Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity

Journal of Neuroimmunology

Volumn 76, Issue 1-2, 1997, Pages 132-138

  Dangond, Fernando ^a   Windhagen, Anja ^a   Groves, Christopher J ^b   Hafler, David A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Tum Immunol Div Dana Farber C   (United States)

Author keywords

Costimulation; Glia; Immunity

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; GENE EXPRESSION; HELPER CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; MICROGLIA; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ADOLESCENT; ANTIGENS, CD80; AUTOIMMUNITY; BRAIN; CELLS, CULTURED; CHILD, PRESCHOOL; FEMALE; HUMANS; MALE; MICROGLIA;

EID: 0030964198     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(97)00043-X     Document Type: Article

References (26)

1. Azuma M., Yssel H., Phillips J.H., Lanier L.L. Functional expression of B7/BB1 on activated T-lymphocytes. J. Exp. Med. 177:1993;845-850.
2. Becher B., Antel J.P. Comparison of phenotypic and functional properties of immediately ex vivo and cultured human adult microglia. Glia. 18:1996;1-10.
3. Bieganowska, K.D., Ausubel, L.J., Modabber, Y., et al., 1997. Direct ex vivo analysis of activatd, fas sensitive autoreactive T cells in human autoimmune disease. J. Exp. Med., in press.
4. Cash E., Zhang Y., Rott O. Microglia present myelin antigens to T-cells after phagocytosis of oligodendrocytes. Cell. Immunol. 147:1993;129-138.
5. Caux C., Vanbervliet B., Massacrier C.et al. B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells. J. Exp. Med. 180:1994;1841-1847.
6. De Simone R., Giampaolo A., Giometto B.et al. The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions. J. Neuropathol. Exp. Neurol. 54:1995;175-187.
7. Engel P., Gribben J.G., Freeman G.J.et al. The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B-lymphocytes is the CD86 differentiation antigen. Blood. 84:1994;1402-1407.
8. Freeman G.J., Boussiotis V.A., Anumanthan A.et al. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity. 2:1995;523-532.
9. Grenier Y., Ruijs T.C.G., Robitaille Y.et al. Immunohistochemical studies of adult human glial cells. J. Neuroimmunol. 21:1989;103-115.
10. Kuchroo V.J., Prabhu Das M., Brown J.A.et al. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy. Cell. 80:1995;707-718.
11. Kwok S., Higuchi R. Avoiding false positive with PCR. Nature. 339:1989;237-238.
12. Lenschow D.J., Ho S.C., Sattar H.et al. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J. Exp. Med. 181:1995;1145-1155.
13. Matsumoto Y., Ohmori K., Fujiwara M. Immune regulation by brain cells in the central nervous system: Microglia but not astrocytes present myelin basic protein to encephalitogenic T-cells under in vivo-mimicking conditions. Immunology. 76:1992;209-216.
14. Nickoloff B.J., Mitra R.S., Lee K.et al. Discordant expression of CD28 ligands, BB-1 and B7 on keratinocytes in vitro and psoriatic cells in vivo. Am. J. Pathol. 142:1993;1029-1040.
15. Panitch H.S., Hirsch R.L., Schindler J., Johnson K.P. Treatment of multiple sclerosis with gamma interferon: Exacerbations associated with activation of the immune system. Neurology. 37:1987;1097-1102.
16. Perrin P.J., Scott D., Quigley L.et al. Role of B7/CD28 CTLA-4 in the induction of chronic relapsing experimental allergic encephalomyelitis. J. Immunol. 154:1995;1481-1490.
17. Puissant C., Houdebine L. An improvement of the single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Biotechniques. 8:1991;148-149.
18. Racke M.K., Scott D.E., Quigley L.et al. Distinct roles for B7-1 (CD-80) and B7-2 (CD86) in the initiation of experimental allergic encephalomyelitis. J. Clin. Invest. 96:1995;2195-2203.
19. Satoh J.-I., Lee Y.B., Kim S.U. T-cell costimulatory molecules B7-1 (CD80) and B7-2 (CD86) are expressed in human microglia but not in astrocytes in culture. Brain Res. 704:1995;92-96.
20. Schlaak J.F., Buslau M., Jochum W.et al. T-cells involved in psoriasis vulgaris belong to the Th1 subset. J. Invest. Dermatol. 102:1994;145-149.
21. Schwartz R.H. Costimulation of T-lymphocytes: The role of CD28, CTLA4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell. 71:1992;1065-1068.
22. Southern E. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98:1975;503-517.
23. Williams K., Ulvestad E., Antel J.P. B7/BB-1 antigen expression on adult human microglia studied in vitro and in situ. Eur. J. Immunol. 24:1994;3031-3037.
24. Windhagen A., Newcombe J., Dangond F.et al. Expression of IL-12 and B7 costimulatory molecules in multiple sclerosis lesions. J. Exp. Med. 182:1995;1985-1996.
25. Yong, V.W., Antel, J.P., 1992. In: Federoff, S., Richardson, A. (Eds.), Protocols for Neural Cell Culture. The Humana Press, pp. 81-96.
26. Zhang J., Markovic S., Lacet B.et al. Increased frequency of Interleukin-2 responsive T-cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J. Exp. Med. 179:1994;973-984.