Bacterial toxins that target rho proteins

Journal of Clinical Investigation

Volumn 99, Issue 5, 1997, Pages 827-829

  Aktories, Klaus ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN; CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; CLOSTRIDIUM TOXIN; GUANOSINE TRIPHOSPHATASE; RAS PROTEIN; TRANSCRIPTION TERMINATION FACTOR RHO; UNCLASSIFIED DRUG;

ADENOSINE DIPHOSPHATE RIBOSYLATION; BACTERIAL INFECTION; CYTOPATHOGENIC EFFECT; DIARRHEA; ENTEROCOLITIS; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; PROTEIN TARGETING; REVIEW;

EID: 0031003475     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119245     Document Type: Review

References (10)

1. Machesky, L.M., and A. Hall. 1996. Rho: a connection between membrane receptor signalling and the cytoskeleton. Trends Cell Biol. 6:304-310.
2. Aktories, K., C. Mohr, and G. Koch. 1992. Clostridium botulinum C3 ADP-ribosyltransferase. Curr. Top. Microbiol. Immunol. 175:115-131.
3. Lyerly, D.M., and T.D. Wilkins. 1995. Clostridium difficile. In Infections of the Gastrointestinal Tract. M.J. Blaser, P.D. Smith, J.I. Ravdin, H.B. Greenberg, and R.L. Guerrant, editors. Raven Press, Ltd., New York, 867-891.
4. Just, I., J. Selzer, M. Wilm, C. Von Eichel-Streiber, M. Mann, and K. Aktories. 1995. Glucosylation of Rho proteins by Clostridium difficile toxin B. Nature (Lond.). 375:500-503.
5. Nusrat, A., M. Giry, J.R. Turner, S.P. Colgan, C.A. Parkos, D. Carnes, E. Lemichez, P. Boquet, and J.L. Madara. 1995. Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia. Proc. Natl. Acad. Sci. USA. 92:10629-10633.
6. Von Eichel-Streiber, C., P. Boquet, M. Sauerborn, and M. Thelestam. 1996. Large clostridial cytotoxins: a family of glycosyltransferases modifying small GPT-binding proteins. Trends Microbiol. 376:375-382.
7. Horiguchi, Y., T. Senda, N. Sugimoto, J. Katahira, and M. Matsuda. 1995. Bordetella bronchiseptica dermonecrotizing toxin stimulates assembly of actin stress fibers and focal adhesions by modifying the small GTP-binding protein rho. J. Cell Sci. 108:3243-3251.
8. Oswald, E., M. Sugai, A. Labigne, H.C. Wu, C. Fiorentini, P. Boquet, and A.D. O'Brien. 1994. Cytotoxic necrotizing factor type 2 produced by virulent Escherichia coli modifies the small GTP-binding protein Rho involved in assembly of actin stress fibers. Proc. Natl. Acad. Sci. USA. 91:3814-3818.
9. Adam, T., M. Giry, P. Boquet, and P. Sansonetti. 1996. Rho-dependent membrane folding causes Shigella entry into epithelial cells. EMBO Eur. Mol. Biol. Organ. J. 15:3315-3321.
10. Chen, L.-M., S. Hobbie, and J.E. Galan. 1996. Requirement of Cdc42 for Salmonella-induced cytoskeletal and nuclear responses. Science (Wash. DC). 274:2115-2118.