Central role for CD40 / CD40 ligand (CD 154) interactions in transplant rejection

Pediatric Transplantation

Volumn 2, Issue 1, 1998, Pages 6-15

  Denton, Mark D ^b   Reul, Ross M ^b   Dharnidharka, Vikas R ^b   Fang, James C ^b   Ganz, Peter ^b   Briscoe, David M ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b NONE

Author keywords

Allograft rejection; C040 CD154 interaction

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; LIGAND; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY;

ANIMAL; BIOSYNTHESIS; CD4+ T LYMPHOCYTE; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; GRAFT REJECTION; HAPLORHINI; HEART TRANSPLANTATION; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; PATHOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD40; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; GRAFT REJECTION; HAPLORHINI; HEART TRANSPLANTATION; HUMANS; LIGANDS; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; SIGNAL TRANSDUCTION;

EID: 0031987905     PISSN: 13973142     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. TULLIUS S, TILNEY N. Both alloantigen-dependent and -independent factors influence chronic allograft rejection. Transplantation 1995: 59: 313.
2. FOY T, ARUFFO A, BAJORATH J, BUHLMANN J, NOELLE R. Immune regulation by CD40 and its ligand GP39. Annu Rev Immunol 1996: 14: 591-617.
3. GREWAL I, FLAVELL R. A central role of CD40 ligand in the regulation of CD4 T cell responses. Immunol Today 1996: 17: 410-414.
4. STOUT R, SUTTLES J. The many roles of CD40 in cell-mediated inflammatory responses. Immunol Today 1996: 17: 487-492.
5. ALDERSON M, ARMITAGE R, TOUGH T, STROCKBINE L, FANSLOW W, SPRIGGS M. CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. J Exp Med 1993: 180: 669-674.
6. HOLLENBAUGH D, MISCHEL PN, EDWARDS CP, et al. Expression of functional CD40 by vascular endothelial cells. J Exp Med 1995: 182: 33-40.
7. YELLIN M, WINIKOFF S, FORTUNE S, et al. Ligation of CD40 on fibroblasts induces CD54 (ICAM-1), CD106 (VCAM-1) upregulation and IL-6 production and proliferation. J Leuk Biol 1995: 58: 209-216.
8. VAN KOOTEN C, GERRITSMA JS, PAAPE ME, VAN ES, BANCHEREAU J, DAHA MR. Possible role for CD40-CD40L in the regulation of interstitial infiltration in the kidney. Kidney Int 1997: 51: 711-721.
9. SATO T, IRIE S, REED J. A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. FEBS Lett 1995: 358: 113.
10. ROTHE M, SHARMA V, DIXIT V, GOEDDEL D. TRAF-2 mediated activation of NF-kB by TNF receptor 2 and CD40. Science 1995: 269: 1424-1427.
11. ROY M, WALDSCHMIDT T, ARUFFO A, LEDBETTER J, NOELLE R. The regulation of the expression of GP39, the CD40 ligand, on normal and cloned CD4 T cells. J Immunol 1993: 151: 2497.
12. GRAMMER A, BERGMAN M, MIURA Y, FUJIITA K, DAVIS L, LIPSKY P. The CD40 ligand expressed by human B cells costimulates B cell responses. J Immunol 1995: 154: 4996-5010.
13. PINCHUK L, KLAUS S, MAGALETTI D, PINCHUK G, MORSEN J, CLARK E. Functional CD40 ligand expressed by human blood dendritic cells is upregulated by CD40 ligation. J Immunol 1996: 157: 4363-4370.
14. CARBONE E, RUGGIERO G, TERRAZZANO G, et al. A new mechanism of NK cell cytotoxicity activation: the CD40-CD40 ligand interaction. J Exp Med 1997: 185: 2053-2060.
15. MACH F, SCHONBECK U, SUKHOVA GK, et al. Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis. Proc Natl Acad Sci USA 1997: 94: 1931-1936.
16. REUL R, FANG J, DENTON M, et al. CD40 and CD40 ligand (CD 154) are co-expressed on microvessels in vivo in human cardiac allograft rejection. Transplantation 1997: 64: 1-10.
17. 16a. Henn V et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 1998: 391: 591-594.
18. KARMANN K, HUGHES CC, FANSLOW WC, POBER JS. Endothelial cells augment the expression of CD40 ligand on newly activated human CD4+ T cells through a CD2/LFA-3 signaling pathway. Eur J Immunol 1996: 26: 610-617.
19. KLAUS S, PINCHUK L, OCHS H, et al. Costimulation through CD28 enhances T cell dependant B cell activation via CD40-CD40L interaction. J Immunol 1994: 152: 5643-5652.
20. GRAF D, MULLER S, KORTHAUER U, VAN Kooten C, WEISE C, KROCZEK R. A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activation. Eur J Immunol 1995: 25: 1749-1754.
21. LUDEWIG B, HENN V, SCHRODER J, GRAF D, KROCZEK R. Induction, regulation and function of soluble TRAP (CD40 ligand) during interaction of primary CD4+ CD45RA+ T cells with dendritic cells. Eur J Immunol 1996: 26: 3137-3143.