Assessment of lesion pathology in multiple sclerosis using quantitative MRI morphometry and magnetic resonance spectroscopy

Brain

Volumn 119, Issue 3, 1996, Pages 715-722

  Matthews, P M ^a,b,c   Pioro, E ^a,d   Narayanan, S ^a   De Stefano, N ^a   Fu, L ^a   Francis, G ^a   Antel, J ^a   Wolfson, C ^b   Arnold, D L ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c RADCLIFFE INFIRMARY   (United Kingdom)

^d LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Magnetic resonance spectroscopy; MRI; Multiple sclerosis; N acetyl aspartate; Pathology

Indexed keywords

CREATININE; N ACETYLASPARTIC ACID;

ADOLESCENT; ADULT; ARTICLE; BRAIN INJURY; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; HUMAN; MALE; MORPHOMETRICS; MULTIPLE SCLEROSIS; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD;

ADULT; ASPARTIC ACID; BRAIN DISEASES; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; TIME FACTORS;

EID: 0029943953     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/119.3.715     Document Type: Article

References (34)

1. Arnold DL, Matthews PM, Francis G, Antel J. Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: assessment of the load of disease. Magn Reson Med 1990; 14: 154-9.
2. Arnold DL, Matthews PM, Francis GS, O'Connor J, Antel JP. Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques. Ann Neurol 1992; 31: 235-41.
3. Arnold DL, Riess GT, Matthews PM, Francis GS, Collins DL, Wolfson C, et al. Use of proton magnetic resonance spectroscopy for monitoring disease progression in multiple sclerosis. Ann Neurol 1994; 36: 76-82.
4. Barnes D, Munro PM, Youl BD, Prineas JW, McDonald WI. The longstanding MS lesion. A quantitative MRI and electron microscopic study. Brain 1991; 114: 1271-80.
5. Christiansen P, Gideon P, Thomsen C, Stubgaard M, Henriksen O, Larsson HB. Increased water self-diffusion in chronic plaques and in apparently normal white matter in patients with multiple sclerosis. Acta Neurol Scand 1993; 87: 195-9.
6. Clark CM, James G, Li D, Oger J, Paty D, Klonoff H. Ventricular size, cognitive function and depression in patients with multiple sclerosis. Can J Neurol Sci 1992; 19: 352-6.
7. Coffey CE, Wilkinson WE, Parashos IA, Soady SA, Sullivan RJ, Patterson LJ, et al. Quantitative cerebral anatomy of the aging human brain: a cross-sectional study using magnetic resonance imaging. Neurology 1992; 42: 527-36.
8. Davie C A, Hawkins CP, Barker GJ, Brennan A, Tofts PS, Miller DH, et al. Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain 1994; 117: 49-58.
9. DeCarli C, Haxby JV, Gillette JA, Teichberg D, Rapoport SI, Schapiro MB. Longitudinal changes in lateral ventricular volume in patients with dementia of the Alzheimer type. Neurology 1992; 42: 2029-36.
10. De Stefano N, Francis G, Antel JP, Arnold DL. Reversible decreases of N-acetylaspartate in the brain of patients with relapsing-remitting multiple sclerosis. Proc Soc Magn Reson Med 1993; 1: 280.
11. Dousset V, Grossman RI, Ramer KN, Schnall MD, Young LH, Gonzalez-Scarano F, et al. Experimental allergic encephalomyelitis and multiple sclerosis: lesion characterization with magnetization transfer imaging [published erratum appears in Radiology 1992; 183: 878]. Radiology 1992; 182: 483-91.
12. Evans AC, Marrett S, Neelin P, Collins L, Worsley K, Dai W, et al. Anatomical mapping of functional activation in stereotactic coordinate space. Neuroimage 1992; 1: 43-53.
13. Filippi M, Horsfield MA, Morrissey SP, MacManus DG, Rudge P, McDonald WI, et al. Quantitative brain MRI lesion load predicts the course of clinically isolated syndromes suggestive of multiple sclerosis. Neurology 1994; 44: 635-41.
14. Filippi M, Paty DW, Kappos L, Barkhof F, Compston DAS, Thompson AJ, et al. Correlations between changes in disability and T2-weighted brain MRI activity in multiple sclerosis: a follow-up study. Neurology 1995; 45: 255-60.
15. Hohol MJ, Orav EJ, Weiner HL. Disease steps in multiple sclerosis: a simple approach to evaluate disease progression. Neurology 1995; 45: 251-5.
16. Husted C. Contributions of neuroimaging to diagnosis and monitoring of multiple sclerosis. [Review]. Curr Opi Neurol 1994; 7: 234-41.
17. Kamber M. Automated detection of multiple sclerosis lesions in magnetic resonance images of the human brain [Master's Thesis]. Montreal; Concordia University, 1991.
18. Kermode AG, Thompson AJ, Tofts P, MacManus DG, Kendall BE, Kingsley DP, et al. Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis. Pathogenetic and clinical implications. Brain 1990; 113: 1477-89.
19. Khoury SJ, Guttmann CRG, Orav EJ, Hohol MJ, Ahn SS, Hsu L, et al. Longitudinal MRI in multiple sclerosis: correlation between disability and lesion burden. Neurology 1994; 44: 2120-4.
20. Liu CK, Miller BL, Cummings JL, Mehringer CM, Goldberg MA, Howng SL, et al. A quantitative MRI study of vascular dementia. Neurology 1992; 42: 138-43.
21. Matthews PM, Francis G, Antel J, Arnold DL. Proton magnetic resonance spectroscopy for metabolic characterization of plaques in multiple sclerosis [published erratum appears in Neurology 1991; 41: 1828], Neurology 1991; 41: 1251-6.
22. McDonald WI. Rachelle Fishman-Matthew Moore Lecture. The pathological and clinical dynamics of multiple sclerosis. [Review]. J Neuropathol Exp Neurol 1994; 53: 338-43.
23. McDonald WI, Miller DH, Barnes D. The pathological evolution of multiple sclerosis. [Review]. Neuropathol Appl Neurobiol 1992; 18: 319-34.
24. Miller DH. Magnetic resonance in monitoring the treatment of multiple sclerosis. [Review]. Ann Neurol 1994; 36 Suppl: S91-4.
25. Miller DH, Austin SJ, Connelly A, Youl BD, Gadian DG. McDonald WI. Proton magnetic resonance spectroscopy of an acute and chronic lesion in multiple sclerosis [letter] [see comments]. Lancet 1991; 337: 58-9. Comment in: Lancet 1991; 337: 362.
26. Miller DH, Austin SJ, Connelly A, Youl BD, Gadian DG. McDonald WI. Proton magnetic resonance spectroscopy of an acute and chronic lesion in multiple sclerosis [letter] [see comments]. Lancet 1991; 337: 58-9. Comment in: Lancet 1991; 337: 362.
27. Newcombe J, Hawkins CP, Henderson CL, Patel HA, Woodroofe MN, Hayes GM, et al. Histopathology of multiple sclerosis lesions detected by magnetic resonance imaging in unfixed postmortem central nervous system tissue. Brain 1991; 114: 1013-23.
28. Paty DW, Li DK. Interferon beta-lb is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group [see comments]. Neurology 1993; 43: 662-7. Comment in: Neurology 1993; 641-3.
29. Paty DW, Li DK. Interferon beta-lb is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group [see comments]. Neurology 1993; 43: 662-7. Comment in: Neurology 1993; 641-3.
30. Paty DW, Li DKB, Oger J-L, Kastrukoff L, Koopmans R, Tanton E, et al. Magnetic resonance imaging in the evaluation of clinical trials in multiple sclerosis. Ann Neurol 1994; 36 Suppl: S956.
31. Rao SM, Leo GJ, Haughton VM, St. Aubin-Faubert P, Bernardin L. Correlation of magnetic resonance imaging with neuropsychological testing in multiple sclerosis. Neurology 1989; 39: 161-6.
32. Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain: 3-dimensional proportional system: an approach to cerebral imaging. Stuttgart: G. Thieme, 1988.
33. Thompson AJ, Kermode AG, Wicks D, MacManus DG, Kendall BE, Kingsley DP, et al. Major differences in the dynamics of primary and secondary progressive multiple sclerosis. Ann Neurol 1991; 29: 53-62.
34. Van Hecke P, Marchal G, Johannik K, Demaerel P, Wilms G, Carton H, et al. Human brain proton localized NMR spectroscopy in multiple sclerosis. Magn Reson Med 1991; 18: 199-206.