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Bennett KL, Modrell B, Greenfield B, Bartolazzi A, Stamenkovic I, Peach R, Jackson DG, Spring F, Aruffo A. Regulation of CD44 binding to hyaluronan by glycosylation of variably spliced exons. J Cell Biol. 131:1995;1623-1633.
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Glycosylation: Heterogeneity and the 3D structure of proteins
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of outstanding interest. A comprehensive review on the current understanding of the factors that control glycosylated variants of a single polypeptide. The authors illustrate, using several examples, the putative role that such heterogeneity may have in specific biological interactions.
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Rudd PM, Dwek RA. Glycosylation: heterogeneity and the 3D structure of proteins. of outstanding interest Crit Rev Biochem Mol Biol. 32:1997;1-100 A comprehensive review on the current understanding of the factors that control glycosylated variants of a single polypeptide. The authors illustrate, using several examples, the putative role that such heterogeneity may have in specific biological interactions.
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Palmitoylation: A post-translational modification that regulates signalling from G-protein coupled receptors
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of special interest. This review discusses the biological importance of the dynamic palmitoylation of G-protein-coupled receptors and their cognate G proteins and geranylgeranylation of G proteins in receptor phosphorylation and desensitization.
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Morello JP, Bouvier M. Palmitoylation: a post-translational modification that regulates signalling from G-protein coupled receptors. of special interest Biochem Cell Biol. 74:1996;449-457 This review discusses the biological importance of the dynamic palmitoylation of G-protein-coupled receptors and their cognate G proteins and geranylgeranylation of G proteins in receptor phosphorylation and desensitization.
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Kawate N, Peegel H, Menon KM. Role of palmitoylation of conserved cysteine residues of luteinizing hormone/human choriogonadotropin receptors in receptor down-regulation. Mol Cell Endocrinol. 127:1997;211-219.
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Horstmeyer A, Cramer H, Sauer T, Muller-Esterl W, Schroeder C. Palmitoylation of endothelin receptor A. Differential modulation of signal transduction activity by post-translational modification. J Biol Chem. 271:1996;20811-20819.
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Palmitoylation of muscarinic acetylcholine receptor m2 subtypes: Reduction in their ability to activate G proteins by mutation of a putative palmitoylation site, cysteine 457, in the carboxyl-terminal tail
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Hayashi MK, Haga T. Palmitoylation of muscarinic acetylcholine receptor m2 subtypes: reduction in their ability to activate G proteins by mutation of a putative palmitoylation site, cysteine 457, in the carboxyl-terminal tail. Arch Biochem Biophys. 340:1997;376-382.
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of outstanding interest. The authors give a detailed review on one of the first small molecule inhibitors rationally designed based on studies of oncogenes that might advance to a novel cancer therapeutic. The article covers structures of farnesyl transferase inhibitors, their efficacy and selectivity for tumour cells in vitro and in vivo. It also addresses issues on other biological activities and limitations of these inhibitors.
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Gibbs JB, Oliff A. The potential of farnesyltransferase inhibitors as cancer chemotherapeutics. of outstanding interest Annu Rev Pharmacol Toxicol. 37:1997;143-166 The authors give a detailed review on one of the first small molecule inhibitors rationally designed based on studies of oncogenes that might advance to a novel cancer therapeutic. The article covers structures of farnesyl transferase inhibitors, their efficacy and selectivity for tumour cells in vitro and in vivo. It also addresses issues on other biological activities and limitations of these inhibitors.
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Oncoprotein networks
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of outstanding interest. This review discusses principles of cell regulation through recent examples of oncoproteins and tumour suppressor proteins to illustrate a regulatory network of growth factor- and growth inhibitory-initiated signaling pathways whose imbalance are a fundamental cause of cancer. The paper also clarifies the important principle of protein-tyrosine kinase dimerization in their activation process. Furthermore, it stresses the important role of the rho family and small G proteins, the cytoskeleton and the mitogen-activated protein kinase pathway in cellular transformation.
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Hunter T. Oncoprotein networks. of outstanding interest Cell. 88:1997;333-346 This review discusses principles of cell regulation through recent examples of oncoproteins and tumour suppressor proteins to illustrate a regulatory network of growth factor- and growth inhibitory-initiated signaling pathways whose imbalance are a fundamental cause of cancer. The paper also clarifies the important principle of protein-tyrosine kinase dimerization in their activation process. Furthermore, it stresses the important role of the rho family and small G proteins, the cytoskeleton and the mitogen-activated protein kinase pathway in cellular transformation.
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Cell
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Hunter, T.1
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of special interest. of outstanding interest. The article complements the review by Hunter, 1997 [13], and adds another layer of complexicity to regulation through protein phosphorylation. It surveys the increasing list of proteins targeting protein phosphatase 1 and 2 A, protein kinase C (PKC), PKC substrates, activated PKC, protein kinase A and multi-enzyme signaling complexes to a particular cellular compartment.
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of special interest Faux MC, Scott JD. More on target with protein phosphorylation: conferring specificity by location. of outstanding interest Trends Biochem Sci. 21:1996;312-315 The article complements the review by Hunter, 1997 [13], and adds another layer of complexicity to regulation through protein phosphorylation. It surveys the increasing list of proteins targeting protein phosphatase 1 and 2 A, protein kinase C (PKC), PKC substrates, activated PKC, protein kinase A and multi-enzyme signaling complexes to a particular cellular compartment.
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Li S, Couet J, Lisanti MP. Src tyrosine kinases, Gα subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J Biol Chem. 271:1996;29182-29190.
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of special interest. The focal point of this paper is apoptosis controlled by cytokines and compares the signal cascade of the two death factors Fas ligand and tumor necrosis factor and their receptors. It also summarises the downstream cascade of interleukin-1β converting enzyme proteases and describes Fas mediated killing during activation induced suicide of T-cells, CTL-mediated killing of target cells and killing of inflammatory cells in immune privilege sites.
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Nagata S. Apoptosis by death factor. of special interest Cell. 88:1997;355-365 The focal point of this paper is apoptosis controlled by cytokines and compares the signal cascade of the two death factors Fas ligand and tumor necrosis factor and their receptors. It also summarises the downstream cascade of interleukin-1β converting enzyme proteases and describes Fas mediated killing during activation induced suicide of T-cells, CTL-mediated killing of target cells and killing of inflammatory cells in immune privilege sites.
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of outstanding interest. The role of dynamic O-GlcNAcylation of cystosolic and nuclear proteins is examined and its implication in transcriptional initiation, cytoskeletal assembly and organization are discussed. A model of a reciprocal relationship between phosphorylation of a hydroxyl moiety and its O-GlcNAcylation is illustrated on c-myc and is being discussed based on examples of protein post-translational modifications in mitogen activated lymphocytes.
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of outstanding interest. p53 is the most extensively studied tumour suppressor gene product. This paper lists p53-regulated genes with known or suspected growth regulatory properties. A survey of wild-type p53 and p53 mutations in various cancers and strategies for restoring lost p53 function exemplifies how recently discovered structural and biochemical properties of p53 have led to novel therapeutic strategies.
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Beaudry GA, Bertelsen AH, Sherman MI. Therapeutic targeting of the p53 tumor suppressor gene. of outstanding interest Curr Opin Biotechnol. 7:1996;592-600 p53 is the most extensively studied tumour suppressor gene product. This paper lists p53-regulated genes with known or suspected growth regulatory properties. A survey of wild-type p53 and p53 mutations in various cancers and strategies for restoring lost p53 function exemplifies how recently discovered structural and biochemical properties of p53 have led to novel therapeutic strategies.
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of outstanding interest. This article reviews the mechanism of action and pharmacology of various inhibitors of interleukin-β converting enzymes (ICE) and related proteases as a new strategy to treat chronic inflammatory and neurodegenerative diseases.
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Livingston DJ. In vitro and in vivo studies of ICE inhibitors. of outstanding interest J Cell Biochem. 64:1997;19-26 This article reviews the mechanism of action and pharmacology of various inhibitors of interleukin-β converting enzymes (ICE) and related proteases as a new strategy to treat chronic inflammatory and neurodegenerative diseases.
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J Cell Biochem
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