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Biophysical Chemistry

Volumn 66, Issue 2-3, 1997, Pages 159-177

Principles and methods of evolutionary biotechnology

(2) Koltermann, Andre a Kettling, Ulrich a

a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY (Germany)

Author keywords

Applied molecular evolution; Combinatorial biosynthesis; Combinatorial libraires; Drug design; Evolutionary biotechnology; High throughput selection

Indexed keywords

BIOTECHNOLOGY; DRUG DESIGN; DRUG MANUFACTURE; EVOLUTION; IN VITRO STUDY; MUTAGENESIS; MUTATION; PRIORITY JOURNAL; REVIEW; TECHNIQUE; THEORY;

EID: 0030759165 PISSN: 03014622 EISSN: None Source Type: Journal
DOI: 10.1016/S0301-4622(97)00063-X Document Type: Article

Times cited : (17)

References (198)

1
- 0021472534
- M. Eigen and W. Gardiner, Pure. Appl. Chera., 56 (1984) 967.
- (1984) Pure. Appl. Chera. , vol.56 , pp. 967
- Eigen, M.¹ Gardiner, W.²

2
- 0015133749
- M. Eigen, Naturwissenschaften, 58 ( 1971 ) 465.
- (1971) Naturwissenschaften , vol.58 , pp. 465
- Eigen, M.¹

3
- 0002124659
- M. Eigen, Chemica Scripta, 26B (1985) 13.
- (1985) Chemica Scripta , vol.26 B , pp. 13
- Eigen, M.¹

4
- 0000085306
- M. Eigen, J. McCaskill and P. Schuster, Adv. Chem. Phys., (1989) 149.
- (1989) Adv. Chem. Phys., , pp. 149
- Eigen, M.¹ McCaskill, J.² Schuster, P.³

5
- 0014107493
- D.R. Mills, R.L. Peterson and S. Spiegelman, Proc. Natl. Acad. Sci. USA, 58 (1967) 217.
- (1967) Proc. Natl. Acad. Sci. USA , vol.58 , pp. 217
- Mills, D.R.¹ Peterson, R.L.² Spiegelman, S.³

6
- 0014542276
- R. Levisohn and S. Spiegelman, Proc. Natl. Acad. Sci. USA, 63 (1969) 805.
- (1969) Proc. Natl. Acad. Sci. USA , vol.63 , pp. 805
- Levisohn, R.¹ Spiegelman, S.²

7
- 0014827737
- R. Saffhill, H. Schneider-Bernloehr, L.E. Orgel and S. Spiegelman, J. Mol. Biol., 51 (1970) 531.
- (1970) J. Mol. Biol. , vol.51 , pp. 531
- Saffhill, R.¹ Schneider-Bernloehr, H.² Orgel, L.E.³ Spiegelman, S.⁴

8
- 0017667182
- M. Eigen and P. Schuster, Naturwissenschaften, 64 (1977) 541.
- (1977) Naturwissenschaften , vol.64 , pp. 541
- Eigen, M.¹ Schuster, P.²

9
- 0018085524
- M. Eigen and P. Schuster, Naturwissenschaften, 65 (1978) 7.
- (1978) Naturwissenschaften , vol.65 , pp. 7
- Eigen, M.¹ Schuster, P.²

10
- 0017864801
- M. Eigen and P. Schuster, Naturwissenschaften, 65 (1978) 341.
- (1978) Naturwissenschaften , vol.65 , pp. 341
- Eigen, M.¹ Schuster, P.²

11
- 0027738626
- M. Eigen, Gene, 135 (1993) 37.
- (1993) Gene , vol.135 , pp. 37
- Eigen, M.¹

12
- 0042925053
- P. Schuster, Chemica Scripta, 26 ( 1986) 27.
- (1986) Chemica Scripta , vol.26 , pp. 27
- Schuster, P.¹

13
- 0028196714
- P. Schuster, W. Fontana, P.F. Stadler and I.L. Hofacker, Proceedings of the Royal Society of London - Series B: Biological Sciences, 255 (1994) 279.
- (1994) Proceedings of the Royal Society of London - Series B: Biological Sciences , vol.255 , pp. 279
- Schuster, P.¹ Fontana, W.² Stadler, P.F.³ Hofacker, I.L.⁴

14
- 0029160643
- P. Schuster, J. Biotechnol., 41 (1995) 239.
- (1995) J. Biotechnol. , vol.41 , pp. 239
- Schuster, P.¹

15
- 0027768233
- P. Schuster, Orig. Life. Evol. Biosph., 23 (1993) 373.
- (1993) Orig. Life. Evol. Biosph. , vol.23 , pp. 373
- Schuster, P.¹

16
- 0028027058
- G.W. Zhou, J. Guo, W. Huang, R.J. Fletterick and T.S. Scanlan, Science, 265 (1994) 1059.
- (1994) Science , vol.265 , pp. 1059
- Zhou, G.W.¹ Guo, J.² Huang, W.³ Fletterick, R.J.⁴ Scanlan, T.S.⁵

17
- 85045502002
- R.C. Cadwell and G.F. Joyce, PCR Methods Appl., 2 (1992) 28.
- (1992) PCR Methods Appl. , vol.2 , pp. 28
- Cadwell, R.C.¹ Joyce, G.F.²

18
- 0343822876
- this issue
- S. Brakmann, this issue.
- Brakmann, S.¹

19
- 0015590736
- C.K. Biebricher and L.E. Orgel, Proc. Natl. Acad. Sci. USA, 70 (1973) 934.
- (1973) Proc. Natl. Acad. Sci. USA , vol.70 , pp. 934
- Biebricher, C.K.¹ Orgel, L.E.²

20
- 0021826423
- J.A. Wells, M. Vasser and D.B. Powers, Gene, 34 (1985) 315.
- (1985) Gene , vol.34 , pp. 315
- Wells, J.A.¹ Vasser, M.² Powers, D.B.³

21
- 0024338892
- M.S. Horwitz, D.K. Dube and L.A. Loeb, Genome, 31 (1989) 112.
- (1989) Genome , vol.31 , pp. 112
- Horwitz, M.S.¹ Dube, D.K.² Loeb, L.A.³

22
- 0029001280
- B. Borrego, A. Wienecke and A. Schwienhorst, Nucleic. Acids. Res., 23 (1995) 1834.
- (1995) Nucleic. Acids. Res. , vol.23 , pp. 1834
- Borrego, B.¹ Wienecke, A.² Schwienhorst, A.³

23
- 0342951831
- this issue
- C.K. Biebricher, this issue.
- Biebricher, C.K.¹

24
- 0021099437
- C.K. Biebricher, M. Eigen and W.C. Gardiner, Jr. Biochemistry, 22 (1983) 2544.
- (1983) Biochemistry , vol.22 , pp. 2544
- Biebricher, C.K.¹ Eigen, M.² Gardiner W.C., Jr.³

25
- 0343822874
- in press
- J. Putz, J. Wientges, M. Sissler, R. Giege, C. Florentz and A. Schwienhorst, Nucleic. Acids. Res., (in press).
- Nucleic. Acids. Res.
- Putz, J.¹ Wientges, J.² Sissler, M.³ Giege, R.⁴ Florentz, C.⁵ Schwienhorst, A.⁶

26
- 0027446944
- K. Harada and L.E. Orgel, Proc. Natl. Acad. Sci. USA, 90 (1993) 1576.
- (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 1576
- Harada, K.¹ Orgel, L.E.²

27
- 0029031094
- L. Gold, J. Biol. Chem., 270 (1995) 13581.
- (1995) J. Biol. Chem. , vol.270 , pp. 13581
- Gold, L.¹

28
- 0026555493
- J.W. Szostak, Trends. Biochem. Sci., 17 (1992) 89.
- (1992) Trends. Biochem. Sci. , vol.17 , pp. 89
- Szostak, J.W.¹

29
- 0022965004
- K. Mullis, F. Faloona, S. Scharf, R. Saiki, G. Horn and H. Erlich, Cold. Spring. Harb. Symp. Quant. Biol., 51 Pt 1 (1986) 263.
- (1986) Cold. Spring. Harb. Symp. Quant. Biol. , vol.51 , Issue.PART 1 , pp. 263
- Mullis, K.¹ Faloona, F.² Scharf, S.³ Saiki, R.⁴ Horn, G.⁵ Erlich, H.⁶

30
- 0026207444
- E. Fahy, D.Y. Kwoh and T.R. Gingeras, PCR Methods Appl., 1 (1991) 25.
- (1991) PCR Methods Appl. , vol.1 , pp. 25
- Fahy, E.¹ Kwoh, D.Y.² Gingeras, T.R.³

31
- 0030042364
- M. Gebinoga and F. Oehlenschlager, Eur. J. Biochem., 235 (1996) 256.
- (1996) Eur. J. Biochem. , vol.235 , pp. 256
- Gebinoga, M.¹ Oehlenschlager, F.²

32
- 0029020446
- N. Rohde, H. Daum and C.K. Biebricher, J. Mol. Biol., 249 (1995) 754.
- (1995) J. Mol. Biol. , vol.249 , pp. 754
- Rohde, N.¹ Daum, H.² Biebricher, C.K.³

33
- 0029160633
- S.T. Sigurdsson and F. Eckstein, Trends. Biotechnol., 13 (1995) 286.
- (1995) Trends. Biotechnol. , vol.13 , pp. 286
- Sigurdsson, S.T.¹ Eckstein, F.²

34
- 0025194307
- C. Tuerk and L. Gold, Science, 249 (1990) 505.
- (1990) Science , vol.249 , pp. 505
- Tuerk, C.¹ Gold, L.²

35
- 0025074907
- A.D. Ellington and J.W. Szostak, Nature, 346 (1990) 818.
- (1990) Nature , vol.346 , pp. 818
- Ellington, A.D.¹ Szostak, J.W.²

36
- 0028869690
- L. Gold, B. Polisky, O. Uhlenbeck and M. Yarus, Annu. Rev. Biochem., 64 (1995) 763.
- (1995) Annu. Rev. Biochem. , vol.64 , pp. 763
- Gold, L.¹ Polisky, B.² Uhlenbeck, O.³ Yarus, M.⁴

37
- 0028191743
- S.J. Klug and M. Famulok, Mol. Biol. Rep., 20 (1994) 97.
- (1994) Mol. Biol. Rep. , vol.20 , pp. 97
- Klug, S.J.¹ Famulok, M.²

38
- 0028430587
- A.D. Ellington, Curr. Biol., 4 (1994) 427.
- (1994) Curr. Biol. , vol.4 , pp. 427
- Ellington, A.D.¹

39
- 0028926048
- E.M. Phizicky and S. Fields, Microbiol. Rev., 59 (1995) 94.
- (1995) Microbiol. Rev. , vol.59 , pp. 94
- Phizicky, E.M.¹ Fields, S.²

40
- 0026599465
- A.D. Ellington and J.W. Szostak, Nature, 355 ( 1992) 850.
- (1992) Nature , vol.355 , pp. 850
- Ellington, A.D.¹ Szostak, J.W.²

41
- 0029446727
- H. Ellegren, C.R. Primmer and B.C. Sheldon, Nat. Genet., 11 (1995) 360.
- (1995) Nat. Genet. , vol.11 , pp. 360
- Ellegren, H.¹ Primmer, C.R.² Sheldon, B.C.³

42
- 0028965943
- D.E. Huizenga and J.W. Szostak, Biochemistry, 34 (1995) 656.
- (1995) Biochemistry , vol.34 , pp. 656
- Huizenga, D.E.¹ Szostak, J.W.²

43
- 0028058105
- J.R. Lorsch and J.W. Szostak, Biochemistry, 33 (1994) 973.
- (1994) Biochemistry , vol.33 , pp. 973
- Lorsch, J.R.¹ Szostak, J.W.²

44
- 0029138009
- C.T. Lauhon and J.W. Szostak, J. Am. Chem. Soc., 117 (1995) 1246.
- (1995) J. Am. Chem. Soc. , vol.117 , pp. 1246
- Lauhon, C.T.¹ Szostak, J.W.²

45
- 0030582678
- D.H. Burke, L. Scates, K. Andrews and L. Gold, J. Mol. Biol., 264 (1996) 650.
- (1996) J. Mol. Biol. , vol.264 , pp. 650
- Burke, D.H.¹ Scates, L.² Andrews, K.³ Gold, L.⁴

46
- 0029165745
- D.J. Schneider, J. Feigon, Z. Hostomsky and L. Gold, Biochemistry, 34 (1995) 9599.
- (1995) Biochemistry , vol.34 , pp. 9599
- Schneider, D.J.¹ Feigon, J.² Hostomsky, Z.³ Gold, L.⁴

47
- 0026651981
- C. Tuerk, S. MacDougal and L. Gold, Proc. Natl. Acad. Sci. USA, 89 (1992) 6988.
- (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 6988
- Tuerk, C.¹ MacDougal, S.² Gold, L.³

48
- 0026575221
- L.C. Bock, L.C. Griffin, J.A. Latham, E.H. Vermaas and J.J. Toole, Nature, 355 (1992) 564.
- (1992) Nature , vol.355 , pp. 564
- Bock, L.C.¹ Griffin, L.C.² Latham, J.A.³ Vermaas, E.H.⁴ Toole, J.J.⁵

49
- 0027380687
- K.Y. Wang, S.H. Krawczyk, N. Bischofberger, S. Swaminathan and P.H. Bolton, Biochemistry, 32 (1993) 11285.
- (1993) Biochemistry , vol.32 , pp. 11285
- Wang, K.Y.¹ Krawczyk, S.H.² Bischofberger, N.³ Swaminathan, S.⁴ Bolton, P.H.⁵

50
- 0028337051
- M.F. Kubik, A.W. Stephens, D. Schneider, R.A. Marlar and D. Tasset, Nucleic. Acids. Res., 22 (1994) 2619.
- (1994) Nucleic. Acids. Res. , vol.22 , pp. 2619
- Kubik, M.F.¹ Stephens, A.W.² Schneider, D.³ Marlar, R.A.⁴ Tasset, D.⁵

51
- 0020417286
- K. Kruger, P.J. Grabowski, A.J. Zaug, J. Sands, D.E. Gottschling and T.R. Cech, Cell, 31 (1982) 147.
- (1982) Cell , vol.31 , pp. 147
- Kruger, K.¹ Grabowski, P.J.² Zaug, A.J.³ Sands, J.⁴ Gottschling, D.E.⁵ Cech, T.R.⁶

52
- 0022555857
- T.R. Cech and B.L. Bass, Annu. Rev. Biochem., 55 (1986) 599.
- (1986) Annu. Rev. Biochem. , vol.55 , pp. 599
- Cech, T.R.¹ Bass, B.L.²

53
- 36849148382
- W. Gilbert, Nature, 319 (1986) 618.
- (1986) Nature , vol.319 , pp. 618
- Gilbert, W.¹

54
- 0025332385
- D.L. Robertson and G.F. Joyce, Nature, 344 (1990) 467.
- (1990) Nature , vol.344 , pp. 467
- Robertson, D.L.¹ Joyce, G.F.²

55
- 0026649231
- A.A. Beaudry and G.F. Joyce, Science, 257 (1992) 635.
- (1992) Science , vol.257 , pp. 635
- Beaudry, A.A.¹ Joyce, G.F.²

56
- 0028233951
- J. Tsang and G.F. Joyce, Biochemistry, 33 (1994) 5966.
- (1994) Biochemistry , vol.33 , pp. 5966
- Tsang, J.¹ Joyce, G.F.²

57
- 0028124128
- J.R. Lorsch and J.W. Szostak, Nature, 371 (1994) 31.
- (1994) Nature , vol.371 , pp. 31
- Lorsch, J.R.¹ Szostak, J.W.²

58
- 0027180473
- M. Sassanfar and J.W. Szostak, Nature, 364 (1993) 550.
- (1993) Nature , vol.364 , pp. 550
- Sassanfar, M.¹ Szostak, J.W.²

59
- 0028875594
- J.R. Lorsch and J.W. Szostak, Biochemistry, 34 (1995) 15315.
- (1995) Biochemistry , vol.34 , pp. 15315
- Lorsch, J.R.¹ Szostak, J.W.²

60
- 0022992561
- A. Tramontano, K.D. Janda and R.A. Lerner, Science, 234 (1986) 1566.
- (1986) Science , vol.234 , pp. 1566
- Tramontano, A.¹ Janda, K.D.² Lerner, R.A.³

61
- 0022991435
- S.J. Pollack, J.W. Jacobs and P.C. Schultz, Science, 234 (1986) 1570.
- (1986) Science , vol.234 , pp. 1570
- Pollack, S.J.¹ Jacobs, J.W.² Schultz, P.C.³

62
- 0028030688
- J.R. Prudent, T. Uno and P.G. Schultz, Science, 264 (1994) 1924.
- (1994) Science , vol.264 , pp. 1924
- Prudent, J.R.¹ Uno, T.² Schultz, P.G.³

63
- 0028556622
- K.N. Morris, T.M. Tarasow, C.M. Julin, S.L. Simons, D. Hilvert and L. Gold, Proc. Natl. Acad. Sci. USA, 91 (1994) 13028.
- (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 13028
- Morris, K.N.¹ Tarasow, T.M.² Julin, C.M.³ Simons, S.L.⁴ Hilvert, D.⁵ Gold, L.⁶

64
- 0028243847
- M.A. Gallop, R.W. Barrett, W.J. Dower, S.P. Fodor and E.M. Gordon, J. Med. Chem., 37 (1994) 1233.
- (1994) J. Med. Chem. , vol.37 , pp. 1233
- Gallop, M.A.¹ Barrett, R.W.² Dower, W.J.³ Fodor, S.P.⁴ Gordon, E.M.⁵

65
- 0028318863
- E.M. Gordon, R.W. Barrett, W.J. Dower, S.P. Fodor and M.A. Gallop, J. Med. Chem., 37 (1994) 1385.
- (1994) J. Med. Chem. , vol.37 , pp. 1385
- Gordon, E.M.¹ Barrett, R.W.² Dower, W.J.³ Fodor, S.P.⁴ Gallop, M.A.⁵

66
- 0029761897
- D.H. Lee, J.R. Granja, J.A. Martinez, K. Severin and M.R. Ghadri, Nature, 382 (1996) 525.
- (1996) Nature , vol.382 , pp. 525
- Lee, D.H.¹ Granja, J.R.² Martinez, J.A.³ Severin, K.⁴ Ghadri, M.R.⁵

67
- 0026770470
- G. Cesareni, FEBS Lett., 307 (1992) 66.
- (1992) FEBS Lett. , vol.307 , pp. 66
- Cesareni, G.¹

68
- 0029948948
- J.B. Burritt, C.W. Bond, K.W. Doss and A.J. Jesaitis, Anal. Biochem., 238 (1996) 1.
- (1996) Anal. Biochem. , vol.238 , pp. 1
- Burritt, J.B.¹ Bond, C.W.² Doss, K.W.³ Jesaitis, A.J.⁴

69
- 0030253986
- D. Mcgregor, Mol. Biotechnol., 6 (1996) 155.
- (1996) Mol. Biotechnol. , vol.6 , pp. 155
- Mcgregor, D.¹

70
- 0021818675
- G.P. Smith, Science, 228 (1985) 1315.
- (1985) Science , vol.228 , pp. 1315
- Smith, G.P.¹

71
- 0025226085
- J. McCafferty, A.D. Griffiths, G. Winter and D.J. Chiswell, Nature, 348 (1990) 552.
- (1990) Nature , vol.348 , pp. 552
- McCafferty, J.¹ Griffiths, A.D.² Winter, G.³ Chiswell, D.J.⁴

72
- 0027962758
- G. Winter, A.D. Griffiths, R.E. Hawkins and H.R. Hoogenboom, Annu. Rev. Immunol., 12 (1994) 433.
- (1994) Annu. Rev. Immunol. , vol.12 , pp. 433
- Winter, G.¹ Griffiths, A.D.² Hawkins, R.E.³ Hoogenboom, H.R.⁴

73
- 0342951829
- Dissertation, Technische Universität Braunschweig
- C. Buta, Dissertation, Technische Universität Braunschweig (1996).
- (1996)
- Buta, C.¹

74
- 0027136213
- T. Klauser, J. Kraemer, K. Otzelberger, J. Pohlner and T. Meyer, F. J. Mol. Biol., 234 (1993) 579.
- (1993) J. Mol. Biol. , vol.234 , pp. 579
- Klauser, T.¹ Kraemer, J.² Otzelberger, K.³ Pohlner, J.⁴ Meyer, T.F.⁵

75
- 0343822869
- personal communication
- J. Pohlner, personal communication.
- Pohlner, J.¹

76
- 0027454891
- G. Georgiou, H.L. Poetschke, C. Stathopoulos and J.A. Francisco, Trends. Biotechnol., 11 (1993) 6.
- (1993) Trends. Biotechnol. , vol.11 , pp. 6
- Georgiou, G.¹ Poetschke, H.L.² Stathopoulos, C.³ Francisco, J.A.⁴

77
- 0028686614
- J.A. Francisco and G. Georgiou, Ann. N. Y. Acad. Sci., 745 (1994) 372.
- (1994) Ann. N. Y. Acad. Sci. , vol.745 , pp. 372
- Francisco, J.A.¹ Georgiou, G.²

78
- 0031012062
- G. Georgiou, C. Stathopoulos, P.S. Daugherty, A.R. Nayak, B.L. Iverson and R. Curtiss, Nat. Biotechnol., 15 (1997) 29.
- (1997) Nat. Biotechnol. , vol.15 , pp. 29
- Georgiou, G.¹ Stathopoulos, C.² Daugherty, P.S.³ Nayak, A.R.⁴ Iverson, B.L.⁵ Curtiss, R.⁶

79
- 0026546880
- M.G. Cull, J.F. Miller and P.J. Schatz, Proc. Natl. Acad. Sci. USA, 89 (1992) 1865.
- (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 1865
- Cull, M.G.¹ Miller, J.F.² Schatz, P.J.³

80
- 0028592703
- L.C. Mattheakis, R.R. Bhatt and W.J. Dower, Proc. Natl. Acad. Sci. USA, 91 (1994) 9022.
- (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 9022
- Mattheakis, L.C.¹ Bhatt, R.R.² Dower, W.J.³

81
- 0029762164
- J.P. Manfredi, C. Klein, J.J. Herrero, D.R. Byrd, J. Truehart, W.T. Wiesler, D.M. Fowlkes and J.R. Broach, Mol. Cell. Biol., 16 (1996) 4700.
- (1996) Mol. Cell. Biol. , vol.16 , pp. 4700
- Manfredi, J.P.¹ Klein, C.² Herrero, J.J.³ Byrd, D.R.⁴ Truehart, J.⁵ Wiesler, W.T.⁶ Fowlkes, D.M.⁷ Broach, J.R.⁸

82
- 0343387233
- personal communication
- G. Gonzaliz-Gil, personal communication.
- Gonzaliz-Gil, G.¹

83
- 0342951828
- unpublished results
- A. Koltermann, unpublished results.
- Koltermann, A.¹

84
- 0027933750
- M. Duenas and C.A. Borrebaeck, Biotechnology (N Y), 12 (1994) 999.
- (1994) Biotechnology (N Y) , vol.12 , pp. 999
- Duenas, M.¹ Borrebaeck, C.A.²

85
- 0028670306
- K. Gramatikoff, O. Georgiev and W. Schaffner, Nucleic. Acids. Res., 22 (1994) 5761.
- (1994) Nucleic. Acids. Res. , vol.22 , pp. 5761
- Gramatikoff, K.¹ Georgiev, O.² Schaffner, W.³

86
- 0029585566
- C. Krebber, S. Spada, D. Desplancq and A. Plückthun, FEBS Lett, 377 (1995) 227.
- (1995) FEBS Lett , vol.377 , pp. 227
- Krebber, C.¹ Spada, S.² Desplancq, D.³ Plückthun, A.⁴

87
- 0028001658
- J. Winter, Drug Development Research, 33 (1994) 71.
- (1994) Drug Development Research , vol.33 , pp. 71
- Winter, J.¹

88
- 0025004285
- J.J. Devlin, L.C. Panganiban and P.E. Devlin, Science, 249 (1990) 404.
- (1990) Science , vol.249 , pp. 404
- Devlin, J.J.¹ Panganiban, L.C.² Devlin, P.E.³

89
- 0027287466
- B.K. Kay, N.B. Adey, Y.S. He, J.P. Manfredi, A.H. Mataragnon and D.M. Fowlkes, Gene, 128 (1993) 59.
- (1993) Gene , vol.128 , pp. 59
- Kay, B.K.¹ Adey, N.B.² He, Y.S.³ Manfredi, J.P.⁴ Mataragnon, A.H.⁵ Fowlkes, D.M.⁶

90
- 0028808005
- L.B. Giebel, R.T. Cass, D.L. Milligan, D.C. Young, R. Arze and C.R. Johnson, Biochemistry, 34 (1995) 15430.
- (1995) Biochemistry , vol.34 , pp. 15430
- Giebel, L.B.¹ Cass, R.T.² Milligan, D.L.³ Young, D.C.⁴ Arze, R.⁵ Johnson, C.R.⁶

91
- 0028841829
- B.A. Katz, Biochemistry, 34 (1995) 15421.
- (1995) Biochemistry , vol.34 , pp. 15421
- Katz, B.A.¹

92
- 0029851323
- P.J. Meijer, N. Holmberg, G. Grundstrom and L. Bulow, Protein Eng., 9 (1996) 1051.
- (1996) Protein Eng. , vol.9 , pp. 1051
- Meijer, P.J.¹ Holmberg, N.² Grundstrom, G.³ Bulow, L.⁴

93
- 0029670330
- A. Crameri, E.A. Whitehorn, E. Tate and W.P.C. Stemmer, Nat. Biotechnol., 14 (1996) 315.
- (1996) Nat. Biotechnol. , vol.14 , pp. 315
- Crameri, A.¹ Whitehorn, E.A.² Tate, E.³ Stemmer, W.P.C.⁴

94
- 0029973636
- B.P. Cormack, R.H. Valdivia and S. Falkow, Gene, 173 (1996) 33.
- (1996) Gene , vol.173 , pp. 33
- Cormack, B.P.¹ Valdivia, R.H.² Falkow, S.³

95
- 0029590248
- E. Dufour, A.C. Storer and R. Menard, Biochemistry, 34 (1995) 16382.
- (1995) Biochemistry , vol.34 , pp. 16382
- Dufour, E.¹ Storer, A.C.² Menard, R.³

96
- 0026530977
- W. Bode and R. Huber, Eur. J. Biochem., 204 (1992) 433.
- (1992) Eur. J. Biochem. , vol.204 , pp. 433
- Bode, W.¹ Huber, R.²

97
- 0028175483
- P. Soumillion, L. Jespers, M. Bouchet, J. Marchand-Brynaert, G. Winter and J. Fastrez, J. Mol. Biol., 237 (1994) 415.
- (1994) J. Mol. Biol. , vol.237 , pp. 415
- Soumillion, P.¹ Jespers, L.² Bouchet, M.³ Marchand-Brynaert, J.⁴ Winter, G.⁵ Fastrez, J.⁶

98
- 0342951824
- P.C. Clarke, Chemica Scripta, 26B (1986) 337.
- (1986) Chemica Scripta , vol.26 B , pp. 337
- Clarke, P.C.¹

99
- 0003750552
- Plenum Press, New York
- R.P. Mortlock, Microorganisms as Model Systems for Studying Evolution (Plenum Press, New York, 1984).
- (1984) Microorganisms as Model Systems for Studying Evolution
- Mortlock, R.P.¹

100
- 0015258586
- J.C. Francis and P.E. Hansche, Genetics, 70 (1972) 59.
- (1972) Genetics , vol.70 , pp. 59
- Francis, J.C.¹ Hansche, P.E.²

101
- 0342517635
- J.H. Campbell, J.A. Lengyel and J. Langridge, Proc. Natl. Acad. Sci. USA, 70 (1973) 1841.
- (1973) Proc. Natl. Acad. Sci. USA , vol.70 , pp. 1841
- Campbell, J.H.¹ Lengyel, J.A.² Langridge, J.³

102
- 0017616896
- B.C. Hall, J. Bacteriol., 129 (1977) 540.
- (1977) J. Bacteriol. , vol.129 , pp. 540
- Hall, B.C.¹

103
- 0019874718
- B.G. Hall, Biochemistry, 20 (1981) 4042.
- (1981) Biochemistry , vol.20 , pp. 4042
- Hall, B.G.¹

104
- 0021752682
- M. Kricker and B.G. Hall, Mol. Biol. Evol., 1 (1984) 171.
- (1984) Mol. Biol. Evol. , vol.1 , pp. 171
- Kricker, M.¹ Hall, B.G.²

105
- 0023102268
- M. Kricker and B.G. Hall, Genetics, 115 (1987) 419.
- (1987) Genetics , vol.115 , pp. 419
- Kricker, M.¹ Hall, B.G.²

106
- 0021173092
- R.C. Doten and R.P. Mortlock, J. Bacteriol., 159 (1984) 730.
- (1984) J. Bacteriol. , vol.159 , pp. 730
- Doten, R.C.¹ Mortlock, R.P.²

107
- 0021004801
- B.G. Hall, S. Yokoyama and D.H. Calhoun, Mol. Biol. Evol., 1 (1983) 109.
- (1983) Mol. Biol. Evol. , vol.1 , pp. 109
- Hall, B.G.¹ Yokoyama, S.² Calhoun, D.H.³

108
- 0029113263
- K.H. Schneider, G. Jakel, R. Hoffmann and F. Giffhom, Microbiology, 141 (1995) 1865.
- (1995) Microbiology , vol.141 , pp. 1865
- Schneider, K.H.¹ Jakel, G.² Hoffmann, R.³ Giffhom, F.⁴

109
- 0342367772
- H. Liao, T. McKenzie and R. Hageman, Proc. Natl. Acad. Sci. USA, 83 (1986) 576.
- (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 576
- Liao, H.¹ McKenzie, T.² Hageman, R.³

110
- 0024309854
- D.K. Dube and L.A. Loeb, Biochemistry, 28 (1989) 5703.
- (1989) Biochemistry , vol.28 , pp. 5703
- Dube, D.K.¹ Loeb, L.A.²

111
- 0024358138
- A.R. Oliphant and K. Struhl, Proc. Natl. Acad. Sci. USA, 86 (1989) 9094.
- (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 9094
- Oliphant, A.R.¹ Struhl, K.²

112
- 0029883624
- M.E. Black, T.G. Newcomb, H.M. Wilson and L.A. Loeb, Proc. Natl. Acad. Sci. USA, 93 (1996) 3525.
- (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3525
- Black, M.E.¹ Newcomb, T.G.² Wilson, H.M.³ Loeb, L.A.⁴

113
- 0028079324
- K.M. Munir, D.C. French, D.K. Dube and L.A. Loeb, Protein Eng., 7 (1994) 83.
- (1994) Protein Eng. , vol.7 , pp. 83
- Munir, K.M.¹ French, D.C.² Dube, D.K.³ Loeb, L.A.⁴

114
- 0027731712
- D.K. Dube, M.E. Black, K.M. Munir and L.A. Loeb, Gene, 137 (1993) 41.
- (1993) Gene , vol.137 , pp. 41
- Dube, D.K.¹ Black, M.E.² Munir, K.M.³ Loeb, L.A.⁴

115
- 0027501570
- M.E. Black and L.A. Loeb, Biochemistry, 32 (1993) 11618.
- (1993) Biochemistry , vol.32 , pp. 11618
- Black, M.E.¹ Loeb, L.A.²

116
- 0027192014
- K.M. Munir, D.C. French and L.A. Loeb, Proc. Natl. Acad. Sci. USA, 90 (1993) 4012.
- (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 4012
- Munir, K.M.¹ French, D.C.² Loeb, L.A.³

117
- 0026646614
- K.M. Munir, D.C. French, D.K. Dube and L.A. Loeb, J. Biol. Chem., 267 (1992) 6584.
- (1992) J. Biol. Chem. , vol.267 , pp. 6584
- Munir, K.M.¹ French, D.C.² Dube, D.K.³ Loeb, L.A.⁴

118
- 0026646614
- K. Munir, M, D. French, C, D. Dube, K and L. Loeb, A. J. Biol. Chem., 267 (1992) 6584.
- (1992) J. Biol. Chem. , vol.267 , pp. 6584
- Munir, K.M.¹ French, C.D.² Dube, D.K.³ Loeb, L.A.⁴

119
- 0026323945
- D.K. Dube, J.D. Parker, D.C. French, D.S. Cahill, S. Dube, M.S. Horwitz, K.M. Munir and L.A. Loeb, Biochemistry, 30 (1991) 11760.
- (1991) Biochemistry , vol.30 , pp. 11760
- Dube, D.K.¹ Parker, J.D.² French, D.C.³ Cahill, D.S.⁴ Dube, S.⁵ Horwitz, M.S.⁶ Munir, K.M.⁷ Loeb, L.A.⁸

120
- 0029929724
- F.C. Christians and L.A. Loeb, Proc. Natl. Acad. Sci. USA, 93 (1996) 6124.
- (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 6124
- Christians, F.C.¹ Loeb, L.A.²

121
- 0029981387
- B. Kim, T.R. Hathaway and L.A. Loeb, J. Biol. Chem., 271 (1996) 4872.
- (1996) J. Biol. Chem. , vol.271 , pp. 4872
- Kim, B.¹ Hathaway, T.R.² Loeb, L.A.³

122
- 0029845979
- M. Suzuki, D. Baskin, L. Hood and L.A. Loeb, Proc. Natl. Acad. Sci. USA, 93 (1996) 9670.
- (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9670
- Suzuki, M.¹ Baskin, D.² Hood, L.³ Loeb, L.A.⁴

123
- 0028878167
- B. Kim and L.A. Loeb, Proc. Natl. Acad. Sci. USA, 92 (1995) 684.
- (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 684
- Kim, B.¹ Loeb, L.A.²

124
- 0029076396
- J.B. Sweasy, M. Chen and L.A. Loeb, J. Bacteriol., 177 (1995) 2923.
- (1995) J. Bacteriol. , vol.177 , pp. 2923
- Sweasy, J.B.¹ Chen, M.² Loeb, L.A.³

125
- 0027158355
- J.B. Sweasy and L.A. Loeb, Proc. Natl. Acad. Sci. USA, 90 (1993) 4626.
- (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 4626
- Sweasy, J.B.¹ Loeb, L.A.²

126
- 0026708313
- E.M. Witkin and V. Roegner-Maniscalco, J. Bacteriol., 174 (1992) 4166.
- (1992) J. Bacteriol. , vol.174 , pp. 4166
- Witkin, E.M.¹ Roegner-Maniscalco, V.²

127
- 0029680175
- M.E. Black and L.A. Loeb, Methods Mol. Biol., 57 (1996) 335.
- (1996) Methods Mol. Biol. , vol.57 , pp. 335
- Black, M.E.¹ Loeb, L.A.²

128
- 0029680343
- L.A. Loeb, Adv. Pharmacol., 35 (1996) 321.
- (1996) Adv. Pharmacol. , vol.35 , pp. 321
- Loeb, L.A.¹

129
- 0030252433
- M. Suzuki, F.C. Christians, B. Kim, A. Skandalis, M.E. Black and L.A. Loeb, Molecular Diversity, 2 (1996) 111.
- (1996) Molecular Diversity , vol.2 , pp. 111
- Suzuki, M.¹ Christians, F.C.² Kim, B.³ Skandalis, A.⁴ Black, M.E.⁵ Loeb, L.A.⁶

130
- 0027245444
- L.D. Graham, K.D. Haggett, P.A. Jennings, D.S. Le Brocque, R.G. Whittaker and P.A. Schober, Biochemistry, 32 (1993) 6250.
- (1993) Biochemistry , vol.32 , pp. 6250
- Graham, L.D.¹ Haggett, K.D.² Jennings, P.A.³ Le Brocque, D.S.⁴ Whittaker, R.G.⁵ Schober, P.A.⁶

131
- 0029969577
- L. You and F.H. Arnold, Protein Eng., 9 (1996) 77.
- (1996) Protein Eng. , vol.9 , pp. 77
- You, L.¹ Arnold, F.H.²

132
- 0027205210
- K. Chen and F.H. Arnold, Proc. Natl. Acad. Sci. USA, 90 (1993) 5618.
- (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 5618
- Chen, K.¹ Arnold, F.H.²

133
- 0026334373
- K.Q. Chen and F.H. Arnold, Biotechnology (N Y), 9 (1991) 1073.
- (1991) Biotechnology (N Y) , vol.9 , pp. 1073
- Chen, K.Q.¹ Arnold, F.H.²

134
- 0026124848
- K.Q. Chen, A.C. Robinson, M.E. Van Dam, P. Martinez, C. Economou and F.H. Arnold, Biotechnol. Prog., 7 (1991) 125.
- (1991) Biotechnol. Prog. , vol.7 , pp. 125
- Chen, K.Q.¹ Robinson, A.C.² Van Dam, M.E.³ Martinez, P.⁴ Economou, C.⁵ Arnold, F.H.⁶

135
- 0001050205
- B.C. Cunningham and J.A. Wells, Protein Eng., 1 (1987) 319.
- (1987) Protein Eng. , vol.1 , pp. 319
- Cunningham, B.C.¹ Wells, J.A.²

136
- 0022989294
- P.N. Bryan, M.L. Rollence, M.W. Pantoliano, J. Wood, B.C. Finzel, Gilliland, GL, A.J. Howard and T.L. Poulos, Proteins, 1 (1986) 326.
- (1986) Proteins , vol.1 , pp. 326
- Bryan, P.N.¹ Rollence, M.L.² Pantoliano, M.W.³ Wood, J.⁴ Finzel, B.C.⁵ Gilliland, G.L.⁶ Howard, A.J.⁷ Poulos, T.L.⁸

137
- 0001284457
- S. Riva and A. Klibanov, M. J. Am. Chem. Soc., 110 (1988) 3291.
- (1988) J. Am. Chem. Soc. , vol.110 , pp. 3291
- Riva, S.¹ Klibanov, A.M.²

138
- 33845280481
- S. Riva, J. Chopineau, A. Kieboom, P G and A. Klibanov, M. J. Am. Chem. Soc., 110 (1988) 584.
- (1988) J. Am. Chem. Soc. , vol.110 , pp. 584
- Riva, S.¹ Chopineau, J.² Kieboom, A.P.G.³ Klibanov, A.M.⁴

139
- 0000008747
- A.L. Margolin, P.A. Fitzpatrick, P.L. Dubin and A.M. Klibanov, J. Am. Chem. Soc., 113 (1991) 4693.
- (1991) J. Am. Chem. Soc. , vol.113 , pp. 4693
- Margolin, A.L.¹ Fitzpatrick, P.A.² Dubin, P.L.³ Klibanov, A.M.⁴

140
- 0025831025
- C.H. Wong and K.T. Wang, Experientia, 47 (1991) 1123.
- (1991) Experientia , vol.47 , pp. 1123
- Wong, C.H.¹ Wang, K.T.²

141
- 0027318293
- F.H. Arnold, FASEB J., 7 (1993) 744.
- (1993) FASEB J. , vol.7 , pp. 744
- Arnold, F.H.¹

142
- 85059706241
- L. You and F.H. Arnold, Protein Eng., 9 (1996) 719.
- (1996) Protein Eng. , vol.9 , pp. 719
- You, L.¹ Arnold, F.H.²

143
- 0029670577
- J.C. Moore and F.H. Arnold, Nat. Biotechnol., 14 (1996) 458.
- (1996) Nat. Biotechnol. , vol.14 , pp. 458
- Moore, J.C.¹ Arnold, F.H.²

144
- 0028050350
- W.P. Stemmer, Nature, 370 (1994) 389.
- (1994) Nature , vol.370 , pp. 389
- Stemmer, W.P.¹

145
- 0028110130
- W.P. Stemmer, Proc. Natl. Acad. Sci. USA, 91 (1994) 10747.
- (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 10747
- Stemmer, W.P.¹

146
- 33947547892
- L. Pauling, Chem. Eng. News, 24 (1946) 1375.
- (1946) Chem. Eng. News , vol.24 , pp. 1375
- Pauling, L.¹

147
- 0003408336
- McGraw-Hill Book Company, New York, USA
- W.P. Jencks, in: Catalysis in Chemistry and Enzymology, (McGraw-Hill Book Company, New York, USA, 1969) p. 288.
- (1969) Catalysis in Chemistry and Enzymology , pp. 288
- Jencks, W.P.¹

148
- 0023201967
- A.D. Napper, S.J. Benkovic, A. Tramontano and R.A. Lerner, Science, 237 (1987) 1041.
- (1987) Science , vol.237 , pp. 1041
- Napper, A.D.¹ Benkovic, S.J.² Tramontano, A.³ Lerner, R.A.⁴

149
- 0023759322
- K.D. Janda, D. Schloeder, S.J. Benkovic and R.A. Lerner, Science, 241 (1988) 1188.
- (1988) Science , vol.241 , pp. 1188
- Janda, K.D.¹ Schloeder, D.² Benkovic, S.J.³ Lerner, R.A.⁴

150
- 0024584165
- K.D. Janda, S.J. Benkovic and R.A. Lerner, Science, 244 (1989) 437.
- (1989) Science , vol.244 , pp. 437
- Janda, K.D.¹ Benkovic, S.J.² Lerner, R.A.³

151
- 0023969085
- R.A. Lerner and A. Tramontano, Sci. Am., 258 (1988) 58-60, 65.
- (1988) Sci. Am. , vol.258 , pp. 58-60
- Lerner, R.A.¹ Tramontano, A.²

152
- 0028817877
- P.G. Schultz and R.A. Lerner, Science, 269 (1995) 1835.
- (1995) Science , vol.269 , pp. 1835
- Schultz, P.G.¹ Lerner, R.A.²

153
- 0024845655
- A. Plückthun and A. Skerra, Methods Enzymol., 178 (1989) 497.
- (1989) Methods Enzymol. , vol.178 , pp. 497
- Plückthun, A.¹ Skerra, A.²

154
- 0025699942
- A. Plückthun, Nature, 347 (1990) 497.
- (1990) Nature , vol.347 , pp. 497
- Plückthun, A.¹

155
- 0025835310
- T. Clackson, H.R. Hoogenboom, A.D. Griffiths and G. Winter, Nature, 352 (1991) 624.
- (1991) Nature , vol.352 , pp. 624
- Clackson, T.¹ Hoogenboom, H.R.² Griffiths, A.D.³ Winter, G.⁴

156
- 0024833055
- W.D. Huse, L. Sastry, S.A. Iverson, A.S. Kang, M. Alting-Mees, D.R. Burton, S.J. Benkovic and R.A. Lerner, Science, 246 (1989) 1275.
- (1989) Science , vol.246 , pp. 1275
- Huse, W.D.¹ Sastry, L.² Iverson, S.A.³ Kang, A.S.⁴ Alting-Mees, M.⁵ Burton, D.R.⁶ Benkovic, S.J.⁷ Lerner, R.A.⁸

157
- 0026535931
- H. Gram, LA. Marconi, C.F. Barbas, 3d, T.A. Collet, R.A. Lerner and A.S. Kang, Proc. Natl. Acad. Sci. USA, 89 (1992) 3576.
- (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 3576
- Gram, H.¹ Marconi, L.A.² Barbas C.F. III³ Collet, T.A.⁴ Lerner, R.A.⁵ Kang, A.S.⁶

158
- 0029175543
- R.A. Lerner and K.D. Janda, EXS, 73 (1995) 121.
- (1995) EXS , vol.73 , pp. 121
- Lerner, R.A.¹ Janda, K.D.²

159
- 0029582962
- J.R. Jacobsen and P.G. Schultz, Curr. Opin. Struct. Biol., 5 (1995) 818.
- (1995) Curr. Opin. Struct. Biol. , vol.5 , pp. 818
- Jacobsen, J.R.¹ Schultz, P.G.²

160
- 0028438370
- A. Tramontano, Appl. Biochem. Biotechnol., 47 (1994) 257.
- (1994) Appl. Biochem. Biotechnol. , vol.47 , pp. 257
- Tramontano, A.¹

161
- 4244130640
- eds. R.F. Masseyeff, W.H. Albert and N.A. Staines VCH-Verlag, Weinheim
- A. Plückthun, in: Methods of Immunological Analysis, eds. R.F. Masseyeff, W.H. Albert and N.A. Staines (VCH-Verlag, Weinheim, 1993) p. 414.
- (1993) Methods of Immunological Analysis , pp. 414
- Plückthun, A.¹

162
- 0028330751
- C.R. Hutchinson, Biotechnology (N Y), 12 (1994) 375.
- (1994) Biotechnology (N Y) , vol.12 , pp. 375
- Hutchinson, C.R.¹

163
- 0026696678
- G.W. Huffman, P.D. Gesellchen, J.R. Turner, R.B. Rothenberger, H.E. Osborne, F.D. Miller, J.L. Chapman and S.W. Queener, J. Med. Chem., 35 (1992) 1897.
- (1992) J. Med. Chem. , vol.35 , pp. 1897
- Huffman, G.W.¹ Gesellchen, P.D.² Turner, J.R.³ Rothenberger, R.B.⁴ Osborne, H.E.⁵ Miller, F.D.⁶ Chapman, J.L.⁷ Queener, S.W.⁸

164
- 0026031407
- J.E. Baldwin, G.P. Lynch and J. Pitlik, J. Antibiot., 44 (1991) 1.
- (1991) J. Antibiot. , vol.44 , pp. 1
- Baldwin, J.E.¹ Lynch, G.P.² Pitlik, J.³

165
- 0026741927
- O. Hara and C.R. Hutchinson, J. Bacteriol., 174 (1992) 5141.
- (1992) J. Bacteriol. , vol.174 , pp. 5141
- Hara, O.¹ Hutchinson, C.R.²

166
- 0024796844
- J.K. Epp, M.L. Huber, J.R. Turner, T. Goodson and B.E. Schoner, Gene, 85 (1989) 293.
- (1989) Gene , vol.85 , pp. 293
- Epp, J.K.¹ Huber, M.L.² Turner, J.R.³ Goodson, T.⁴ Schoner, B.E.⁵

167
- 0027455631
- D. Stassi, S. Donadio, M.J. Staver and L. Katz, J. Bacteriol., 175 (1993) 182.
- (1993) J. Bacteriol. , vol.175 , pp. 182
- Stassi, D.¹ Donadio, S.² Staver, M.J.³ Katz, L.⁴

168
- 0026588622
- R.G. Summers, E. Wendt-Pienkowski, H. Motamedi and C.R. Hutchinson, J. Bacteriol., 174 (1992) 1810.
- (1992) J. Bacteriol. , vol.174 , pp. 1810
- Summers, R.G.¹ Wendt-Pienkowski, E.² Motamedi, H.³ Hutchinson, C.R.⁴

169
- 0027243104
- H. Decker, H. Motamedi and C.R. Hutchinson, J. Bacteriol., 175 (1993) 3876.
- (1993) J. Bacteriol. , vol.175 , pp. 3876
- Decker, H.¹ Motamedi, H.² Hutchinson, C.R.³

170
- 0027229139
- K. Madduri, F. Torti, A.L. Colombo and C.R. Hutchinson, J. Bacteriol., 175 (1993) 3900.
- (1993) J. Bacteriol. , vol.175 , pp. 3900
- Madduri, K.¹ Torti, F.² Colombo, A.L.³ Hutchinson, C.R.⁴

171
- 0025999536
- S.F. Haydock, J.A. Dowson, N. Dhillon, G.A. Roberts, J. Cortes and P.F. Leadlay, Mol. Gen. Genet., 230 (1991) 120.
- (1991) Mol. Gen. Genet. , vol.230 , pp. 120
- Haydock, S.F.¹ Dowson, J.A.² Dhillon, N.³ Roberts, G.A.⁴ Cortes, J.⁵ Leadlay, P.F.⁶

172
- 0027413467
- R.H. Proctor and T.M. Hohn, J. Biol. Chem., 268 (1993) 4543.
- (1993) J. Biol. Chem. , vol.268 , pp. 4543
- Proctor, R.H.¹ Hohn, T.M.²

173
- 0027326096
- D.E. Cane, Z. Wu, J.S. Oliver and T.M. Hohn, Arch. Biochem. Biophys., 300 (1993) 416.
- (1993) Arch. Biochem. Biophys. , vol.300 , pp. 416
- Cane, D.E.¹ Wu, Z.² Oliver, J.S.³ Hohn, T.M.⁴

174
- 0030249160
- C. Khosla and R. Zawada, J X. Trends. Biotechnol., 14 (1996) 335.
- (1996) J X. Trends. Biotechnol. , vol.14 , pp. 335
- Khosla, C.¹ Zawada, R.²

175
- 0025606149
- D.A. Hopwood and D.H. Sherman, Annu. Rev. Genet., 24 (1990) 37.
- (1990) Annu. Rev. Genet. , vol.24 , pp. 37
- Hopwood, D.A.¹ Sherman, D.H.²

176
- 0027382486
- L. Katz and S. Donadio, Annu. Rev. Microbiol., 47 (1993) 875.
- (1993) Annu. Rev. Microbiol. , vol.47 , pp. 875
- Katz, L.¹ Donadio, S.²

177
- 0027024882
- D.A. Hopwood and C. Khosla, Ciba. Found. Symp., 171 (1992) 88.
- (1992) Ciba. Found. Symp. , vol.171 , pp. 88
- Hopwood, D.A.¹ Khosla, C.²

178
- 0027445230
- D.A. Hopwood, Curr. Opin. Biotechnol., 4 (1993) 531.
- (1993) Curr. Opin. Biotechnol. , vol.4 , pp. 531
- Hopwood, D.A.¹

179
- 0028811381
- C.R. Hutchinson and I. Fujii, Annu. Rev. Microbiol., 49 (1995) 201.
- (1995) Annu. Rev. Microbiol. , vol.49 , pp. 201
- Hutchinson, C.R.¹ Fujii, I.²

180
- 0021844476
- D.A. Hopwood, F. Malpartida, H.M. Kieser, H. Ikeda, J. Duncan, I. Fujii, B.A. Rudd, H.G. Floss and S. Omura, Nature, 314 (1985) 642.
- (1985) Nature , vol.314 , pp. 642
- Hopwood, D.A.¹ Malpartida, F.² Kieser, H.M.³ Ikeda, H.⁴ Duncan, J.⁵ Fujii, I.⁶ Rudd, B.A.⁷ Floss, H.G.⁸ Omura, S.⁹

181
- 0027908014
- R. McDaniel, S. Ebert-Khosla, D.A. Hopwood and C. Khosla, Science, 262 (1993) 1546.
- (1993) Science , vol.262 , pp. 1546
- McDaniel, R.¹ Ebert-Khosla, S.² Hopwood, D.A.³ Khosla, C.⁴

182
- 0027932534
- L.R. Kao, L. Katz and C. Khosla, Science, 265 (1994) 509.
- (1994) Science , vol.265 , pp. 509
- Kao, L.R.¹ Katz, L.² Khosla, C.³

183
- 0029161160
- D.J. Bedford, E. Schweizer, D.A. Hopwood and C. Khosla, J. Bacteriol., 177 (1995) 4544.
- (1995) J. Bacteriol. , vol.177 , pp. 4544
- Bedford, D.J.¹ Schweizer, E.² Hopwood, D.A.³ Khosla, C.⁴

184
- 0020116564
- Y. Husimi, K. Nishigaki, Y. Kinoshita and T. Tanaka, Rev. Sci. Instrum., 53 (1982) 517.
- (1982) Rev. Sci. Instrum. , vol.53 , pp. 517
- Husimi, Y.¹ Nishigaki, K.² Kinoshita, Y.³ Tanaka, T.⁴

185
- 0006046737
- Y. Husimi and H.-C. Keweloh, Rev. Sci. Instrum., 58 (1987) 1109.
- (1987) Rev. Sci. Instrum. , vol.58 , pp. 1109
- Husimi, Y.¹ Keweloh, H.-C.²

186
- 13344260698
- A. Schwienhorst, B. Lindemann, F and M. Eigen, Biotechnol. Bioeng., 50 (1996) 217.
- (1996) Biotechnol. Bioeng. , vol.50 , pp. 217
- Schwienhorst, A.¹ Lindemann, B.F.² Eigen, M.³

187
- 0343387220
- unpublished results
- U. Kettling, unpublished results.
- Kettling, U.¹

188
- 0027238226
- J.S. McCaskill and G.J. Bauer, Proc. Natl. Acad. Sci. USA, 90 (1993) 4191.
- (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 4191
- McCaskill, J.S.¹ Bauer, G.J.²

189
- 0000024369
- G.J. Bauer, J.S. McCaskill and H. Otten, Proc. Natl. Acad. Sci. USA, 86 (1989) 7937.
- (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 7937
- Bauer, G.J.¹ McCaskill, J.S.² Otten, H.³

190
- 0027956149
- N. Walter, G and G. Strunk, Proc. Natl. Acad. Sci. USA, 91 (1994) 7937.
- (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 7937
- Walter, N.G.¹ Strunk, G.²

191
- 0342517622
- this issue
- G. Strunk and T. Ederhof, this issue.
- Strunk, G.¹ Ederhof, T.²

192
- 0028986229
- A. Schober, N.G. Walter, U. Tangen, G. Strunk, T. Ederhof, J. Dapprich and M. Eigen, Biotechniques, 18 (1995) 652.
- (1995) Biotechniques , vol.18 , pp. 652
- Schober, A.¹ Walter, N.G.² Tangen, U.³ Strunk, G.⁴ Ederhof, T.⁵ Dapprich, J.⁶ Eigen, M.⁷

193
- 0343387219
- in press
- A. Schober, R. Günther, U. Tangen, G. Goldmann, T. Ederhof, A. Koltermann, A. Wienecke, A. Schwienhorst and M. Eigen, Rev. Sci. Instrum., (1997) (in press).
- (1997) Rev. Sci. Instrum.
- Schober, A.¹ Günther, R.² Tangen, U.³ Goldmann, G.⁴ Ederhof, T.⁵ Koltermann, A.⁶ Wienecke, A.⁷ Schwienhorst, A.⁸ Eigen, M.⁹

194
- 0028229903
- M. Eigen and R. Rigler, Proc. Natl. Acad. Sci. USA, 91 (1994) 5740.
- (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5740
- Eigen, M.¹ Rigler, R.²

195
- 0342951799
- this issue
- P. Schwille, J. Bieschke and F. Oehlenschläger, this issue.
- Schwille, P.¹ Bieschke, J.² Oehlenschläger, F.³

196
- 0342951800
- this issue
- M. Brinkmeier, K. Dörre, K. Riebeseel and R. Rigler, this issue.
- Brinkmeier, M.¹ Dörre, K.² Riebeseel, K.³ Rigler, R.⁴

197
- 85176206406
- J.R. Broach and J. Thorner, Nature, 384 (1996) 14.
- (1996) Nature , vol.384 , pp. 14
- Broach, J.R.¹ Thorner, J.²

198
- 0031016380
- S. Sterrer and K. Henco, J. Recept. Signal. Transduct. Res., 17 (1997) 511.
- (1997) J. Recept. Signal. Transduct. Res. , vol.17 , pp. 511
- Sterrer, S.¹ Henco, K.²

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