Can graft endothelial cells initiate a host anti-graft immune response?

Transplantation

Volumn 61, Issue 3, 1996, Pages 343-349

  Pober, Jordan S ^a   Orosz, Charles G ^b   Rose, Marlene L ^c   Savage, Caroline O S ^d  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c HAREFIELD HOSPITAL   (United Kingdom)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN PRESENTING CELL; CROSS REACTION; ENDOTHELIUM CELL; GRAFT REJECTION; GRAFT SURVIVAL; HUMAN; IMMUNE RESPONSE; LYMPHOCYTE SUBPOPULATION; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; REVIEW;

ANTIGEN-PRESENTING CELLS; CELLS, CULTURED; CYTOKINES; ENDOTHELIUM, VASCULAR; HLA ANTIGENS; HOST VS GRAFT REACTION; HUMANS; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTE SUBSETS; TRANSPLANTATION IMMUNOLOGY;

EID: 0030027139     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199602150-00001     Document Type: Review

References (72)

1. Hirschberg H, Evensen SA, Henriksen T, Thorsby E. The human mixed lymphocyte-endothelium culture interaction. Transplantation 1975; 19: 495.
2. Nunez G, Ball EJ, Stastny P. Accessory cell function of human endothelial cells. A subpopulation of Ia positive cells is required for antigen presentation. J Immunol 1983; 131: 666.
3. Sayegh MH, Watschinger B, Carpenter CB. Overview: mechanisms of T cell recognition of alloantigen. The role of peptides. Transplantation 1994; 57: 1295.
4. Janeway CAJ, Bottomly K. Signals and signs for lymphocyte responses. Cell 1994; 76: 275.
5. Croft M, Bradley LM, Swain SL. Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells. J Immunol 1994; 152: 2675.
6. Kato K, Koyanagi M, Okada H, et al. CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation. J Exp Med 1992; 176: 1241.
7. Murray AG, Khodadoust MM, Pober JS, Bothwell ALM. Porcine aortic endothelial cells strongly activate human T cells: direct presentation of swine MHC antigens and effective costimulation by swine ligands for human CD2 and CD28. Immunity 1994; 1: 57.
8. Collins T, Korman AJ, Wake CT, et al. Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts. Proc Natl Acad Sci USA 1984; 81: 4917.
9. Collins T, Lapierre LA, Fiers W, Strominger JL, Pober JS. Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro. Proc Natl Acad Sci USA 1986; 83: 446.
10. Lapierre LA, Fiers W, Pober JS. Three distinct classes of regulatory cytokines control endothelial cell MHC antigen expression: interactions with immune (γ) interferon differentiate the effects of tumor necrosis factor and lymphotoxin from those of leukocyte (α) and fibroblast (β) interferons. J Exp Med 1988; 167: 794.
11. Vallee I, Watier H, Thibault G, et al. Evidence of noninvolvement of swine HMC class II in the in vitro proliferative response of human lymphocytes to porcine endothelial cells. Transplantation 1995; 59: 897.
12. Watson CA, Petzelbauer P, Zhou J, Pardi R, Bender JR. Contact-dependent endothelial class II HLA gene activation induced by NK cells is mediated by IFN-γ-dependent and-independent mechanisms. J Immunol 1995; 154: 3222.
13. Baldwin WM, Claas FHJ, van Es LA, van Rood JJ. Distribution of endothelial-monocyte and HLA antigens on renal vascular endothelium. Transplant Proc 1981; 23: 103.
14. Page C, Rose M, Yacoub M, Pigotti R. Antigenic heterogeneity of vascular endothelium. Am J Pathol 1992; 141: 673.
15. Munro JM, Pober JS, Cotran RS. Tumor necrosis factor and interferon-γ induce distinct patterns of endothelial activation and associated leukocyte accumulation in skin of Papio anubis. Am J Pathol 1989; 135: 121.
16. Groenewegen G, Buurman WA, van der Linden CJ. Lymphokine dependence of in vivo expression of MHC class II antigens by endothelium. Nature 1985; 316: 361.
17. Sims TN, Vincent D, Urmson J, Halloran PF. MHC regulation in non-lymphoid tissues of IFN-γ gene knockout (GKO) mice: evidence for a unique role for IFN-γ in MHC induction. FASEB J 1995; 9: A491.
18. Milton AD, Fabre JW. Massive induction of donor-type class I and class II major histocompatability complex antigens in rejecting cardiac allografts in the rat. J Exp Med 1985; 161: 98.
19. Germain RH, Margulies DH. The biochemistry and cell biology of antigen processing and presentation. Annu Rev Immunol 1993; 11: 403.
20. Epperson DE, Arnold D, Spies T, Cresswell P, Pober JS, Johnson DR. Cytokines increase transporter in antigen processing-1 (TAP-1) expression more rapidly than HLA class I expression in endothelial cells. J Immunol 1992; 149: 3297.
21. Clayberger C, Uyehara T, Hardy B, Eaton J, Karasele M, Krensky AM. Target specificity and cell surface structures involved in the human cytolytic T lymphocyte response to endothelial cells. J Immunol 1985; 135: 12.
22. Pardi R, Bender JR. Signal requirements for the generation of CD4+ and CD8+ T-cell responses to human allogeneic microvascular endothelium. Circ Res 1991; 69: 1269.
23. Fling SP, Arp B, Pious D. HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells. Nature 1994; 368: 554.
24. Ceman S, Rudersdorf RA, Peteren JM, DeMars A. DMA and DMB are the only genes in the class II region of the human MHC needed for class II-associated antigen processing. J Immunol 1995; 154: 2545.
25. Vora M, Yssel H, de Vries JE, Karasek MA. Antigen presentation by human dermal microvascular endothelial cells. Immunoregulatory effect of IFN-γ and IL-10. J Immunol 1994; 152: 5734.
26. Savage COS, Brooks CJ, Harcourt GC, et al. Human vascular endothelial cells process and present autoantigen to human T cell lines. Int Immunol 1995; 7: 471.
27. Hughes CCW, Savage COS, Pober JS. Endothelial cells augment T cell IL-2 production by a contact-dependent mechanism involving CD2:LFA-3 interaction. J Exp Med 1990; 171: 1453.
28. Karmann K, Pober JS, Hughes CCW. Endothelial cell-induced resistance to cyclosporin A in human peripheral blood T cells requires contact-dependent interactions involving CD2 but not CD28. J Immunol 1994; 153: 3929.
29. Page C, Thompson C, Yacoub M, Rose M. Human endothelial stimulation of allogeneic T cells via a CTLA-4 independent pathway. Transplant Immunol 1994; 2: 342.
30. van Seventer GA, Newman W, Shimizu Y, et al. Analysis of T cell stimulation by superantigen plus major histocompatibility complex class II molecules or by CD3 monoclonal antibody: costimulation by purified adhesion ligands VCAM-1, ICAM-1 but not ELAM-1. J Exp Med 1991; 174: 901.
31. Springer TA. Adhesion receptors of the immune system. Nature 1990; 346: 425.
32. Pober JS, Gimbrone MA Jr, Lapierre LA, et al. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J Immunol 1986; 137: 1893.
33. Pober JS, Lapierre LA, Stolpen AH, et al. Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species. J Immunol 1987; 138: 3319.
34. Karmann K, Hughes CCW, Schechner J, Fanslow WC, Pober JS. CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression. Proc Natl Acad Sci USA 1995; 92: 4342.
35. Doukas J, Pober JS. IFN-γ enhances endothelial activation induced by TNF but not IL-1. J Immunol 1990; 145: 1727.
36. Thornhill MH, Haskard DO. IL-4 regulates endothelial cell activation by IL-1, tumor necrosis factor, or IFN-γ. J Immunol 1990; 145: 865.
37. Briscoe DM, Schoen FJ, Rice GE, Bevilacqua MP, Ganz P, Pober JS. Induced expression of endothelial-leukocyte adhesion molecules in human cardiac allografts. Transplantation 1991; 51: 537.
38. Briscoe DM, Pober JS, Harmon WE, Cotran RS. Expression of vascular cell adhesion molecule-1 (VCAM-1) in human renal allografts. J Am Soc Nephrol 1992; 3: 1180.
39. Pober JS, Bevilacqua MP, Mendrick DL, Lapierre LA, Fiers W, Gimbrone MA Jr. Two distinct monokines, interleukin 1 and tumor necrosis factor each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells. J Immunol 1986; 136: 1680.
40. Luscinskas FW, Ding H, Lichtman AH. P-selectin and vascular cell adhesion molecule 1 mediate rolling and arrest, respectively, of CD4+ T lymphocytes on tumor necrosis factor α-activated vascular endothelium under flow. J Exp Med 1995; 181: 1179.
41. Spertini O, Luscinskas FW, Kansas GS, et al. Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. J Immunol 1991; 147: 2565.
42. Seth A, Gote L, Nagarkatti M, Nagarkatti P. T-cell-receptor-independent activation of cytolytic activity of cytotoxic T lymphocytes mediated through CD44 and gp90 MEL-14. Proc Natl Acad Sci USA 1991; 88: 7877.
43. Strauch UG, Holzmann B. Triggering of L-selectin (gp90 MEL-14) induces homotypic lymphocyte adhesion by a mechanism independent of LFA-1. Int Immunol 1993; 5: 393.
44. Murakawa Y, Minami Y, Strober W, James SP. Association of human lymph node homing receptor (Leu 8) with the TCR/CD3 complex. J Immunol 1992; 148: 1771.
45. Savage COS, Hughes CCW, Pepinsky RS, Wallner BP, Freedman AS, Pober JS. Endothelial cell lymphocyte function-associated antigen-3 and an unidentified ligand act in concert to provide costimulation to human peripheral blood CD4+ T cells. Cell Immunol 1991; 137: 150.
46. Pober JS, Cotran RS. Cytokines and endothelial cell biology. Physiol Rev 1990; 70: 427.
47. Wagner CR, Vetto RM, Burger DR. The mechanism of antigen presentation by endothelial cells. Immunobiology 1984; 168: 453.
48. Umetsu DT, Pober JS, Jabara HJ, et al. Human dermal fibroblasts present tetanus toxoid antigen to antigen specific T cell clones. J Clin Invest 1985; 76: 254.
49. Fabry Z, Sandor M, Gajewski TF, et al. Differential activation of Th1 and Th2 CD4+ cells by murine brain microvessel endothelial cells and smooth muscle pericytes. J Immunol 1993; 151: 38.
50. Briscoe DM, DesRoches LE, Lichtman AH. Selective activation of T helper cell subsets by endothelium: role for interleukin 12 and endothelial ICAM-1. FASEB J 1995; 9: A38.
51. Pober JS, Collins T, Gimbrone MA Jr, et al. Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon. Nature 1983; 305: 726.
52. Pober JS, Collins T, Gimbrone MAJ, Libby P, Reiss CS. Overview: inducible expression of class II major histocompatibility complex antigens and the immunogenicity of vascular endothelium. Transplantation 1986; 41: 141.
53. Murray AG, Libby P, Pober JS. Human vascular smooth muscle cells poorly costimulate and actively inhibit allogeneic CD4+ T cell proliferation in vitro. J Immunol 1995; 154: 151.
54. Epperson DE, Pober JS. Antigen-presenting function of human endothelial cells, direct activation of resting CD8 T cells. J Immunol 1994; 153: 5042.
55. Doukas J, Pober JS. Lymphocyte-mediated activation of cultured endothelial cells (EC): CD4+ T cells inhibit class II MHC antigen expression despite secreting IFN-γ and increasing EC class I MHC and ICAM-1 antigen expression. J Immunol 1990; 145: 1088.
56. Brooks CJ, Stackpoole A, Savage COS. Synergistic interactions of CD4+ and CD8+ T cell subsets with human vascular endothelial cells in primary proliferative allogeneic responses. Int Immunol 1993; 5: 1041.
57. Page CS, Holloway N, Smith H, Yacoub M, Rose ML. Alloproliferative responses of purified CD4+ and CD8+ T cells to endothelial cells in the absence of contaminating accessory cells. Transplantation 1994; 57: 1628.
58. + T cells proliferate to HLA-DR+ allogeneic vascular endothelium: identification of accessory interactions. Transplantation 1993; 56: 128.
59. Adams PW, Lee HS, Waldman WJ, et al. Alloantigenicity of human endothelial cells. J Immunol 1992; 148: 3753.
60. Adams PW, Lee HS, Ferguson RM, Orosz CG. Alloantigenicity of human endothelial cells. II. Analysis of interleukin 2 production and proliferation by T cells after contact with allogeneic endothelia. Transplantation 1994; 57: 115.
61. Adams PW, Lee HS, Waldman HJ, Sedmak DD, Orosz CG. Alloantigenicity of human endothelial cells. III. Quantitated indirect presentation of endothelial alloantigens to human helper T lymphocytes. Transplantation 1994; 58: 476.
62. Murray AG, Petzelbauer P, Hughes CCW, Costa J, Askenase P, Pober JS. Human T cell-mediated destruction of allogeneic dermal microvessels in a SCID mouse. Proc Natl Acad Sci USA 1994; 91: 9146.
63. Guinan EC, Smith BR, Doukas JT, Miller RA, Pober JS. Vascular endothelial cells enhance T cell responses by markedly augmenting IL-2 concentrations. Cell Immunol 1989; 118: 166.
64. Westphal JR, Williams HW, Tax WJM, Koene RAP, Ruiter DJ, deWaal RMW. The proliferative response of human T cells to allogeneic IFN-γ treated endothelial cells is mediated via both CD2/LFA-3 and LFA-1/ICAM-1 and -2 adhesion pathways. Transplant Immunol 1994; 1: 183.
65. Huang EH, Morgan CJ, Sedmak DD, Ferguson RM, Orosz CG. Alloantigenicity of human endothelial cells. IV. Derivation, characterization, and utilization of gonadal vein endothelia to control endothelial alloantigenicity during lymphocyte-endothelial interactins. Transplantation 1994; 57: 703.
66. Geppert TD, Lipsky PE. Antigen presentation by interferon-treated endothelial cells and fibroblasts: differential ability to function as antigen-presenting cells despite comparable Ia expression. J Immunol 1985; 135: 3750.
67. Geppert TD, Lipsky PE. Dissection of defective antigen presentation by interferon-γ-treated fibroblasts. J Immunol 1987; 138: 385.
68. Savage COS, Brooks CJ. Human vascular endothelial cells do not induce anergy in allogeneic CD4+ T cells unless co-stimulation is prevented. Transplantation 1995; 60: 1.
69. Roska AK, Johnson AR, Lipsky DE. Immunologic function of endothelial cells: guinea pig aortic endothelial cells support mitogen-induced T lymphocyte activation, but do not function as antigen-presenting cells. J Immunol 1984; 132: 136.
70. Fabry Z, Waldschmidt MM, Moore SA, Hart MN. Antigen presentation by brain microvessel smooth muscle and endothelium. J Neuroimmunol 1990; 28: 63.
71. Lodge P, Haisch CE. T cell subset responses to allogeneic endothelium. Proliferation by CD8+ but not CD4+ lymphocytes. Transplantation 1993; 56: 656.
72. Ferry B, Haltutunen J, Leszczynski D, Shellekens H, van der Medie PH, Hayry P. Impact of class V major histocompatibility complex antigen expression on the immunogenic potential of isolated rat vascular endothelial cells. Transplantation 1987; 44: 499.