Carrier mediated transport of conjugated bile acids across the basolateral membrane of biliary epithelial cells

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 272, Issue 6 35-6, 1997, Pages

  Benedetti, A ^a   Di Sario, A ^a   Marucci, L ^a   Svegliati Baroni, G ^a   Schteingart, C D ^b   Ton Nu, H T ^b   Hofmann, A F ^b  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Basolateral plasma membrane transport; Fluorescent conjugated bile acids; Isolated bile ductules; Organic anions

Indexed keywords

ANIMAL TISSUE; ANION TRANSPORT; ARTICLE; BASOLATERAL MEMBRANE; BILE DUCT; BILE FLOW; CONTROLLED STUDY; FLUORESCENCE; MEMBRANE POTENTIAL; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030858601     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1997.272.6.g1416     Document Type: Article

References (49)

1. Alpini, G., R. Lenzi, W. R. Zhai, P. A. Slott, M. H. Liu, L. Sarkozi, and N. Tavoloni. Bile secretory function of intrahepatic biliary epithelium in the rat. Am. J. Physiol. 257 (Gastrointest. Liver Physiol. 20): G124-G133, 1989.
2. Anwer, M. S., E. R. L. O'Maille, A. F. Hofmann, R. A. DiPietro, and E. Michelotti. Influence of side chain charge on hepatic transport of bile acids and bile acid analogues. Am. J. Physiol. 249 (Gastrointest. Liver Physiol. 12): G479-G488, 1985.
3. Ballatori, N., R. Jacob, C. Barrett, and J. L. Boyer. Biliary catabolism of glutathione and differential reabsorption of its amino acid constituents. Am. J. Physiol. 254 (Gastrointest. Liver Physiol. 17): G1-G7, 1988.
4. Ballatori, N., R. Jacob, and J. L. Boyer. Intrabiliary glutathione hydrolysis. A source of glutamate in bile. J. Biol. Chem. 26: 7860-7865, 1986.
5. Benedetti, A., C. Bassotti, K. Rapino, L. Marucci, and A. M. Jezequel. Amorphometric study of the epithelium lining the rat intrahepatic biliary tree. J. Hepatol. 24: 335-342, 1996.
6. Benedetti, A., L. Marucci, C. Bassotti, R. Mancini, S. Contucci, A. M. Jezequel, and F. Orlandi. Tubulovesicular transcytotic pathway in rat biliary epithelium: a study in perfused rat liver and in isolated intrahepatic bile duct. Hepatology 18: 422-432, 1993.
7. Benedetti, A., L. Marucci, A. Di Sario, G. Svegliati Baroni, C. D. Schteingart, H.-T. Ton-Nu, and A. F. Hofmann. Serial quantitative image analysis of uptake and transport of fluorescent bile acids in polarized biliary epithelial cells. In: Bile Acids in Gastroenterology. Basic and Clinical Advances, edited by A. F. Hofmann, G. Paumgartner, and A. Stiehl. Lancaster, UK: Kluwer, 1995, p. 191-194.
8. Clerici, C., G. Dozzini, E. Distrutti, G. Gentili, B. M. Sadeghpour, B. Natalini, R. Pellicciari, R. Rizzoli, A. Roda, and M. A. Pelli. Effect of intraduodenal administration of 23-methyl-UDCA diastereoisomers on bile flow in hamsters. Dig. Dis. Sci. 37: 791-798, 1992.
9. Dumaswala, R., K. D. R. Setchell, M. D. Moyer, and F. J. Suchy. An anion exchanger mediates bile acid transport across the placental microvillus membrane. Am. J. Physiol. 264 (Gastrointest. Liver Physiol. 27): G1016-G1023, 1993.
10. Dumont, M., S. Erlinger, and S. Uchman. Hypercholeresis induced by ursodeoxycholic acid and 7-ketolithocholic acid in rat. Possible role of bicarbonate transport. Gastroenterology 79: 82-89, 1980.
11. Elsing, C., H. Sagesser, and J. Reichen. Ursodeoxycholate induced hypercholeresis in cirrhotic rats: further evidence for cholehepatic shunting. Hepatology 20: 1048-1054, 1984.
12. Farges, O., M. Corbic, M. Dumont, M. Maurice, and S. Erlinger. Permeability of the rat biliary tree to ursodeoxycholic acid. Am. J. Physiol. 256 (Gastrointest. Liver Physiol. 19): G653-G660, 1989.
13. Fini, A., and A. Roda. Chemical properties of bile acids. IV. Acidity constants of glycine-conjugated bile acids. J. Lipid Res. 18: 404-407, 1987.
14. Grant, A. G., and B. H. Billing. The isolation and characterization of a bile ductule cell population from normal and bile duct-ligated rat livers. Br. J. Exp. Pathol. 58: 301-310, 1977.
15. Gurantz, D., C. D. Schteingart, L. R. Hagey, J. H. Steinbach, T. Grotmol, and A. F. Hofmann. Hypercholeresis induced by unconjugated bile acid infusion correlates with recovery in bile of unconjugated bile acids. Hepatology 13: 540-550, 1991.
16. Guzelian, P., and J. L. Boyer. Glucose reabsorption from bile: evidence for a biliohepatic circulation. J. Clin. Invest. 53: 526-535, 1974.
17. +-linked cotransport of organic solutes. Membr. Transp. Processes 1: 13-30, 1978.
18. Hoek, J. B., D. G. Nicholls, and J. R. Williamson. Determination of the mitochondrial protonmotive force in isolated hepatocytes. J. Biol. Chem. 255: 1458-1464, 1980.
19. Hofmann, A. F. The cholehepatic circulation of unconjugated bile acids: an update. In: Bile Acids and the Hepatobiliary System, edited by G. Paumgartner, A. Stiehl, and W. Gerok. Boston, MA: Kluwer, 1993, p. 143-160.
20. Hylemon, P. B., P. M. Bohdan, A. E. Sirica, D. M. Heuman, and Z. R. Vlahcevic. Cholesterol and bile acid metabolism in cultures of primary rat bile ductular epithelial cells. Hepatology 11: 982-986, 1990.
21. Ishii, M., B. Vroman, and N. F. LaRusso. Isolation and morphologic characterization of bile duct epithelial cells from normal rat liver. Gastroenterology 97: 1236-1247, 1989.
22. Jacobs, J. M. J., T. P. Pretlow, N. Fausto, A. Pitts, and T. G. Pretlow. Separation of two populations of cells with gamma-glutamyl-transpeptidase from carcinogen-treated rat liver. J. Natl. Cancer Inst. 66: 967-973, 1981.
23. +-independent organic anion transporter. Proc. Natl. Acad. Sci. USA 91: 133-137, 1994.
24. Kitani, K., and S. Kanai. Effect of ursodeoxycholate on the bile flow in the rat. Life Sci. 31: 1973-1985, 1982.
25. Kullak-Ublick, G. A., B. Hagenbuch, B. Stieger, C. D. Schteingart, A. F. Hofmann, A. M. Wolkoff, and P. J. Meier. Molecular and functional characterization of an organic anion transporting polypeptide (oatp) cloned from human liver. Gastroenterology 109: 1274-1282, 1995.
26. + exchange in the rat is associated with decreased ursodeoxycholate hypercholeresis, decreased secretion of unconjugated ursodeoxycholate, and increased ursodeoxycholate glucuronidation. Gastroenterology 95: 454-463, 1988.
27. Lamri, Y., S. Erlinger, M. Dumont, A. Roda, and G. Feldmann. Immunoperoxidase localization of ursodeoxycholic acid in rat biliary epithelial cells. Evidence for a cholehepatic circulation. Liver 12: 351-354, 1992.
28. +-dependent taurocholate co-transporter (Abstract). Hepatology 24: A897, 1996.
29. Lira, M., C. D. Schteingart, J. H. Steinbach, K. Lambert, J. McRoberts, and A. F. Hofmann. Sugar absorption by the biliary epithelium of the rat: evidence for two transport systems. Gastroenterology 102: 563-571, 1992.
30. Maglova, L. M., A. M. Jackson, X.-J. Meng, M. W. Carruth, C. D. Schteingart, H.-T. Ton-Nu, A. F. Hofmann, and S. A. Weinman. Transport characteristics of three fluorescent conjugated bile acid analogs in isolated rat hepatocytes and couplets. Hepatology 22: 637-647, 1995.
31. Marin, J. J., M. A. Serrano, M. Y. el-Mir, N. Eleno, and C. A. Boyd. Bile acid transport by basal membrane vesicles of human term placental trophoblast. Gastroenterology 99: 1431-1438, 1990.
32. Mennone, A., D. Alvaro, W. Cho, and J. L. Boyer. Isolation of small polarized bile duct units. Proc. Natl. Acad. Sci. USA 92: 6527-6531, 1995.
33. Monson, J. M., and P. Bornstein. Identification of a disulfide-linked procollagen as the biosynthetic precursor of chick-bone collagen. Proc. Natl. Acad. Sci. USA 70: 3521-3525, 1973.
34. Palmer, K. R., D. Gurantz, A. F. Hofmann, L. M. Clayton, and S. Cecchetti. Hypercholeresis induced by norchenodeoxycholate in biliary fistula rodent. Am. J. Physiol. 252 (Gastrointest. Liver Physiol. 15): G219-G228, 1987.
35. Parola, M., K. H. Cheeseman, M. E. Biocca, M. U. Dianzani, and T. F. Slater. Isolation and characterization of biliary epithelial cells from normal rat liver. J. Hepatol. 6: 175-186, 1988.
36. Roberts, S. K., S. M. Kuntz, G. J. Gores, and N. F. La Russo. Regulation of bicarbonate-dependent ductular secretion assessed by lumenal micropuncture of isolated rodent intrahepatic intact bile ducts. Proc. Natl. Acad. Sci. USA 90: 9080-9084, 1993.
37. Rutemberg, A. M., H. Kim, J. W. Fischbein, J. S. Hanker, H. L. Wassenkrug, and A. M. Seligman. Histochemical and ultrastructural demonstration of gamma-glutamyl-transpeptidase activity. J. Histochem. Cytochem. 17: 517-526, 1969.
38. Schteingart, C. D., S. Eming, H.-T. Ton-Nu, D. L. Crombie, and A. F. Hofmann. Synthesis, structure, and transport properties of fluorescent derivatives of conjugated bile acids. In: Bile Acids and the Hepatobiliary System, edited by G. Paumgartner, A. Stiehl, and W. Gerok. Boston, MA: Kluwer, 1993, p. 143-160.
39. Strazzabosco, M., A. Mennone, and J. L. Boyer. Intracellular pH regulation in isolated rat bile duct epithelial cells. J. Clin. Invest. 87: 1503-1512, 1991.
40. Takahashi, T., J. M. Lasker, A. S. Rosman, and C. S. Lieber. Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA. Hepatology 17: 236-245, 1993.
41. Tavoloni, N. Role of ductular bile water reabsorption in canine bile secretion. J. Lab. Clin. Med. 106: 154-161, 1985.
42. Tavoloni, N. Bile acid structure and bile formation in the guinea pig. Biochim. Biophys. Acta 879: 186-201, 1986.
43. Tserng, K.-Y., D. K. Hachey, and P. D. Klein. An improved procedure for the synthesis of glycine and taurine conjugates of bile acids. J. Lipid Res. 18: 404-407, 1977.
44. Ullrich, K. J. Specificity of transporters for "organic anions" and "organic cations" in the kidney. Biochim. Biophys. Acta 1197: 45-62, 1994.
45. - ions. Acta Physiol. Scand. 146: 369-376, 1992.
46. Weinberg, S. L., G. Burckhardt, and F. A. Wilson. Taurocholate transport by rat intestinal basolateral membrane vesicles. Evidence for the presence of an anion exchange transport system. J. Clin. Invest. 78: 44-50, 1986.
47. Yoon, Y. B., L. R. Hagey, A. F. Hofmann, D. Gurantz, E. L. Michelotti, and J. H. Steinbach. Effect of side-chain shortening on the physiologic properties of bile acids: hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents. Gastroenterology 90: 837-852, 1986.
48. Zouboulis-Vafiadis, I., M. Dumont, and S. Erlinger. Conjugation of rate limiting in hepatic transport of ursodeoxycholate in the rat. Am. J. Physiol. 243 (Gastrointest. Liver Physiol. 6): G208-G213, 1982.
49. Zouboulis-Vafiadis, I., M. Dumont, and S. Erlinger. Hypercholeretic bile acids. Hepatic metabolism and effect on bile secretion of 23-methyl-ursodeoxycholic acid. In: Bile Acids and the Liver, edited by G. Paumgartner, A. Stiehl, and W. Gerok. Lancaster, UK: MTP, 1987, p. 195-198.