Rodríguez, L.A.1    Jick, H.2
  • 58
    • 0028353941 scopus 로고
    • Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs
    • Langman M.I.S. Weil J. Wainwright P. Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs Lancet 343 1994 1075 1078
    • (1994) Lancet , vol.343 , pp. 1075-1078
    • Langman, M.I.S.1    Weil, J.2    Wainwright, P.3
  • 59
    • 8944227048 scopus 로고    scopus 로고
    • Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborativemeta-analysis
    • Henry D. Lim L.L.-Y. García Rodríguez L.A. Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborativemeta-analysis Br Med J 312 1996 1563 1566
    • (1996) Br Med J , vol.312 , pp. 1563-1566
    • Henry, D.1    Lim, L.L.-Y.2    García Rodríguez, L.A.3
  • 60
    • 0028926813 scopus 로고
    • New insights into the mode of action of anti-inflammatory drugs
    • Vane J.R. Botting R.M. New insights into the mode of action of anti-inflammatory drugs Inflamm Res 44 1995 1 10
    • (1995) Inflamm Res , vol.44 , pp. 1-10
    • Vane, J.R.1    Botting, R.M.2
  • 61
    • 0027146692 scopus 로고
    • Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase
    • Mitchell J.A. Akarasereenont P. Thiemermann C. Flower R.J. Vane J.R. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase Proc Natl Acad Sci U S A 90 1993 11693 11697
    • (1993) , pp. 11693-11697
    • Mitchell, J.A.1    Akarasereenont, P.2    Thiemermann, C.3    Flower, R.J.4    Vane, J.R.5
  • 62
    • 0029029296 scopus 로고
    • Inhibition of constitutive and inducible cyclooxygenase activity in human platelets and mononuclear cells by NSAIDs and Cox 2 inhibitors
    • Grossman C.J. Wiseman J. Lucas F.S. Trevethick M.A. Birch P.J. Inhibition of constitutive and inducible cyclooxygenase activity in human platelets and mononuclear cells by NSAIDs and Cox 2 inhibitors Inflamm Res 44 1995 253 257
    • (1995) Inflamm Res , vol.44 , pp. 253-257
    • Grossman, C.J.1    Wiseman, J.2    Lucas, F.S.3    Trevethick, M.A.4    Birch, P.J.5
  • 63
    • 0027986841 scopus 로고
    • Differential inhibition of human prostaglandin endoperoxide H syntheses-I and -2 by nonsteroidal antiinflammatory drugs
    • Laneuville O. Breuer D.K. DeWitt D.L. Hla T. Funk C.D. Smith W.L. Differential inhibition of human prostaglandin endoperoxide H syntheses-I and -2 by nonsteroidal antiinflammatory drugs J Pharmacol Exp Ther 271 1994 927 934
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 927-934
    • Laneuville, O.1    Breuer, D.K.2    DeWitt, D.L.3    Hla, T.4    Funk, C.D.5    Smith, W.L.6
  • 65
    • 0027480087 scopus 로고
    • Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs
    • Meade E.A. Smith W.L. DeWitt D.L. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs J Biol Chem 268 1993 6610 6614
    • (1993) J Biol Chem , vol.268 , pp. 6610-6614
    • Meade, E.A.1    Smith, W.L.2    DeWitt, D.L.3
  • 66
    • 0030030129 scopus 로고    scopus 로고
    • Meloxicam: influence on arachidonic acid metabolism. Part I. In vitro findings
    • Engelhardt G. Bogel R. Schnitzer Chr. Utzmann R. Meloxicam: influence on arachidonic acid metabolism. Part I. In vitro findings Biochem Pharmacol 51 1996 21 28
    • (1996) Biochem Pharmacol , vol.51 , pp. 21-28
    • Engelhardt, G.1    Bogel, R.2    Schnitzer, Chr.3    Utzmann, R.4
  • 68
    • 0028089109 scopus 로고
    • NS398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro
    • Futaki N. Takahashi S. Yokoyama M. Arai S. Higuchi S. Otomo S. NS398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro Prostaglandins 47 1994 55 59
    • (1994) Prostaglandins , vol.47 , pp. 55-59
    • Futaki, N.1    Takahashi, S.2    Yokoyama, M.3    Arai, S.4    Higuchi, S.5    Otomo, S.6
  • 69
    • 0028123502 scopus 로고
    • Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal antiinflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid
    • O'Neill G.P. Mancini J.A. Kargman S. Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal antiinflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid Mol Pharmacol 45 1994 245 254
    • (1994) Mol Pharmacol , vol.45 , pp. 245-254
    • O'Neill, G.P.1    Mancini, J.A.2    Kargman, S.3
  • 70
    • 0028830109 scopus 로고
    • Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase
    • Gierse J.K. Hauser S.D. Creely D.P. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase Biochem J 305 1995 479 484
    • (1995) Biochem J , vol.305 , pp. 479-484
    • Gierse, J.K.1    Hauser, S.D.2    Creely, D.P.3
  • 71
    • 0027940487 scopus 로고
    • Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide syntheses
    • Patrignani P. Panara M.R. Greco A. Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide syntheses J Pharmacol Exp Ther 271 1994 1705 1712
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 1705-1712
    • Patrignani, P.1    Panara, M.R.2    Greco, A.3
  • 72
    • 0029953233 scopus 로고    scopus 로고
    • Human whole blood assays for inhibition of prostaglandin G/H syntheses-1 and -2 using A23187 and lipopolysaccharide stimulation of thromboxane B2production
    • Young J.M. Panah S. Satchawatcharaphong C. Cheung P.S. Human whole blood assays for inhibition of prostaglandin G/H syntheses-1 and -2 using A23187 and lipopolysaccharide stimulation of thromboxane B2production Inflamm Res 45 1996 246 253
    • (1996) Inflamm Res , vol.45 , pp. 246-253
    • Young, J.M.1    Panah, S.2    Satchawatcharaphong, C.3    Cheung, P.S.4
  • 73
    • 0027748232 scopus 로고
    • Activity of nimesulide on constitutive and inducible prostaglandin cyclo-oxygenase
    • (Abstract) Tavares I.A. Bennett A. Activity of nimesulide on constitutive and inducible prostaglandin cyclo-oxygenase Int J Tissue React 15 1993 49
    • (1993) Int J Tissue React , vol.15 , pp. 49
    • Tavares, I.A.1    Bennett, A.2
  • 74
    • 0029867820 scopus 로고    scopus 로고
    • Review of clinical trials and benefit/risk ratio of meloxicam
    • Barner A. Review of clinical trials and benefit/risk ratio of meloxicam Scand J Rheumatol 25 Suppl 102 1996 29 37
    • (1996) Scand J Rheumatol , vol.25 , Issue.Suppl 102 , pp. 29-37
    • Barner, A.1
  • 75
    • 0027944075 scopus 로고
    • Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain
    • Seibert K. Zhang Y. Leahy K. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain Proc Natl Acad Sci U S A 91 1994 12013 12017
    • (1994) , pp. 12013-12017
    • Seibert, K.1    Zhang, Y.2    Leahy, K.3
  • 76
    • 0029033219 scopus 로고
    • Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach
    • Chan C.C. Boyce S. Brideau C. Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach J Pharmacol Exp Ther 274 1995 1531 1537
    • (1995) J Pharmacol Exp Ther , vol.274 , pp. 1531-1537
    • Chan, C.C.1    Boyce, S.2    Brideau, C.3
  • 77
    • 33646124789 scopus 로고    scopus 로고
    • SC-58635, a highly selective inhibitor of COX-2, is an effective analgesic in an acute post-surgical pain model
    • Hubbard R.C. Mehlisch D.R. Jasper D.R. Nugent M.J. Yu S. Isakson P.C. SC-58635, a highly selective inhibitor of COX-2, is an effective analgesic in an acute post-surgical pain model J Invest Med 44 1996 293A
    • (1996) J Invest Med , vol.44 , pp. 293A
    • Hubbard, R.C.1    Mehlisch, D.R.2    Jasper, D.R.3    Nugent, M.J.4    Yu, S.5    Isakson, P.C.6
  • 78
    • 12244294731 scopus 로고    scopus 로고
    • Nimesulide: a selective cyclooxygenase 2 inhibitor anfiinflammatory drug
    • Rabasseda X. Nimesulide: a selective cyclooxygenase 2 inhibitor anfiinflammatory drug Drugs of Today 33 Supp12 1997 1 25
    • (1997) Drugs of Today , vol.33 , Issue.Supp12 , pp. 1-25
    • Rabasseda, X.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.