Imaging of axonal damage in multiple sclerosis: Spatial distribution of magnetic resonance imaging lesions

Annals of Neurology

Volumn 41, Issue 3, 1997, Pages 385-391

  Narayanan, S ^a   Fu, L ^b   Pioro, E ^a   De Stefano, N ^a   Collins, D L ^a   Francis, G S ^a   Antel, J P ^a   Matthews, P M ^b   Arnold, D L ^a,c  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c NONE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE; N ACETYLASPARTIC ACID;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISABILITY; DISEASE COURSE; FEMALE; HUMAN; IMAGE ANALYSIS; MALE; MULTIPLE SCLEROSIS; NERVE FIBER DEGENERATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL NOISE RATIO;

ADULT; ASPARTIC ACID; AXONS; BRAIN; CREATINE; FEMALE; HUMANS; IMAGE ENHANCEMENT; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; RISK ASSESSMENT; STATISTICS, NONPARAMETRIC;

EID: 0031048695     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.410410314     Document Type: Article

References (32)

1. Lee JH, Arcinue E, Ross BD. Brief report: organic osmolytes in the brain of an infant with hypernatremia. N Engl J Med 1994; 331:439-442
2. Graham GD, Blamire AM, Howseman AM, et al. Proton magnetic resonance spectroscopy of cerebral lactate and other metabolites in stroke patients. Stroke 1992;23:333-340
3. Arnold DL, Shoubridge EA, Villemure JG, Feindel W. Proton and phosphorus magnetic resonance spectroscopy of human astrocytomas in vivo. Preliminary observations on tumor grading. NMR Biomed 1990;3:184-189
4. Menon DK, Baudouin CJ, Tomlinson D, Hoyle C. Proton MR spectroscopy and imaging of the brain in AIDS: evidence of neuronal loss in regions that appear normal with imaging. J Comput Assist Tomogr 1990;14:882-885
5. Arnold DL, Matthews PM, Francis G, Antel J. Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: assessment of the load of disease. Magn Reson Med 1990;14:154-159
6. Cendes F, Andermann F, Preul MC, Arnold DL. Lateralization of temporal lobe epilepsy based on regional metabolic abnormalities in proton magnetic resonance spectroscopic images. Ann Neurol 1994;35:211-216
7. Matthews PM, Andermann F, Silver K, et al. Proton MR spectroscopic characterization of differences in regional brain metabolic abnormalities in mitochondrial encephalomyopathies. Neurology 1993;43:2484-2490
8. Simmons ML, Frondoza CG, Coyle JT. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience 1991;45:37-45
9. Moffett JR, Namboodiri MAA, Cangro CB, Neale JH. Immunohistochemical localization of N-acetylaspartate in rat brain Neuroreport 1991;2:131-134
10. Fox PT, Mintun MA, Reiman EM, Raichle ME. Enhanced detection of focal brain responses using intersubject averaging and change-distribution analysis of subtracted PET images. J Cereb Blood Flow Metab 1988;8:642-653
11. Fox PT, Perlmutter JS, Raichle ME. A stereotactic method of anatomical localization for positron emission tomography. J Comput Assist Tomogr 1985;9:141-153
12. Fox PT. Functional brain mapping with positron emission tomography. Semin Neurol 1989;9:323-329 (Review)
13. Evans AC, Marrett S, Torrescorzo J, et al. MRI-PET correlation in three dimensions using a volume-of-interest (VOI) atlas. J Cereb Blood Flow Metab 1991;11:A69-A78
14. Evans AC, Marrett S, Neelin P, et al. Anatomical mapping of functional activation in stereotactic coordinate space. Neuroimage 1992;1:43-63
15. McDonald WI. Rachelle Fishman-Matthew Moore Lecture. The pathological and clinical dynamics of multiple sclerosis J Neuropathol Exp Neurol 1994;153:338-343 (Review)
16. Raine CS, Cross AH. Axonal dystrophy as a consequence of long-term demyelination. Lab Invest 1989;60:714-725
17. Matthews PM, Pioro E, Narayanan S, et al. Assessment of lesion pathology in multiple sclerosis using quantitative MRI morphometry and magnetic resonance spectroscopy. Brain 1996;119:715-722
18. Pary DW, Li DK, Oger JJ, et al. Magnetic resonance imaging in the evaluation of clinical trials in multiple sclerosis. Ann Neurol 1994;36(suppl):S95-S96
19. Bruhn H, Frahm J, Merboldt KD, et al. Multiple sclerosis in children: cerebral metabolic alterations monitored by localized proton magnetic resonance spectroscopy in vivo. Ann Neurol 1992;32:140-150
20. 1H spectroscopic imaging. Ann Neurol 1994;36:157-165
21. Talairach J, Tournoux P. Co-planar stereotactic atlas of the human brain 3-dimensional proportional system - an approach to cerebral imaging. Stuttgart: Georg Thieme Verlag, 1988
22. Kamber M. Automated detection of multiple sclerosis lesions in magnetic resonance images of the human brain. Master's thesis, Department of Computer Science, Concordia University, Montreal, Quebec, 1991
23. Manly BFJ. Randomization and Monte Carlo methods in biology. New York: Chapman and Hall, 1991
24. Dawson-Saunders B, Trapp RG. Basic and clinical biostatistics. Norwalk, CT: Appleton & Lange, 1990
25. Fu L, Wolfson C, Worsley KJ, et al. Statistics for investigation of multimodal MR imaging data and an application to multiple sclerosis patients. NMR Biomed 1996 (in press)
26. Matthews PM, Francis G, Antel J, Arnold DL. Proton magnetic resonance spectroscopy for metabolic characterization of plaques in multiple sclerosis. Neurology 1991;41:1251-1256
27. De Stefano N, Matthews PM, Antel JP, et al. Chemical pathology of acute demyelinating lesions and its correlation with disability. Ann Neurol 1995;38:901-909
28. Arnold DL, Matthews PM, Francis GS, et al. Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques. Ann Neurol 1992;31:235-241
29. Gass A, Barker GJ, Kidd D, et al. Correlation of magnetization transfer ratio with clinical disability in multiple sclerosis. Ann Neurol 1994;36:62-67
30. Grossman RI. Magnetization transfer in multiple sclerosis. Ann Neurol 1994;36(suppl):S97-S99
31. Barnes D, Munro PMG, Youl BD, et al. The longstanding MS lesion; a quantitative MRI and electron microscopic study. Brain 1991;114:1271-1280
32. Filippi M, Barker GJ, Horsfield MA, et al. Benign and secondary progressive multiple sclerosis: a preliminary quantitative MRI study. J Neurol 1994;241:246-251