Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG

Genes and Development

Volumn 12, Issue 8, 1998, Pages 1176-1188

  Tsang, Alice P ^a   Fujiwara, Yuko ^a   Horn, Dennis B ^a   Orkin, Stuart H ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Cofactor; Friend of GATA 1 (FOG); GATA 1; Gene targeting; Hematopoiesis

Indexed keywords

TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

ANEMIA; ARTICLE; CELL DIFFERENTIATION; EMBRYO; EMBRYO DEVELOPMENT; ERYTHROPOIESIS; GENE DISRUPTION; MEGAKARYOPOIESIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

RODENTIA;

EID: 0032522474     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.8.1176     Document Type: Article

References (55)

1. Andrews, N.C., H. Erdjument-Bromage, M.B. Davidson, P. Tempst, and S.H. Orkin. 1993. Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. Nature 362: 722-728.
2. Baron, M.H. and T. Maniatis. 1986. Rapid reprogramming of globin gene expression in transient heterokaryons. Cell 46: 591-602.
3. Blobel, G.A., M.C. Simon, and S.H. Orkin. 1995. Rescue of GATA-1-deficient embryonic stem cells by heterologous GATA-binding proteins. Mol. Cell. Biol. 15: 626-633.
4. Chomczynski, P. and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal. Biochem. 162: 156-159.
5. Cubadda, Y., P. Heitzler, R.P. Ray, M. Bourouis, P. Ramain, W. Gelbart, P. Simpson, and M. Haenlin. 1997. u-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila. Genes & Dev. 11: 3083-3095.
6. Evans, T. and G. Felsenfeld. 1989. The erythroid-specific transcription factor eryf1: A new finger protein. Cell 58: 877-885.
7. Fujiwara, Y., C.P. Browne, K. Cunniff, S.C. Goff, and S.H. Orkin. 1996. Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc. Natl. Acad. Sci. 93: 12355-12358.
8. Gstaiger, M., O. Georgiev, H. van Leeuwen, P. van der Vliet, and W. Schaffner. 1996. The B cell coactivator Bob1 shows DNA sequence-dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation. EMBO J. 15: 2781-2790.
9. Haenlin, M., Y. Cubadda, F. Blondeau, P. Heitzler, Y. Lutz, P. Simpson, and P. Ramain. 1997. Transcriptional activity of Pannier is regulated negatively by heterodimerization of the GATA DNA-binding domain with a cofactor encoded by the u-shaped gene of Drosophila. Genes & Dev. 11: 3096-3108.
10. Keller, G., M. Kennedy, T. Papayannopoulou, and M.V. Wiles. 1993. Hematopoietic commitment during embryonic stem cell differentiation in culture. Mol. Cell Biol. 13: 472-486.
11. Kudla, B., M.X. Caddick, T. Langdon, N.M. Martinez-Rossi, C.F. Bennett, S. Sibley, R.W. Davies, and H.N. Arst, Jr. 1990. The regulatory gene areA mediating nitrogen metabolite repression in Aspergillus nidulans. Mutations affecting specificity of gene activation alter a loop residue of a putative zinc finger. EMBO J. 9: 1355-1364.
12. Kulessa, H., J. Frampton, and T. Graf. 1995. GATA-1 reprograms avian myelomonocytic cells into eosinophils, thromboblasts and erythroblasts. Genes & Dev. 9: 1250-1262.
13. Kuo, C.T., E.E. Morrisey, R. Anandappa, K. Sigrist, M.M. Lu, M.S. Parmacek, C. Soudais, and J.M. Leiden. 1997. The GATA-4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes & Dev. 11: 1048-1060.
14. Laverriere, A.C., C. MacNeill, C. Mueller, R.E. Poelmann, J.B. Burch, and T. Evans. 1994. GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut. J. Biol Chem. 269: 23177-23184.
15. Martin, D.I.K. and S.H. Orkin. 1990. Transcriptional activation and DNA-binding by the erythroid factor GF-1/NF-E1/Eryf 1. Genes & Dev. 4: 1886-1898.
16. McDonald, T.P. and C.W. Jackson. 1990. Thrombopoietin derived from human embryonic kidney cells stimulates an increase in DNA content of murine megakaryocytes in vivo. Exper. Hematol 18: 758-763.
17. Merika, M. and S.H. Orkin. 1995. Functional synergy and physical interactions of the erythroid transcription factor GATA-1 and Krüppel family proteins, Sp1 and EKLF. Mol. Cell. Biol. 15: 2437-2447.
18. Molkentin, J.D., Q. Lin, S.A. Duncan, and E.N. Olson. 1997. Requirement of the transcription factor GATA-4 for heart tube formation and ventral morphogenesis. Genes & Dev. 11: 1061-1072.
19. Molla, A., A. Andrieux, A. Chapel, A. Schweitzer, R. Berthier, and G. Marguerie. 1992. Lack of transcription and expression of the aIIb integrin in human early haematopoietic stem cells. Br. J. Haematol. 82: 635-639.
20. Mortensen, R.M., D.A. Conner, S. Chao, A.A.T. Geisterfer-Lowrance, and J.G. Seidman. 1992. Production of homozygous mutant ES cells with a single targeting construct. Mol. Cell. Biol. 12: 2391-2395.
21. Mucenski, M.L., K. McLain, A.B. Kier, S.H. Swerdlow, C.M. Schreiner, T.A. Miller, D.W. Pietryga, W.J. Scott, Jr., and S.S. Potter. 1991. A functional c-myb gene is required for normal fetal hepatic hematopoiesis. Cell 65: 677-689.
22. Okuda, T., J. van Deursen, S.W. Hiebert, G. Grosveld, and J.R. Downing. 1996. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84: 321-330.
23. Orkin, S.H. 1992. GATA-binding transcription factors in hematopoietic cells. Blood 80: 575-581.
24. _. 1998. Transcription factors regulating early hematopoietic development and lineage commitment. In Molecular biology of B-cell and T-cell development (ed. J.G. Monroe and E.V. Rothenberg). Humana Press, Totowa, NJ. (In Press.)
25. Osada, H., G. Grutz, H. Axelson, A. Forster, and T.H. Rabbitts. 1995. Association of erythroid transcription factors: Complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. Proc. Natl. Acad. Sci. 92: 9585-9589.
26. Perkins, A.C., A.H. Sharpe, and S.H. Orkin. 1995. Lethal β-thalassemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature 375: 318-322.
27. Pevny, L., M.C. Simon, E. Robertson, W.H. Klein, S.F. Tsai, V. D'Agati, S.H. Orkin, and F. Costantini. 1991. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature 349: 257-260.
28. Pevny, L., C.S. Lin, V. D'Agati, M.C. Simon, S.H. Orkin, and F. Costantini. 1995. Development of hematopoietic cells lacking transcription factor GATA-1. Development 121: 163-172.
29. Poncz, M., S. Surrey, P. LaRocco, M.J. Weiss, E.F. Rappaport, T.M. Conway, and E. Schwartz. 1987. Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemia cell line. Blood 69: 219-223.
30. Porcher, C., W. Swat, K. Rockwell, Y. Fujiwara, F.W. Alt, and S.H. Orkin. 1996. The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell 86: 47-57.
31. Ramain, P., P. Heitzler, M. Haenlin, and P. Simpson. 1993. Pannier, a negative regulator of achaete and scute in Drosophila, encodes, a zinc finger protein with homology to the vertebrate transcription factor GATA-1. Development 119: 1277-1291.
32. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular cloning: A laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
33. Shivdasani, R.A. 1997. Transcription factors in megakaryocyte differentiation and gene expression. In Thrombopoiesis and thrombopoietins (ed. D.J. Kuter, P. Hunt, W. Sheridan, and D. Zucker-Franklin), pp. 189-202. Humana Press, Totawa, NJ.
34. Shivdasani, R.A., E.L. Mayer, and S.H. Orkin. 1995a. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature 373: 432-434.
35. Shivdasani, R.A., M.F. Rosenblatt, D. Zucker-Franklin, C.W. Jackson, P. Hunt, C.J. Saris, and S.H. Orkin. 1995b. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell 81: 695-704.
36. Shivdasani, R.A., Y. Fujiwara, M.A. McDevitt, and S.H. Orkin. 1997. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 16: 3965-3973.
37. Spieth, J., Y.H. Shim, K. Lea, R. Conrad, and T. Blumenthal. 1991. elt-1, an embryonically expressed Caenorhabditis elegans gene homologous to the GATA transcription factor family. Mol. Cell. Biol. 9: 4651-4659.
38. Ting, C.N., M.C. Olson, K.P. Barton, and J.M. Leiden. 1996. Transcription factor GATA-3 is required for development of the T-cell lineage. Nature 384: 474-478.
39. Tsai, F.Y. and S.H. Orkin. 1997. Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. Blood 89: 3636-3643.
40. Tsai, S.F., D.I. Martin, L.I. Zon, A.D. D'Andrea, G.G. Wong, and S.H. Orkin. 1989. Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature 339: 446-451.
41. Tsai, F.Y., G. Keller, F.C. Kuo, M. Weiss, J. Chen, M. Rosenblatt, F.W. Alt, and S.H. Orkin. 1994. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 371: 221-226.
42. Tsang, A.P., J.E. Visvader, C.A. Turner, Y. Fujiwara, C. Yu, M.J. Weiss, M. Crossley, and S.H. Orkin. 1997. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell 90: 109-119.
43. Tybulewicz, V.L.J., C.E. Crawford, P.K. Jackson, R.T. Bronson, and R.C. Mulligan. 1991. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl protooncogene. Cell 65: 1153-1163.
44. Visvader, J.E., A.G. Elefanty, A. Strasscr, and J.M. Adams. 1992. GATA-1 but not SCL induces megakaryocytic differentiation in an early myeloid line. EMBO J. 11: 4557-4564.
45. Visvader, J.E., M. Crossley, J. Hill, S.H. Orkin, and J.M. Adams. 1995. The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line. Mol. Cell. Biol. 15: 634-641.
46. Wadman, I.A., H. Osada, G.G. Grutz, A.D. Agulnick, H. Westphal, A. Forster, and T.H. Rabbitts. 1997. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J. 16: 3145-3157.
47. Wang, Q., T. Stacy, J.D. Miller, A.F. Lewis, T.-L. Gu, X. Huang, J.H. Bushweller, J.-C. Bories, F.W. Alt, G. Ryan, P.P. Liu, A. Wynshaw-Boris, M. Binder, M. Marin-Padilla, A.H. Sharpe, and N.A. Speck. 1996. The CBFβ subunit is essential for CBFα2(AML1) function in vivo. Cell 87: 697-708.
48. Warren, A.J., W.H. Colledge, M.B.L. Carlton, M.J. Evans, A.J.H. Smith, and T.H. Rabbitts. 1994. The oncogenic cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development. Cell 78: 45-57.
49. Weiss, M.J. and S.H. Orkin. 1995. Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. Proc. Natl. Acad. Sci. 92: 9623-9627.
50. Weiss, M.J., G. Keller, and S.H. Orkin. 1994. Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells. Genes & Dev. 8: 1184-1197.
51. Weiss, M.J., C. Yu, and S.H. Orkin. 1997. Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. Mol. Cell. Biol. 17: 1642-1651.
52. Whitelaw, E., S.F. Tsai, P. Hogben, and S.H. Orkin. 1990. Regulated expression of globin chains and the erythroid transcription factor GATA-1 during erythropoiesis in the developing mouse. Mol Cell. Biol. 10: 6596-6606.
53. Wong, P.M.C., S.W. Chung, D.H.K. Chui, and C.J. Eaves. 1986. Properties of the earliest clonogenic hemopoietic procursors to appear in the developing murine yolk sac. Proc. Natl. Acad. Sci. 83: 3851-3854.
54. Zheng, W. and R.A. Flavell. 1997. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89: 587-596.
55. Zhu, J., R.J. Hill, P.J. Heid, M. Fukuyama, A. Sugimoto, J.R. Priess, and J.H. Rothman. 1997. end-1 encodes an apparent GATA factor that specifies the endoderm precursor in Caenorhabditis elegans embryos. Genes & Dev. 11: 2883-2896.