Reduction of voltage-dependent Mg2+ blockade of NMDA current in mechanically injured neurons

Science

Volumn 274, Issue 5294, 1996, Pages 1921-1923

  Zhang, Lei ^a,b   Rzigalinski, Beverly A ^a   Ellis, Earl F ^a   Satin, Leslie S ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CALPHOSTIN C; MAGNESIUM ION; N METHYL DEXTRO ASPARTIC ACID;

ANIMAL CELL; ARTICLE; BRAIN CELL; CALCIUM CELL LEVEL; CONTROLLED STUDY; ION CURRENT; NERVE CELL LESION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN INJURIES; CALCIUM; CELLS, CULTURED; CEREBRAL CORTEX; DIZOCILPINE MALEATE; ENZYME INHIBITORS; EXCITATORY AMINO ACID ANTAGONISTS; MAGNESIUM; MEMBRANE POTENTIALS; N-METHYLASPARTATE; NAPHTHALENES; NEURONS; PATCH-CLAMP TECHNIQUES; PROTEIN KINASE C; RATS; RECEPTORS, N-METHYL-D-ASPARTATE;

ANIMALIA;

EID: 0030451738     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.274.5294.1921     Document Type: Article

References (28)

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28. We thank S. Tavalin, J. Woodward, and T. Mirshahi for helpful discussions. We also thank J. McKinney, K. Willoughby, and S. Moore for the cell cultures; D. Compton for help with curve fitting; J. Povlishock and B. Lyeth for comments on the manuscript; and S. Holt for assistance with manuscript preparation. Supported by NIH Training Grant HL07537-14 (L.Z.) and Jacob Javits Neuroscience Investigator Award NS 27214 (E.F.E.). This work was supported in part by a Center of Excellence Grant-in-Aid from the Commonwealth of Virginia to J. Povlishock.