-
1
-
-
0036132096
-
Estimates of the worldwide prevalence of cancer for 25 sites in the adult population
-
Pisani P, Bray F, Parkin DM: Estimates of the worldwide prevalence of cancer for 25 sites in the adult population. Int J Cancer 97:72-81, 2002
-
(2002)
Int J Cancer
, vol.97
, pp. 72-81
-
-
Pisani, P.1
Bray, F.2
Parkin, D.M.3
-
2
-
-
0035467993
-
Global cancer statistics in the year 2000
-
Parkin DM: Global cancer statistics in the year 2000. Lancet Oncol 2:533-543, 2001
-
(2001)
Lancet Oncol
, vol.2
, pp. 533-543
-
-
Parkin, D.M.1
-
3
-
-
0033762484
-
The pursuit of optimal outcomes in cancer therapy in a new age of rationally designed target-based anticancer agents
-
Rowinsky E: The pursuit of optimal outcomes in cancer therapy in a new age of rationally designed target-based anticancer agents. Drugs 60:1-14, 2000 (suppl 1)
-
(2000)
Drugs
, vol.60
, Issue.SUPPL. 1
, pp. 1-14
-
-
Rowinsky, E.1
-
5
-
-
0028955388
-
Epidermal growth factor-related peptides and their receptors in human malignancies
-
Salomon DS, Brandt R, Ciardiello F, et al: Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 19:183-232, 1995
-
(1995)
Crit Rev Oncol Hematol
, vol.19
, pp. 183-232
-
-
Salomon, D.S.1
Brandt, R.2
Ciardiello, F.3
-
7
-
-
0035884231
-
The epidermal growth factor receptor: From mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia
-
Arteaga CL: The epidermal growth factor receptor: From mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia. J Clin Oncol 19:32S-40S, 2001
-
(2001)
J Clin Oncol
, vol.19
-
-
Arteaga, C.L.1
-
8
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon DJ, Clark GM, Wong SG, et al: Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235:177-182, 1987
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
-
9
-
-
0032125556
-
Cell cycle: Molecular targets for diagnosis and therapy: Tumor suppressor genes and cell cycle progression in cancer
-
Giordano A, Rustum YM, Wenner CE: Cell cycle: molecular targets for diagnosis and therapy: Tumor suppressor genes and cell cycle progression in cancer. J Cell Biochem 70:1-7, 1998
-
(1998)
J Cell Biochem
, vol.70
, pp. 1-7
-
-
Giordano, A.1
Rustum, Y.M.2
Wenner, C.E.3
-
10
-
-
0031884413
-
Expression of growth factors, growth-inhibiting factors, and their receptors in invasive breast cancer. II: Correlations with proliferation and angiogenesis
-
de Jong JS, van Diest PJ, van der Valk P, et al: Expression of growth factors, growth-inhibiting factors, and their receptors in invasive breast cancer. II: Correlations with proliferation and angiogenesis. J Pathol 184:53-57, 1998
-
(1998)
J Pathol
, vol.184
, pp. 53-57
-
-
De Jong, J.S.1
Van Diest, P.J.2
Van der Valk, P.3
-
11
-
-
0032731892
-
Tumor invasion: Role of growth factor-induced cell motility
-
Wells A: Tumor invasion: Role of growth factor-induced cell motility. Adv Cancer Res 78:31-101, 2000
-
(2000)
Adv Cancer Res
, vol.78
, pp. 31-101
-
-
Wells, A.1
-
12
-
-
0033580853
-
Epidermal growth factor protects epithelial cells against Fas-induced apoptosis. Requirement for Akt activation
-
Gibson S, Tu S, Oyer R, et al: Epidermal growth factor protects epithelial cells against Fas-induced apoptosis. Requirement for Akt activation. J Biol Chem 274:17612-17618, 1999
-
(1999)
J Biol Chem
, vol.274
, pp. 17612-17618
-
-
Gibson, S.1
Tu, S.2
Oyer, R.3
-
13
-
-
0028168569
-
Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity
-
Guy PM, Platko JV, Cantley LC, et al: Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity. Proc Natl Acad Sci U S A 91:8132-8136, 1994
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 8132-8136
-
-
Guy, P.M.1
Platko, J.V.2
Cantley, L.C.3
-
14
-
-
0031961980
-
Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor
-
Moscatello DK, Holgado-Madruga M, Emlet DR, et al: Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor. J Biol Chem 273:200-206, 1998
-
(1998)
J Biol Chem
, vol.273
, pp. 200-206
-
-
Moscatello, D.K.1
Holgado-Madruga, M.2
Emlet, D.R.3
-
15
-
-
7144227965
-
Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials
-
Voldborg BR, Damstrup L, Spang-Thomsen M, et al: Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials. Ann Oncol 8:1197-1206, 1997
-
(1997)
Ann Oncol
, vol.8
, pp. 1197-1206
-
-
Voldborg, B.R.1
Damstrup, L.2
Spang-Thomsen, M.3
-
16
-
-
0033009389
-
Binding specificities and affinities of egf domains for ErbB receptors
-
Jones JT, Akita RW, Sliwkowski MX: Binding specificities and affinities of egf domains for ErbB receptors. FEBS Lett 447:227-231, 1999
-
(1999)
FEBS Lett
, vol.447
, pp. 227-231
-
-
Jones, J.T.1
Akita, R.W.2
Sliwkowski, M.X.3
-
17
-
-
0034959016
-
The type 1 growth factor receptors and their ligands considered as a complex system
-
Gullick WJ: The type 1 growth factor receptors and their ligands considered as a complex system. Endocr Relat Cancer 8:75-82, 2001
-
(2001)
Endocr Relat Cancer
, vol.8
, pp. 75-82
-
-
Gullick, W.J.1
-
18
-
-
2142843806
-
Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions
-
Pinkas-Kramarski R, Soussan L, Waterman H, et al: Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J 15:2452-2467, 1996
-
(1996)
EMBO J
, vol.15
, pp. 2452-2467
-
-
Pinkas-Kramarski, R.1
Soussan, L.2
Waterman, H.3
-
19
-
-
20244367576
-
Bivalence of EGF-like ligands drives the ErbB signaling network
-
Tzahar E, Pinkas-Kramarski R, Moyer JD, et al: Bivalence of EGF-like ligands drives the ErbB signaling network. EMBO J 16:4938-4950, 1997
-
(1997)
EMBO J
, vol.16
, pp. 4938-4950
-
-
Tzahar, E.1
Pinkas-Kramarski, R.2
Moyer, J.D.3
-
20
-
-
0030944455
-
ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
-
Graus-Porta D, Beerli RR, Daly JM, et al: ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J 16:1647-1655, 1997
-
(1997)
EMBO J
, vol.16
, pp. 1647-1655
-
-
Graus-Porta, D.1
Beerli, R.R.2
Daly, J.M.3
-
21
-
-
0033608993
-
The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors
-
Klapper LN, Glathe S, Vaisman N, et al: The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors. Proc Natl Acad Sci U S A 96:4995-5000, 1999
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 4995-5000
-
-
Klapper, L.N.1
Glathe, S.2
Vaisman, N.3
-
22
-
-
0037434791
-
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
-
Cho H, Mason K, Ramyar K, et al: Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 421:756-760, 2003
-
(2003)
Nature
, vol.421
, pp. 756-760
-
-
Cho, H.1
Mason, K.2
Ramyar, K.3
-
23
-
-
0034644539
-
Cell signaling by receptor tyrosine kinases
-
Schlessinger J: Cell signaling by receptor tyrosine kinases. Cell 103:211-225, 2000
-
(2000)
Cell
, vol.103
, pp. 211-225
-
-
Schlessinger, J.1
-
24
-
-
0027233448
-
Signal transduction via the MAP kinases: Proceed at your own RSK
-
Blenis J: Signal transduction via the MAP kinases: Proceed at your own RSK. Proc Natl Acad Sci U S A 90:5889-5892, 1993
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 5889-5892
-
-
Blenis, J.1
-
25
-
-
0029160069
-
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
-
Burgering BM, Coffer PJ: Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376:599-602, 1995
-
(1995)
Nature
, vol.376
, pp. 599-602
-
-
Burgering, B.M.1
Coffer, P.J.2
-
26
-
-
0347997608
-
MAPK signal pathways in the regulation of cell proliferation in mammalian cells
-
Zhang W, Liu HT: MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res 12: 9-18, 2002
-
(2002)
Cell Res
, vol.12
, pp. 9-18
-
-
Zhang, W.1
Liu, H.T.2
-
27
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley LC: The phosphoinositide 3-kinase pathway. Science 296:1655-1657, 2002
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
28
-
-
0028800035
-
Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors
-
Moscatello DK, Holgado-Madruga M, Godwin AK, et al: Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors. Cancer Res 55:5536-5539, 1995
-
(1995)
Cancer Res
, vol.55
, pp. 5536-5539
-
-
Moscatello, D.K.1
Holgado-Madruga, M.2
Godwin, A.K.3
-
29
-
-
0027225697
-
Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas
-
Garcia de Palazzo IE, Adams GP, Sundareshan P, et al: Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas. Cancer Res 53:3217-3220, 1993
-
(1993)
Cancer Res
, vol.53
, pp. 3217-3220
-
-
Garcia de Palazzo, I.E.1
Adams, G.P.2
Sundareshan, P.3
-
30
-
-
0032446636
-
Comparative analysis of epidermal growth factor receptor mRNA levels in normal, benign hyperplastic and carcinomatous prostate
-
Kumar VL, Majumder PK, Gujral S, et al: Comparative analysis of epidermal growth factor receptor mRNA levels in normal, benign hyperplastic and carcinomatous prostate. Cancer Lett 134:177-180, 1998
-
(1998)
Cancer Lett
, vol.134
, pp. 177-180
-
-
Kumar, V.L.1
Majumder, P.K.2
Gujral, S.3
-
31
-
-
0035142469
-
Aberrant receptor signaling in human malignant gliomas: Mechanisms and therapeutic implications
-
Nagane M, Lin H, Cavenee WK, et al: Aberrant receptor signaling in human malignant gliomas: Mechanisms and therapeutic implications. Cancer Lett 162:S17-S21, 2001 (suppl)
-
(2001)
Cancer Lett
, vol.162
, Issue.SUPPL.
-
-
Nagane, M.1
Lin, H.2
Cavenee, W.K.3
-
32
-
-
0036847724
-
Expression of epidermal growth factor receptor correlates with disease relapse and progression to androgen-independence in human prostate cancer
-
Di Lorenzo G, Tortora G, D'Armiento FP, et al: Expression of epidermal growth factor receptor correlates with disease relapse and progression to androgen-independence in human prostate cancer. Clin Cancer Res 8:3438-3444, 2002
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3438-3444
-
-
Di Lorenzo, G.1
Tortora, G.2
D'Armiento, F.P.3
-
33
-
-
26744476071
-
The biology of erbB-2/neu/HER-2 and its role in cancer
-
Hynes NE, Stern DF: The biology of erbB-2/neu/HER-2 and its role in cancer. Biochim Biophys Acta 30:2-3, 1994
-
(1994)
Biochim Biophys Acta
, vol.30
, pp. 2-3
-
-
Hynes, N.E.1
Stern, D.F.2
-
35
-
-
0036362221
-
Epidermal growth factor receptor dependence in human tumorsmore than just expression?
-
Arteaga CL: Epidermal growth factor receptor dependence in human tumorsmore than just expression? Oncologist 7:31-39, 2002 (suppl 4)
-
(2002)
Oncologist
, vol.7
, Issue.SUPPL. 4
, pp. 31-39
-
-
Arteaga, C.L.1
-
36
-
-
0029032371
-
Expression of messenger RNA for amphiregulin, heregulin, and cripto-1, three new members of the epidermal growth factor family, in human breast carcinomas
-
Normanno N, Kim N, Wen D, et al: Expression of messenger RNA for amphiregulin, heregulin, and cripto-1, three new members of the epidermal growth factor family, in human breast carcinomas. Breast Cancer Res Treat 35:293-297, 1995
-
(1995)
Breast Cancer Res Treat
, vol.35
, pp. 293-297
-
-
Normanno, N.1
Kim, N.2
Wen, D.3
-
37
-
-
0032840643
-
Immunohistochemical comparative analysis of transforming growth factor alpha, epidermal growth factor, and epidermal growth factor receptor in normal, hyperplastic and neoplastic human prostates
-
De Miguel P, Royuela, Bethencourt R, et al: Immunohistochemical comparative analysis of transforming growth factor alpha, epidermal growth factor, and epidermal growth factor receptor in normal, hyperplastic and neoplastic human prostates. Cytokine 11:722-727, 1999
-
(1999)
Cytokine
, vol.11
, pp. 722-727
-
-
De Miguel, P.1
Royuela2
Bethencourt, R.3
-
38
-
-
0034954124
-
The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy
-
Pedersen MW, Meltorn M, Damstrup L, et al: The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy. Ann Oncol 12:745-760, 2001
-
(2001)
Ann Oncol
, vol.12
, pp. 745-760
-
-
Pedersen, M.W.1
Meltorn, M.2
Damstrup, L.3
-
39
-
-
0026548240
-
Structural alterations of the epidermal growth factor receptor gene in human gliomas
-
Wong AJ, Ruppert JM, Bigner SH, et al: Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc Natl Acad Sci U S A 89:2965-2969, 1992
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 2965-2969
-
-
Wong, A.J.1
Ruppert, J.M.2
Bigner, S.H.3
-
40
-
-
0037096945
-
Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion
-
Lal A, Glazer CA, Martinson HM, et al: Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion. Cancer Res 62:3335-3339, 2002
-
(2002)
Cancer Res
, vol.62
, pp. 3335-3339
-
-
Lal, A.1
Glazer, C.A.2
Martinson, H.M.3
-
41
-
-
0036132083
-
Epidermal growth factor receptor mutation type III transfected into a small cell lung cancer cell line is predominantly localized at the cell surface and enhances the malignant phenotype
-
Damstrup L, Wandahl Pedersen M, Bastholm L, et al: Epidermal growth factor receptor mutation type III transfected into a small cell lung cancer cell line is predominantly localized at the cell surface and enhances the malignant phenotype. Int J Cancer 97:7-14, 2002
-
(2002)
Int J Cancer
, vol.97
, pp. 7-14
-
-
Damstrup, L.1
Wandahl Pedersen, M.2
Bastholm, L.3
-
42
-
-
0033605560
-
ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors
-
Worthylake R, Opresko LK, Wiley HS: ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors. J Biol Chem 274:8865-8874, 1999
-
(1999)
J Biol Chem
, vol.274
, pp. 8865-8874
-
-
Worthylake, R.1
Opresko, L.K.2
Wiley, H.S.3
-
43
-
-
0032850677
-
Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
-
Cobleigh MA, Vogel CL, Tripathy D, et al: Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol 17:2639-2648, 1999
-
(1999)
J Clin Oncol
, vol.17
, pp. 2639-2648
-
-
Cobleigh, M.A.1
Vogel, C.L.2
Tripathy, D.3
-
44
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
-
Vogel CL, Cobleigh MA, Tripathy D, et al: Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 20:719-726, 2002
-
(2002)
J Clin Oncol
, vol.20
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
-
45
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER 2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S, et al: Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 344:783-792, 2001
-
(2001)
N Engl J Med
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
46
-
-
0034760143
-
Herceptin alone or in combination with chemotherapy in the treatment of HER2-positive metastatic breast cancer: Pivotal trials
-
Baselga J: Herceptin alone or in combination with chemotherapy in the treatment of HER2-positive metastatic breast cancer: pivotal trials. Oncology 61:14-21, 2001 (suppl 2)
-
(2001)
Oncology
, vol.61
, Issue.SUPPL. 2
, pp. 14-21
-
-
Baselga, J.1
-
47
-
-
19044380618
-
Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
-
Agus DB, Akita RW, Fox WD, et al: Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth. Cancer Cell 2:127-137, 2002
-
(2002)
Cancer Cell
, vol.2
, pp. 127-137
-
-
Agus, D.B.1
Akita, R.W.2
Fox, W.D.3
-
48
-
-
0034329308
-
Enhanced apoptosis with combination C225/Radiation treatment serves as the impetus for clinical investigation in head and neck cancers
-
Bonner JA, Raisch KP, Trummell HQ, et al: Enhanced apoptosis with combination C225/Radiation treatment serves as the impetus for clinical investigation in head and neck cancers. J Clin Oncol 18:47S-53S, 2000
-
(2000)
J Clin Oncol
, vol.18
-
-
Bonner, J.A.1
Raisch, K.P.2
Trummell, H.Q.3
-
49
-
-
0035398021
-
Phase I study of anti-epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer
-
Robert F, Ezekiel MP, Spencer SA, et al: Phase I study of anti-epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer. J Clin Oncol 19:3234-3243, 2001
-
(2001)
J Clin Oncol
, vol.19
, pp. 3234-3243
-
-
Robert, F.1
Ezekiel, M.P.2
Spencer, S.A.3
-
50
-
-
0003241755
-
Final report of the efficacy and safety of the anti-epidermal growth factor antibody, cetuximab (IMC-C225), in combination with cisplatin in patients with recurrent squamous cell carcinoma of the head and neck (SCCHN) refractory to cisplatin containing chemotherapy
-
abstr 925
-
Kies MS, Arquette M, Nabell L, et al: Final report of the efficacy and safety of the anti-epidermal growth factor antibody, cetuximab (IMC-C225), in combination with cisplatin in patients with recurrent squamous cell carcinoma of the head and neck (SCCHN) refractory to cisplatin containing chemotherapy. Proc Am Soc Clin Oncol 21:232a, 2002 (abstr 925)
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Kies, M.S.1
Arquette, M.2
Nabell, L.3
-
51
-
-
0001407134
-
Cetuximab (C225) plus cisplatin/carboplatin is active in patients (pts) with recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) progressing on a same dose and schedule platinum-based regimen
-
abstr 900
-
Baselga J, Trigo JM, Bourhis J, et al: Cetuximab (C225) plus cisplatin/carboplatin is active in patients (pts) with recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) progressing on a same dose and schedule platinum-based regimen. Proc Am Soc Clin Oncol 21:226a, 2002 (abstr 900)
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Baselga, J.1
Trigo, J.M.2
Bourhis, J.3
-
52
-
-
0001413605
-
Phase III trial comparing cisplatin (C) + placebo (P) to C + anti-epidermal growth factor antibody (EGF-R) C225 in patients (pts) with metastatic/recurrent head & neck cancer (HNC)
-
abstr 901
-
Burtness BA, Li Y, Flood W, et al: Phase III trial comparing cisplatin (C) + placebo (P) to C + anti-epidermal growth factor antibody (EGF-R) C225 in patients (pts) with metastatic/recurrent head & neck cancer (HNC). Proc Am Soc Clin Oncol 21:226a, 2002 (abstr 901)
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Burtness, B.A.1
Li, Y.2
Flood, W.3
-
53
-
-
0002823211
-
Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR)
-
abstr 7
-
Saltz L, Rubin M, Hochster H, et al: Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR). Proc Am Soc Clin Oncol 21:2a, 2001 (abstr 7)
-
(2001)
Proc Am Soc Clin Oncol
, vol.21
-
-
Saltz, L.1
Rubin, M.2
Hochster, H.3
-
54
-
-
0035117355
-
Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy
-
Yang X, Jia X, Corvalan JR, et al: Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. Crit Rev Oncol Hematol 38:17-23, 2001
-
(2001)
Crit Rev Oncol Hematol
, vol.38
, pp. 17-23
-
-
Yang, X.1
Jia, X.2
Corvalan, J.R.3
-
55
-
-
0000568621
-
Phase 2 clinical trial evaluating the safety and effectiveness of ABX-EGF in renal cell cancer (RCC)
-
abstr 91
-
Schwartz G, Dutcher J, Vogelzang N, et al: Phase 2 clinical trial evaluating the safety and effectiveness of ABX-EGF in renal cell cancer (RCC). Proc Am Soc Clin Oncol 21:24a, 2002 (abstr 91)
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Schwartz, G.1
Dutcher, J.2
Vogelzang, N.3
-
56
-
-
0033109155
-
Biodistribution of 99mTc-labeled anti-human epidermal growth factor receptor (EGF-R) humanized monoclonal antibody h-R3 in a xenograft model of human lung adenocarcinoma
-
Morales-Morales A, Duconge J, Caballero-Torres I, et al: Biodistribution of 99mTc-labeled anti-human epidermal growth factor receptor (EGF-R) humanized monoclonal antibody h-R3 in a xenograft model of human lung adenocarcinoma. Nucl Med Biol 26:275-279, 1999
-
(1999)
Nucl Med Biol
, vol.26
, pp. 275-279
-
-
Morales-Morales, A.1
Duconge, J.2
Caballero-Torres, I.3
-
57
-
-
0010433354
-
Use of the anti-EGFR antibody h-R3 in combination with radiotherapy in the treatment of advanced head and neck cancer
-
abstr 53
-
Crombet T, Osorio M, Cruz T, et al: Use of the anti-EGFR antibody h-R3 in combination with radiotherapy in the treatment of advanced head and neck cancer. Proc Am Soc Clin Oncol 21:14a, 2002 (abstr 53)
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Crombet, T.1
Osorio, M.2
Cruz, T.3
-
58
-
-
0001100611
-
A phase I dose escalation study of a humanized monoclonal antibody to EGFR (hR3) in patients with locally advanced squamous cell cancer of the head and neck (SCCHN) treated with radiotherapy (RT)
-
abstr 926
-
Winquist E, Nabid A, Sicheri D, et al: A phase I dose escalation study of a humanized monoclonal antibody to EGFR (hR3) in patients with locally advanced squamous cell cancer of the head and neck (SCCHN) treated with radiotherapy (RT). Proc Am Soc Clin Oncol 21:232a, 2002 (abstr 926)
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Winquist, E.1
Nabid, A.2
Sicheri, D.3
-
59
-
-
0141599428
-
Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor
-
Stamos J, Sliwkowski MX, Eigenbrot C: Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. J Biol Chem 277:46265-46272, 2002
-
(2002)
J Biol Chem
, vol.277
, pp. 46265-46272
-
-
Stamos, J.1
Sliwkowski, M.X.2
Eigenbrot, C.3
-
60
-
-
0036044979
-
HER-targeted tyrosine-kinase inhibitors
-
Baselga J, Hammond L: HER-targeted tyrosine-kinase inhibitors. Oncology 63:6-16, 2002
-
(2002)
Oncology
, vol.63
, pp. 6-16
-
-
Baselga, J.1
Hammond, L.2
-
61
-
-
0036016088
-
Anti-epidermal growth factor receptor drugs in cancer therapy
-
Ciardiello F, Tortora G: Anti-epidermal growth factor receptor drugs in cancer therapy. Expert Opin Invest Drugs 11:755-768, 2002
-
(2002)
Expert Opin Invest Drugs
, vol.11
, pp. 755-768
-
-
Ciardiello, F.1
Tortora, G.2
-
62
-
-
0036490442
-
Smart drugs: Tyrosine kinase inhibitors in cancer therapy
-
Shawver LK, Slamon D, Ullrich A: Smart drugs: Tyrosine kinase inhibitors in cancer therapy. Cancer Cell 1:117-123, 2002
-
(2002)
Cancer Cell
, vol.1
, pp. 117-123
-
-
Shawver, L.K.1
Slamon, D.2
Ullrich, A.3
-
63
-
-
0037106273
-
Targeting the epidermal growth factor receptor for cancer therapy
-
Mendelsohn J: Targeting the epidermal growth factor receptor for cancer therapy. J Clin Oncol 20:1S-13S, 2002
-
(2002)
J Clin Oncol
, vol.20
-
-
Mendelsohn, J.1
-
64
-
-
0013459319
-
Inhibition of mutant EGFRvIII transformed cells by tyrosine kinase inhibitor OSI-774 (Tarceva)
-
abstr 79
-
Iwata KK, Provoncha K, Gibson N: Inhibition of mutant EGFRvIII transformed cells by tyrosine kinase inhibitor OSI-774 (Tarceva). Proc Am Soc Clin Oncol 21:21a, 2002 (abstr 79)
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Iwata, K.K.1
Provoncha, K.2
Gibson, N.3
-
65
-
-
0036848833
-
Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (Iressa)
-
Heimberger AB, Learn CA, Archer GE, et al: brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (Iressa). Clin Cancer Res 8:3496-3502, 2002
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3496-3502
-
-
Heimberger, A.B.1
Learn, C.A.2
Archer, G.E.3
-
66
-
-
0030774045
-
Induction of apoptosis and cell cycle arrest by CP-358, 774, an inhibitor of epidermal growth factor receptor tyrosine kinase
-
Moyer JD, Barbacci EG, Iwata KK, et al: Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res 57:4838-4848, 1997
-
(1997)
Cancer Res
, vol.57
, pp. 4838-4848
-
-
Moyer, J.D.1
Barbacci, E.G.2
Iwata, K.K.3
-
67
-
-
0033763084
-
ZD1839 ("Iressa") as an anticancer agent
-
Baselga J, Averbuch SD: ZD1839 ("Iressa") as an anticancer agent. Drugs 60:33-40, 2000 (suppl 1)
-
(2000)
Drugs
, vol.60
, Issue.SUPPL. 1
, pp. 33-40
-
-
Baselga, J.1
Averbuch, S.D.2
-
68
-
-
0012452746
-
Effects of the EGFR inhibitor Tarceva on activated ErbB2
-
abstr 4973
-
Akita RW, Dugger D, Lewis Phillips G, et al: Effects of the EGFR inhibitor Tarceva on activated ErbB2. Proc Am Assoc Cancer Res 43:1003, 2002 (abstr 4973)
-
(2002)
Proc Am Assoc Cancer Res
, vol.43
, pp. 1003
-
-
Akita, R.W.1
Dugger, D.2
Lewis Phillips, G.3
-
69
-
-
0035893560
-
Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo
-
Moulder SL, Yakes FM, Muthuswamy SK, et al: Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo. Cancer Res 61:8887-8895, 2001
-
(2001)
Cancer Res
, vol.61
, pp. 8887-8895
-
-
Moulder, S.L.1
Yakes, F.M.2
Muthuswamy, S.K.3
-
70
-
-
0035476803
-
The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells
-
Moasser MM, Basso A, Averbuch SD, et al: The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res 61:7184-7188, 2001
-
(2001)
Cancer Res
, vol.61
, pp. 7184-7188
-
-
Moasser, M.M.1
Basso, A.2
Averbuch, S.D.3
-
71
-
-
0035892346
-
ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFR-positive cancer cell lines with or without erbB 2 overexpression
-
Anderson N, Ahmad T, Chan K, et al: ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFR-positive cancer cell lines with or without erbB2 overexpression. Int J Cancer 94:774-782, 2001
-
(2001)
Int J Cancer
, vol.94
, pp. 774-782
-
-
Anderson, N.1
Ahmad, T.2
Chan, K.3
-
72
-
-
0032695910
-
Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: Dynamics of receptor inhibition in situ and antitumor effects in athymic mice
-
Pollack VA, Savage DM, Baker DA, et al: Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: Dynamics of receptor inhibition in situ and antitumor effects in athymic mice. J Pharmacol Exp Ther 291:739-748, 1999
-
(1999)
J Pharmacol Exp Ther
, vol.291
, pp. 739-748
-
-
Pollack, V.A.1
Savage, D.M.2
Baker, D.A.3
-
73
-
-
0037109014
-
ZD1838 (Iressa): An orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy
-
Wakeling A, Guy S, Woodburn J, et al: ZD1838 (Iressa): an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res 62:5749-5754, 2002
-
(2002)
Cancer Res
, vol.62
, pp. 5749-5754
-
-
Wakeling, A.1
Guy, S.2
Woodburn, J.3
-
74
-
-
0035398631
-
Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
-
Hidalgo M, Siu LL, Nemunaitis J, et al: Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. J Clin Oncol 19:3267-3279, 2001
-
(2001)
J Clin Oncol
, vol.19
, pp. 3267-3279
-
-
Hidalgo, M.1
Siu, L.L.2
Nemunaitis, J.3
-
75
-
-
0000329007
-
A phase II trial of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor OSI-774, following platinum-based chemotherapy, in patients (pts) with advanced-EGFR-expressing, non-small cell lung cancer (NSCLC)
-
abstr 1235
-
Pérez-Soler R, Chachoua A, Huberman M, et al: A phase II trial of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor OSI-774, following platinum-based chemotherapy, in patients (pts) with advanced-EGFR-expressing, non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 20:310a, 2001 (abstr 1235)
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Pérez-Soler, R.1
Chachoua, A.2
Huberman, M.3
-
76
-
-
4243506537
-
Determinants of tumor response and survival in patients with relapsing NSCLC treated with Tarceva (erlotinib HCI; OSI-774). Final report of a phase II study
-
November 8-10, San Diego, CA
-
Pérez-Soler R, Chachoua A, Huberman M., et al: Determinants of tumor response and survival in patients with relapsing NSCLC treated with Tarceva (erlotinib HCI; OSI-774). Final report of a phase II study. Presented at the American Society of Clinical Oncology Molecular Therapy Symposium, November 8-10, 2002, San Diego, CA
-
(2002)
American Society of Clinical Oncology Molecular Therapy Symposium
-
-
Pérez-Soler, R.1
Chachoua, A.2
Huberman, M.3
-
77
-
-
0001069404
-
Phase 2 evaluation of OSI-774, a potent oral antagonist of the EGFR-TK in patients with advanced ovarian carcinoma
-
abstr 831
-
Finkler N, Gordon A, Crozier M, et al: Phase 2 evaluation of OSI-774, a potent oral antagonist of the EGFR-TK in patients with advanced ovarian carcinoma. Proc Am Soc Clin Oncol 20:208a, 2001 (abstr 831)
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Finkler, N.1
Gordon, A.2
Crozier, M.3
-
78
-
-
0003264493
-
Phase 2 evaluation of OSI-774, a potent oral antagonist of the EGFR-TK in patients with advanced squamous cell carcinoma of the head and neck
-
abstr 6
-
Senzer NN, Soulieres D, Siu L, et al: Phase 2 evaluation of OSI-774, a potent oral antagonist of the EGFR-TK in patients with advanced squamous cell carcinoma of the head and neck. Proc Am Soc Clin Oncol 20:2a, 2001 (abstr 6)
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Senzer, N.N.1
Soulieres, D.2
Siu, L.3
-
80
-
-
0036569870
-
ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: Results of a phase I trial
-
Ranson M, Hammond LA, Ferry D, et al: ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: results of a phase I trial. J Clin Oncol 20:2240-2250, 2002
-
(2002)
J Clin Oncol
, vol.20
, pp. 2240-2250
-
-
Ranson, M.1
Hammond, L.A.2
Ferry, D.3
-
81
-
-
0036842170
-
Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types
-
Baselga J, Rischin D, Ranson M, et al: Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types. J Clin Oncol 20:4292-4302, 2002
-
(2002)
J Clin Oncol
, vol.20
, pp. 4292-4302
-
-
Baselga, J.1
Rischin, D.2
Ranson, M.3
-
82
-
-
0003336304
-
Final results from a phase II trial of ZD1839 ('Iressa') for patients with advanced non-small cell lung cancer (IDEAL 1)
-
abstr 1188
-
Fukouka M, Yano S, Giaccone G, et al: Final results from a phase II trial of ZD1839 ('Iressa') for patients with advanced non-small cell lung cancer (IDEAL 1). Proc Am Soc Clin Oncol 21:298a, 2002 (abstr 1188)
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Fukouka, M.1
Yano, S.2
Giaccone, G.3
-
83
-
-
0001303063
-
A phase II trial of ZD1839 ('Iressa') in advanced non-small cell lung cancer (NSCLC) patients who had failed platinum- and docetaxel-based regimens (IDEAL 2)
-
abstr 1166
-
Kris MG, Natale RB, Herbst RS, et al: A phase II trial of ZD1839 ('Iressa') in advanced non-small cell lung cancer (NSCLC) patients who had failed platinum- and docetaxel-based regimens (IDEAL 2). Proc Am Soc Clin Oncol 21:292a, 2002 (abstr 1166)
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
-
84
-
-
0033988085
-
Activity of docetaxel in platinum-treated non-small-cell lung cancer: Results of a phase II multicenter trial
-
Gandara DR, Vokes E, Green M, et al: Activity of docetaxel in platinum-treated non-small-cell lung cancer: Results of a phase II multicenter trial. J Clin Oncol 18:131-135, 2000
-
(2000)
J Clin Oncol
, vol.18
, pp. 131-135
-
-
Gandara, D.R.1
Vokes, E.2
Green, M.3
-
85
-
-
0034283120
-
Phase II study of docetaxel in the treatment of patients with advanced nonsmall cell lung cancer in routine daily practice
-
Mattson K, Bosquee L, Dabouis G, et al: Phase II study of docetaxel in the treatment of patients with advanced nonsmall cell lung cancer in routine daily practice. Lung Cancer 29:205-216, 2000
-
(2000)
Lung Cancer
, vol.29
, pp. 205-216
-
-
Mattson, K.1
Bosquee, L.2
Dabouis, G.3
-
86
-
-
0002806626
-
A phase III clinical trial of ZD1839 ('Iressa') in combination with gemcitabine and cisplatin in chemotherapy-naive patients with advanced non-small cell lung cancer (INTACT I)
-
abstr 4
-
Giaccone G: A phase III clinical trial of ZD1839 ('Iressa') in combination with gemcitabine and cisplatin in chemotherapy-naive patients with advanced non-small cell lung cancer (INTACT I). Ann Oncol 13:2, 2002 (suppl 5) (abstr 4)
-
(2002)
Ann Oncol
, vol.13
, Issue.SUPPL. 5
, pp. 2
-
-
Giaccone, G.1
-
87
-
-
0000780450
-
ZD1839 ('Iressa') in combination with paclitaxel and carboplatin in chemotherapy-naive patients with advanced non-small-cell lung cancer (NSCLC): Results from a phase III clinical trial (INTACT II)
-
abstr 468
-
Johnson D: ZD1839 ('Iressa') in combination with paclitaxel and carboplatin in chemotherapy-naive patients with advanced non-small-cell lung cancer (NSCLC): Results from a phase III clinical trial (INTACT II). Ann Oncol 13:127, 2002 (suppl 5) (abstr 468)
-
(2002)
Ann Oncol
, vol.13
, Issue.SUPPL. 5
, pp. 127
-
-
Johnson, D.1
-
88
-
-
0034489914
-
Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase
-
Sirotnak FM, Zakowski MF, Miller VA, et al: Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase. Clin Cancer Res 6:4885-4892, 2000
-
(2000)
Clin Cancer Res
, vol.6
, pp. 4885-4892
-
-
Sirotnak, F.M.1
Zakowski, M.F.2
Miller, V.A.3
-
89
-
-
0034068319
-
Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
-
Ciardiello F, Caputo R, Bianco R, et al: Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin Cancer Res 6:2053-2063, 2000
-
(2000)
Clin Cancer Res
, vol.6
, pp. 2053-2063
-
-
Ciardiello, F.1
Caputo, R.2
Bianco, R.3
-
90
-
-
0035679211
-
High levels of HER-2 expression alter the ability of epidermal growth factor receptor (EGFR) family tyrosine kinase inhibitors to inhibit EGFR phosphorylation in vivo
-
Christensen JG, Schreck RE, Chan E, et al: High levels of HER-2 expression alter the ability of epidermal growth factor receptor (EGFR) family tyrosine kinase inhibitors to inhibit EGFR phosphorylation in vivo. Clin Cancer Res 7:4230-4238, 2001
-
(2001)
Clin Cancer Res
, vol.7
, pp. 4230-4238
-
-
Christensen, J.G.1
Schreck, R.E.2
Chan, E.3
-
91
-
-
0001412078
-
Acne-like rash predicts response in patients treated with cetuximab (IMC-C225) plus irinotecan (CPT-11) in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR)
-
abstr 559
-
Saltz L, Rubin M, Hochster H: Acne-like rash predicts response in patients treated with cetuximab (IMC-C225) plus irinotecan (CPT-11) in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR). Clin Cancer Res 7:3766, 2001 (suppl) (abstr 559)
-
(2001)
Clin Cancer Res
, vol.7
, Issue.SUPPL.
, pp. 3766
-
-
Saltz, L.1
Rubin, M.2
Hochster, H.3
-
92
-
-
0016719486
-
Isolation and structure of urogastrone and its relationship to epidermal growth factor
-
Gregory H: Isolation and structure of urogastrone and its relationship to epidermal growth factor. Nature 257:325-327, 1975
-
(1975)
Nature
, vol.257
, pp. 325-327
-
-
Gregory, H.1
-
93
-
-
0019304894
-
Sarcoma growth factor from mouse sarcoma virus-transformed cells. Purification by binding and elution from epidermal growth factor receptor-rich cells
-
De Larco JE, Reynolds R, Carlberg K, et al: Sarcoma growth factor from mouse sarcoma virus-transformed cells. Purification by binding and elution from epidermal growth factor receptor-rich cells. J Biol Chem 255:3685-3690, 1980
-
(1980)
J Biol Chem
, vol.255
, pp. 3685-3690
-
-
De Larco, J.E.1
Reynolds, R.2
Carlberg, K.3
-
94
-
-
0000276099
-
Amphiregulin: A bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7
-
Shoyab M, McDonald VL, Bradley JG, et al: Amphiregulin: A bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7. Proc Natl Acad Sci U S A 85:6528-6532, 1988
-
(1988)
Proc Natl Acad Sci U S A
, vol.85
, pp. 6528-6532
-
-
Shoyab, M.1
McDonald, V.L.2
Bradley, J.G.3
-
95
-
-
0027400724
-
Betacellulin: A mitogen from pancreatic beta cell tumors
-
Shing Y, Christofori G, Hanahan D, et al: Betacellulin: A mitogen from pancreatic beta cell tumors. Science 259:1604-1607, 1993
-
(1993)
Science
, vol.259
, pp. 1604-1607
-
-
Shing, Y.1
Christofori, G.2
Hanahan, D.3
-
96
-
-
0028937620
-
Epiregulin. A novel epidermal growth factor with mitogenic activity for rat primary hepatocytes
-
Toyoda H, Komurasaki T, Uchida D, et al: Epiregulin. A novel epidermal growth factor with mitogenic activity for rat primary hepatocytes. J Biol Chem 270:7495-7500, 1995
-
(1995)
J Biol Chem
, vol.270
, pp. 7495-7500
-
-
Toyoda, H.1
Komurasaki, T.2
Uchida, D.3
|