Tuberous sclerosis-like lesions in epileptogenic human neocortex lack allelic loss at the TSC1 and TSC2 regions

Acta Neuropathologica

Volumn 93, Issue 1, 1996, Pages 93-96

  Wolf, Helmut K ^a,c   Normann, Sabine ^a   Green, Andrew J ^b   Von Bakel, Inge ^b   Blümcke, Ingmar ^a   Pietsch, Torsten ^a   Wiestler, Otmar D ^a   Von Deimling, Andreas ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Chromosome 16; Chromosome 9; Epilepsy; Hamartoma; Pathology

Indexed keywords

REPRESSOR PROTEIN; TUBERIN; TUMOR SUPPRESSOR PROTEIN;

ADOLESCENT; ADULT; ALLELE; ARTICLE; BRAIN CORTEX; CHILD; CHROMOSOME 16; CHROMOSOME 9; EPILEPSY; GENE DELETION; GENETIC MARKER; GENETICS; HETEROZYGOTE; HUMAN; PATHOLOGY; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR GENE;

ADOLESCENT; ADULT; ALLELES; CEREBRAL CORTEX; CHILD; CHROMOSOMES, HUMAN, PAIR 16; CHROMOSOMES, HUMAN, PAIR 9; EPILEPSY; GENE DELETION; GENES, TUMOR SUPPRESSOR; GENETIC MARKERS; HETEROZYGOTE; HUMANS; REPRESSOR PROTEINS; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR PROTEINS;

EID: 0030639826     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050587     Document Type: Article

References (20)

1. Andermann F, Palmini AL (1992) Neuronal migration disorders, tuberous sclerosis, and Sturge-Weber syndrome. In: Lüders H (ed) Epilepsy surgery. Raven Press, New York, pp 203-211
2. Bender B, Wiestler OD, Deimling A von (1994) A device for processing large acrylamide gels. Biotechniques 16: 204-206
3. Budowle B, Chakraborty R, Giusti AM, Eisenberg AJ, Allen RC (1991) Analysis of the VNTR locus D1S80 by the PCR followed by high-resolution PAGE. Am J Hum Genet 48: 137-144
4. Carbonara C, Longa L, Grosso E, Borrone C, Garre MG, Brisigotti M, Migone N (1994) 9q34 loss of heterozygosity in a tuberous sclerosis astrocytoma suggests a growth suppressor-like activity also for the TSC1 gene. Hum Mol Genet 3: 1829-1832
5. Critchley M, Earl CJC (1932) Tuberous sclerosis and allied conditions. Brain 55: 311-346
6. Deimling A von, Bender B, Louis DN, Wiestler OD (1993) A rapid and non-radioactive PCR based assay for the detection of allelic loss in human gliomas. Neuropathol Appl Neurobiol 19: 524-529
7. Green AJ, Johnson PH, Yates JR (1994) The tuberous sclerosis gene on chromosome 9q34 acts as a growth suppressor. Hum Mol Genet 3: 1833-1834
8. Green AJ, Smith M, Yates JRW (1994) Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients. Nature Genet 6: 193-196
9. Hirose T, Scheithauer BW, Lopes MBS, Gerber HA, Altermatt HJ, Hukee MJ, VandenBerg SR, Charlesworth JC (1995) Tuber and subependymal giant cell astrocytoma associated with tuberous sclerosis: an immunohistochemical study. Acta Neuropathol 90: 387-399
10. Jay V, Becker LE, Otsubo H, Hwang PA, Hoffman HJ, Harwood ND (1993) Pathology of temporal lobectomy for refractory seizures in children. Review of 20 cases including some unique malformative lesions. J Neurosurg 79: 53-61
11. Louis DN, Deimling A von, Seizinger BR (1992) A (CA)n dinucleotide repeat assay for evaluating loss of allelic heterozygosity in small and archival human brain tumor specimens. Am J Pathol 141: 777-782
12. Palmini A, Andermann F, Olivier A, Tampieri D, Robitaille Y, Andermann E, Wright G (1991) Focal neuronal migration disorders and intractable epilepsy: a study of 30 patients. Ann Neurol 30: 741-749
13. Perot P, Weir B, Rasmussen T (1966) Tuberous sclerosis. Surgical therapy for seizures. Arch Neurol 15: 498-506
14. Sambrook J, Fritsch EF, Maniatis T (eds) (1989) Molecular cloning: a laboratory manual, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor
15. Sepp T, Yates JRW, Green AJ (1996) Loss of heterozygosity in tuberous sclerosis hamartomas. J Med Genet (in press)
16. Taylor DC, Falconer MA, Bruton CJ, Corsellis JAN (1971) Focal dysplasia of the cerebral cortex in epilepsy. J Neurol Neurosurg Psychiatry 34: 369-387
17. Wolf HK, Wiestler OD (1993) Surgical pathology of chronic epileptic seizure disorders. Brain Pathol 3: 371-380
18. Wolf HK, Zentner J, Hufnagel A, Campos MG, Schramm J, Elger CE, Wiestler OD (1993) Surgical pathology of chronic epileptic seizure disorders: experience with 63 specimens from extratemporal corticectomies, lobectomies and functional hemispherectomies. Acta Neuropathol 86: 466-472
19. Wolf HK, Birkholz T, Wellmer J, Blümcke I, Pietsch T, Wiestler OD (1995) Neurochemical profile of glioneuronal lesions from patients with chronic pharmacoresistant epilepsies. J Neuropathol Exp Neurol 54: 689-697
20. Wolf HK, Wellmer J, Müller MB, Wiestler OD, Hufnagel A, Pietsch T (1995) Glioneuronal malformative lesions and dysembryoplastic neuroepithelial tumors in patients with chronic pharmacoresistant epilepsies. J Neuropathol Exp Neurol 54: 245-254