Differential expression of antiapoptotic gene BAG-1 in human breast normal and cancer cell lines and tissues

Clinical Cancer Research

Volumn 5, Issue 7, 1999, Pages 1816-1822

  Yang, Xiaolong ^a   Hao, Yawei ^a   Ding, Zhihu ^a   Pater, Alan ^a   Tang, Shou Ching ^b,c  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^b Dr H Bliss Murphy Cancer Centre   (Canada)

^c NONE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BAG 1 PROTEIN; GENE PRODUCT; PROTEIN BCL 2; PROTEIN BCL X; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER CELL CULTURE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; PROTEIN PROTEIN INTERACTION; TRANSLATION INITIATION;

ADENOCARCINOMA; BCL-X PROTEIN; BREAST; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARRIER PROTEINS; CELLS, CULTURED; DNA-BINDING PROTEINS; HUMANS; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 0032764259     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Boise, L. H., Gonzalez-Garcia, M., Postema, C. E., Ding, L., Lindsten, T., Turka, L. A., Mao, X., Nunez, G., and Thompson, C. B. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell, 74: 597-608, 1993.
2. Boyd, J. M., Gallo, G. J., Elangovan, B., Houghton, A. B., Malstrom, S., Avery, B. J., Ebb, R. G., Subramanian, T., Chittenden, T., Lutz, R. J., Chinnadurai, G. Bik, a novel death-inducing protein, shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. Oncogene, 11: 1921-1928, 1995.
3. Kiefer, M. C., Brauer, M. J., Powers, V. C., Wu, J. J., Umansky, S. R., Tomei, L. D., and Barr, P. J. Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature (Lond.), 374: 736-739, 1995.
4. Kozopas, K. M., Yang, T., Buchan, H. L., Zhou, P., Craig, R. W. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL-2. Proc. Natl. Acad. Sci. USA, 90: 3516-3520, 1993.
5. Oltvai, Z. N., Milliman, C. L., Korsmeyer, S. J. Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell, 74: 609-619, 1993.
6. Takayama, S., Sato, T., Krajewski, S., Kochel, K., Irie, S., Millan, J. A., and Reed, J. C. Cloning and functional analysis of BAG-1: a novel bcl-2-binding protein with anti-cell death activity. Cell, 80: 279-284, 1995.
7. Yang, E., Zha, J., Jockel, J., Boise, L. H., Thompson, C. B., and Korsmeyer, S. J. Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death. Cell, 80: 285-291, 1995.
8. Williams, G. T. Programmed cell death: apoptosis and oncogenesis. Cell, 65: 1097-1098, 1991.
9. Orrenius, S. Apoptosis: molecular mechanisms and implications for human disease. J. Intern. Med., 237: 529-536, 1995.
10. Thompson, C. B. Apoptosis in the pathogenesis and treatment of disease. Science (Washington DC), 267: 1456-1462, 1995.
11. Tsujimoto, Y., and Croce, C. M. Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc. Natl. Acad. Sci. USA, 83: 5214-5218, 1986.
12. Hollstein, M., Sidransky, D., Vogelstein, B., and Harris, C. C. p53 mutations in human cancers. Science (Washington DC), 253: 49-53, 1991.
13. McDonnell, T. J., Troncoso, P., Brisbay, S. M., Logothetis, C., Chung, L. W. K., Hsieh, J.-T., Tu, S.-M., and Cambel, M. L. Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer. Cancer Res., 52: 6940-6944, 1992.
14. Haldar, S., Negrini, M., Monne, M., Sabbioni, S., and Croce, C. M. Down-regulation of bcl-2 by p53 in breast cancer cells. Cancer Res., 54: 2095-2097, 1994.
15. Ikegaki, N., Katsumata, M., Minna, J., and Tsujimoto, Y. Expression of bcl-2 in small cell lung carcinoma cells. Cancer Res., 54: 6-8, 1994.
16. Reed, J. C. Bcl-2 and the regulation of programmed cell death. J. Cell. Biol., 124: 1-6, 1994.
17. Liang, X. H., Mungal, S., Ayscue, A., Meissner, J. D., Wodnicki, P., Hockenbery, D., Lockett, S., and Herman, B. Bcl-2 protooncogene expression in cervical carcinoma cell lines containing inactive p53. J. Cell. Biochem., 57: 509-521, 1995.
18. Sinicrope, F. A., Ruan, S. B., Cleary, K. R., Stephens, L. C., Lee, J. J., and Levin, B. bcl-2 and p53 oncogene expression during colorectal tumorigenesis. Cancer Res., 55: 237-241, 1995.
19. Schulz, J. B., Bremen, D., Reed, J. C., Lommatzsch, J., Takayama, S., Wullner, U., Loschmann, P. A., Klockgether, T., and Weller, M. Cooperative interception of neuronal apoptosis by BCL-2 and BAG-1 expression: prevention of caspase activation and reduced production of reactive oxygen species. J. Neurochem., 69: 2075-2086, 1997.
20. Clevenger, C. V., Thickman, K., Ngo, W., Chang, W.-P., Takayama, S., and Reed, J. C. Role of Bag-1 in the survival and proliferation of the cytokine-dependent lymphocyte lines, Ba/F3 and Nb2. Mol. Endocrinol., 11: 608-618, 1997.
21. Bardelli, A., Longati, P., Albero, D., Goruppi, S., Schneider, C., Ponzetto, C., and Comoglio, P. M. HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. EMBO J., 15: 6205-6212, 1996.
22. Zeiner, M., and Gehring, U. A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning. Proc. Natl. Acad. Sci. USA, 92: 11465-11469, 1995.
23. Froesch, B. A., Takayama, S., and Reed, J. BAG-1L protein enhances androgen receptor function. J. Biol. Chem., 272: 11660-11666, 1998.
24. Kullmann, M., Schneikert, J., Moll, J., Heck, S., Zeiner, M., Gehring, U., Cato, A. C. RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis. J. Biol. Chem., 273: 14620-14625, 1998.
25. Zapata, J. M., Krajewska, M., Krajewski, S., Huang, R. P., Takayama, S., Wang, H. G., Adamson, E., and Reed, J. C. Expression of multiple apoptosis-regulatory genes in human breast cancer cell lines and primary tumors. Breast Cancer Res. Treat., 47: 129-140, 1998.
26. Yang, X., Chernenko, G., Hao, Y., Ding, Z., Pater, M. M., Pater, A., and Tang, S.-C. Human BAG-1/RAP46 is expressed as four isoforms by alternative translation initiation and overexpressed in human cancers. Oncogene, 16: 981-989, 1998.
27. Sambrook, J., Fritsch, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1989.
28. Yang, X., Nakao, Y., Pater, M. M., Tang, S-C., and Pater, A. Expression of cellular genes in HPV16-immortalized and cigarette smoke condensate-transformed human endocervical cells. J. Cell. Biochem., 66: 309-321, 1997.
29. Pisani, P., Parkin, D. M., and Ferlay, J. Estimates of the worldwide mortality from eighteen major cancers in 1985: implications for prevention and projections of future burden. Int. J. Cancer, 55: 891-903, 1993.
30. Bargou, R. C., Daniel, P. T., Mapara, M. Y., Bommert, K., Wagener, C., Kallinich, B., Royer, H. D., and Dorken, B. Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax expression in tumor cells correlates with resistance towards apoptosis. Int. J. Cancer, 60: 854-859, 1995.
31. Bargou, R. C., Wagener, C., Bommert, K., Mapara, M. Y., Daniel, P. T., Arnold, W., Dietel, M., Guski, H., Feller, A., Royer, H. D., and Dorken, B. Overexpression of the death-promoting gene bax which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice. J. Clin. Invest., 97: 2651-2659, 1995.
32. Steck, S., McDonnell, T., Sneige, N., and El-Naggar, A. Flow cytometry analysis of apoptosis and Bcl-2 in primary breast carcinomas: clinical and biological implications. Cytometry, 24: 116-122, 1996.
33. Leek, R. D., Kaklamanis, L., Pezzella, F., Gatter, K. C. and Harris, A. L. bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer. Br. J. Cancer, 69: 135-139, 1994.
34. Krajewski, S., Blomqvist, C., Franssila, K., Krajewska, M., Wasenius, V. M., Niskanen, E., Nordling, S., and Reed, J. C. Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res., 55: 4471-4478, 1995.
35. Sabourin, J. C., Martin, A., Baruch, J., Truc, J. B., Gompel, A., and Poitout, P. bcl-2 expression in normal breast tissue during the menstrual cycle. Int. J. Cancer, 59: 1-6, 1994.
36. Teixeira, C., Reed, J. C., and Pratt, M. A. Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells. Cancer Res., 55: 3902-3907, 1995.
37. Tang, S.-C., Shaheta, N., Chernenko, G., Pater, A., Khalifa, M., and Wang, X. Expression of BAG-1 in invasive breast carcinomas. J. Clin. Oncol., in press, 1999.