In vitro central nervous system models of mechanically induced trauma: A review

Journal of Neurotrauma

Volumn 15, Issue 11, 1998, Pages 911-928

  Morrison III, Barclay ^a   Saatman, Kathryn E ^b   Meaney, David F ^a   McIntosh, Tracy K ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cell culture; Glia; Injury mechanisms; Intervention; Mechanical stimulus; Neurons

Indexed keywords

(3 IODOBENZYL)GUANIDINE; 21 [4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]PREGNA 1,4,9(11) TRIENE 3,20 DIONE; 21 [4 [5,6 BIS(DIETHYLAMINO) 2 PYRIDYL] 1 PIPERAZINYL] 16ALPHA METHYLPREGNA 1,4,9(11) TRIENE 3,20 DIONE; 3 AMINOBENZAMIDE; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; ANTIMONY DERIVATIVE; ARACHIDONIC ACID; AZELASTINE; CALCIUM; CALPHOSTIN C; CYTOKINE; DIZOCILPINE; DNA; ENZYME; ETHIDIUM; FREE RADICAL; FURA 2; GLIAL FIBRILLARY ACIDIC PROTEIN; HEME OXYGENASE; ION CHANNEL; LACTATE DEHYDROGENASE; LIPID; MAGNESIUM; MESSENGER RNA; METALLOPORPHYRIN; METHYLPREDNISOLONE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NOVOBIOCIN; POTASSIUM; PROPIDIUM IODIDE; PROTEIN KINASE C; SODIUM; SUPEROXIDE DISMUTASE; VERLUKAST;

ACCELERATION; BRAIN INJURY; CELL CULTURE; CENTRAL NERVOUS SYSTEM; COMPRESSION; FINITE ELEMENT ANALYSIS; GENE THERAPY; HUMAN; HYDRODYNAMICS; HYDROSTATIC PRESSURE; ION CURRENT; MECHANICAL STIMULATION; MEMBRANE DAMAGE; METABOLISM; MODEL; NERVE CELL LESION; NERVE FIBER TRANSECTION; NEUROPROTECTION; NONHUMAN; REVIEW; SPINAL CORD INJURY; ULTRASTRUCTURE;

EID: 0031771017     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.1998.15.911     Document Type: Review

References (137)

1. ADAMS, J.H., GRAHAM, D.I., MURRAY, L.S., and SCOTT, G. (1981). Diffuse axonal injury due to nonmissile head injury in humans: an analysis of 45 cases. Ann. Neurol. 12, 557-563.
2. ALLEN, A.R. (1914). Remarks on the histopathological changes in the spinal cord due to impact: an experimental study. J. Nerv. Ment. Dis. 41, 141.
3. BALENTINE, J.D., GREENE, W.B., and BORNSTEIN, M. (1988). In vitro spinal cord injury. Lab. Invest. 58, 93-99.
4. BIRD, M.M. (1978). Microsurgical transection of small nerve fibre bundles in vitro. Effects on axons, growth cones and glial cells. Cell Tissue Res. 190, 525-538.
5. BRAMLETT, H.M., DIETRICH, W.D., GREEN, E.J., and BUSTO, R. (1997). Chronic histopathological consequences of fluid-percussion brain injury in rats: effects of post-traumatic hypothermia. Acta Neuropathol. 93, 190-199.
6. BREWER, G.J., TORRICELLI, J.R., EVEGE, E.K., and PRICE, P.J. (1993). Optimized survival of hippocampal neurons in B27-supplemented Neurobasal™, a new serum-free medium combination. J. Neurosci. Res. 35, 567-576.
7. BRUNE, B., DIMMELER, S., MOLINA Y VEDIA, L., and LAPETINA, E.G. (1994). Nitric oxide: a signal for ADP-ribosylation of proteins. Life Sci. 54, 61-70.
8. BUCHAN, A., and PULSINELLI, W.A. (1990). Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia. J. Neurosci. 10, 311-316.
9. i in NG108-15 cells subjected to high strain rate deformation and chemical hypoxia: an in vitro model for neural trauma. J. Neurotrauma 13, 396-407.
10. CHARLES, A.C. (1994). Glia-neuron intercellular calcium signaling. Dev. Neurosci. 16, 196-206.
11. CHEESEMAN, K.H. (1993). Mechanisms and effects of lipid peroxidation. Mol. Aspects Med. 14, 191-197.
12. CHEN, Q.X., PERKINS, K.L., CHOI, D.W., and WONG, R.K.S. (1997). Secondary activation of a cation conductance is responsible for NMDA toxicity in acutely isolated hippocampal neurons. J. Neurosci. 17, 4031-4036.
13. CHOI, D.W. (1994). Calcium and excitotoxic neuronal injury. Ann. N. Y. Acad. Sci. 747, 162-171.
14. CHRISTMAN, C.W., GRADY, M.S., WALKER, S.A., HOLLOWAY, K.L., and POVLISHOCK, J.T. (1994). Ultrastructural studies of diffuse axonal injury in humans. J. Neurotrauma 11, 173-186.
15. CHU, C., LIN, M., HUANG, H.M., and LEE, M.C. (1994). Finite element analysis of cerebral contusion. J. Biomechanics 27, 187-194.
16. CLARK, W.M., HAZEL, J.S., and COULL, B.M. (1995). Lazaroids. CNS pharmacology and current research. Drugs 50, 971-983.
17. COBURN, K. (1992). Traumatic brain injury: the silent epidemic. AACN Clin. Issues 3, 9-18.
18. 2 levels in rats. J. Neurotrauma 5, 303-313.
19. DIETRICH, W.D., ALONSO, O., BUSTO, R., GLOBUS, M.Y.T., and GINSBERG, M.D. (1994). Post-traumatic brain hypothermia reduces histopathological damage following concussive brain injury in the rat. Acta Neuropathol. 87, 250-258.
20. DIMMELER, S., ANKARCRONA, M., NICOTERA, P., and BRUNE, B. (1993). Exogenous nitric oxide (NO) generation or IL-1β-induced intracellular NO production stimulates inhibitory auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase in RINm5F cells. J. Immunol. 150, 2964-2971.
21. EDBLADH, M., TONGE, D., GOLDING, J., EKSTROM, A.R., and EDSTROM, A. (1994). Early regeneration in vitro of adult mouse sciatic axons is dependent on local protein synthesis but may not involve neurotrophins. Neurosci. Lett. 168, 37-40.
22. EKSTROM, P.A. (1995a). Neurones and glial cells of the mouse sciatic nerve undergo apoptosis after injury in vivo and in vitro. Neuroreport 6, 1029-1032.
23. EKSTROM, P.A. (1995b). Increased cyclic AMP in in vitro regenerating frog sciatic nerves inhibits Schwann cell proliferation but has no effect on axonal outgrowth. J. Neurosci. Res. 42, 54-62.
24. ELLIS, E.F., McKINNEY, J.S., WILLOUGHBY, K.A., LIANG, S., and POVLISHOCK, J.T. (1995). A new model for rapid stretch-induced injury of cells in culture: characterization of the model using astrocytes. J. Neurotrauma 12, 325-339.
25. EMERY, D.G., LUCAS, J.H., and GROSS, G.W. (1987). The sequence of ultrastructural changes in cultured neurons after dendrite transection. Exp. Brain Res. 67, 41-51.
26. EMERY, D.G., LUCAS, J.H., and GROSS, G.W. (1991). Contributions of sodium and chloride to ultrastructural damage after dendrotomy. Exp. Brain Res. 86, 60-72.
27. ENGIN, A.E., and WANG, H.C. (1970). A mathematical model to determine viscoelastic behavior of in vivo primate brain. J. Biomechanics 3, 283-296.
28. EPSTEIN, M.H. (1971). Relative susceptibility of elements of the cerebral cortex to mechanical trauma in the rat. J. Neurosurg. 35, 517-522.
29. FAN, L., YOUNG, P.R., BARONE, F., FEUERSTEIN, G.Z., SMITH, D.H., and McINTOSH, T.K. (1995). Experimental brain injury induces expression of interleukin-1β mRNA in the rat brain. Brain Res. Mol. Brain Res. 30, 125-130.
30. FAN, L., YOUNG, P.R., BARONE, F.C., FEUERSTEIN, G.Z., SMITH, D.H., and McINTOSH, T.K. (1996). Experimental brain injury induces differential expression of tumor necrosis factor-α mRNA in the CNS. Brain Res. Mol. Brain Res. 36, 287-291.
31. 45Ca autoradiographic study. Brain Res. 624, 94-102.
32. FODA, M.A.A., and MARMAROU, A. (1994). A new model of diffuse brain injury in rats. Part II. Morphological characterization. J. Neurosurg. 80, 301-313.
33. GENNARELLI, T.A., THIBAULT, L.E., ADAMS, J.H., GRAHAM, D.I., THOMPSON, C.J., and MARCINCIN, R.P. (1982). Diffuse axonal injury and traumatic coma in the primate. Ann. Neurol. 12, 564-574.
34. GIRARD, J., PANIZZON, K., and WALLIS, R.A. (1996). Azelastine protects against CA1 traumatic neuronal injury in the hippocampal slice. Eur. J. Pharmacol. 300, 43-49.
35. GRAHAM, D.I., ADAMS, J.H., DOYLE, D., et al. (1993). Quantification of primary and secondary lesions in severe head injury. Acta Neurochir. Suppl. (Wien) 57, 41-48.
36. GROSS, G.W., LUCAS, J.H., and HIGGINS, M.L. (1983). Laser microbeam surgery: ultrastructural changes associated with neunte transection in culture. J. Neurosci. 3, 1979-1993.
37. GROSS, G.W., and HIGGINS, M.L. (1987). Cytoplasmic damage gradients in dendrites after transection lesions. Exp. Brain Res. 67, 52-60.
38. HALL, E.D. (1992). The neuroprotective pharmacology of methylprednisolone. J. Neurosurg. 76, 13-22.
39. HARIRI, R.J., CHANG, V.A., BARIE, P.S., WANG, R.S., SHARIF, S.F., and GHAJAR, J.B. (1994). Traumatic injury induces interleukin-6 production by human astrocytes. Brain Res. 636, 139-142.
40. HOVDA, D.A., BECKER, D.P., and KATAYAMA, Y. (1992). Secondary injury and acidosis. J. Neurotrauma 9, S47-S60.
41. KATAYAMA, Y., BECKER, D.P., TAMURA, T., and HOVDA, D.A. (1990). Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. J. Neurosurg. 73, 889-900.
42. KING, A.I., RUAN, J.S., ZHOU, C., HARDY, W.N., and KHALIL, T.B. (1995). Recent advances in biomechanics of brain injury research: a review. J. Neurotrauma 12, 651-658.
43. KIRKPATRICK, J.B., HIGGINS, M.L., LUCAS, J.H., and GROSS, G.W. (1985). In vitro simulation of neural trauma by laser. J. Neuropathol. Exp. Neurol. 44, 268-284.
44. KONTOS, H.A. (1989). Oxygen radicals in CNS damage. Chem. Biol. Interact. 72, 229-255.
45. KRAUS, J.F., McARTHUR, D.L., and SILBERMAN, T.A. (1994). Epidemiology of mild brain injury. Semin. Neurol. 14, 1-7.
46. KRAUS, J.F., and McARTHUR, D.L. (1996). Epidemiologie aspects of brain injury. Neurol. Clin. 14, 435-450.
47. KRAUS, J.F., and SORENSON, S.B. (1994). Epidemiology, in: Neuropsychiatry of Traumatic Brain Injury. J.M. Silver, S.C. Yudofsky, and R.E. Hales (eds), American Psychiatric Press. Inc.: Washington, DC, pps. 3-41.
48. KRAUSE, T.L., FISHMAN, H.M., BALLINGER, M.L., and BITTNER, G.D. (1994). Extent and mechanism of sealing in transected giant axons of squid and earthworms. J. Neurosci. 14, 6638-6651.
49. LAMB, R.G., HARPER, C.C., McKINNEY, J.S., RZIGALINSKI, B.A., and ELLIS, E.F. (1997). Alterations in phosphatidylcholine metabolism of stretch-injured cultured rat astrocytes. J. Neurochem. 68, 1904-1910.
50. LAPLACA, M.C., LEE, V.M., and THIBAULT, L.E. (1997). An in vitro model of traumatic neuronal injury: loading rate-dependent changes in acute cytosolic calcium and lactate dehydrogenase release. J. Neurotrauma 14, 355-368.
51. LAPLACA, M.C., and THIBAULT, L.E. (1997). An in vitro traumatic injury model to examine the response of neurons to a hydrodynamically induced deformation. Ann. Biomed. Eng. 25, 665-677.
52. LEFRANCOIS, T., FAGES, C., PESCHANSKI, M., and TARDY, M. (1997). Neuritic outgrowth associated with astroglial phenotypic changes induced by antisense glial fibrillary acidic protein (GFAP) mRNA in injured neuron-astrocyte cocultures. J. Neurosci. 17, 4121-4128.
53. + and spinal cord edema following impact trauma in rats. Biochem. Biophys. Res. Commun. 147, 1170-1175.
54. LEVI, G., and MEYER, H. (1945). Reactive, regressive, and regenerative processes of neurons, cultivated in vitro and injured with the micromanipulator. J. Exp. Zool. 99, 141-181.
55. LEYBAERT, L., and DE HEMPTINNE, A. (1996). Changes of intracellular free calcium following mechanical injury in a spinal cord slice preparation. Exp. Brain Res. 112, 392-402.
56. LEYBAERT, L., and DE LEY, G. (1994). Interstitial and tissue cations and electrical potential after experimental spinal cord injury. Exp. Brain Res. 100, 369-375.
57. LOPACHIN, R.M., and LEHNING, E.J. (1997). Mechanism of calcium entry during axon injury and degeneration. Toxicol. Appl. Pharmacol. 143, 233-244.
58. LOWENSTEIN, D.H., THOMAS, M.J., SMITH, D.H., and MCINTOSH, T.K. (1992). Selective vulnerability of dentate hilar neurons following traumatic brain injury: a potential mechanistic link between head trauma and disorders of the hippocampus. J. Neurosci. 12, 4846-4853.
59. LUCAS, J.H., GROSS, G.W., EMERY, D.G., and GARDNER, C.R. (1985). Neuronal survival or death after dendrite transection close to the perikaryon: correlation with electrophysiologic, morphologic, and ultrastructural changes. CNS Trauma 2, 231-255.
60. LUCAS, J.H. (1987). Proximal segment retraction increases the probability of nerve cell survival after dendrite transection. Brain Res. 425, 384-387.
61. LUCAS, J.H., EMERY, D.G., HIGGINS, M.L., and GROSS, G.W. (1990a). Neuronal survival and dynamics of ultrastructural damage after dendrotomy in low calcium. J. Neurotrauma 7, 169-192.
62. LUCAS, J.H., WANG, G.F., and GROSS, G.W. (1990b). Paradoxical effect of hypothermia on survival of lesioned and uninjured mammalian spinal neurons. Brain Res. 517, 354-357.
63. LUCAS, J.HJ., EMERY, D.G., WANG, G., ROSENBERG-SCHAFFER, L.J., JORDAN, R.S., and GROSS, G.W. (1994). In vitro investigations of the effects of nonfreezing low temperatures on lesioned and uninjured mammalian spinal neurons. J. Neurotrauma 11, 35-61.
64. LUCAS, J.H., EMERY, D.G., and ROSENBERG, L.J. (1997). Physical injury of neurons: important roles for sodium and chloride ions. Neuroscientist 3, 89-101.
65. LUCAS, J.H., and WOLF, A. (1991). In vitro studies of multiple impact injury to mammalian CNS neurons: prevention of perikaryal damage and death by ketamine. Brin Res. 543, 181-193.
66. MARGULIES, S.C., THIBAULT, L.E., and GENNARELLI, T.A. (1990). Physical model simulations of brain injury in the primate. J. Biomech. 23, 823-836.
67. McINTOSH, T.K., VINK, R., NOBLE, L., et al. (1989). Traumatic brain injury in the rat: characterization of a lateral fluid percussion model. Neuroscience 28, 233-244.
68. MCINTOSH, T.K., SMITH, D.H., MEANEY, D.F., KOTAPKA, M.J., GENNARELLI, T.A., and GRAHAM, D.I. (1996). Neuropathological sequelae of traumatic brain injury: relationship to neurochemical and biomechanical mechanisms. Lab. Invest. 74, 315-342.
69. MCKINNEY, J.S., WILLOUGHBY, K.A., LIANG, S., and ELLIS, E.F. (1996). Stretch-induced injury of cultured neuronal, glial, and endothelial cells: effect of polyethylene glycol-conjugated superoxide dismutase. Stroke. 27, 934-940.
70. MEANEY, D.F., and THIBAULT, L.E. (1990). Physical model studies of cortical brain deformation in response to high strain rate inertial loading, in: International Conference on the Biomechanics of Impacts. D. Cesari, and A. Charpenne (eds), IRCOBI: Lyon, France, pps. 215-224.
71. MIRE, J.J., HENDELMAN, W.J., and BUNGE, R.P. (1970). Observations on a transient phase of focal swelling in degenerating unmyelinated nerve fibers. J. Cell Biol. 45, 9-22.
72. MIYAZAKI, S., KATAYAMA, Y., LYETH, B.G., et al. (1992). Enduring suppression of hippocampal long-term potentiation following traumatic brain injury in rat. Brain Res. 585, 335-339.
73. MORIYA, T., HASSAN, A.Z., YOUNG, W., and CHESLER, M. (1994). Dynamics of extracellular calcium activity following contusion of the rat spinal cord. J. Neurotrauma 11, 255-263.
74. MORRISON III, B., EBERWINE, J.H., MEANEY, D.F., and MCINTOSH, T.K. (1997). Alteration of gene expression in organotypic brain cultures in response to mechanical injury. Ann. Biomed. Eng. 25, S-49.
75. MORRISON III, B., MEANEY, D.F., and MCINTOSH, T.K. (1998). Mechanical characterization of an in vitro device to quantitatively injure living brain tissue. Ann. Biomed. Eng. 26, 381-390.
76. MUHKIN, A.G., IVANOVA, S.A., KNOBLACH, S.M., and FADEN, A.I. (1997). New in vitro model of traumatic neuronal injury: evaluation of secondary injury and glutamate receptor-mediated neurotoxicity. J. Neurotrauma 14, 651-663.
77. MURPHY, E.J., and HORROCKS, L.A. (1993). A model for compression trauma: pressure-induced injury in cell cultures. J. Neurotrauma 10, 431-444.
78. MURPHY, E.J., and HORROCKS, L.A. (1994). Models of neurotrauma ex vivo, in: The Neurobiology of Central Nervous System Trauma. S.K. Salzman and A.I. Faden (eds), Oxford University Press: New York, pps. 28-40.
79. NILSSON, P., LAURSEN, H., HILLERED, L., and HANSEN, A.J. (1996). Calcium movements in traumatic brain injury: the role of glutamate receptor-operated ion channels. J. Cereb. Blood Flow Metab. 16, 262-270.
80. OLNEY, J.W. (1994). New mechanisms of excitatory transmitter neurotoxicity. J. Neural Transm. Suppl. 43, 47-51.
81. PANIZZON, K.L., DWYER, B.E., NISHIMURA, R.N., and WALLIS, R.A. (1996). Neuroprotection against CA1 injury with metalloporphyrins. Neuroreport 7, 662-666.
82. PLEASURE, S.J., and LEE, V.M. (1993). NTera 2 cells: a human cell line which displays characteristics expected of a human committed neuronal progenitor cell. J. Neurosci. Res. 35, 585-602.
83. POPE, A.M., and TARLOV, A.R. (1991). Disability in America: Toward a National Agenda for Prevention, National Academic Press: Washington, DC.
84. POVLISHOCK, J.T. (1993). Pathobiology of traumatically induced axonal injury in animals and man. Ann. Emerg. Med. 22, 980-986.
85. POVLISHOCK, J.T., MARMAROU, A., MCINTOSH, T.K., TROJANOWSKI, J.Q., and MOROI, J. (1997). Impact acceleration injury in the rat: evidence for focal axolemmal change and related neurofilament sidearm alteration. J. Neuropathol. Exp. Neurol. 56, 347-359.
86. POVLISHOCK, J.T., and CHRISTMAN, C.W. (1995). The pathobiology of traumatically induced axonal injury in animals and humans: a review of current thoughts. J. Neurotrauma 12, 555-564.
87. RAMON Y CAJAL, S. (1928). Degeneration and Regeneration of the Nervous System. R.M. May (ed.), Hafner Publisher Co.: New York.
88. RAND, C.W., and COURVILLE, C.B. (1934). Histological changes in the brain in cases of fatal injury to the head. Arch. Neurol. Psychiatry 31, 526-555.
89. REEVES, T.M., LYETH, B.G., and POVLISHOCK, J.T. (1995). Long-term potentiation deficits and excitability changes following traumatic brain injury. Exp. Brain Res. 106, 248-256.
90. REEVES, T.M., LYETH, B.G., PHILLIPS, L.L., HAMM, R.J., and POVLISHOCK, J.T. (1997). The effects of traumatic brain injury on inhibition in the hippocampus and dentate gyrus. Brain Res. 757, 119-132.
91. REGAN, R.F., and CHOI, D.W. (1994). The effect of NMDA, AMPA/kainate, and calcium channel antagonists on traumatic cortical neuronal injury in culture. Brain Res. 633, 236-242.
92. REGAN, R.F., and PANTER, S.S. (1995). Traumatic neuronal injury in cortical cell culture is attenuated by 21-amino-steroids. Brain Res. 682, 144-150.
93. RICE, D., and MACKENZIE, E. (1989). Cost of Injury in the United States. Institute for Health and Aging, University of California: San Francisco.
94. ROSENBERG, L.J., JORDAN, R.S., GROSS, G.W., EMERY, D.G., and LUCAS, J.H. (1996). Effects of methylprednisolone on lesioned and uninjured mammalian spinal neurons: viability, ultrastructure, and network electrophysiology. J. Neurotrauma. 13, 417-437.
95. ROSENBERG, L.J., and LUCAS, J.H. (1996). Reduction of NaCl increases survival of mammalian spinal neurons subjected to dendrite transection injury. Brain Res. 734, 349-353.
96. ROSENBERG-SCHAFFER, L.J., and LUCAS, J.H. (1993). An in vitro study of the effects of methylprednisolone on lesioned and uninjured mammalian spinal neurons. Brain Res. 605, 327-331.
97. ROSSIGNOL, S., and BARBEAU, H. (1993). Pharmacology of locomotion: an account of studies in spinal cats and spinal cord injured subjects. J. Am. Paraplegia Soc. 16, 190-196.
98. ROTHMAN, S.M., and OLNEY, J.W. (1995). Excitotoxicity and the NMDA receptor - still lethal after eight years. Trends Neurosci. 18, 57-58.
99. ROTHWELL, N.J., LUHESHI, G., and TOULMOND, S. (1997). Cytokines and their receptors in the central nervous system: physiology, pharmacology, and pathology. Pharmacol. Ther. 69, 85-95.
100. ROTHWELL, N.J., and RELTON, J.K. (1993). Involvement of cytokines in acute neurodegeneration in the CNS. Neurosci. Biobehav. Rev. 17, 217-227.
101. ROTHWELL, N.J., and STRIJBOS, P.J. (1995). Cytokines in neurodegeneration and repair. Int. J. Dev. Neurosci. 13, 179-185.
102. RUAN, J.S., KHALIL, T.B., and KING, A.I. (1993). Finite element modeling of direct head impact, in: 37th Stapp Car Crash Conference Proceedings. Society of Automotive Engineers: Warrendale, PA, pps. 69-81.
103. RUAN, J.S., KHALIL, T., and KING, A.I. (1994). Dynamic response of the human head to impact by three-dimensional finite element analysis. J. Biomech. Eng. 116, 44-50.
104. RUNGE, J.W. (1993). The cost of injury. Emerg. Med. Clin. North Am. 11, 241-253.
105. 2+ on in vitro astrocyte injury. J. Neurochem. 68, 289-296.
106. SAHAY, K.B., MEHROTRA, R., SACHDEVA, U., and BANERJI, A.K. (1992). Elastomechanical characterization of brain tissue. J. Biomech. 25, 319-326.
107. SCHLAEPFER, W.W., and BUNGE, R.P. (1973). Effects of calcium ion concentration on the degeneration of amputated axons in tissue culture. J. Cell Biol. 59, 456-470.
108. SHAPIRA, Y., YADID, G., COTEV, S., and SHOHAMI, E. (1989). Accumulation of calcium in the brain following head trauma. Neurol. Res. 11, 169-172.
109. SHAW, G., and BRAY, D. (1977). Movement and extension of isolated growth cones. Exp. Cell Res. 104, 55-62.
110. SHEPARD, S.R., GHAJAR, J.B.G., GIANNUZZI, R., KUPFERMAN, S., and HARIRI, R.J. (1991). Fluid percussion barotrauma chamber: a new in vitro model for traumatic brain injury. J. Surg. Res. 51, 411-424.
111. SHOHAMI, E., SHAPIRA, Y., SIDI, A., and COTEV, S. (1987). Head injury induces increased prostaglandin synthesis in rat brain. J. Cereb. Blood Flow Metab. 7, 58-63.
112. SHOHAMI, E., SHAPIRA, Y., YADID, G., REISFELD, N., and YEDGAR, S. (1989). Brain phospholipase A: is activated after experimental closed-head injury in the rat. J. Neurochem. 53, 1541-1546.
113. SHOHAMI, E., NOVIKOV, M., BASS, R., YAMIN, A., and GALLILY, R. (1994). Closed head injury triggers early production of TNF-α and IL-6 by brain tissue. J. Cereb. Blood Flow Metab. 14, 615-619.
114. SHUCK, L.Z., and ADVANI, S.H. (1972). Rheological response of human brain tissue in shear. Trans. ASME J. Basic Eng. 12, 905-911.
115. SIESJO, B.K. (1993). Basic mechanisms of traumatic brain damage. Ann. Emerg. Med. 22, 959-969.
116. SOARES, H.D., THOMAS, M., CLOHERTY, K., and McINTOSH, T.K. (1992). Development of prolonged focal cerebral edema and regional cation changes following experimental brain injury in rat. J. Neurochem. 58, 1845-1852.
117. SOLE, G.M. (1980). The effects of microsurgical transection of neurite bundles in vitro before and after exposure to colchicine. J. Anat. 130, 777-788.
118. SOSIN, D.M., SACKS, J.J., and SMITH, S.M. (1989). Head injury-associated deaths in the United States from 1979 to 1986. JAMA 262, 2251-2255.
119. TAKAHASHI, H., MANAKA, S., and SANO, K. (1981). Changes in extracellular potasssium concentration in cortex and brain stem during the acute phase of experimental closed head injury. J. Neurosurg. 55, 708-717.
120. TATOR, C.H. (1995). Update on the pathophysiology and pathology of acute spinal cord injury. Brain Pathol. 5, 407-413.
121. TAUPIN, V., TOULMOND, S., SERRANO, A., BENAVIDES, J., and ZAVALA, F. (1993). Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre- and post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand. J. Neuroimmunol. 42, 177-185.
122. TAVALIN, S.J., ELLIS, E.F., and SATIN, L.S. (1995). Mechanical perturbation of cultured cortical neurons reveals a stretch-induced delayed depolarization. J. Neurophysiol. 74, 2767-2773.
123. TAVALIN, S.J., ELLIS, E.F., and SATIN, L.S. (1997). Inhibition of the electrogenic Na pump underlies delayed depolarization of cortical neurons after mechanical injury or glutamate. J. Neurophysiol. 77, 632-638.
124. TECOMA, E.S., MONYER, H., GOLDBERG, M.P., and CHOI, D.W. (1989). Traumatic neuronal injury in vitro is attenuated by NMDA antagonists. Neuron 2, 1541-1545.
125. UENO, K., and MELVIN, J.W. (1995). Finite element model study of head impact based on Hybrid III head acceleration: the effects of rotational and translational acceleration. J. Biomech. Eng. 117, 319-328.
126. VILLA, R.F., and GORINI, A. (1997). Pharmacology of lazaroids and brain energy metabolism: a review. Pharmacol. Rev. 49, 99-136.
127. VOIGT, G.E., LOWENHIELM, C.G.P., and LJUNG, C.B.A. (1997). Rotational cerebral injuries near the superior margin of the brain. Acta Neuropathol. 39, 201-209.
128. WALLECK, C.A. (1992). Preventing secondary brain injury. AACN Clin. Issues 3, 19-30.
129. WALLIS, R.A., PANIZZON, K.L., and GIRARD, J.M. (1996). Traumatic neuroprotection with inhibitors of nitric oxide and ADP-ribosylation. Brain Res. 710, 169-177.
130. WALLIS, R.A., and PANIZZON, K.L. (1995). Felbamate neuroprotection against CA1 traumatic neuronal injury. Eur. J. Pharmacol. 294, 475-482.
131. WANG, H.C., and WINEMAN, A.S. (1972). A mathematical model for the determination of viscoelastic behavior of brain in vivo. I. oscillatory response. J. Biomech. 5, 431-446.
132. WOODROOFE, M.N., SARNA, G.S., WADHWA, M., et al. (1991). Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production. J. Neuroimmunol. 33, 227-236.
133. YAWO, H., and KUNO, M. (1985). Calcium dependence of membrane sealing at the cut end of the cockroach giant axon. J. Neurosci. 6, 1626-1632.
134. YOUNG, W. (1992). Role of calcium in central nervous system injuries. J. Neurotrauma 9, S9-S25.
135. ZHANG, J., DAWSON, V.L., DAWSON, T.M., and SNYDER, S.H. (1994). Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science 263, 687-689.
136. 2+ blockade of NMDA current in mechanically injured neurons. Science 274, 1921-1923.
137. ZHOU, C., KHALIL, T.B., and KING, A.I. (1995). A new model comparing impact responses of the homogenous and inhomogenous human brain, in: 39th Stapp Car Crash Conference Proceedings. Society of Automotive Engineers: Warrendale, PA, pps. 121-129.