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Volumn 18, Issue 3, 1998, Pages 287-294

Etiology and pathogenesis of multiple sclerosis

Author keywords

Multiple sclerosis; Pathogenesis

Indexed keywords

AUTOIMMUNE DISEASE; CLINICAL RESEARCH; GENETIC SUSCEPTIBILITY; HUMAN; INCIDENCE; INFLAMMATORY CELL; MULTIPLE SCLEROSIS; NERVE FIBER; OLIGODENDROGLIA; PREVALENCE; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE ACTIVATION; TISSUE INJURY;

EID: 0031739621     PISSN: 02718235     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1040879     Document Type: Review
Times cited : (45)

References (86)
  • 2
    • 0030054522 scopus 로고    scopus 로고
    • Multiple loci for multiple sclerosis
    • Bell JI, Lathrop GM. Multiple loci for multiple sclerosis. Nat Genet 1996;13:377-378
    • (1996) Nat Genet , vol.13 , pp. 377-378
    • Bell, J.I.1    Lathrop, G.M.2
  • 3
    • 15844366743 scopus 로고    scopus 로고
    • A full genome search in multiple sclerosis
    • Ebers GC, Kukay K, Bulman DE, et al. A full genome search in multiple sclerosis. Nat Genet 1996;13:472-476
    • (1996) Nat Genet , vol.13 , pp. 472-476
    • Ebers, G.C.1    Kukay, K.2    Bulman, D.E.3
  • 4
    • 0009573338 scopus 로고    scopus 로고
    • A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex
    • The Multiple Sclerosis Genetics Group
    • Haines JL, TerMinassian M, Bazyk A, et al. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. The Multiple Sclerosis Genetics Group. Nat Genet 1996;13:469-471
    • (1996) Nat Genet , vol.13 , pp. 469-471
    • Haines, J.L.1    TerMinassian, M.2    Bazyk, A.3
  • 5
    • 15844368830 scopus 로고    scopus 로고
    • A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22
    • Sawcer S, Jones HB, Feakes R, et al A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat Genet 1996;13:464-468
    • (1996) Nat Genet , vol.13 , pp. 464-468
    • Sawcer, S.1    Jones, H.B.2    Feakes, R.3
  • 6
    • 0030941362 scopus 로고    scopus 로고
    • Evidence for linkage disequilibrium between HLADRB1 gene and multiple sclerosis
    • Yaouanq J, Semana G, Eichenbaum S, et al. Evidence for linkage disequilibrium between HLADRB1 gene and multiple sclerosis. Science 1997;276:661
    • (1997) Science , vol.276 , pp. 661
    • Yaouanq, J.1    Semana, G.2    Eichenbaum, S.3
  • 7
    • 0024406282 scopus 로고
    • A susceptibility locus for multiple sclerosis is linked to the T cell receptor beta chain complex
    • Seboun E, Robinson M, Doolittle T, et al. A susceptibility locus for multiple sclerosis is linked to the T cell receptor beta chain complex. Cell 1989;57:1095-1100
    • (1989) Cell , vol.57 , pp. 1095-1100
    • Seboun, E.1    Robinson, M.2    Doolittle, T.3
  • 8
    • 0027170328 scopus 로고
    • Skewed T cell receptor repertoire in genetically identical twins with multiple sclerosis correlates with disease
    • Utz U, Biddison W, McFarland H, et al. Skewed T cell receptor repertoire in genetically identical twins with multiple sclerosis correlates with disease. Nature 1993;364:243-247
    • (1993) Nature , vol.364 , pp. 243-247
    • Utz, U.1    Biddison, W.2    McFarland, H.3
  • 9
    • 0026670087 scopus 로고
    • Genetic susceptibility to multiple sclerosis linked to myelin basic protein gene
    • Tienari P, Wikstrom J, Sajantila A, et al. Genetic susceptibility to multiple sclerosis linked to myelin basic protein gene. Lancet 1992;340:987-991
    • (1992) Lancet , vol.340 , pp. 987-991
    • Tienari, P.1    Wikstrom, J.2    Sajantila, A.3
  • 10
    • 0027398162 scopus 로고
    • Epidemiology of multiple sclerosis: A critical overview
    • Sadovnick A, Ebers G. Epidemiology of multiple sclerosis: a critical overview. Can J Neurol Sci 1993;20:17-29
    • (1993) Can J Neurol Sci , vol.20 , pp. 17-29
    • Sadovnick, A.1    Ebers, G.2
  • 11
    • 0029121088 scopus 로고
    • A genetic basis for familial aggregation in multiple sclerosis
    • Ebers GC, Sadovnick A, Risch N. A genetic basis for familial aggregation in multiple sclerosis. Nature 1995;377:150-151
    • (1995) Nature , vol.377 , pp. 150-151
    • Ebers, G.C.1    Sadovnick, A.2    Risch, N.3
  • 12
    • 0030007661 scopus 로고    scopus 로고
    • Evidence for genetic basis of multiple sclerosis
    • Sadovnick A, Ebers GC, Dyment D, et al. Evidence for genetic basis of multiple sclerosis. Lancet 1996;347:1728-1730
    • (1996) Lancet , vol.347 , pp. 1728-1730
    • Sadovnick, A.1    Ebers, G.C.2    Dyment, D.3
  • 13
    • 0027537583 scopus 로고
    • A population-based study of multiple sclerosis in twins: Update
    • Sadovnick A, Armstrong H, Rice G, et al. A population-based study of multiple sclerosis in twins: Update. Ann Neurol 1993; 33:281-285
    • (1993) Ann Neurol , vol.33 , pp. 281-285
    • Sadovnick, A.1    Armstrong, H.2    Rice, G.3
  • 14
    • 0022868088 scopus 로고
    • A population-based study of multiple sclerosis in twins
    • Ebers GC, Bulman D, Sadovnick A, et al. A population-based study of multiple sclerosis in twins. N Eng J Med 1986;315: 1638-1642
    • (1986) N Eng J Med , vol.315 , pp. 1638-1642
    • Ebers, G.C.1    Bulman, D.2    Sadovnick, A.3
  • 15
    • 0029979038 scopus 로고    scopus 로고
    • Epidemiology of multiple sclerosis
    • Weinshenker BG. Epidemiology of multiple sclerosis. Neurol Clin 1996;14:291-308
    • (1996) Neurol Clin , vol.14 , pp. 291-308
    • Weinshenker, B.G.1
  • 16
    • 0025275195 scopus 로고
    • The role of interferon-γ in the pathogenesis of experimental autoimmune disease of the peripheral nervous system
    • Hartung HP, Schafer B, van der Meide PH, et al. The role of interferon-γ in the pathogenesis of experimental autoimmune disease of the peripheral nervous system. Ann Neurol 1990; 27:247-257
    • (1990) Ann Neurol , vol.27 , pp. 247-257
    • Hartung, H.P.1    Schafer, B.2    Van Der Meide, P.H.3
  • 18
    • 0018377382 scopus 로고
    • Multiple sclerosis in the Faroe Islands. I. Clinical and epidemiological features
    • Kurtzke JF, Hyllested K. Multiple sclerosis in the Faroe Islands. I. Clinical and epidemiological features. Ann Neurol 1979;5:6
    • (1979) Ann Neurol , vol.5 , pp. 6
    • Kurtzke, J.F.1    Hyllested, K.2
  • 19
    • 0021592979 scopus 로고
    • Biology of disease. Analysis of autoimmune demyelination: Its impact upon multiple sclerosis
    • Raine CS. Biology of disease. Analysis of autoimmune demyelination: Its impact upon multiple sclerosis. Lab Invest 1984;50: 608-635
    • (1984) Lab Invest , vol.50 , pp. 608-635
    • Raine, C.S.1
  • 21
    • 0025854496 scopus 로고
    • Cytokines in the central nervous system of mice during chronic relapsing experimental allergic encephalomyelitis
    • Baker D, O'Neill JK, Turk JL. Cytokines in the central nervous system of mice during chronic relapsing experimental allergic encephalomyelitis. Cell Immunol 1991;134:505-510
    • (1991) Cell Immunol , vol.134 , pp. 505-510
    • Baker, D.1    O'Neill, J.K.2    Turk, J.L.3
  • 22
    • 0026707402 scopus 로고
    • Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL10 mRNA expression correlates with recovery
    • Kennedy MK, Torrance DS, Picha KS, et al Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL10 mRNA expression correlates with recovery. J Immunol 1992;149:2496-2505
    • (1992) J Immunol , vol.149 , pp. 2496-2505
    • Kennedy, M.K.1    Torrance, D.S.2    Picha, K.S.3
  • 23
    • 0028926223 scopus 로고
    • Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
    • Wucherpfennig K, Strominger J. Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein. Cell 1995;80:695-706
    • (1995) Cell , vol.80 , pp. 695-706
    • Wucherpfennig, K.1    Strominger, J.2
  • 24
    • 0027333418 scopus 로고
    • Superantigens: Bacterial and viral proteins that manipulate the immune system
    • Scherer MT, Ignatowitz L, Winslow GM, et al. Superantigens: Bacterial and viral proteins that manipulate the immune system. Annu Rev Cell Biol 1993;9:101-128
    • (1993) Annu Rev Cell Biol , vol.9 , pp. 101-128
    • Scherer, M.T.1    Ignatowitz, L.2    Winslow, G.M.3
  • 25
    • 0025717402 scopus 로고
    • Migration of hematogenous cells through the blood-brain barrier and the initiation of CNS inflammation
    • Hickey W. Migration of hematogenous cells through the blood-brain barrier and the initiation of CNS inflammation. Brain Pathol 1991;1:97-105
    • (1991) Brain Pathol , vol.1 , pp. 97-105
    • Hickey, W.1
  • 26
    • 13144282503 scopus 로고
    • Suppression of experimental autoimmune neuritis by the oxygen radical scavengers superoxide dismutase and catalase
    • Hartung HP, Schafer B, Heininger K, et al. Suppression of experimental autoimmune neuritis by the oxygen radical scavengers superoxide dismutase and catalase. Ann Neurol 1988;60, 3:458
    • (1988) Ann Neurol , vol.60 , Issue.3 , pp. 458
    • Hartung, H.P.1    Schafer, B.2    Heininger, K.3
  • 27
    • 0023949286 scopus 로고
    • The role of macrophages in experimental autoimmune neuritis induced by a P2-specific T cell line
    • Heininger K, Schafer B, Hartung HP, et al. The role of macrophages in experimental autoimmune neuritis induced by a P2-specific T cell line. Ann Neurol 1988;23:326-331
    • (1988) Ann Neurol , vol.23 , pp. 326-331
    • Heininger, K.1    Schafer, B.2    Hartung, H.P.3
  • 28
    • 0027454052 scopus 로고
    • Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen
    • Brocke S, Gaur A, Piercy C, et al. Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen. Nature 1993;365:642-644
    • (1993) Nature , vol.365 , pp. 642-644
    • Brocke, S.1    Gaur, A.2    Piercy, C.3
  • 29
    • 13144261492 scopus 로고
    • Pilot study of antipan T cell monoclonal antibodies for the treatment of progressive multiple sclerosis
    • Hafler DA, Fallis RJ, Dawson DM, et al. Pilot study of antipan T cell monoclonal antibodies for the treatment of progressive multiple sclerosis. Neurology 1985;35:103-103
    • (1985) Neurology , vol.35 , pp. 103-103
    • Hafler, D.A.1    Fallis, R.J.2    Dawson, D.M.3
  • 30
    • 0021889168 scopus 로고
    • In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis
    • Hafler D, Fox DA, Manning ME, et al. In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. N Engl J Med 1985;312:1405-1411
    • (1985) N Engl J Med , vol.312 , pp. 1405-1411
    • Hafler, D.1    Fox, D.A.2    Manning, M.E.3
  • 31
    • 0025138302 scopus 로고
    • T cells responsive to myelin basic protein in patients with multiple sclerosis
    • Allegretta M, Nicklas J, Sriram S, et al. T cells responsive to myelin basic protein in patients with multiple sclerosis. Science 1990;247:718-721
    • (1990) Science , vol.247 , pp. 718-721
    • Allegretta, M.1    Nicklas, J.2    Sriram, S.3
  • 32
    • 0028242718 scopus 로고
    • Homologies between T cell receptor junctional sequences unique to multiple sclerosis and T cells mediating experimental allergic encephalomyelitis
    • Allegretta M, Albertini R, Howell M, et al. Homologies between T cell receptor junctional sequences unique to multiple sclerosis and T cells mediating experimental allergic encephalomyelitis. J Clin Invest 1994
    • (1994) J Clin Invest
    • Allegretta, M.1    Albertini, R.2    Howell, M.3
  • 33
    • 0027464785 scopus 로고
    • Reactive nitrogen intermediates: Effector molecules of immunemediated inflammatory nervous system disorders?
    • Hartung HP, Zielasek J, Toyka KV. Reactive nitrogen intermediates: Effector molecules of immunemediated inflammatory nervous system disorders [letter; comment]? Ann Neurol 1993;33:422
    • (1993) Ann Neurol , vol.33 , pp. 422
    • Hartung, H.P.1    Zielasek, J.2    Toyka, K.V.3
  • 34
    • 0025981021 scopus 로고
    • T lymphocyte entry into the central nervous system
    • Hickey WF, Hsu BL, Kimura H. T lymphocyte entry into the central nervous system. J Neurosci Res 1991;28:254-260
    • (1991) J Neurosci Res , vol.28 , pp. 254-260
    • Hickey, W.F.1    Hsu, B.L.2    Kimura, H.3
  • 35
    • 0030272760 scopus 로고    scopus 로고
    • To stick or not to stick: The new leukocyte homing paradigm
    • Dunon D, Pali L, Imhof BA. To stick or not to stick: The new leukocyte homing paradigm. Curr Opin Cell Biol 1996;8:714-718
    • (1996) Curr Opin Cell Biol , vol.8 , pp. 714-718
    • Dunon, D.1    Pali, L.2    Imhof, B.A.3
  • 36
    • 0028883140 scopus 로고
    • Leukocyte migration and adhesion
    • Imhof BA, Dunon D. Leukocyte migration and adhesion. Adv Immun 1995;58:345-416
    • (1995) Adv Immun , vol.58 , pp. 345-416
    • Imhof, B.A.1    Dunon, D.2
  • 37
    • 0027982876 scopus 로고
    • Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
    • Springer T. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell 1994;76: 301-314
    • (1994) Cell , vol.76 , pp. 301-314
    • Springer, T.1
  • 38
    • 0026342111 scopus 로고
    • Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity
    • Butcher E. Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity. Cell 1991;67:1033-1036
    • (1991) Cell , vol.67 , pp. 1033-1036
    • Butcher, E.1
  • 39
    • 0030001675 scopus 로고    scopus 로고
    • Lymphocyte homing and homeostasis
    • Butcher EC, Picker LJ. Lymphocyte homing and homeostasis. Science 1996;272:60-67
    • (1996) Science , vol.272 , pp. 60-67
    • Butcher, E.C.1    Picker, L.J.2
  • 41
    • 0030690228 scopus 로고    scopus 로고
    • Requirement for CD44 in activated T cell extravasation into an inflammatory site
    • DeGrendele H, Estess P, Siegelman M. Requirement for CD44 in activated T cell extravasation into an inflammatory site. Science 1997;278:672-674
    • (1997) Science , vol.278 , pp. 672-674
    • Degrendele, H.1    Estess, P.2    Siegelman, M.3
  • 42
    • 0030511866 scopus 로고    scopus 로고
    • Targets for the therapeutic action of interferonβ in multiple sclerosis
    • Hartung HP, Kieseier BC. Targets for the therapeutic action of interferonβ in multiple sclerosis [editorial]. Ann Neurol 1996;40:825-826
    • (1996) Ann Neurol , vol.40 , pp. 825-826
    • Hartung, H.P.1    Kieseier, B.C.2
  • 43
    • 0025897537 scopus 로고
    • Serum interleukin2 concentrations in Guillain-Barre syndrome and chronic idiopathic demyelinating polyradiculoneuropathy: Comparison with other neurological diseases of presumed immunopathogenesis
    • Hartung HP, Reiners K, Schmidt B, et al. Serum interleukin2 concentrations in Guillain-Barre syndrome and chronic idiopathic demyelinating polyradiculoneuropathy: Comparison with other neurological diseases of presumed immunopathogenesis. Ann Neurol 1991;30:48-53
    • (1991) Ann Neurol , vol.30 , pp. 48-53
    • Hartung, H.P.1    Reiners, K.2    Schmidt, B.3
  • 44
    • 0027521002 scopus 로고
    • Interferon β1b is effective in relapsing-remitting multiple sclerosis. II. MRI results of a multicenter, randomized, doubleblind, placebo-controlled trial
    • Paty D, Li D, Group U, et al. Interferon β1b is effective in relapsing-remitting multiple sclerosis. II. MRI results of a multicenter, randomized, doubleblind, placebo-controlled trial. Neurology 1993;43:662-667
    • (1993) Neurology , vol.43 , pp. 662-667
    • Paty, D.1    Li, D.2    Group, U.3
  • 45
    • 0023949553 scopus 로고
    • Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
    • Hickey WF, Kimura H. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 1988;239:290-292
    • (1988) Science , vol.239 , pp. 290-292
    • Hickey, W.F.1    Kimura, H.2
  • 46
    • 0028231281 scopus 로고
    • Detection of MHC class II-antigens on macrophages and microglia, but on astrocytes and endothelia in active MS
    • Bo L, Mork S, Kong P, et al. Detection of MHC class II-antigens on macrophages and microglia, but on astrocytes and endothelia in active MS. J Neuroimmunol 1994;51:135-146
    • (1994) J Neuroimmunol , vol.51 , pp. 135-146
    • Bo, L.1    Mork, S.2    Kong, P.3
  • 47
    • 0030799954 scopus 로고    scopus 로고
    • Role of cervical lymph nodes in autoimmune encephalomyelitis in the Lewis rat
    • Phillips MJ, Needham M, Weller RO. Role of cervical lymph nodes in autoimmune encephalomyelitis in the Lewis rat. J Pathol 1997;182:457-464
    • (1997) J Pathol , vol.182 , pp. 457-464
    • Phillips, M.J.1    Needham, M.2    Weller, R.O.3
  • 48
    • 0024353079 scopus 로고
    • TH1 and TH2 cells. Different patterns of lymphokine secretion lead to different functional properties
    • Mosmann TR, Coffman RL, TH1 and TH2 cells. Different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-173
    • (1989) Annu Rev Immunol , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 49
    • 0028985320 scopus 로고
    • Tumor necrosis factor-α messenger RNA expression in patients with relapsing-remitting multiple sclerosis is associated with disease activity
    • Rieckmann P, Albrecht M, Kitze B, et al. Tumor necrosis factor-α messenger RNA expression in patients with relapsing-remitting multiple sclerosis is associated with disease activity. Ann Neurol 1995;37:82-88
    • (1995) Ann Neurol , vol.37 , pp. 82-88
    • Rieckmann, P.1    Albrecht, M.2    Kitze, B.3
  • 50
    • 0025773147 scopus 로고
    • Association between tumor necrosis factora and disease progression in chronic progressive multiple sclerosis
    • Sharief M, Henteges R. Association between tumor necrosis factora and disease progression in chronic progressive multiple sclerosis. N Engl J Med 1991;325:467-472
    • (1991) N Engl J Med , vol.325 , pp. 467-472
    • Sharief, M.1    Henteges, R.2
  • 51
    • 0023794099 scopus 로고
    • Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations?
    • Beck J, Rondot P, Catinot L, et al. Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations? Acta Neurol Scand 1988;78:318-323
    • (1988) Acta Neurol Scand , vol.78 , pp. 318-323
    • Beck, J.1    Rondot, P.2    Catinot, L.3
  • 52
    • 0027506423 scopus 로고
    • Cytokine production by peripheral blood monocytes/macrophages in multiple sclerosis patients
    • Imamura K, Suzumura A, Hayashi F, et al. Cytokine production by peripheral blood monocytes/macrophages in multiple sclerosis patients. Acta Neurol Scand 1993;87:281-285
    • (1993) Acta Neurol Scand , vol.87 , pp. 281-285
    • Imamura, K.1    Suzumura, A.2    Hayashi, F.3
  • 53
    • 0029112447 scopus 로고
    • Circulating adhesion molecules and tumor necrosis factor receptor in multiple sclerosis: Correlation with magnetic resonance imaging
    • Hartung HP, Reiners K, Archelos JJ, et al. Circulating adhesion molecules and tumor necrosis factor receptor in multiple sclerosis: Correlation with magnetic resonance imaging. Ann Neurol 1995;38:186-193
    • (1995) Ann Neurol , vol.38 , pp. 186-193
    • Hartung, H.P.1    Reiners, K.2    Archelos, J.J.3
  • 54
    • 0028578704 scopus 로고
    • B7/BB1 antigen expression on adult human microglia studied in vitro and in situ
    • Williams K, Ulvestad E, Antel JP. B7/BB1 antigen expression on adult human microglia studied in vitro and in situ. Eur J Immunol 1994;24:3031-3037
    • (1994) Eur J Immunol , vol.24 , pp. 3031-3037
    • Williams, K.1    Ulvestad, E.2    Antel, J.P.3
  • 55
    • 0030964198 scopus 로고    scopus 로고
    • Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity
    • Dangond F, Windhagen A, Groves CJ, et al. Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity. J Neuroimmunol 1997;76: 132-138
    • (1997) J Neuroimmunol , vol.76 , pp. 132-138
    • Dangond, F.1    Windhagen, A.2    Groves, C.J.3
  • 56
    • 0028964455 scopus 로고
    • The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions
    • De SR, Giampaolo A, Giometto B, et al. The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions. J Neurol Neurosurg Psychiatry 1995;54:175-187
    • (1995) J Neurol Neurosurg Psychiatry , vol.54 , pp. 175-187
    • De, S.R.1    Giampaolo, A.2    Giometto, B.3
  • 57
    • 0028970060 scopus 로고
    • Interleukin 12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • Trinchieri G. Interleukin 12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995; 13:251-276
    • (1995) Annu Rev Immunol , vol.13 , pp. 251-276
    • Trinchieri, G.1
  • 58
    • 0028923747 scopus 로고
    • Activated T cells of nonneural specificity open the blood-nerve barrier to circulating antibody
    • Pollard JD, Westland KW, Harvey GK, et al. Activated T cells of nonneural specificity open the blood-nerve barrier to circulating antibody. Ann Neurol 1995;37:467-475
    • (1995) Ann Neurol , vol.37 , pp. 467-475
    • Pollard, J.D.1    Westland, K.W.2    Harvey, G.K.3
  • 59
    • 0030892402 scopus 로고    scopus 로고
    • Differential and time-dependent expression of monocyte chemoattractant protein1 mRNA by astrocytes and macrophages in rat brain: Effects of ischemia and peripheral lipopolysaccharide administration
    • Gourmala NG, Buttini M, Limonta S, et al. Differential and time-dependent expression of monocyte chemoattractant protein1 mRNA by astrocytes and macrophages in rat brain: Effects of ischemia and peripheral lipopolysaccharide administration. J Neuroimmunol 1997;74:35-44
    • (1997) J Neuroimmunol , vol.74 , pp. 35-44
    • Gourmala, N.G.1    Buttini, M.2    Limonta, S.3
  • 60
    • 0019468319 scopus 로고
    • The effects of macrophage depletion on the clinical and pathologic expression of experimental allergic encephalomyelitis
    • Brosnan CF, Bornstein MB, Bloom BR. The effects of macrophage depletion on the clinical and pathologic expression of experimental allergic encephalomyelitis. J Immunol 1981; 126:614-620
    • (1981) J Immunol , vol.126 , pp. 614-620
    • Brosnan, C.F.1    Bornstein, M.B.2    Bloom, B.R.3
  • 61
    • 0025739518 scopus 로고
    • Presence of the terminal complement complex (C5b9) precedes myelin degradation in immune-mediated demyelination of the rat peripheral nervous system
    • Stoll G, Schmidt B, Jander S, et al. Presence of the terminal complement complex (C5b9) precedes myelin degradation in immune-mediated demyelination of the rat peripheral nervous system. Ann Neurol 1991;30:147-155
    • (1991) Ann Neurol , vol.30 , pp. 147-155
    • Stoll, G.1    Schmidt, B.2    Jander, S.3
  • 62
    • 0028941871 scopus 로고
    • The adhesion molecule and cytokine profile of multiple sclerosis lesions
    • Cannella B, Raine CS. The adhesion molecule and cytokine profile of multiple sclerosis lesions. Ann Neurol 1995;37: 424-435
    • (1995) Ann Neurol , vol.37 , pp. 424-435
    • Cannella, B.1    Raine, C.S.2
  • 63
    • 0029794737 scopus 로고    scopus 로고
    • Distribution of immunoglobulin superfamily members ICAM1, 2, 3 and the b2 integrin LFA1 in multiple sclerosis lesions
    • Bo L, Peterson JW, Mork S, et al. Distribution of immunoglobulin superfamily members ICAM1, 2, 3 and the b2 integrin LFA1 in multiple sclerosis lesions. J Neurol Exp Neuropathol 1996; 55:1066-1072
    • (1996) J Neurol Exp Neuropathol , vol.55 , pp. 1066-1072
    • Bo, L.1    Peterson, J.W.2    Mork, S.3
  • 64
    • 0028044630 scopus 로고
    • Expression and functional significance of alternatively spliced CS1 fibronectin in rheumatoid arthritis microvasculature
    • Elices MJ, Tsai V, Strahl D, et al. Expression and functional significance of alternatively spliced CS1 fibronectin in rheumatoid arthritis microvasculature. J Clin Invest 1994;93: 405-416
    • (1994) J Clin Invest , vol.93 , pp. 405-416
    • Elices, M.J.1    Tsai, V.2    Strahl, D.3
  • 65
    • 0026506799 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against a 4b1 integrin
    • Yednock T, Cannon C, Fritz L, et al. Prevention of experimental autoimmune encephalomyelitis by antibodies against a 4b1 integrin. Nature 1992;356:63-66
    • (1992) Nature , vol.356 , pp. 63-66
    • Yednock, T.1    Cannon, C.2    Fritz, L.3
  • 66
    • 0027400491 scopus 로고
    • Augmentation of adoptively transferred experimental allergic encephalomyelitis by administration of a monoclonal antibody specific for LFA1a
    • Welsh C, Rose J, Hill K, et al. Augmentation of adoptively transferred experimental allergic encephalomyelitis by administration of a monoclonal antibody specific for LFA1a. J Neuroimmunol 1993;43:161-167
    • (1993) J Neuroimmunol , vol.43 , pp. 161-167
    • Welsh, C.1    Rose, J.2    Hill, K.3
  • 67
    • 0030825407 scopus 로고    scopus 로고
    • Chemokines
    • Rollins BJ. Chemokines. Blood 1997;90:909-928
    • (1997) Blood , vol.90 , pp. 909-928
    • Rollins, B.J.1
  • 68
    • 0030949298 scopus 로고    scopus 로고
    • Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation
    • Pan Y, Lloyd C, Zhou H, et al. Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature 1997;387:611-617
    • (1997) Nature , vol.387 , pp. 611-617
    • Pan, Y.1    Lloyd, C.2    Zhou, H.3
  • 69
    • 0031036347 scopus 로고    scopus 로고
    • A new class of membrane-bound chemokine with a CX(3)C motif
    • Bazan JF, Bacon KB, Hardiman G, et al. A new class of membrane-bound chemokine with a CX(3)C motif. Nature 1997; 385: 640-644
    • (1997) Nature , vol.385 , pp. 640-644
    • Bazan, J.F.1    Bacon, K.B.2    Hardiman, G.3
  • 70
    • 0030183050 scopus 로고    scopus 로고
    • Chemokines in immune-mediated inflammation of the central nervous system
    • Ransohoff R, Glabinski A, Tani M. Chemokines in immune-mediated inflammation of the central nervous system. Cytokine Growth Factor Rev 1996;7:35-46
    • (1996) Cytokine Growth Factor Rev , vol.7 , pp. 35-46
    • Ransohoff, R.1    Glabinski, A.2    Tani, M.3
  • 71
    • 0030017084 scopus 로고    scopus 로고
    • Neutrophil infiltration, glial reaction and neurological disease in transgenic mice expressing the chemokine N51/KC in oligodendrocytes
    • Tani M, Fuentes ME, Peterson JW, et al. Neutrophil infiltration, glial reaction and neurological disease in transgenic mice expressing the chemokine N51/KC in oligodendrocytes. J Clin Invest 1996;98:529-539
    • (1996) J Clin Invest , vol.98 , pp. 529-539
    • Tani, M.1    Fuentes, M.E.2    Peterson, J.W.3
  • 72
    • 0028803845 scopus 로고
    • An important role for the chemokine macrophage inflammatory protein1a in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis
    • Karpus WJ, Lukacs NW, McRae BL, et al. An important role for the chemokine macrophage inflammatory protein1a in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis. J Immunol 1995; 155:5003-5010
    • (1995) J Immunol , vol.155 , pp. 5003-5010
    • Karpus, W.J.1    Lukacs, N.W.2    McRae, B.L.3
  • 73
    • 9044231453 scopus 로고
    • Treatment of mice with antiMIP1 alpha prevents PLP peptide-induced experimental autoimmune encephalomyelitis
    • Karpus WJ, Lukacs NW, McRae BL, et al. Treatment of mice with antiMIP1 alpha prevents PLP peptide-induced experimental autoimmune encephalomyelitis [abstract]. FASEB J 1994;8:A199
    • (1994) FASEB J , vol.8
    • Karpus, W.J.1    Lukacs, N.W.2    McRae, B.L.3
  • 74
    • 0027406406 scopus 로고
    • Selection for T cell receptor VDJ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis
    • Oksenberg J, Panzura M, Begovich A, et al. Selection for T cell receptor VDJ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature 1993;362:68-70
    • (1993) Nature , vol.362 , pp. 68-70
    • Oksenberg, J.1    Panzura, M.2    Begovich, A.3
  • 75
    • 0016753383 scopus 로고
    • Pathology of the early lesions of multiple sclerosis
    • Prineas JW. Pathology of the early lesions of multiple sclerosis. Hum Pathol 1975;6:531
    • (1975) Hum Pathol , vol.6 , pp. 531
    • Prineas, J.W.1
  • 76
    • 0019469331 scopus 로고
    • Multiple sclerosis: Capping of surface immunoglobulin G on macrophages engaged in myelin breakdown
    • Prineas JW, Graham JS. Multiple sclerosis: Capping of surface immunoglobulin G on macrophages engaged in myelin breakdown Ann Neurol 1981;10:149-158
    • (1981) Ann Neurol , vol.10 , pp. 149-158
    • Prineas, J.W.1    Graham, J.S.2
  • 77
    • 0023904746 scopus 로고
    • Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro
    • Selmaj KW, Raine CS. Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann Neurol 1988;23: 339-346
    • (1988) Ann Neurol , vol.23 , pp. 339-346
    • Selmaj, K.W.1    Raine, C.S.2
  • 78
    • 0027973242 scopus 로고
    • Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains
    • Bo L, Dawson TM, Wesselingh S, et al. Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Ann Neurol 1994;36:778-786
    • (1994) Ann Neurol , vol.36 , pp. 778-786
    • Bo, L.1    Dawson, T.M.2    Wesselingh, S.3
  • 79
    • 0027193351 scopus 로고
    • T cells specific for the myelin oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system
    • Linington C, Berger T, Perry L, et al. T cells specific for the myelin oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system. Eur J Immunol 1993;23:1364-1372
    • (1993) Eur J Immunol , vol.23 , pp. 1364-1372
    • Linington, C.1    Berger, T.2    Perry, L.3
  • 80
    • 0030056764 scopus 로고    scopus 로고
    • Distinct pattern of multiple sclerosis pathology indicates heterogeneity in pathogenesis
    • Lucchinetti C, Bruck W, Rodriquez M, et al. Distinct pattern of multiple sclerosis pathology indicates heterogeneity in pathogenesis. Brain Pathol 1996;6:259-259
    • (1996) Brain Pathol , vol.6 , pp. 259-259
    • Lucchinetti, C.1    Bruck, W.2    Rodriquez, M.3
  • 81
    • 0030453516 scopus 로고    scopus 로고
    • Progressive cerebral atrophy in multiple sclerosis. A serial MRI study
    • Losseff NA, Wang L, Lang HM, et al. Progressive cerebral atrophy in multiple sclerosis. A serial MRI study. Brain 1996; 119:2009-2019
    • (1996) Brain , vol.119 , pp. 2009-2019
    • Losseff, N.A.1    Wang, L.2    Lang, H.M.3
  • 82
    • 0031048695 scopus 로고    scopus 로고
    • Imaging of axonal damage in multiple sclerosis: Spatial distribution of magnetic resonance imaging lesions
    • Narayanan S, Fu L, Pioro E, et al. Imaging of axonal damage in multiple sclerosis: Spatial distribution of magnetic resonance imaging lesions. Ann Neurol 1997;41:385-391
    • (1997) Ann Neurol , vol.41 , pp. 385-391
    • Narayanan, S.1    Fu, L.2    Pioro, E.3
  • 83
    • 0029943953 scopus 로고    scopus 로고
    • Assessment of lesion pathology in multiple sclerosis using quantitative MRI morphometry and magnetic resonance spectroscopy
    • Matthews PM, Pioro E, Narayanan S, et al. Assessment of lesion pathology in multiple sclerosis using quantitative MRI morphometry and magnetic resonance spectroscopy. Brain 1996; 119:715-722
    • (1996) Brain , vol.119 , pp. 715-722
    • Matthews, P.M.1    Pioro, E.2    Narayanan, S.3
  • 84
    • 0031002545 scopus 로고    scopus 로고
    • Axonal damage in acute multiple sclerosis lesions
    • Ferguson B, Matyszak M, Esiri M, et al. Axonal damage in acute multiple sclerosis lesions. Brain 1997;120:393-399
    • (1997) Brain , vol.120 , pp. 393-399
    • Ferguson, B.1    Matyszak, M.2    Esiri, M.3
  • 85
    • 85038552004 scopus 로고    scopus 로고
    • Axonal transection in multiple sclerosis lesions
    • in press
    • Trapp B, Peterson J, Ransohoff R, et al. Axonal transection in multiple sclerosis lesions. N Engl J Med (in press)
    • N Engl J Med
    • Trapp, B.1    Peterson, J.2    Ransohoff, R.3


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