Cytoprotection by glycine against hypoxia-induced injury in cultured hepatocytes

Liver

Volumn 17, Issue 2, 1997, Pages 57-62

  Nagatomi, Atsuko ^a   Sakaida, Isao ^a   Matsumura, Yasuhiro ^a   Okita, Kiwamu ^a  

^a YAMAGUCHI UNIVERSITY   (Japan)

Author keywords

Cytoprotection; Glycine; Hypoxia

Indexed keywords

ADENOSINE TRIPHOSPHATE; CHLORIDE CHANNEL; CHLORIDE CHANNEL BLOCKING AGENT; CHLORIDE ION; FUROSEMIDE; GLYCINE; LACTIC ACID; STRYCHNINE;

ANAEROBIC GLYCOLYSIS; ANIMAL CELL; ARTICLE; CELL DEATH; CELL PROTECTION; CHLORIDE TRANSPORT; CONTROLLED STUDY; HYPOXIA; LIVER CELL CULTURE; LIVER CELL DAMAGE; LIVER PRESERVATION; LIVER TRANSPLANTATION; MALE; NONHUMAN; PH; RAT;

EID: 0030887120     PISSN: 01069543     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0676.1997.tb00781.x     Document Type: Article

References (24)

1. CASINI A, GIORLI M, HYLAND R J, SERRONI A, GILFOR D, FARBER J L. Mechanisms of cell injury in the killing of cultured hepatocytes by bromobenzene J Biol Chem 1982: 257: 6721-6728.
2. CHIEN K R J, ABRAMS J, SERRONI A, FARBER J L. Accelerated phospholipid degradation and associated membrane dysfunction in irreversible liver cell injury. J Biol Chem 1978: 253: 4809-4817.
3. FARBER J L, YOUNG E E. Accelerated phospholipid degradation in anoxic rat hepatocytes. Arch Biochem Biophys 1981: 211: 312-320.
4. HERMAN B, NIEMINEN A L, GORES G J, LEMASTERS J J. Irreversible injury in anoxic hepatocytes precipitated by an abrupt increase in plasma membrane permeability. FASEB J 1988: 2: 146-151.
5. MARSH D C, VREUGDENHIL P K, MACK V E, BELZER F O, SOUTHARD J H. Glycine protects hepatocytes from injury caused by anoxia, cold ischemia and mitochondrial inhibitors, but not injury caused by calcium ionophores or oxidative stress. Hepatology 1993: 17: 91-98.
6. SAKAIDA I, NAGATOMI A, WASAKI S, MATSUMURA Y, YASUNAGA M, OKITA K. Protection by glycine against chemical ischemia (cyanide) in cultured hepatocytes. J Gastroenterol 1996: 31: 684-690.
7. WEINBERG J M, DAVIS J A, ROESER N F, VENKATACHALAM M A. Role of increased cytosolic free calcium in the pathogenesis of rabbit proximal tubule cell injury and protection by glycine or acidosis. J Clin Invest 1991: 87: 581-590.
8. WEINBERG J M, DAVIS J A, ABARZUA M, KIANI T. Relationship between cell adenosine triphosphate and glutathione content and protection by glycine against hypoxic proximal tubule cell injury. J Lab Clin Med 1989: 113: 612-622.
9. WEINBERG J M, VENKATACHALAM M A, GARZO-QUINTERO R, ROESER N F, DAVIS J A. Structural requirements for protection by small amino acids against hypoxic injury in kidney proximal tubules. FASEB J 1990: 4: 3347-3354.
10. WEINBERG J M, DAVIS J A, ABARZUA M, RAJAN T. Cytoprotective effects of glycine and glutathione against hypoxic injury to renal tubules. J Clin Invest 1987: 80: 1446-1454.
11. WEINBERG J M, VARANI J, JOHNSON K J, et al. Protection of human umbilical vein endothelial cells by glycine and structurally similar amino acids against calcium and hydrogen peroxide-induced lethal cell injury. Am J Pathol 1992: 140: 457-471.
12. NICHOLS J C, BRONK S F, MELLGREN R L, GORES G J Inhibition of nonlysosomal calcium-dependent proteolysis by glycine during anoxic injury of rat hepatocytes. Gastroenterology 1994: 106: 168-176
13. MILLER G W, SCHNELLMANN R G. Cytoprotection by inhibition of chloride channels: the mechanism of action of glycine and strychnine. Life Sci 1993: 53: 1211-1215.
14. 2+ homeostasis in cultured rat hepatocytes intoxicated with cyanide. Am J Physiol 1992: 263: C684-C690.
15. SEGLEN P O. Preparation of isolated rat liver cells. Meth Cell Biol 1976: 13: 29-83.
16. LOWRY O H, ROSEBROUGH N J, FARR A L, RANDALL R J. Protein measurement with the Folin phenol reagent. J Biol Chem 1951: 193: 265-275.
17. KANE A B, PETROVICH D, STERN R O, FARBER J L. ATP depletion and the loss of cell integrity in anoxic hepatocytes and silica-treated P388D1 macrophases Am J Physiol 1985: 249: C256-C266.
18. SAKAIDA I, THOMAS A P, FARBER J L. Increase in cytosolic calcium ion concentration can be dissociated from the killing of cultured hepatocytes by tert-butyl hydroperoxide. J Biol Chem 1991: 266: 717-722.
19. DICKSON R C, BRONK S F, GORES G J. Glycine cytoprotection during lethal hepatocellular injury from adenosine triphosphate depletion. Gastroenterology 1992: 102: 2098-2107.
20. ROSSER B G, GORES G J. Liver cell necrosis: Cellular mechanism and clinical implications. Gastroenterology 1995: 108: 252-275.
21. GORES G J, NIEMINEN A L, WRAY B E. Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes: protection by intracellular acidosis against the onset of cell death. J Clin Invest 1989: 83: 386-396.
22. BRONK S F, GORES G J. pH dependent, non-lysosomal proteolysis contributes to lethal anoxic cell injury of rat hepatocytes. Am J Physiol 1993: 264: G744-G751.
23. 2+ and the stimulation of a nonlysosomal proteolytic system. J Biol Chem 1986: 261: 14628-14636.
24. TOKUTOMI N, KANEDA M, AKAIKE N. What confers specificity on glycine for its receptor site? Br J Pharmacol 1989: 97: 353-360.