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Müller M, Jansen PLM: Molecular aspects of hepatobiliary transport. Am J Physiol 1997, 272:G1285-G1303.
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0342872090
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Hepatobiliary elimination of cationic drugs: The role of P-glycoproteins and other ATP-dependent transporters
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Meijer DKF, Smit JW, Müller M: Hepatobiliary elimination of cationic drugs: the role of P-glycoproteins and other ATP-dependent transporters. Advanced Drug Delivery Reviews 1997, 25:159-200.
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Meijer, D.K.F.1
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0029924518
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Ion transport in hepatocytes: Mechanisms and correlations to cell volume, hormone actions and metabolism
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Graf J, Häussinger D: Ion transport in hepatocytes: mechanisms and correlations to cell volume, hormone actions and metabolism. J Hepatol 1996, 24(suppl 1):53-77.
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New Insights into cholangiocyte physiology
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Strazzabosco M: New Insights into cholangiocyte physiology. J Hepatol 1997, 27:945-952.
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0031011548
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Reperfusion injury after liver preservation for transplantation
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Lemasters JJ, Thurman RG: Reperfusion injury after liver preservation for transplantation. Ann Rev Pharmacol Toxicol 1997, 37:327-338.
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Ann Rev Pharmacol Toxicol
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Lemasters, J.J.1
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6
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0030994363
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Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin: Mediation of transcriptional activation by Stat5
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Ganguly TC, O'Brien ML, Karpen SJ, Hyde JF, Suchy FJ, Vore M: Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin: mediation of transcriptional activation by Stat5. J Clin Invest 1997, 99:2906-2914. This study showed for the first time a role for STAT5 in transcriptional regulation of ntcp. There was a time-dependent increase in nuclear translocation of liver STAT5 that correlated with serum prolactin levels. Binding of STAT5 to ntcp-GLEs was shown in electrophoretic mobility gel shift assay. A requirement for coexpression of PRLRL and STAT5 was shown by transient cotransfections in HepG2 cells. The short form of the PRL receptor failed to transactivate ntcp GLEs. These results support the conclusion that prolactin acting via PRLRL transcriptionally regulates ntcp by facilitating STAT5 binding to ntcp GLEs.
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J Clin Invest
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Ganguly, T.C.1
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Vore, M.6
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7
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0030767968
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Glucocorticoids upregulate taurocholate transport by ileal brush-border membrane
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Nowicki MJ, Shneider BL, Paul JM, Heubi JE: Glucocorticoids upregulate taurocholate transport by ileal brush-border membrane. Am J Physiol 1997, 273:G197-G203.
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Nowicki, M.J.1
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11
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0029863171
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cGMP stimulates bile acid-independent bile formation and biliary bicarbonate excretion
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Myers NC, Grünee S, Jameson HII, Anwer MS: cGMP stimulates bile acid-independent bile formation and biliary bicarbonate excretion. Am J Physiol 1996, 270:G418-G424.
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Myers, N.C.1
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12
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0030470648
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Ethinyl estradiol cholestasis involves alterations in expression of liver sinusoidal transporters
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+-ATPase activity, and organic anion transport. This is a well-designed study in that the conclusion is based on transport activity, steady state mRNA level, and protein mass.
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Am J Physiol
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Simon, F.R.1
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13
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0030763639
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Green RM, Gollan JL, Hagenbuch B, Meier PJ, Beier DR: Regulation of hepatocyte bile salt transporters during hepatic regeneration. Am J Physiol 1997, 273:G621-G627. Demonstrates that during regeneration following hepatectomy, sinusoidal bile acid transport, ntcp mRNA, and ntcp mass are decreased without any effect on canalicular bile acid transport. These results indicate that the observed decrease in bile acid excretion following partial hepatectomy results from a decrease in bile acid uptake.
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Green, R.M.1
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14
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0030941882
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Hepatic basolateral sodium-dependent-bile acid transporter expression in two unusual cases of hypercholanemia and in extrahepatic biliary atresia
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Shneider BL, Fox VL, Schwarz KB, Watson CL, Ananthanarayanan M, Thevananther S, Christie DM, Hardikar W, Setchell KDR, Meili-Vergani G, Suchy FJ, Mowat AP: Hepatic basolateral sodium-dependent-bile acid transporter expression in two unusual cases of hypercholanemia and in extrahepatic biliary atresia. Hepatology 1997, 25:1176-1183. Shows that NTCP is downregulated in human patients with biliary atresia as it has been shown in rats with common bile duct ligation. More importantly, two patients with hypercholanemia showed no changes in NTCP expression or primary defect in the deduced amino acid sequence, raising the possibility that these patients may have a defect in a gene or genes other than NTCP.
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(1997)
Hepatology
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Shneider, B.L.1
Fox, V.L.2
Schwarz, K.B.3
Watson, C.L.4
Ananthanarayanan, M.5
Thevananther, S.6
Christie, D.M.7
Hardikar, W.8
Setchell, K.D.R.9
Meili-Vergani, G.10
Suchy, F.J.11
Mowat, A.P.12
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15
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0031014582
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+/taurocholate cotransporter is regulated in vivo by retention of biliary constituents but not their depletion
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+/taurocholate cotransporter is regulated in vivo by retention of biliary constituents but not their depletion. Hepatology 1997, 25:284-290. This well-designed study demonstrates that retention of biliary constituents downregulates ntcp, but depletion does not upregulate ntcp. Because ntcp mRNA but not ntcp mass was decreased in the retention model, posttranslational regulation may be involved.
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(1997)
Hepatology
, vol.25
, pp. 284-290
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Gartung, C.1
Schuele, S.2
Schlosser, S.F.3
Boyer, J.L.4
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16
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33745370013
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Effect of endotoxin on bile acid transport in rat liver: A potential model for sepsis-associated cholestatsis
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Moseley RH, Wang W, Takeda H, Lown K, Shick L, Ananthanarayanan M, Suchy FJ: Effect of endotoxin on bile acid transport in rat liver: a potential model for sepsis-associated cholestatsis. Am J Physiol 1996, 271:G137-G146.
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Moseley, R.H.1
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Ananthanarayanan, M.6
Suchy, F.J.7
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17
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0030841172
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Effect of cholestasis on regulation of cAMP synthesis by glucagon and bile acids in isolated hepatocytes
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Matsuzaki Y, Bouscarel B, Le M, Ceryak S, Gettys TW, Shoda J, Fromm H: Effect of cholestasis on regulation of cAMP synthesis by glucagon and bile acids in isolated hepatocytes. Am J Physiol 1997, 273:G164-G174. Shows that regulatory mechanisms affecting cAMP synthesis are compromised in bile duct ligated hamsters, indicating that cAMP-mediated regulations may be compromised in cholestasis.
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Matsuzaki, Y.1
Bouscarel, B.2
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18
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0029889501
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Hepatocellular sinusoidal membrane organic anion transport and transporters
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Wolkoff AW: Hepatocellular sinusoidal membrane organic anion transport and transporters. Semin Liver Dis 1996, 16:121-127.
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Wolkoff, A.W.1
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19
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0030296680
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Multispecific amphipathic substrate transport by an organic anion transporter of human liver
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Bossuyt X, Muller M, Meier PJ: Multispecific amphipathic substrate transport by an organic anion transporter of human liver. J Hepatol 1996, 25:733-773.
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Bossuyt, X.1
Muller, M.2
Meier, P.J.3
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20
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0030886124
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Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain
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Noé B, Hagenbuch B, Stieger B, Meier PJ: Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc Natl Acad Sci U S A 1997, 94:10346-10350. The presence of a novel oatp2 in the liver is described.
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Proc Natl Acad Sci U S A
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Noé, B.1
Hagenbuch, B.2
Stieger, B.3
Meier, P.J.4
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22
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0030858601
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Carrier-mediated transport of conjugated bile acids across the basolateral membrane of biliary epithelial cells
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Benedetti A, Di Sario A, Marucci L, Svegliati-Baroni G, Schteingart CD, Ton-nu H-T, Hofmann AF: Carrier-mediated transport of conjugated bile acids across the basolateral membrane of biliary epithelial cells. Am J Physiol 1997, 272:G1416-G1424. The first demonstration of the presence of bile acid transporter in bile duct epithelial cells, indicating that cholangiocytes may contribute to bile formation by transporting organic anions.
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Am J Physiol
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Benedetti, A.1
Di Sario, A.2
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Hofmann, A.F.7
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23
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0030909687
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Lack of evidence for vesicle trafficking of fluorescent bile salts in rat hepatocyte couplets
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El-Seaidy AZ, Mills CO, Elias E, Crawford JM: Lack of evidence for vesicle trafficking of fluorescent bile salts in rat hepatocyte couplets. Am J Physiol 1997, 272:G298-G309. This study is based on intracellular distribution of fluorescent bile acids obtained by confocal scanning fluorescence microscopy, and includes a discussion on the limitations of studies with fluorescent bile acids.
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Am J Physiol
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El-Seaidy, A.Z.1
Mills, C.O.2
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24
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0030007590
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Role of vesicle-mediated transport pathways in hepatocellular bile secretion
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Crawford JM: Role of vesicle-mediated transport pathways in hepatocellular bile secretion. Semin Liver Dis 1996, 16:169-189.
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Semin Liver Dis
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Crawford, J.M.1
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25
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0031040979
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Adaptive regulation of hepatic bile salt transport: Role of bile salt hydrophobicity and microtubule-dependent vesicular pathway
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Arrese M, Pizarro M, Solis N, Accatino L: Adaptive regulation of hepatic bile salt transport: role of bile salt hydrophobicity and microtubule-dependent vesicular pathway. J Hepatol 1997, 26:694-702.
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J Hepatol
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Arrese, M.1
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Accatino, L.4
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26
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0030907544
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Regulation and translocation of ATP-dependent apical membrane proteins in rat liver
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Gatmaitan ZC, Nies AT, Arias IM: Regulation and translocation of ATP-dependent apical membrane proteins in rat liver. Am J Physiol 1997, 272:G1041-G1049. This study provided biochemical evidence in support of the hypothesis that taurocholate and cAMP increase relative amounts of ATP-dependent transporters in the canalicular membrane, an effect dependent on intact microtubule.
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Am J Physiol
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Gatmaitan, Z.C.1
Nies, A.T.2
Arias, I.M.3
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27
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0030908321
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Disruption of actin organization by cytochalasin D does not impair biliary secretion of organic anions in the rat
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St-Pierre MV, Dufour JFJ, Arias IM: Disruption of actin organization by cytochalasin D does not impair biliary secretion of organic anions in the rat. Hepatology 1997, 25:970-975.
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Hepatology
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St-Pierre, M.V.1
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Arias, I.M.3
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28
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0030756571
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Regulation of endocytic-transcytotic pathways and bile secretion by phosphatidylinositiol 3-kinase in rats
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Folli F, Alvaro D, Gigliozzi A, Bassotti C, Kahn CR, Pontiroli AE, Capocaccia L, Jezequel AM, Benedetti A: Regulation of endocytic-transcytotic pathways and bile secretion by phosphatidylinositiol 3-kinase in rats. Gastroenterology 1997, 113:954-965. This is the first demonstration of a role for P13K in bile formation, thus identifying another mechanism by which vesicular trafficking may be regulated in hepatocytes.
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(1997)
Gastroenterology
, vol.113
, pp. 954-965
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Folli, F.1
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Kahn, C.R.5
Pontiroli, A.E.6
Capocaccia, L.7
Jezequel, A.M.8
Benedetti, A.9
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29
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0029968296
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Phosphoinositides as regulators in membrane traffic
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De Camilli P, Emr SD, McPherson PS, Novick P: Phosphoinositides as regulators in membrane traffic. Science 1996, 271:1533-1538.
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De Camilli, P.1
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Novick, P.4
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30
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0029817155
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Protein phosphates independently regulate vesicle movement and microtubule subpopulations in hepatocytes
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Hamm-Alvarez SF, Wei X, Berndt N, Runnegar M: Protein phosphates independently regulate vesicle movement and microtubule subpopulations in hepatocytes. Am J Physiol 1996, 271:C929-C943.
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Am J Physiol
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Hamm-Alvarez, S.F.1
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31
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0031000418
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Transferrin receptor recycling in rat hepatocytes is regulated by protein phosphatase 2A, possibly through effects on microtubule-dependent transport
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Runnegar M, Wei X, Berndt N, Hamm-Alvarez SF: Transferrin receptor recycling in rat hepatocytes is regulated by protein phosphatase 2A, possibly through effects on microtubule-dependent transport. Hepatology 1997, 26:176-185. By showing that protein phosphatase 2A regulates receptor recycling, this study underscores the importance of phosphorylation and dephosphorylation in vesicular trafficking. This study should provide the basis for further studies to define the regulatory pathways in vesicular movements in hepatocytes.
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(1997)
Hepatology
, vol.26
, pp. 176-185
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Runnegar, M.1
Wei, X.2
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32
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0030955621
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The expression of endosomal rab proteins correlates with endocytic rate in rat liver cells
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Juvet LK, Bert T, Gjoen T: The expression of endosomal rab proteins correlates with endocytic rate in rat liver cells. Hepatology 1997, 25:1204-1212.
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Hepatology
, vol.25
, pp. 1204-1212
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Juvet, L.K.1
Bert, T.2
Gjoen, T.3
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33
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0029935722
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Effects of biliary obstruction on the endocytic activity in hepatocyte and liver sinusoidal endothelial cells in rats
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Tanabe D, Kamimoto Y, Kai M, Hiraoka T, Tashire S, Miyauchi Y: Effects of biliary obstruction on the endocytic activity in hepatocyte and liver sinusoidal endothelial cells in rats. Eur Surg Res 1996, 28:201-211.
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Eur Surg Res
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Tanabe, D.1
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Miyauchi, Y.6
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34
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0029970141
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Hepatocellular transport: Role of ATP-binding cassette proteins
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Lomri N, Fitz JG, Scharschmidt BF: Hepatocellular transport: role of ATP-binding cassette proteins. Semin Liver Dis 1996, 16:201-210.
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Semin Liver Dis
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Lomri, N.1
Fitz, J.G.2
Scharschmidt, B.F.3
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35
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0031014807
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Prolactin increases ATP-dependent taurocholate transport in canalicular plasma membrane from rat liver
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Liu Y, Suchy FJ, Silverman JA, Vore M: Prolactin increases ATP-dependent taurocholate transport in canalicular plasma membrane from rat liver. Am J Physiol 1997, 272:G46-G53.
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Am J Physiol
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Liu, Y.1
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36
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Bile acid transport across the hepatocyte canalicular membrane
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Suchy FJ, Sippel CJ, Ananthanarayanan M: Bile acid transport across the hepatocyte canalicular membrane. FASEB J 1997, 11:199-205.
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Suchy, F.J.1
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37
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0030963905
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Evidence for an ATP-dependent bile acid transport protein other than the canicular liver ecto-ATPase in rats
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Luther TT, Hammerman P, Rahmaoui CM, Lee PP, Sela-Herman S, Matula GS, Ananthanarayanan M, Suchy FJ, Cavalieri RR, Lomri N, Scharschmidt BF: Evidence for an ATP-dependent bile acid transport protein other than the canicular liver ecto-ATPase in rats. Gastroenterology 1997, 113:249-254. Provides convincing evidence supporting the hypothesis that a protein or proteins other than ecto-ATPase may be involved in ATP-dependent bile acid transport.
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Gastroenterology
, vol.113
, pp. 249-254
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Luther, T.T.1
Hammerman, P.2
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Lee, P.P.4
Sela-Herman, S.5
Matula, G.S.6
Ananthanarayanan, M.7
Suchy, F.J.8
Cavalieri, R.R.9
Lomri, N.10
Scharschmidt, B.F.11
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38
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0000893484
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The sister P-glycoprotein of rat liver mediates ATP-dependent taurocholate (TCA) transport
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Gerloff T, Steiger B, Hagenbuch B, Landmann L, Meier PJ: The sister P-glycoprotein of rat liver mediates ATP-dependent taurocholate (TCA) transport [abstract]. Hepatology 1997, 26:358A.
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Hepatology
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Gerloff, T.1
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Meier, P.J.5
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39
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0030031467
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Regulation of taurocholate excretion by a hypo-osmolarity-activated signal transduction pathway in rat liver
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Noé B, Schliess F, Wettstein M, Heinrich S, Haussinger D: Regulation of taurocholate excretion by a hypo-osmolarity-activated signal transduction pathway in rat liver. Gastroenterology 1996, 110:858-865.
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, pp. 858-865
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Noé, B.1
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40
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0030829597
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Mitogen-activated protein kinase mediate the Stimulation of bile acid secretion by tauroursodeoxycholate in rat liver
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Schliess F, Kurz AK, vom Dahl S, Haussinger D: Mitogen-activated protein kinase mediate the Stimulation of bile acid secretion by tauroursodeoxycholate in rat liver. Gastroenterology 1997, 113:1306-1313. This study in cultured hepatocytes and perfused rat livers shows that TUDC induces activation of MAP kinases, and TUDC-induced stimulation of bile acid excretion is inhibited by a MAP kinase inhibitor, supporting the hypothesis that bile acid excretion may be regulated by MAP kinases.
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Gastroenterology
, vol.113
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Schliess, F.1
Kurz, A.K.2
Vom Dahl, S.3
Haussinger, D.4
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42
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0030994468
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A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnosn syndrome
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Paulosma CC, Kool M, Bosma PJ, Scheffer GL, Ter Borg F, Scheper RJ, Tytgat GNJ, Borst P, Baas F, Oude Elferink RPJ: A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnosn syndrome. Hepatology 1997, 25:1539-1542. A human homologue of rat cmoat, human cMOAT, was cloned and compared with the corresponding cDNA from fibroblasts of a patient with Dubin-Johnson syndrome. Results revealed a C- to-T mutation resulting in the conversion of the codon for arginine to a stop codon in the patient with Dubin-Johnson syndrome, thus providing an explanation for the transport defect in these patients.
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(1997)
Hepatology
, vol.25
, pp. 1539-1542
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Paulosma, C.C.1
Kool, M.2
Bosma, P.J.3
Scheffer, G.L.4
Ter Borg, F.5
Scheper, R.J.6
Tytgat, G.N.J.7
Borst, P.8
Baas, F.9
Oude Elferink, R.P.J.10
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43
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0030963906
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The rat canicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis
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Trauner M, Arrese M, Soroka CJ, Ananthanarayanan M, Koeppel TA, Schlosser SF, Suchy FJ, Keppler D, Boyer JL: The rat canicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 1997, 113:255-264. In three different models of cholestasis, namely endotoxin, ethinyl estradiol, and bile duct ligation, there was a specific reduction of mrp2 protein, indicating that the downregulation of mrp2 may underlie the impaired biliary transport of organic anion conjugates in cholestasis.
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Gastroenterology
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, pp. 255-264
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Trauner, M.1
Arrese, M.2
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Ananthanarayanan, M.4
Koeppel, T.A.5
Schlosser, S.F.6
Suchy, F.J.7
Keppler, D.8
Boyer, J.L.9
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44
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0030957234
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Hepatobiliary transport mechanism for the cyclopentapeptide endothelin antagonist BQ-123
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Shin H-C, Kato Y, Yamada T, Niinuma K, Hisaka A, Sugiyama Y: Hepatobiliary transport mechanism for the cyclopentapeptide endothelin antagonist BQ-123. Am J Physiol 1997, 272:G979-G986.
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Shin, H.-C.1
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Sugiyama, Y.6
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45
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0029845053
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ATP-dependent transport of beta-estradiol 17-(beta-D-glucuronide) in rat canalicular membrane vesicles
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Vore M, Hoffman T, Gosland M: ATP-dependent transport of beta-estradiol 17-(beta-D-glucuronide) in rat canalicular membrane vesicles. Am J Physiol 1996, 271:G791-G798.
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Vore, M.1
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47
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0030912039
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Different effect of cold storage and rewarming on three pH regulating transporters in isolated rat hepatocytes
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- cotransport, providing a possible mechanistic explanation for disturbances in pH homeostasis under these conditions.
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Forestal, D.A.1
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Serrar H, Haddad P: Effects of cold preservation and rewarming on rat liver cell volume regulation and concentrative amino acid uptake. Gastroenterology 1997, 112:1344-1353.
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49
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