-
1
-
-
0029680343
-
Unnatural nucleotide sequences in biopharmaceutics
-
Loeb, L.A., Unnatural nucleotide sequences in biopharmaceutics, Adv. Pharmacol., 35 (1996) 321-347.
-
(1996)
Adv. Pharmacol.
, vol.35
, pp. 321-347
-
-
Loeb, L.A.1
-
2
-
-
0014107493
-
An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule
-
Mills, D.R., Peterson, R.L. and Spiegelman, S., An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule, Proc. Natl. Acad. Sci. USA, 58 (1967) 217-224.
-
(1967)
Proc. Natl. Acad. Sci. USA
, vol.58
, pp. 217-224
-
-
Mills, D.R.1
Peterson, R.L.2
Spiegelman, S.3
-
3
-
-
0024476917
-
RNA evolution and the origins of life
-
Joyce, G.F., RNA evolution and the origins of life, Nature, 338 (1989) 217-224.
-
(1989)
Nature
, vol.338
, pp. 217-224
-
-
Joyce, G.F.1
-
4
-
-
0025074907
-
In vitro selection of RNA molecules that bind specific ligands
-
Ellington, A.D. and Szostak, J.W., In vitro selection of RNA molecules that bind specific ligands, Nature, 34 (1990) 818-822.
-
(1990)
Nature
, vol.34
, pp. 818-822
-
-
Ellington, A.D.1
Szostak, J.W.2
-
5
-
-
0025194307
-
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
-
Tuerk, C. and Gold, L., Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase, Science, 249 (1990) 505-510.
-
(1990)
Science
, vol.249
, pp. 505-510
-
-
Tuerk, C.1
Gold, L.2
-
6
-
-
0026575221
-
Selection of single-stranded DNA molecules that bind and inhibit human thrombin
-
Bock, L.C., Griffin, L.C., Latham, J.A., Vermaas, E.H. and Toole, J.J., Selection of single-stranded DNA molecules that bind and inhibit human thrombin, Nature, 355 (1992) 564-566.
-
(1992)
Nature
, vol.355
, pp. 564-566
-
-
Bock, L.C.1
Griffin, L.C.2
Latham, J.A.3
Vermaas, E.H.4
Toole, J.J.5
-
7
-
-
0345976511
-
Selective amplification techniques for optimization of ribozyme function
-
Murray, J.A.H. (Ed.) Wiley-Liss, New York, NY, U.S.A.
-
Joyce, G.F., Selective amplification techniques for optimization of ribozyme function, In Murray, J.A.H. (Ed.) Antisense RNA and DNA, Wiley-Liss, New York, NY, U.S.A., 1992, pp. 353-372.
-
(1992)
Antisense RNA and DNA
, pp. 353-372
-
-
Joyce, G.F.1
-
8
-
-
0027525989
-
Evolution in vitro of an RNA enzyme with altered metal dependence
-
Lehman, N. and Joyce, G.F., Evolution in vitro of an RNA enzyme with altered metal dependence, Nature, 361 (1993) 182-185.
-
(1993)
Nature
, vol.361
, pp. 182-185
-
-
Lehman, N.1
Joyce, G.F.2
-
9
-
-
0027137780
-
Evolution in vitro: Analysis of a lineage of ribozymes
-
Lehman, N. and Joyce, G.F., Evolution in vitro: Analysis of a lineage of ribozymes, Curr. Biol., 3 (1993) 723-734.
-
(1993)
Curr. Biol.
, vol.3
, pp. 723-734
-
-
Lehman, N.1
Joyce, G.F.2
-
10
-
-
0027180473
-
An RNA motif that binds ATP
-
Sassanfar, M. and Szostak, J.W., An RNA motif that binds ATP, Nature, 364 (1993) 550-553.
-
(1993)
Nature
, vol.364
, pp. 550-553
-
-
Sassanfar, M.1
Szostak, J.W.2
-
11
-
-
0028911845
-
In vitro evolution of a self-alkylating ribozyme
-
Wilson, C. and Szostak, J.W., In vitro evolution of a self-alkylating ribozyme, Nature, 374 (1995) 777-782.
-
(1995)
Nature
, vol.374
, pp. 777-782
-
-
Wilson, C.1
Szostak, J.W.2
-
12
-
-
0025112794
-
Searching for peptide ligands with an epitope library
-
Scott, J.K. and Smith, G.P., Searching for peptide ligands with an epitope library, Science, 249 (1990) 386-390.
-
(1990)
Science
, vol.249
, pp. 386-390
-
-
Scott, J.K.1
Smith, G.P.2
-
13
-
-
0025730616
-
At the crossroads of chemistry and immunology: Catalytic antibodies
-
Lerner, R.A., Benkovic, S.J. and Schultz, P.G., At the crossroads of chemistry and immunology: Catalytic antibodies, Science, 252 (1991) 659-667.
-
(1991)
Science
, vol.252
, pp. 659-667
-
-
Lerner, R.A.1
Benkovic, S.J.2
Schultz, P.G.3
-
14
-
-
0025978976
-
Man-made antibodies
-
Winter, G. and Milstein, C., Man-made antibodies, Nature, 349 (1991) 293-299.
-
(1991)
Nature
, vol.349
, pp. 293-299
-
-
Winter, G.1
Milstein, C.2
-
15
-
-
0027199771
-
Direct selection of antibodies that coordinate metals from semisynthetic combinatorial libraries
-
Barbas III, C.F., Rosenblum, J.S. and Lerner, R.A., Direct selection of antibodies that coordinate metals from semisynthetic combinatorial libraries, Proc. Natl. Acad. Sci. USA, 90 (1993) 6385-6389.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 6385-6389
-
-
Barbas III, C.F.1
Rosenblum, J.S.2
Lerner, R.A.3
-
16
-
-
3242742774
-
Promoters selected from random DNA sequences
-
Horwitz, M.S.Z. and Loeb, L.A., Promoters selected from random DNA sequences, Proc. Natl. Acad. Sci. USA, 83 (1986) 7405-7409.
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 7405-7409
-
-
Horwitz, M.S.Z.1
Loeb, L.A.2
-
17
-
-
0023949179
-
Combinatorial cassette mutagenesis as a probe of the informational content of protein sequences
-
Reidhaar-Olson, J.F. and Sauer, R.T., Combinatorial cassette mutagenesis as a probe of the informational content of protein sequences, Science, 241 (1988) 53-57.
-
(1988)
Science
, vol.241
, pp. 53-57
-
-
Reidhaar-Olson, J.F.1
Sauer, R.T.2
-
18
-
-
0027731712
-
Selection of new biologically active molecules from random nucleotide sequences
-
Dube, D.K., Black, M.E., Munir, K.M. and Loeb, L.A., Selection of new biologically active molecules from random nucleotide sequences, Gene, 137 (1993) 41-47.
-
(1993)
Gene
, vol.137
, pp. 41-47
-
-
Dube, D.K.1
Black, M.E.2
Munir, K.M.3
Loeb, L.A.4
-
19
-
-
0024309854
-
Mutants generated by the insertion of random oligonucleotides into the active site of the β-lactamase gene
-
Dube, D.K. and Loeb, L.A., Mutants generated by the insertion of random oligonucleotides into the active site of the β-lactamase gene, Biochemistry, 28 (1989) 5703-5707.
-
(1989)
Biochemistry
, vol.28
, pp. 5703-5707
-
-
Dube, D.K.1
Loeb, L.A.2
-
20
-
-
0026646614
-
Permissible amino acid substitutions within the putative nucleoside binding site of herpes simplex virus type 1 encoded thymidine kinase established by random sequence mutagenesis
-
Munir, K.M., French, D.C., Dube, D.K. and Loeb, L.A., Permissible amino acid substitutions within the putative nucleoside binding site of herpes simplex virus type 1 encoded thymidine kinase established by random sequence mutagenesis, J. Biol. Chem., 267 (1992) 6584-6589.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 6584-6589
-
-
Munir, K.M.1
French, D.C.2
Dube, D.K.3
Loeb, L.A.4
-
21
-
-
0027501570
-
Identification of important residues within the putative nucleoside binding site of HSV-1 thymidine kinase by random sequence selection: Analysis of selected mutants in vitro
-
Black, M.E. and Loeb, L.A., Identification of important residues within the putative nucleoside binding site of HSV-1 thymidine kinase by random sequence selection: Analysis of selected mutants in vitro. Biochemistry, 32 (1993) 11618-11626.
-
(1993)
Biochemistry
, vol.32
, pp. 11618-11626
-
-
Black, M.E.1
Loeb, L.A.2
-
22
-
-
0027192014
-
Thymidine kinase mutants obtained by random sequence selection
-
Munir, K.M., French, D.C. and Loeb, L.A., Thymidine kinase mutants obtained by random sequence selection, Proc. Natl. Acad. Sci. USA, 90 (1993) 4012-4016.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 4012-4016
-
-
Munir, K.M.1
French, D.C.2
Loeb, L.A.3
-
23
-
-
0029883624
-
Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy
-
Black, M.E., Newcomb, T.G., Wilson, H.-M.P. and Loeb, L.A., Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy, Proc. Natl. Acad. Sci. USA, 93 (1996) 3525-3529.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 3525-3529
-
-
Black, M.E.1
Newcomb, T.G.2
Wilson, H.-M.P.3
Loeb, L.A.4
-
24
-
-
0029981387
-
Human immunodeficiency virus reverse transcriptase: Functional mutants obtained by random mutagenesis coupled with genetic selection in Escherichia coli
-
Kim, B., Hathaway, T.R. and Loeb, L.A., Human immunodeficiency virus reverse transcriptase: Functional mutants obtained by random mutagenesis coupled with genetic selection in Escherichia coli, J. Biol. Chem., 271 (1996) 4872-4878.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 4872-4878
-
-
Kim, B.1
Hathaway, T.R.2
Loeb, L.A.3
-
25
-
-
0029845979
-
Random mutagenesis of Thermus aquaticus DNA polymerase I: Concordance of immutable sties in vivo with the crystal structure
-
in press
-
Suzuki, M., Baskin, D., Hood, L. and Loeb, L.A., Random mutagenesis of Thermus aquaticus DNA polymerase I: Concordance of immutable sties in vivo with the crystal structure, Proc. Natl. Acad. Sci. USA, (1996) in press.
-
(1996)
Proc. Natl. Acad. Sci. USA
-
-
Suzuki, M.1
Baskin, D.2
Hood, L.3
Loeb, L.A.4
-
26
-
-
0029929724
-
Novel human DNA alkyltransferases obtained by random substitution and genetic selection in bacteria
-
Christians, F.C. and Loeb, L.A., Novel human DNA alkyltransferases obtained by random substitution and genetic selection in bacteria, Proc. Natl. Acad. Sci. USA, 93 (1996) 6124-6128.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 6124-6128
-
-
Christians, F.C.1
Loeb, L.A.2
-
27
-
-
0028110130
-
DNA shuffling by random fragmentation and reassembly: In vitro recombination for molecular evolution
-
Stemmer, W.P., DNA shuffling by random fragmentation and reassembly: In vitro recombination for molecular evolution, Proc. Natl. Acad. Sci. USA, 91 (1994) 10747-10751.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 10747-10751
-
-
Stemmer, W.P.1
-
28
-
-
0028050350
-
Rapid evolution of a protein in vitro by DNA shuffling
-
Stemmer, W.P., Rapid evolution of a protein in vitro by DNA shuffling, Nature, 370 (1994) 389-391.
-
(1994)
Nature
, vol.370
, pp. 389-391
-
-
Stemmer, W.P.1
-
29
-
-
0028878167
-
Human immunodeficiency virus reverse transcriptase substitutes for DNA polymerase I in Escherichia coli
-
Kim, B. and Loeb, L.A., Human immunodeficiency virus reverse transcriptase substitutes for DNA polymerase I in Escherichia coli, Proc. Natl. Acad. Sci. USA, 92 (1995) 684-688.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 684-688
-
-
Kim, B.1
Loeb, L.A.2
-
30
-
-
0025040632
-
An attempt to unify the structure of polymerases
-
Delarue, M., Poch, O., Tordo, N., Moras, D. and Argos, P., An attempt to unify the structure of polymerases, Protein Eng., 3 (1990) 461-467.
-
(1990)
Protein Eng.
, vol.3
, pp. 461-467
-
-
Delarue, M.1
Poch, O.2
Tordo, N.3
Moras, D.4
Argos, P.5
-
31
-
-
0025898648
-
A general structure for DNA-dependent DNA polymerases [published erratum appeared in Gene, 108 (1991) 165]
-
Blanco, L., Bernad, A., Blasco, M.A. and Salas, M., A general structure for DNA-dependent DNA polymerases [published erratum appeared in Gene, 108 (1991) 165], Gene, 100 (1991) 27-38.
-
(1991)
Gene
, vol.100
, pp. 27-38
-
-
Blanco, L.1
Bernad, A.2
Blasco, M.A.3
Salas, M.4
-
32
-
-
0027217643
-
Compilation, alignment, and phylogenetic relationships of DNA polymerases
-
Braithwaite, D.K. and Ito, J., Compilation, alignment, and phylogenetic relationships of DNA polymerases, Nucleic Acids Res., 21 (1993) 787-802.
-
(1993)
Nucleic Acids Res.
, vol.21
, pp. 787-802
-
-
Braithwaite, D.K.1
Ito, J.2
-
33
-
-
0020490301
-
Nucleotide sequence of the Escherichia coli pol a gene and primary structure of DNA polymerase I
-
Joyce, C.M., Kelley, W.S. and Grindley, N.D., Nucleotide sequence of the Escherichia coli pol A gene and primary structure of DNA polymerase I, J. Biol. Chem., 257 (1982) 1958-1964.
-
(1982)
J. Biol. Chem.
, vol.257
, pp. 1958-1964
-
-
Joyce, C.M.1
Kelley, W.S.2
Grindley, N.D.3
-
34
-
-
0024560060
-
Isolation, characterization, and expression in Escherichia coli of the DNA polymerase gene from Thermus aquaticus
-
Lawyer, F.C., Stoffel, S., Saiki, R.K., Myambo, K., Drummond, R. and Gelfand, D.H., Isolation, characterization, and expression in Escherichia coli of the DNA polymerase gene from Thermus aquaticus, J. Biol. Chem., 264 (1989) 6427-6437.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 6427-6437
-
-
Lawyer, F.C.1
Stoffel, S.2
Saiki, R.K.3
Myambo, K.4
Drummond, R.5
Gelfand, D.H.6
-
35
-
-
0021984004
-
Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP
-
Ollis, D.L., Brick, P., Hamlin, R., Xuong, N.G. and Steitz, T.A., Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP, Nature, 313 ( 1985) 762-766.
-
(1985)
Nature
, vol.313
, pp. 762-766
-
-
Ollis, D.L.1
Brick, P.2
Hamlin, R.3
Xuong, N.G.4
Steitz, T.A.5
-
36
-
-
0028983795
-
Crystal structure of Thermus aquaticus DNA polymerase
-
Kim, Y., Eom, S.H., Wang, J., Lee, D.-S., Suh, S.W. and Steitz, T.A., Crystal structure of Thermus aquaticus DNA polymerase, Nature, 376 (1995) 612-616.
-
(1995)
Nature
, vol.376
, pp. 612-616
-
-
Kim, Y.1
Eom, S.H.2
Wang, J.3
Lee, D.-S.4
Suh, S.W.5
Steitz, T.A.6
-
37
-
-
0029056926
-
Crystal structure of the large fragment of Thermus aquaticus DNA polymerase I at 2.5-angstrom resolution: Structural basis for thermostability
-
Korolev, S., Nayal, M., Barnes, W.M., DiCera, E. and Waksman, G., Crystal structure of the large fragment of Thermus aquaticus DNA polymerase I at 2.5-angstrom resolution: Structural basis for thermostability, Proc. Natl. Acad. Sci. USA, 92 (1995) 9264-9268.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 9264-9268
-
-
Korolev, S.1
Nayal, M.2
Barnes, W.M.3
DiCera, E.4
Waksman, G.5
-
38
-
-
0026772206
-
In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
-
Culver, K.W., Ram, Z., Wallbridge, S., Ishii, H., Oldfield, E.H. and Blaese, R.M., In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors, Science, 256 (1992) 1550-1552.
-
(1992)
Science
, vol.256
, pp. 1550-1552
-
-
Culver, K.W.1
Ram, Z.2
Wallbridge, S.3
Ishii, H.4
Oldfield, E.H.5
Blaese, R.M.6
-
39
-
-
0025640814
-
Herpes-viral deoxythymidine kinases contain a site analogous to the phosphoryl-binding arginine-rich region of porcine adenylate kinase; comparison of secondary structure predictions and conservation
-
Balasubramaniam, N.K., Veerisetty, V. and Gentry, G.A., Herpes-viral deoxythymidine kinases contain a site analogous to the phosphoryl-binding arginine-rich region of porcine adenylate kinase; comparison of secondary structure predictions and conservation, J. Gen. Virol., 71 (1990) 2979-2987.
-
(1990)
J. Gen. Virol.
, vol.71
, pp. 2979-2987
-
-
Balasubramaniam, N.K.1
Veerisetty, V.2
Gentry, G.A.3
-
40
-
-
0028206048
-
Function and structure relationships in DNA polymerases
-
Joyce, C.M. and Steitz, T.A., Function and structure relationships in DNA polymerases, Annu. Rev. Biochem., 63 (1994) 777-822.
-
(1994)
Annu. Rev. Biochem.
, vol.63
, pp. 777-822
-
-
Joyce, C.M.1
Steitz, T.A.2
-
41
-
-
0028010888
-
Hhal methyltransferase flips its target base out of the DNA helix
-
Klimasauskas, S., Kumar, S., Roberts, R.J. and Cheng, X., Hhal methyltransferase flips its target base out of the DNA helix, Cell, 76 (1994) 357-369.
-
(1994)
Cell
, vol.76
, pp. 357-369
-
-
Klimasauskas, S.1
Kumar, S.2
Roberts, R.J.3
Cheng, X.4
-
42
-
-
0029068629
-
The crystal structure of HaeIII methyltransferase covalently complexed to DNA: An extrahelical cytosine and rearranged base pairing
-
Reinisch, K.M., Chen, L., Verdine, G.L. and Lipscomb, W.N., The crystal structure of HaeIII methyltransferase covalently complexed to DNA: An extrahelical cytosine and rearranged base pairing, Cell, 82 (1995) 143-153.
-
(1995)
Cell
, vol.82
, pp. 143-153
-
-
Reinisch, K.M.1
Chen, L.2
Verdine, G.L.3
Lipscomb, W.N.4
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