LIGHT sensitizes IFNγ-mediated apoptosis of MDA-MB-231 breast cancer cells leading to down-regulation of anti-apoptosis Bcl-2 family members

Cancer Letters

Volumn 195, Issue 2, 2003, Pages 201-210

  Zhang, Manchao ^a,b   Guo, Ribo ^a   Zhai, Yifan ^a   Yang, Dajun ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Bcl 2; LIGHT; MDA MB 231

Indexed keywords

BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3 INHIBITOR; CASPASE 6; CASPASE 7; CASPASE 8; CASPASE 9; GAMMA INTERFERON; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; TUMOR NECROSIS FACTOR DERIVATIVE; TUMOR NECROSIS FACTOR LIGHT; UNCLASSIFIED DRUG; BAK1 PROTEIN, HUMAN; BAX PROTEIN, HUMAN; BCL2 ASSOCIATED ATHANOGENE 1 PROTEIN; BCL2-ASSOCIATED ATHANOGENE 1 PROTEIN; BCL2L1 PROTEIN, HUMAN; BENZOYLCARBONYL ASPARTYL GLUTAMYL VALYL ASPARTYL FLUOROMETHYL KETONE; BENZOYLCARBONYL-ASPARTYL-GLUTAMYL-VALYL-ASPARTYL-FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL ALANYL ASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; BID PROTEIN, HUMAN; CARRIER PROTEIN; CASPASE; CYSTEINE PROTEINASE INHIBITOR; DNA BINDING PROTEIN; DNA FRAGMENTATION FACTOR, HUMAN; HERPESVIRUS ENTRY MEDIATOR LIGAND; MCL1 PROTEIN; MEMBRANE PROTEIN; OLIGOPEPTIDE; ONCOPROTEIN; PEPTIDE CHLOROMETHYL KETONE; PROTEIN; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL X; PROTEIN BID; TNFSF14 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CARCINOMA CELL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; SENSITIZATION; UPREGULATION; ADENOCARCINOMA; BIOSYNTHESIS; BREAST TUMOR; CELL CULTURE; DRUG EFFECT; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROTO ONCOGENE;

HERPESVIRIDAE;

ADENOCARCINOMA; AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; BREAST NEOPLASMS; CARRIER PROTEINS; CASPASES; CYSTEINE PROTEINASE INHIBITORS; DNA-BINDING PROTEINS; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BCL-2; HUMANS; INTERFERON TYPE II; MEMBRANE PROTEINS; NEOPLASM PROTEINS; OLIGOPEPTIDES; POLY(ADP-RIBOSE) POLYMERASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0012731458     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(03)00148-4     Document Type: Article

References (59)

1. Mauri D.N., Ebner R., Montgomery R.I., Kochel K.D., Cheung T.C., Yu G.L., Ruben S., Murphy M., Eisenberg R.J., Cohen G.H., Spear P.G., Ware C.F. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. Immunity. 8:1998;21-30.
2. Harrop J.A., McDonnell P.C., Brigham-Burke M., Lyn S.D., Minton J., Tan K.B., Dede K., Spampanato J., Silverman C., Hensley P., DiPrinzio R., Emery J.G., Deen K., Eichman C., Chabot-Fletcher M., Truneh A., Young P.R. Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth. J. Biol. Chem. 273:1998;27548-27556.
3. Rooney I.A., Butrovich K.D., Glass A.A., Borboroglu S., Benedict C.A., Whitbeck J.C., Cohen G.H., Eisenberg R.J., Ware C.F. The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. J. Biol. Chem. 275:2000;14307-14315.
4. Zhai Y., Guo R., Hsu T.L., Yu G.L., Ni J., Kwon B.S., Jiang G.W., Lu J., Tan J., Ugustus M., Carter K., Rojas L., Zhu F., Lincoln C., Endress G., Xing L., Wang S., Oh K.O., Gentz R., Ruben S., Lippman M.E., Hsieh S.L., Yang D. LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer. J. Clin. Invest. 102:1998;1142-1151.
5. Tamada K., Shimozaki K., Chapoval A.I., Zhai Y., Su J., Chen S.F., Hsieh S.L., Nagata S., Ni J., Chen L. LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. J. Immunol. 164:2000;4105-4110.
6. Tamada K., Shimozaki K., Chapoval A.I., Zhu G., Sica G., Flies D., Boone T., Hsu H., Fu Y.X., Nagata S., Ni J., Chen L. Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nat. Med. 6:2000;283-289.
7. Lama J., Ware C.F. Human immunodeficiency virus type 1 Nef mediates sustained membrane expression of tumor necrosis factor and the related cytokine LIGHT on activated T cells. J. Virol. 74:2000;9396-9402.
8. Yu K.Y., Kwon B., Ni J., Zhai Y., Ebner R., Kwon B.S., newly A. identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. J. Biol. Chem. 274:1999;13733-13736.
9. Chen M.C., Hsu T.L., Luh T.Y., Hsieh S.L. Overexpression of bcl-2 enhances LIGHT- and interferon-gamma-mediated apoptosis in Hep3BT2 cells. J. Biol. Chem. 275:2000;38794-38801.
10. Amundson S.A., Myers T.G., Scudiero D., Kitada S., Reed J.S., Fornace A.J. Jr. An informatics approach identifying markers of chemosensitivity in human cancer cell lines. Cancer Res. 60:2000;6101-6110.
11. Jiang C., Wang Z., Ganther H., Lu J. Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells. Cancer Res. 61:2001;3062-3070.
12. Woo M., Hakem R., Mak T.W. Executionary pathway for apoptosis: lessons from mutant mice. Cell Res. 10:2000;267-278.
13. Daniel P.T. Dissecting the pathways to death. Leukemia. 14:2000;2035-2044.
14. Sabol S.L., Li R., T Y., Lee R. Inhibition of apoptosis-associated DNA fragmentation activity in nonapoptotic cells: the role of DNA fragmentation factor-45 (DFF45/ICAD). Biochem. Biophys. Res. Commun. 253:1998;151-158.
15. Simbulan-Rosenthal C.M., Rosenthal D.S., Iyer S., Boulares H., Smulson M.E. Involvement of PARP and poly(ADP-ribosyl)ation in the early stages of apoptosis and DNA replication. Mol. Cell Biochem. 193:1999;137-148.
16. DiPaola R.S., Aisner J. Overcoming bcl-2- and p53-mediated resistance in prostate cancer. Semin. Oncol. 26:1999;112-116.
17. Strasser A., Huang D.C., Vaux D.L. The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy. Biochim. Biophys. Acta. 1333:1997;F151-F178.
18. Schorr K., Li M., Krajewski S., Reed J.C., Furth P.A. Bcl-2 gene family and related proteins in mammary gland involution and breast cancer. J. Mammary Gland. Biol. Neoplasia. 4:1999;153-164.
19. Yang X., Hao Y., Ding Z., Pater A., Tang S.C. Differential expression of antiapoptotic gene BAG-1 in human breast normal and cancer cell lines and tissues. Clin. Cancer Res. 5:1999;1816-1822.
20. Zapata J.M., Krajewska M., Krajewski S., Huang R.P., Takayama S., Wang H.G., Adamson E., Reed J.C. Expression of multiple apoptosis-regulatory genes in human breast cancer cell lines and primary tumors. Breast Cancer Res. Treat. 47:1998;129-140.
21. Burow M.E., Weldon C.B., Tang Y., Navar G.L., Krajewski S., Reed J.C., Hammond T.G., Clejan S., Beckman B.S. Differences in susceptibility to tumor necrosis factor alpha-induced apoptosis among MCF-7 breast cancer cell variants. Cancer Res. 58:1998;4940-4946.
22. Rochaix P., Krajewski S., Reed J.C., Bonnet F., Voigt J.J., Brousset P. In vivo patterns of Bcl-2 family protein expression in breast carcinomas in relation to apoptosis. J. Pathol. 187:1999;410-415.
23. Zhou X.M., Liu Y., Payne G., Lutz R.J., Chittenden T. Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155. J. Biol. Chem. 275:2000;25046-25051.
24. del Peso L., Gonzalez-Garcia M., Page C., Herrera R., Nunez G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science. 278:1997;687-689.
25. Datta S.R., Katsov A., Hu L., Petros A., Fesik S.W., Yaffe M.B., Greenberg M.E. 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol. Cell. 6:2000;41-51.
26. Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., Greenberg M.E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 91:1997;231-241.
27. Boersma A.W., Nooter K., Burger H., Kortland C.J., Stoter G. Bax upregulation is an early event in cisplatin-induced apoptosis in human testicular germ-cell tumor cell line NT2, as quantitated by flow cytometry. Cytometry. 27:1997;228-275.
28. Kobayashi N., Takada Y., Hachiya M., Ando K., Nakajima N., Akashi M. TNF-alpha induced p21(WAF1) but not Bax in colon cancer cells WiDr with mutated p53: important role of protein stabilization. Cytokine. 12:2000;1745-1754.
29. Li Y., Upadhyay S., Bhuiyan M., Sarkar F.H. Induction of apoptosis in breast cancer cells MDA-MB-231 by genistein. Oncogene. 18:1999;3166-3172.
30. Pearson A.S., Spitz F.R., Swisher S.G., Kataoka M., Sarkiss M.G., Meyn R.E., McDonnell T.J., Cristiano R.J., Roth J.A. Up-regulation of the proapoptotic mediators Bax and Bak after adenovirus-mediated p53 gene transfer in lung cancer cells. Clin. Cancer Res. 6:2000;887-890.
31. Butt A.J., Firth S.M., King M.A., Baxter R.C. Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast cancer cells. J. Biol. Chem. 275:2000;39174-39181.
32. 2+- calpain and caspase-mitochondria-dependent pathways. J. Biol. Chem. 275:2000;39702-39709.
33. Park W.H., Seol J.G., Kim E.S., Hyun J.M., Jung C.W., Lee C.C., Binderup L., Koeffler H.P., Kim B.K., Lee Y.Y. Induction of apoptosis by vitamin D3 analogue EB1089 in NCI-H929 myeloma cells via activation of caspase 3 and p38 MAP kinase. Br. J. Haematol. 109:2000;576-583.
34. Srivastava M., Ahmad N., Gupta S., Mukhtar H. Involvement of Bcl-2 and Bax in photodynamic therapy-mediated apoptosis: Antisense Bcl-2 oligonucleotide sensitizes RIF 1 cells to photodynamic therapy apoptosis. J. Biol. Chem. 276:2001;15481-15488.
35. Asao H., Fu Y.Y. Interferon-gamma has dual potentials in inhibiting or promoting cell proliferation. J. Biol. Chem. 275:2000;867-874.
36. Finnegan N.M., Curtin J.F., Prevost G., Morgan B., Cotter T.G. Induction of apoptosis in prostate carcinoma cells by BH3 peptides which inhibit Bak/Bcl-2 interactions. Br. J. Cancer. 85:2001;115-121.
37. Litvak D.A., Hwang K.O., Evers B.M., Townsend C.M. Jr. Induction of apoptosis in human gastric cancer by sodium butyrate. Anticancer Res. 20:2000;779-784.
38. Pal'tsev M.A., Demura S.A., Kogan E.A., Jaques G., Zende B. Role of Bcl-2, Bax, and Bak in spontaneous apoptosis and proliferation in neuroendocrine lung tumors: immunohistochemical study. Bull. Exp. Biol. Med. 130:2000;697-700.
39. Pataer A., Smythe W.R., Yu R., Fang B., McDonnell T., Roth J.A., Swisher S.G. Adenovirus-mediated Bak gene transfer induces apoptosis in mesothelioma cell lines. J. Thorac. Cardiovasc. Surg. 121:2001;61-67.
40. Li X., Marani M., Mannucci R., Kinsey B., Andriani F., Nicoletti I., Denner L., Marcelli M. Overexpression of BCL-X(L) underlies the molecular basis for resistance to staurosporine-induced apoptosis in PC-3 cells. Cancer Res. 61:2001;1699-1706.
41. Eggert A., Grotzer M.A., Zuzak T.J., Wiewrodt B.R., Ho R., Ikegaki N., Brodeur G.M. Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression. Cancer Res. 61:2001;1314-1319.
42. Fulda S., Meyer E., Friesen C., Susin S.A., Kroemer G., Debatin K.M. Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis. Oncogene. 20:2001;1063-1075.
43. Siegmund D., Mauri D., Peters N., Juo P., Thome M., Reichwein M., Blenis J., Scheurich P., Tschopp J., Wajant H. FADD and Caspase-8 mediate up-regulation of c-fos by FasL and TRAIL via a FLIP-regulated pathway. J. Biol. Chem. 276:2001;32585-32590.
44. Suliman A., Lam A., Datta R., Srivastava R.K. Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and -independent pathways. Oncogene. 20:2001;2122-2133.
45. Green D.R., Reed J.C. Mitochondria and apoptosis. Science. 281:1998;1309-1312.
46. Bratton S.B., Walker G., Srinivasula S.M., Sun X.M., Butterworth M., Alnemri E.S., Cohen G.M. Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes. EMBO J. 20:2001;998-1009.
47. Chauhan D., Rosen S., Reed J.C., Kharbanda S., Anderson K.C. Aaf-1/cytochrome-c independent and SMAC-dependent induction of apoptosis in multiple myeloma (MM) cells. J. Biol. Chem. 276:2001;24453-24456.
48. Purring-Koch C., McLendon G. Cytochrome c binding to Apaf-1: the effects of dATP and ionic strength. Proc. Natl. Acad. Sci. USA. 97:2000;11928-11931.
49. Shi Y., structural A. view of mitochondria-mediated apoptosis. Nat. Struct. Biol. 8:2001;394-401.
50. Granville D.J., Cassidy B.A., Ruehlmann D.O., Choy J.C., Brenner C., Kroemer G., van Breemen C., Margaron P., Hunt D.W., McManus B.M. Mitochondrial release of apoptosis-inducing factor and cytochrome c during smooth muscle cell apoptosis. Am. J. Pathol. 159:2001;305-311.
51. Hisatomi T., Sakamoto T., Murata T., Yamanaka I., Oshima Y., Hata Y., Ishibashi T., Inomata H., Susin S.A., Kroemer G. Relocalization of apoptosis-inducing factor in photoreceptor apoptosis induced by retinal detachment in vivo. Am. J. Pathol. 158:2001;1271-1278.
52. Joza N., Susin S.A., Daugas E., Stanford W.L. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 410:2001;549-554.
53. Loeffler M., Daugas E., Susin S.A., Zamzami N., Metivier D. Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor. FASEB J. 15:2001;758-767.
54. Denecker G., Vercammen D., Declercq W., Vandenabeele P. Apoptotic and necrotic cell death induced by death domain receptors. Cell Mol. Life Sci. 58:2001;356-370.
55. Kolenko V.M., Uzzo R.G., Bukowski R., Finke J.H. Caspase-dependent and -independent death pathways in cancer therapy. Apoptosis. 5:2000;17-20.
56. Miyazaki K., Yoshida H., Sasaki M., Hara H., Kimura G., Mak T.W., Nomoto K. Caspase-independent cell death and mitochondrial disruptions observed in the apaf1-deficient cells. J. Biochem. 129:2001;63-969.
57. Chin Y.E., Kitagawa M., Kuida K., Flavell R.A., Fu X.Y. Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis. Mol. Cell Biol. 17:1997;5328-5337.
58. Spanaus K.S., Schlapbach R., Fontana A. TNF-alpha and IFN-gamma render microglia sensitive to Fas ligand- induced apoptosis by induction of Fas expression and down-regulation of Bcl-2 and Bcl-xL. Eur. J. Immunol. 28:1998;4398-4408.
59. Spets H., Georgii-Hemming P., Siljason J., Nilsson K., Jernberg-Wiklund H. Fas/APO-1 (CD95)-mediated apoptosis is activated by interferon-gamma and interferon- in interleukin-6 (IL-6)-dependent and IL-6-independent multiple myeloma cell lines. Blood. 92:1998;2914-2923.