Experimental and clinical studies on the use of matrix metalloproteinase inhibitors for the treatment of cancer

European Journal of Cancer Part A

Volumn 32, Issue 14, 1996, Pages 2528-2533

  Talbot, D C ^a   Brown, P D ^b  

^a CHURCHILL HOSPITAL   (United Kingdom)

^b British Biotech Pharmaceuticals Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BATIMASTAT; CGS 27023A; MARIMASTAT; METALLOPROTEINASE INHIBITOR; N1 [2,2 DIMETHYL 1 [(METHYLAMINO)CARBONYL]PROPYL] N4 HYDROXY 2 (2 METHYLPROPYL)BUTANEDIAMIDE; UNCLASSIFIED DRUG;

ASCITES TUMOR; CANCER PATIENT; CLINICAL TRIAL; DRUG BIOAVAILABILITY; HUMAN; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG CANCER; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REVIEW;

EID: 0030484843     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(96)00398-X     Document Type: Article

References (42)

1. 1. Gross J, Lapiere CM. Collagenolytic activity in amphibian tissues: a tissue culture assay. Proc Natl Acad Sci USA 1962, 48, 1014-1022.
2. 2. Wilhelm SC, Eisen AZ, Teter M, Clark SD, Kronberger A, Goldberg G. Human fibroblast collagenase: glycosylation and tissue-specific levels of enzyme synthesis. Proc Natl Acad Sci USA 1986, 83, 3756-3760.
3. 3. Wilhelm SM, Collier IE, Kronberger A, et al. Human skin fibroblast stromelysin: structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells. Proc Natl Acad Sci USA 1987, 84, 6725-6729.
4. 4. Collier IE, Wilhelm SM, Eisen AZ, et al. H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen. J Biol Chem 1988, 263, 6579-6587.
5. 5. Muller D, Quantin B, Gesnel MC, Millon-Collard R, Abecassis J, Breathnach R. The collagenase gene family in humans consists of at least four members. Biochem J 1988, 253, 187-192.
6. 6. Quantin B, Murphy G, Breathnach R. Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members. Biochemistry 1989, 28, 5325-5334.
7. 7. Wilhelm SM, Collier IE, Marmer BL, Eisen AZ, Grant GA, Goldberg GI. SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages. J Biol Chem 1989, 264, 17213-17221.
8. 8. Basset P, Bellocq JP, Wolf C, et al. A novel metalloproteinase gene specifically expressed in stromal cell of breast carcinomas. Nature 1990, 348, 699-704.
9. 9. Hasty KA, Pourmotabbed TB, Goldberg GI, et al. Human neutrophil collagenase. J Biol Chem 1990, 265, 11421-11424.
10. 10. Docherty AJP, Lyons A, Smith BJ, Wright EM, Stephens PE, Harris TJR. Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity. Nature 1985, 318, 66-69.
11. 11. Stetler-Stevenson WG, Krutzsch HC, Liotta LA. Tissue inhibitor of metalloproteinase (TIMP-2): a new member of the metalloproteinase inhibitor family. J Biol Chem 1989, 264, 17374-17378.
12. 12. Firestein GS. Mechanisms of tissue destruction and cellular activation in rheumatoid arthritis. Curr Opin Rheumatol 1992, 4, 348-354.
13. 13. Liotta LA, Stetler-Stevenson WG. Metalloproteinases and cancer invasion. Sem Cancer Biol 1990, 1, 99-106.
14. 14. Gijbels K, Masure S, Carton H, Opdenakker G. Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders. J Neuroimmunol 1992, 41, 29-34.
15. 15. Yoshimoto M, Itoh F, Yamamoto H, Hinoda Y, Imai K, Yachi A. Expression of MMP-7 (Pump-1) mRNA in human colorectal cancers. Int J Cancer 1993, 54, 614-618.
16. 16. Brown PD, Bloxidge RE, Stuart NSA, Gatter KC, Carmichael J. Correlation between expression of activated 72-kDa gelatinase and tumour spread in non-small cell lung carcinoma. J Natl Cancer Inst 1993, 85, 574-578.
17. 17. Davies B, Miles DW, Happerfield LC, et al. Activity of type IV collagenases in benign and malignant breast disease. Br J Cancer 1993, 67, 1126-1131.
18. 18. Sato H, Takino T, Okada Y, et al. A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature 1994, 370, 61-65.
19. 19. Strongin A, Collier I, Bannikov G, Marmer BL, Grant GA, Goldberg GI. Mechanism of cell surface activation of 72kDa type IV collagenase. J Biol Chem 1995, 270, 5331-5338.
20. 20. Nomura H, Sato H, Seiki M, Mai M, Okada Y. Expression of membrane-type matrix metalloproteinase in human gastric carcinomas. Cancer Res 1995, 55, 3263-3266.
21. 21. Takino T, Sato H, Shinagawa A, Seiki M. Identification of the second membrane-type matrix metalloproteinase (MT-MMP2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family. J Biol Chem 1995, 270, 23013-23020.
22. 22. Gearing AJH, Beckett P, Christodoulou M, et al. Processing of tumour necrosis factor-precursor by metalloproteinases. Nature 1994, 370, 555-557.
23. 23. Leco KJ, Khokha R, Pavloff N, Hawkes SP, Edwards DR. Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues. J Biol Chem 1994, 269, 9352-9360.
24. 24. Schultz RM, Silberman S, Persky B, Bajkowski AS, Carmichael DF. Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells. Cancer Res 1988, 48, 5539-5545.
25. 25. Alvarez OA, Carmichael DF, DeClerck YA. Inhibition of collagenolytic activity and metastasis of tumour cells by a recombinant human tissue inhibitor of metalloproteinases. J Natl Cancer Inst 1990, 82, 589-595.
26. 26. Fisher C, Gilbertson-Beadling S, Powers EA, Petzold G, Poorman R, Mitchell MA. Interstitial collagenase is required for angiogenesis in vitro. Dev Biol 1994, 162, 499-510.
27. 27. Johnson MD, Kim HR, Chesler L, Tsao-Wu G, Bouck N, Polverini PJ. Inhibition of angiogenesis by tissue inhibitor of metalloproteinase. J Cell Physiol 1994, 160, 194-202.
28. 28. Mainardi CL. Collagenase in rheumatoid arthritis. Ann NY Acad Sci 1985, 460, 345-354.
29. 29. Beckett RP, Davidson AH, Drummond AH, Huxley P, Whittaker M. Recent advances in matrix metalloproteinase inhibitor research. Drug Dev Today 1996, 1, 16-26.
30. 30. Liotta LA. Tumor invasion and metastases - role of the extracellular matrix: Rhoads Memorial Award lecture. Cancer Res 1986, 46, 1-7.
31. 31. Taraboletti G, Garofalo A, Belotti D, et al. Inhibition of angiogenesis and murine hemangioma growth by batimastat, a synthetic inhibitor of matrix metalloproteinases. J Natl Cancer Inst 1995, 87, 293-298.
32. 32. Brown PD, Giavazzi R. Matrix metalloproteinase inhibition: a review of anti-tumour activity. Ann Oncol 1995, 6, 967-974.
33. 33. Eccles SA, Box GM, Court WJ, Bone EA, Thomas W, Brown PD. Control of lymphatic and hematogenous metastases of a rat mammary carcinoma by the matrix metalloproteinase inhibitor batimastat (BB-94). Cancer Res 1996, 56, 2815-2822.
34. 34. Anderson IC, Shipp MA, Docherty AJP, Teicher BA. Combination therapy including a gelatinase inhibitor and cytotoxic agent reduces local invasion and metastasis of murine Lewis lung carcinoma. Cancer Res 1996, 56, 715-710.
35. 35. Davies B, Brown PD, East N, Crimmin MJ, Balkwill FR. A synthetic matrix metalloproteinase inhibitor decreases tumour burden and prolongs survival of mice bearing human ovarian carcinoma xenograft. Cancer Res 1993, 53, 2087-2091.
36. 36. Galardy RE, Cassabonne ME, Giese C, et al. Low molecular weight inhibitors in corneal ulceration. Ann NY Acad Sci 1994, 732, 315-323.
37. 37. Hurewitz AN, Zucker S, Mancuso P, et al. Human pleural effusions are rich in matrix metalloproteinases. Chest 1992, 102, 1808-1814.
38. 38. Grams F, Crimmin M, Hinnes L, et al. Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor. Biochemistry 1995, 34, 14012-14020.
39. 39. Boasberg P, Harbaugh B, Roth B, et al. Marimastat, a novel matrix metalloproteinase inhibitor in patients with hormone-refractory prostate cancer. Proc Am Soc Clin Oncol 1996, 15, 671 (abstract).
40. 40. Rosemurgy A, Harris J, Langleben A, Casper E, Allen R, Rasmussen H. Marimastat, a novel matrix metalloproteinase inhibitor in patients with advanced carcinoma of the pancreas. Proc Am Soc Clin Oncol 1996 15, 470 (abstract).
41. 41. Gore M, A'Hern R, Stankiewicz M, Slevin M. Tumour marker levels during marimastat therapy. Lancet 1996, 348, 263-264.
42. 42. Imren S, Kohn DB, Shimada H, Blavier L, DeClerck YA. Overexpression of tissue inhibitor of metalloproteinases-2 by retroviral-mediated gene transfer in vivo inhibits tumour growth and invasion. Cancer Res 1996, 56, 2891-2895.