A genetic model for cardiac pattern formation and cell fate determination

Genetic Models in Cardiorespiratory Biology

Volumn , Issue , 2001, Pages 179-202

  Lockwood, Wendy K ^a   Liu, Margaret ^a   Su, Ming Tsan ^a   Bodmer, Rolf ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0012358848     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/b14019     Document Type: Chapter

References (95)

1. Abel T, Michelson AM, Maniatis T. (1999). A Drosophila GATA family member that binds to Adh regulatory sequences is expressed in the developing fat body. Development 119:623-633.
2. Azpiazu N, Frasch M. (1993). tinman and bagpipe: Two homeobox genes that determine cell fates in the dorsal mesoderm of Drosophila. Genes Dev 7:1325-1340.
3. Azpiazu N, Lawrence PA, Vincent JP, Frasch M. (1996). Segmentation and specification of the Drosophila mesoderm. Genes Dev 10:3183-3194.
4. Beiman M, Shilo BZ, Volk T. (1996). Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages. Genes Dev 10:2993-3002.
5. Benson DW, Sharkey A, Fatkin D, Lang P, Basson CT, McDonough B, Strauss AW, Seidman JG, Seidman CE. (1998). Reduced penetrance, variable expressivity, and genetic heterogeneity of familial atrial septal defects. Circulation 97:2043-2048.
6. Biben C, Harvey RP. (1997). Homeodomain factor Nkx-2-5 controls left/right asymmetric expression of bHLH gene eHAND during murine heart development. Genes Dev 11:1357-1369.
7. Bodmer R. (1993). The gene tinman is required for specification of the heart and visceral muscles in Drosophila. Development 118:719-729.
8. Bodmer R. (1995). Heart development in Drosophila and its relationship to vertebrate systems. TCM 5:21-28.
9. Bodmer R, Frasch M. (1999). Genetic Determination of Drosophilia Heart Development. In: Rosenthal N, Harvey R, eds. Heart Development. San Diego: Academic Press, pp 65-90.
10. Bodmer R, Golden K, Lockwood WK, Ocorr KA, Park M, Su M-T, Venkatesh T. (1997). Heart development in Drosophila. In: Wasserman P, ed. Advances in Developmental Biology. Greenwich, CT.: JAI Press, pp. 201-205.
11. Bodmer R, Jan LY, Jan YN. (1990). A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila. Development 110:661-669.
12. Brewster R., Bodmer R. (1995). Origin and specification of type II sensory neurons in Drosophila. Development 121:2923-2936.
13. Carmena A, Gisselbrecht S, Harrison J, Jimenez F, Michelson AM. (1998a). Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm. Genes Dev 12:3910-3922.
14. Carmena A, Murugasu-Oei B, Menon D, Jimenez F, Chia W. (1998b). inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis. Genes Dev 12:304-315.
15. Cohen B, Simcox AA, Cohen SM. (1993). Allocation of the thoracic imaginal primordia in the Drosophila embryo. Development 117:597-608.
16. Durocher D, Nemer M. (1998). Combinatorial interactions regulating cardiac transcription. Dev Genet 22:250-262.
17. Durocher D, Charron F, Warren R, Schwartz RJ, Nemer M. (1997). The cardiac transcription factors Nkx2-5 and GATA-4 are mutual co-factors. EMBO J 16:5687-5696.
18. Dye CA, Lee J-K, Atkinson RC, Brewster R, Han P-L, Bellen HJ. (1998). The Drosophila sanpodo gene controls sibling cell fate and encodes a tropomodulin homolog, an actin/tropomyosin associated protein. Development 125:1845-1856.
19. Evans SM, Yan W, Murillo MP, Ponce J, Papalopulu N. (1995). tinman, A Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman. Development 121:3889-3899.
20. Fishman MC, Chien KR. (1997). Fashioning the vertebrate heart: earliest embryonic decisions. Development 124:2099-2117.
21. Fishman MC, Olson EN. (1998). Parsing the heart: genetic modules for organ assembly. Cell 91:153-156.
22. Francois V, Bier E. (1995). Xenopus chordin and Drosophila short gastrulation genes encode homologous proteins functioning in dorsal-ventral axis formation. Cell 80:19-20.
23. Frasch M. (1995). Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo. Nature 374:464-467.
24. Fu Y, Yan W, Mohun TJ, Evans SM. (1998). Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner. Development 125:4439-4449.
25. Gajewski K, Fossett N, Molkentin JD, Schulz RA. (1999). The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila. Development 126:5679-5688.
26. Gisselbrecht S, Skeath JB, Doe CQ, Michelson AM. (1996). heartless Encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo. Genes Dev 10:3003-3017.
27. Grepin C, Robitaille L, Antay T, Nemer M. (1995). Inhibition of transcription factor GATA-4 expression blocks in vitro cardiac muscle differentiation. Mol Cell Biol 15:4095-4102.
28. Grepin C, Dagnino L, Robitaille LL, Haberstroh LL, Antakly T, Nemer M. (1994). A hormone-encoding gene identifies a pathway for cardiac but not skeletal muscle gene transcription. Mol Cell Biol 14:3115-3129.
29. Grepin C, Nemer G, Nemer M. (1997). Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor. Development 124:2387-2395.
30. Grow MW, Krieg PA. (1998). Tinman function is essential for vertebrate heart development:elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5. Dev Biol 204:187-196.
31. Guo M, Jan LY, Jan YN. (1996). Control of daughter cell fates during asymmetric cell division: Interaction of Numb and Notch. Neuron 17:27-24.
32. Harvey RP. (1996). NK-2 homeobox genes and heart development. Dev Biol 178:203-216.
33. Harvey RP, Rosenthal N, eds. (1999). Heart Development. San Diego: Academic Press.
34. Heikinheimo M, Scardrett JM, Wilson DB. (1994). Localization of the transcription factor GATA-4 to regions of the mouse embryo involved in cardiac development. Dev. Biol. 164:361-373.
35. Holley SA, Jackson PD, Sasai Y, Lu B, De Robertis EM, Hoffmann FM, Ferguson EL. (1995). A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin. Nature 376:249-253.
36. Ip HS, Wilson DB, Heikinheimo M, Tang Z, Ting CN, Simon MC, Leiden JM, Parmacek MS. (1994). The GATA-4 transcription factor transactivates the cardiac musclespecific troponin C promoter-enhancer in non-muscle cells. Mol Cell Biol 14:7517-7526.
37. Jagla K, Frasch M, Jagla T, Dretzen G, Bellard F, Bellard M. (1997). ladybird, A new component of the cardiogenic pathway in Drosophila required for the diversification of heart precursors. Development 124:3471-3479.
38. Jiang Y, Evans T. (1996). The Xenopus GATA-4/5/6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis. Dev Biol 174:258-270.
39. Jiang Y, Tarzami S, Burch BE, Evans T. (1998). A common role for each of the cGATA-4/5/6 genes in the regulation of cardiac morphogenesis. Dev Genetics 22:263-277.
40. Kelley C, Blumberg H, Zon LI, Evans T. (1993). GATA-4 is a novel transcription factor expressed in endocardium of the developing heart. Development 118:817-827.
41. Komuro I, Izumo S. (1993). Csx: A murine homeobox-containing gene specifically expressed in the developing heart. PNAS 90:8145-8149.
42. Koutsourakis M, Langeveld A, Patient R, Beddington R, Grosveld F. (1999). The transcription factor GATA6 is essential for early extraembryonic development. Development 126:723-732.
43. Kuo CT, Morrisey EE, Anandappa R, Sigrist K, Lu MM, Parmacek MS, Soudais C, Leiden JM. (1997). GATA-4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes & Dev 11:1048-1060.
44. Lai Z, Fortini ME, Rubin GM. (1991). The embryonic expression patterns of zfh-1 and zfh-2, two Drosophila genes encoding novel zinc-finger homeodomain proteins. Mech Dev 34:123-134.
45. Laverriere AC, NacNeill C, Mueller C, Poelmann RE, Burch JBE, Evans T. (1994). GATA-4/5/6: a subfamily of three transcription factors expressed in developing heart and gut. J Biol Chem 69:23177-23184.
46. Lawrence PA, Bodmer R, Vincent J-P. (1995). Segmental patterning of heart precursors in Drosophila. Development 121:4303-4308.
47. Lee KH, Xu Q, Breitbart RE. (1996). A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm. Dev Biol 180:722-731.
48. Lee Y, Shioi T, Kasahara H, Jobe SM, Wiese RJ, Markham BE, Izumo S. (1998). The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression. Mol Cell Biol 18:3120-3129.
49. Lin WH, Huang LH, Yeh JY, Hoheisel J, Lehrach H, Sun YH, Tsai SF. (1995). Expression of a Drosophila GATA transcription factor in multiple tissues in developing embryos. J Biol Chem 270:25150-25158.
50. Lints TJ, Parsons LM, Hartley L, Lyons I, Harvey P. (1993). Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119:419-431.
51. Lu B, Jan LY, Jan YN. (1998). Asymmetric cell division: lessons from flies and worms. Curr Opin Genet Dev 8:392-399.
52. Lyons I, Parsons LM, Hartley L, Li R, Andrews JE, Robb L, Harvey RP. (1995). Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev 9:1654-1666.
53. Molkentin JD, Lin Q, Duncan SA, Olson EN. (1997). Requirement of the transcription factor GATA-4 for heart tube formation and ventral morphogenesis. Genes & Dev 11:1061-1072.
54. Morrisey EE, Ip HS, Lu MM, Parmacek MS. (1996). GATA-6: A zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. Dev Biol 177:309-322.
55. Morrisey EE, Ip HS, Tang Z, Lu MM, Parmacek MS. (1997). GATA-5: A transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development. Dev Biol 183:21-36.
56. Morrisey EE, Tang Z, Sigrist K, Lu MM, Jiang F, Ip HS, Parmacek MS. (1998). GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo. Genes & Dev 12:3579-3590.
57. Newman CS, Krieg PA. (1998). tinman-related genes expressed during heart development in Xenopus. Dev Genet 22:230-238.
58. Olson EN, Srivastava D. (1996). Molecular pathways controlling heart development. Science 272:671-676.
59. Padgett RW, Wozney JM, Gelbart WM. (1993). Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo. Proc Natl Acad Sci USA 90:2905-2909.
60. Park M, Wu X, Golden K, Axelrod JD, Bodmer R. (1996). The wingless signaling pathway is directly involved in Drosophila heart development. Dev Biol 177:104-116.
61. Park M, Venkatesh TV, Bodmer R. (1998a). A dual role for the zeste-white3/shaggy- encoded kinase in mesoderm and heart development of Drosophila. Dev Genetics 22:201-211.
62. Park M, Lewis C, Turbay D, Chung A, Chen JN, Evans S, Breitbart RE, Fishman MC, Izumo S, Bodmer R. (1998b). Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman-related genes [published erratum appears in Proc Natl Acad Sci USA 1998 Oct 27;95(22):13348]. Proc Natl Acad Sci USA 95:9366-9371.
63. Park M, Yaich LE, Bodmer R. (1998c). Mesodermal cell fate decisions in Drosophila are under the control of the lineage genes numb, Notch, and sanpodo. Mech Dev 75:117-126.
64. Ramain P, Heitzler P, Haenlin M, Simpson P. (1993). pannier, A negative regulator of achaete and scute in Drosophila, encodes a zinc finger protein with homolgy to the vertebrate transcription factor GATA-1. Development 119:1277-1291.
65. Ranganayakulu G, Elliott DA, Harvey RP, Olson EN. (1998). Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice. Development 125:3037-3048.
66. Reecy JM, Yamada M, Cummings K, Schwartz RJ. (1997). Chicken Nkx-2.8: a novel homeobox gene expressed in early heart progenitor cells and the pharyngeal pouch-2 and -3 endoderm. Dev Biol 188:295-311.
67. Rhyu MS, Jan LY, Jan YN. (1994). Asymmetric distribution of Numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell 76:477-491.
68. Riechmann V, Irion U, Wilson R, Grosskortenhaus R, Leptin M. (1997). Control of cell fates and segmentation in the Drosophila mesoderm. Development 124:2915-2922.
69. Ruiz Gomez M, Bate M. (1997). Segregation of myogenic lineages in Drosophila requires numb. Development 124:4857-4866.
70. St Johnston RD, Nüsslein-Volhard C. (1992). The origin of pattern and polarity in the Drosophila embryo. Cell 68:201-219.
71. Schott JJ, Benson DW, Basson CT, Pease W, Silberbach GM, Moak JP, Maron BJ, Seidman CE, Seidman JG. (1998). Congenital heart disease caused by mutations in the transcription factor NKX2-5 [see comments]. Science 281:108-111.
72. Schultheiss TM, Xydas S, Lassar AB. (1995). Induction of avian cardiac myogenesis by anterior endoderm. Development 121:4203-4214.
73. Schultheiss TM, Burch JB, Lassar AB. (1997). A role for bone morphogenetic proteins in the induction of cardiac myogenesis. Genes Dev 11:451-462.
74. Sepulveda JL, Belaguli N, Nigam V, Chen CY, Nemer M, Schwartz RJ. (1998). GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: Role for regulating early cardiac gene expression. Mol Cell Biol 18:3405-3415.
75. Shishido E, Higashijima S-I, Emori Y, Saigo K. (1993). Two FGF-receptor homologues of Drosophila: one is expressed in mesodermal primordium in early embryos. Development 117:751-761.
76. Skeath J, Doe CQ. (1998). Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS. Development 125:1857-1865.
77. Spana EP, Doe CQ. (1996). Numb antagonizes Notch signalling to specify sibling neuron cell fates. Neuron 17:21-26.
78. Spana EP, Kopczynski C, Goodman CS, Doe CQ. (1995). Asymmetric localization of Numb autonomously determines sibling neuron identity in the Drosophila CNS. Development 121:3489-3494.
79. Staehling-Hampton K, Hoffmann FM, Baylies MK, Rushton E, Bate M. (1994). dpp induces mesodermal gene expression in Drosophila. Nature 372:783-786.
80. Su M-T, Fujioka M, Goto T, Bodmer R. (1999). The Drosophila homeobox genes zfh-1 and evenskipped are required for cardiac-specific differentiation of a numbdependent lineage decision. Development 126:3241-3251.
81. Tanaka M, Kasahara H, Bartunkova S, Schinke M, Inagaki H, Lee Y, Lyons GE, Izumo S. (1998). Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development. Dev Genet 22:239-249.
82. Tanaka M, Chen Z, Bartunkova S, Yamasaki N, Izumo S. (1999). The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development 126:1269-1280.
83. Tonissen KF, Drysdale TA, Limts TJ, Harvey RP, Krieg PA. (1994). XNkx2.5: a Xenopus homologue of Nkx-2.5 and tinman. Evidence for a conserved role in cardiac development. Dev Biol 162(1):325-328.
84. Uemura T, Shepherd S, Ackerman L, Jan LY, Jan YN. (1989). numb, A gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Cell 58:349-360.
85. Venkatesh TV, Bodmer R. (1995). How many signals does it take? Bioessays 17:754-757.
86. Venkatesh TV, Park M, Ocorr KA, Nemaceck J, Golden K, Wemple M, Bodmer R. (2000). Cardiac enhancer activity of the homeobox gene tinman depends on CREB consensus binding sites in Drosophila. Genesis 26:55-66.
87. Verdi JM, Schmandt R, Bashirullah A, Jacob S, Salvino R, Craig CG, Program AE, Lipshitz HD, McGlade CJ. (1996). Mammalian Numb is an evolutionarily conserved signaling adaptor protein that specifies cell fate. Curr Biol 6:1134-1145.
88. Vervoort M, Dambly-Chaudiere C, Ghysen A. (1997). Cell fate determination in Drosophila. Curr Opin Neurol 7:21-28.
89. Wu X, Golden K, Bodmer R. (1995). Heart development in Drosophila requires the segment polarity gene wingless. Dev Biol 169:619-628.
90. Xu X, Yin Z, Hudson JB, Ferguson EL, Frasch M. (1998). Smad proteins act in combination with synergistic and antagonistic regulators to target dpp responses to the Drosophila mesoderm. Genes Dev 12:2354-2370.
91. Yin Z, Frasch M. (1998). Regulation and function of tinman during dorsal mesoderm induction and heart specification in Drosophila. Dev Genet 22:187-200.
92. Yin Z, Xu X-L, Frasch M. (1997). Regulation of the Twist target gene tinman by modular cis-regulatory elements during early mesoderm development. Development 124:4971-4982.
93. Zhong W, Feder JN, Jiang MM, Jan LY, Jan YN. (1996). Asymmetric localization of a mammalian Numb homolog during mouse cortical neurogenesis. Neuron 17:43-53.
94. Zhong W, Jiang MM, Weinmaster G, Jan LY, Jan YN. (1997). Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Development 124:1887-1897.
95. Zou Y, Evans S, Chen J, Kou H-C, Harvey RP, Chien KR. (1997). CARP, a ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway. Development 124:793-804.