Differential cellular expression of neurotrophins in cortical tubers of the tuberous sclerosis complex

American Journal of Pathology

Volumn 159, Issue 4, 2001, Pages 1541-1554

  Kyin, Robin ^a   Hua, Yue ^a   Baybis, Marianna ^a   Scheithauer, Bernd ^b   Kolson, Dennis ^a   Uhlmann, Erik ^c   Gutmann, David ^c   Crino, Peter B ^c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MAYO CLINIC   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROTROPHIN;

ARTICLE; BRAIN DEVELOPMENT; CELL DIFFERENTIATION; CELL ULTRASTRUCTURE; CHROMOSOME MICRODISSECTION; CONTROLLED STUDY; ELECTROCORTICOGRAPHY; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; NERVE CELL CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN RNA BINDING; TISSUE HOMOGENATE; TUBEROUS SCLEROSIS;

EID: 0034794788     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)62539-4     Document Type: Article

References (53)

1. Pathology of tuberous sclerosis
2. Clinical, neuropathological, and genetic aspects of the tuberous sclerosis complex
3. New developments in the neurobiology of the tuberous sclerosis complex
4. Surgical treatment of epilepsy in tuberous sclerosis: Strategies and results in 18 patients
5. Surgical treatment for epilepsy in cerebral tuberous sclerosis
6. Epilepsy surgery in children with tuberous sclerosis complex: Presurgical evaluation and outcome
7. Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34
8. Identification and characterization of the tuberous sclerosis gene on chromosome 16
9. Tuber and subependymal giant cell astrocytoma associated with tuberous sclerosis: An immunohistochemical, ultrastructural, and immunoelectron microscopic study
10. Embryonic neuronal markers in tuberous sclerosis: Single cell molecular pathology
11. Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background
12. Subependymal astrocytic hamartomas in the Eker rat model of tuberous sclerosis
13. bFGF, neurotrophins, and the control or cortical neurogenesis
14. Neurotrophin signal transduction in the nervous system
15. Ontogeny of neurotrophin receptor trkC expression in the rat forebrain and anterior hypothalamus with emphasis on the suprachiasmatic nucleus
16. The ciliary neurotrophic factor and its receptor, CNTFR alpha
17. Opposing roles for endogenous BDNF and NT-3 in regulating cortical dendritic growth
18. Neuronal heterotopias in the developing cerebral cortex produced by neurotrophin-4
19. Suppressed kindling epileptogenesis and perturbed BDNF and TrkB gene regulation in NT-3 mutant mice
20. Neurotrophin-evoked rapid excitation through TrkB receptors
21. Immunohistochemical expression of trk receptor proteins in focal cortical dysplasia with intractable epilepsy
22. Netrin-1 promotes thalamic axon growth and is required for proper development of the thalamocortical projection
23. Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons
24. Neurotrophins differentially regulate the survival and morphological complexity of human CNS model neurons
25. Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs
26. Tuberous sclerosis complex consensus conference: Revised clinical diagnostic criteria
27. BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies
28. NeuN, a neuronal specific nuclear protein in vertebrates
29. In situ transcription: Specific synthesis of complementary DNA in fixed tissue sections
30. Preparation of cDNA from single cells and subcellular regions
31. Expression profiles of multiple genes in single neurons of Alzheimer's disease
32. Expression of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 in the somatosensory cortex of the mature rat: Coexpression with high-affinity neurotrophin receptors
33. The distribution of neurotrophin receptor TrkC-like immunoreactive fibers and varicosities in the rhesus monkey brain
34. Predominance of neuronal mRNAs in individual Alzheimer's disease senile plaques
35. Traumatic brain injury alters the molecular fingerprint of TUNEL-positive cortical neurons in vivo: A single cell analysis
36. Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy
37. Differential transcription of neurotransmitter receptor subunits and uptake sites in giant cells and dysplastic neurons in cortical tubers
38. Co-localization of TSC1 and TSC2 gene products in tubers of patients with tuberous sclerosis
39. A role of the tuberous sclerosis gene-2 product during neuronal differentiation
40. Localization of tuberous sclerosis 2 mRNA and its protein product tuberin in normal human brain and in cerebral lesions of patients with tuberous sclerosis
41. The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination
42. Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin
43. Neurotrophin regulation of the developing nervous system: Analyses of knockout mice
44. Activation of neurotrophin-3 receptor TrkC induces apoptosis in medulloblastomas
45. Neocortical neurons lacking the protein-tyrosine kinase B receptor display abnormal differentiation and process elongation in vitro and in vivo
46. TrkB and TrkC signaling are required for maturation and synaptogenesis of hippocampal connections
47. BDNF and NT-4, but not NT-3, promote development of inhibitory synapses in the absence of neuronal activity
48. TrkB receptor ligands promote activity-dependent inhibitory synaptogenesis
49. Mice lacking NT-3, and its receptor TrkC, exhibit profound deficiencies in CNS glial cells
50. Taylor's cortical dysplasia: A confocal and ultrastructural immunohistochemical study
51. Extension of long leading processes and neuronal migration in the mammalian brain directed by the chemoattractant netrin-1
52. Cortical tuber count: A biomarker indicating neurologic severity of tuberous sclerosis complex
53. Neurotrophins and basic fibroblast growth factor induce the differentiation of calbindin-containing neurons in the cerebral cortex