Bile salt-induced apoptosis of hepatocytes involves activation of protein kinase C

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 272, Issue 5 35-5, 1997, Pages

  Jones, Blake A ^a   Rao, Yi Ping ^b   Stravitz, R Todd ^b   Gores, Gregory J ^a,c  

^a MAYO CLINIC   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MAYO CLINIC COLLEGE OF MEDICINE   (United States)

Author keywords

Baculovirus; Cholestasis; Deoxyribonucleic acid fragmentation; Fast protein liquid chromatography; Phospholipid vesicles

Indexed keywords

BILE SALT; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C;

ANIMAL CELL; APOPTOSIS; ARTICLE; CHOLESTASIS; DNA CLEAVAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; LIPID VESICLE; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 0030906632     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1997.272.5.g1109     Document Type: Article

References (31)

1. Adjei, P. N., S. H. Kaufmann, W. Y. Leung, F. Mao, and G. J. Gores. Selective induction of apoptosis in Hep 3B cells by topoisomerase I inhibitors: evidence for a protease-dependent pathway that does not activate CPP32. J. Clin. Invest. 98: 2588-2596, 1996.
2. Beuers, U., D. C. Throckmorton, M. S. Anderson, C. M. Isales, W. Thasler, G. A. Kullak-Ublick, G. Sauter, H. G. Koebe, G. Paumgartner, and J. L. Boyer. Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes. Gastroenterology 110: 1553-1563, 1996.
3. Bøe, R., B. T. Gjertsen, O. K. Vintermyr, G. Houge, M. Lanotte, and S. O. Døskeland. The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Exp. Cell Res. 195: 237-246, 1991.
4. Chen, Y. R., C. F. Meyer, and T. H. Tan. Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in γ radiation-induced apoptosis. J. Biol. Chem. 271: 631-634, 1996.
5. De Vente, J. E., C. A. Kukoly, W. O. Bryant, K. J. Posekany, J. Chen, D. J. Fletcher, P. J. Parker, G. J. Pettit, G. Lozano, P. P. Cook, and D. K. Ways. Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms: role for p53-independent induction of gadd45 in initiating death. J. Clin. Invest. 96: 1874-1886, 1995.
6. Emoto, Y., Y. Manome, G. Meinhardt, H. Kisaki, S. Kharbanda, M. Robertson, T. Ghayur, W. W. Wong, R. Kamen, R. Weichselbaum, and K. Dufe. Proteolytic activation of protein kinase C δ by an ICE-like protease in apoptotic cells. EMBO J. 14: 6148-6156, 1995.
7. Fahey, D. A., M. C. Carey, and J. M. Donovan. Bile acid/ phosphatidylcholine interactions in mixed monomolecular layers: differences in condensation effects but not interfacial orientation between hydrophobic and hydrophilic bile acid species. Biochemistry 34: 10886-10897, 1995.
8. Hannun, Y. A., and R. M. Bell. Rat brain protein kinase C. J. Biol. Chem. 265: 2962-2972, 1990.
9. Hofmann, A. Bile acid hepatotoxicity and the rationale of UDCA therapy in chronic cholestatic liver disease: some hypotheses. In: Strategies for the Treatment of Hepatobiliary Diseases, edited by G. Paumgartner, A. Stiehl, L. Barbara, and E. Roda. Boston, MA: Kluwer, 1989, p. 13-33.
10. Hug, H., and T. F. Sarre. Protein kinase C isozymes: divergence in signal transduction? Biochem. J. 291: 329-343, 1993.
11. Iwata, M., R. Iseki, K. Sato, Y. Tozawa, and Y. Ohaka. Involvement of protein kinase C-ε in glucocorticoid-induced apoptosis in thymocytes. Int. Immunol. 6: 431-438, 1994.
12. Jarvis, W. D., A. J. Turner, L. F. Povirk, R. S. Traylor, and S. Grant. Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacologic inhibitors of protein kinase C. Cancer Res. 54: 1707-1714, 1994.
13. Kiley, S. C., and S. Jaken. Activation of α-protein kinase C leads to association with detergent-insoluble components of GH4C1 cells. Mol. Endocrinol. 4: 59-67, 1990.
14. Kizaki, H., T. Tadakuma, C. Odaka, J. Muramutsa, and T. Ishimura. Activation of a suicide process of thymocytes through DNA fragmentation by calcium ionophores and phorbol esters. J. Immunol. 143: 1790-1794, 1989.
15. Kwo, P., T. Patel, S. F. Bronk, and G. J. Gores. Nuclear serine protease activity contributes to bile acid-induced apoptosis in hepatocytes. Am. J. Physiol. 268 (Gastrointest. Liver Physiol. 31): G613-G621, 1995.
16. Martiny-Baron, G., M. G. Kazanietz, H. Mischak, P. M. Blumberg, G. Kochs, H. Hug, D. Marmé, and C. Schächtele. Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J. Biol. Chem. 268: 9194-9197, 1993.
17. Masmoudi, A., G. Labourdette, M. Mersel, F. L. Huang, K. P. Huang, G. Vincendon, and A. N. Malviya. Protein kinase C located in rat liver nuclei. Partial purification and immunochemical characterization. J. Biol. Chem. 264: 1172-1179, 1989.
18. Ogita, K., Y. Ono, U. Kikkawa, and Y. Nishizuka. Expression, separation, and assay of protein kinase C subspecies. Methods Enzymol. 200: 228-234, 1991.
19. Ojeda, F., M. I. Guarda, C. Maldonado, and H. Folch. Protein kinase-C involvement in thymocyte apoptosis induced by hydrocortisone. Cell. Immunol. 125: 535-539, 1990.
20. Ojeda, F., M. I. Guarda, C. Maldonado, H. Folch, and H. Diehl. Role of protein kinase-C in thymocyte apoptosis induced by irradiation. Int. J. Radiat. Biol. 61: 663-667, 1992.
21. Patel, T., A. Arora, and G. J. Gores. A fluorometric assay for quantitating DNA strand breaks during apoptosis. Anal. Biochem. 229: 229-235, 1995.
22. Patel, T., S. F. Bronk, and G. J. Gores. Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in hepatocytes. J. Clin. Invest. 94: 2183-2192, 1994.
23. Patel, T., and G. J. Gores. Apoptosis and hepatobiliary disease. Hepatology 21: 1725-1741, 1995.
24. Roberts, L. R., T. Patel, S. F. Bronk, and G. J. Gores. Translocation of cathepsin B from the cytoplasm to the nucleus contributes to bile salt-induced hepatocyte apoptosis (Abstract). Hepatology 24: 253A, 1996.
25. Shaposhnikova, V. V., O. R. Dobrovinskaya, L. K. Eidus, and Y. N. Korystov. Dependence of thymocyte apoptosis on protein kinase C and phospholipase A2. FEBS Lett. 348: 317-319, 1994.
26. Slater, S. J., M. B. Kelly, F. J. Taddeo, C. Ho, E. Rubin, and C. D. Stubbs. The modulation of protein kinase C activity by membrane lipid bilayer structure. J. Biol. Chem. 269: 4866-4871, 1994.
27. Stravitz, R. T., Y. P. Rao, Z. R. Vlahcevic, E. C. Gurley, W. D. Jarvis, and P. B. Hylemon. Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7α-hydroxylase. Am. J. Physiol. 271 (Gastrointest. Liver Physiol. 34): G293-G303, 1996.
28. Tsukidate, K., K. Yamamoto, J. W. Snyder, and J. L. Farber. Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. Am. J. Pathol. 143: 918-925, 1993.
29. Vaux, D. L., and A. Strasser. The molecular biology of apoptosis. Proc. Natl. Acad. Sci. USA 93: 2239-2244, 1996.
30. Wong, B. C. Y., N. M. Michell, M. J. S. Langman, and M. C. Eggo. Induction of apoptosis by protein kinase C-β1 activator in Colo-205 human colonic carcinoma cells and its prevention by insulin-like growth factor-1 (Abstract). Gastroenterology 110: A110, 1996.
31. 2+-independent protein kinase. Cell. Immunol. 151: 320-325, 1993.