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Volumn 5, Issue 2, 2016, Pages

Epithelial-mesenchymal transition and breast cancer

Author keywords

Breast cancer; Epithelial cells; Metastasis

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; BETA CATENIN; CYTOKERATIN; FIBRONECTIN; MICRORNA; MULTIDRUG RESISTANCE PROTEIN 1; NERVE CELL ADHESION MOLECULE; NOTCH RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR ZEB1; TRANSCRIPTION FACTOR ZEB2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; WNT PROTEIN;

EID: 85114274056     PISSN: None     EISSN: 20770383     Source Type: Journal    
DOI: 10.3390/jcm5020013     Document Type: Review
Times cited : (159)

References (131)
  • 10
    • 84876451247 scopus 로고    scopus 로고
    • Tumor dissemination: An EMT affair
    • [CrossRef] [PubMed]
    • Thiery, J.P.; Lim, C.T. Tumor dissemination: An EMT affair. Cancer Cell 2013, 23. [CrossRef] [PubMed]
    • (2013) Cancer Cell
    • Thiery, J.P.1    Lim, C.T.2
  • 11
    • 84930179858 scopus 로고    scopus 로고
    • The relevance of EMT in breast cancer metastasis: Correlation or causality
    • Christofori, G.; Bill, R. The relevance of EMT in breast cancer metastasis: Correlation or causality. FEBS 2015, 589, 1577-1587.
    • (2015) FEBS , vol.589 , pp. 1577-1587
    • Christofori, G.1    Bill, R.2
  • 12
    • 0017704436 scopus 로고
    • Metastasis results from preexisting variant cells within a malignant tumor
    • [CrossRef] [PubMed]
    • Fidler, I.J.; Kripke, M.L. Metastasis results from preexisting variant cells within a malignant tumor. Science 1977, 197, 893-895. [CrossRef] [PubMed]
    • (1977) Science , vol.197 , pp. 893-895
    • Fidler, I.J.1    Kripke, M.L.2
  • 13
    • 34047096557 scopus 로고    scopus 로고
    • Cancer stem cells: Models and concepts
    • [CrossRef] [PubMed]
    • Daleba, P.; Cho, R.W.; Clarke, M.F. Cancer stem cells: Models and concepts. Annu. Rev. Med. 2007, 58, 267-284. [CrossRef] [PubMed]
    • (2007) Annu. Rev. Med , vol.58 , pp. 267-284
    • Daleba, P.1    Cho, R.W.2    Clarke, M.F.3
  • 15
    • 77954860302 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44hi/CD24lo/- stemcell phenotype in human breast cancer
    • [CrossRef] [PubMed]
    • Blick, T.; Hugo, H.; Widodo, E.; Waltham, M.; Pinto, C.; Mani, S.A.; Weinberg, R.A.; Neve, R.M.; Lenburg, M.E.; Thompson, E.W. Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44hi/CD24lo/- stemcell phenotype in human breast cancer. J. Mammary Gland Biol. Neoplasia. 2010, 15, 235-252. [CrossRef] [PubMed]
    • (2010) J. Mammary Gland Biol. Neoplasia , vol.15 , pp. 235-252
    • Blick, T.1    Hugo, H.2    Widodo, E.3    Waltham, M.4    Pinto, C.5    Mani, S.A.6    Weinberg, R.A.7    Neve, R.M.8    Lenburg, M.E.9    Thompson, E.W.10
  • 16
    • 75649151387 scopus 로고    scopus 로고
    • Epithelia-mesenchymal transition in cancer development and its clinical significance
    • [CrossRef] [PubMed]
    • Iwatsuki, M.; Mimori, K.; Yokobori, T.; Ishi, H.; Beppu, T.; Nakamori, S.; Baba, H.; Mori, M. Epithelia-mesenchymal transition in cancer development and its clinical significance. Cancer Sci. 2010, 101, 293-299. [CrossRef] [PubMed]
    • (2010) Cancer Sci , vol.101 , pp. 293-299
    • Iwatsuki, M.1    Mimori, K.2    Yokobori, T.3    Ishi, H.4    Beppu, T.5    Nakamori, S.6    Baba, H.7    Mori, M.8
  • 17
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • [CrossRef] [PubMed]
    • Thiery, J.P.; Acloque, H.; Huang, R.Y.J.; Nieto, M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139, 871-890. [CrossRef] [PubMed]
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.J.3    Nieto, M.A.4
  • 18
    • 84861676291 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and breast cancer: Role, molecular mechanisms and clinical impact
    • [CrossRef] [PubMed]
    • Foroni, C.; Broggini, M.; Generali, D.; Damia, G. Epithelial-mesenchymal transition and breast cancer: Role, molecular mechanisms and clinical impact. Cancer Treat. Rev. 2012, 38, 689-697. [CrossRef] [PubMed]
    • (2012) Cancer Treat. Rev , vol.38 , pp. 689-697
    • Foroni, C.1    Broggini, M.2    Generali, D.3    Damia, G.4
  • 19
    • 84892839751 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition: What is the impact on breast cancer stem cells and drug resistance
    • [CrossRef] [PubMed]
    • Mallini, P.; Lennard, T.; Kriby, J.; Meeson, A. Epithelial-to-mesenchymal transition: What is the impact on breast cancer stem cells and drug resistance. Cancer Treat. Rev. 2014, 40, 341-348. [CrossRef] [PubMed]
    • (2014) Cancer Treat. Rev , vol.40 , pp. 341-348
    • Mallini, P.1    Lennard, T.2    Kriby, J.3    Meeson, A.4
  • 20
    • 37149040456 scopus 로고    scopus 로고
    • Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: Identification of genes potentially related to epithelial-mesenchymal transition
    • [CrossRef] [PubMed]
    • Lien, H.C.; Hsiao, Y.H.; Lin, Y.S.; Yao, Y.T.; Juan, H.F.; Kuo, W.H.; Hung, M.C.; Chang, K.J.; Hsieh, F.J. Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: Identification of genes potentially related to epithelial-mesenchymal transition. Oncogene 2007, 26, 7859-7871. [CrossRef] [PubMed]
    • (2007) Oncogene , vol.26 , pp. 7859-7871
    • Lien, H.C.1    Hsiao, Y.H.2    Lin, Y.S.3    Yao, Y.T.4    Juan, H.F.5    Kuo, W.H.6    Hung, M.C.7    Chang, K.J.8    Hsieh, F.J.9
  • 21
    • 84921982917 scopus 로고    scopus 로고
    • Genome-wide activities of RNA binding proteins that regulate cellular changes in the epithelial to mesenchymal transition (EMT)
    • [PubMed]
    • Bebee, T.W.; Cieply, B.W.; Carstens, R.P. Genome-wide activities of RNA binding proteins that regulate cellular changes in the epithelial to mesenchymal transition (EMT). Adv. Exp. Med. Biol. 2014, 825, 267-302. [PubMed]
    • (2014) Adv. Exp. Med. Biol , vol.825 , pp. 267-302
    • Bebee, T.W.1    Cieply, B.W.2    Carstens, R.P.3
  • 22
    • 84904524527 scopus 로고    scopus 로고
    • A signature of epithelial-mesenchymal plasticity and stromal activation in primary tumor modulates late recurrence in breast cancer independent of disease subtype
    • [CrossRef] [PubMed]
    • Cheng, Q.; Chang, J.T.; Gwin, W.R.; Zhu, J.; Ambs, S.; Geradts, J.; Lyerly, H.K. A signature of epithelial-mesenchymal plasticity and stromal activation in primary tumor modulates late recurrence in breast cancer independent of disease subtype. Breast Cancer Res. 2014, 16, 407. [CrossRef] [PubMed]
    • (2014) Breast Cancer Res , vol.16
    • Cheng, Q.1    Chang, J.T.2    Gwin, W.R.3    Zhu, J.4    Ambs, S.5    Geradts, J.6    Lyerly, H.K.7
  • 24
    • 16844379257 scopus 로고    scopus 로고
    • Cadherin switching: Essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition
    • [CrossRef] [PubMed]
    • Maeda, M.; Johnson, K.R.; Wheelock, M.J. Cadherin switching: Essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition. J. Cell Sci. 2005, 118, 873-887. [CrossRef] [PubMed]
    • (2005) J. Cell Sci , vol.118 , pp. 873-887
    • Maeda, M.1    Johnson, K.R.2    Wheelock, M.J.3
  • 25
    • 39449095723 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype
    • [CrossRef] [PubMed]
    • Sarrió, D.; Rodriguez-Pinilla, S.M.; Hardisson, D.; Cano, A.; Moreno-Bueno, G.; Palacios, J. Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype. Cancer Res. 2008, 68, 989-997. [CrossRef] [PubMed]
    • (2008) Cancer Res , vol.68 , pp. 989-997
    • Sarrió, D.1    Rodriguez-Pinilla, S.M.2    Hardisson, D.3    Cano, A.4    Moreno-Bueno, G.5    Palacios, J.6
  • 26
    • 84872270125 scopus 로고    scopus 로고
    • Dysregulated expression of Slug, Vimentin, and E-cadherin correlates with poor clinical outcome in patients with basal-like breast cancer
    • [CrossRef] [PubMed]
    • Liu, T.; Zhang, X.; Shang, M.; Zhang, Y.; Xia, B.; Niu, M.; Liu, Y.; Pang, D. Dysregulated expression of Slug, Vimentin, and E-cadherin correlates with poor clinical outcome in patients with basal-like breast cancer. J. Surg. Oncol. 2013, 107, 188-194. [CrossRef] [PubMed]
    • (2013) J. Surg. Oncol , vol.107 , pp. 188-194
    • Liu, T.1    Zhang, X.2    Shang, M.3    Zhang, Y.4    Xia, B.5    Niu, M.6    Liu, Y.7    Pang, D.8
  • 27
    • 84901680245 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition in early invasive breast cancer: An immunohistochemical and reverse phase protein array study
    • [CrossRef] [PubMed]
    • Aleskandarany, M.A.; Negm, O.H.; Green, A.R.; Ahmed, M.A.H.; Nolan, C.C.; Tighe, P.J.; Ellis, I.; Rakha, E.A. Epithelial mesenchymal transition in early invasive breast cancer: An immunohistochemical and reverse phase protein array study. Breast Cancer Res. Treat. 2014, 145, 339-348. [CrossRef] [PubMed]
    • (2014) Breast Cancer Res. Treat , vol.145 , pp. 339-348
    • Aleskandarany, M.A.1    Negm, O.H.2    Green, A.R.3    Ahmed, M.A.H.4    Nolan, C.C.5    Tighe, P.J.6    Ellis, I.7    Rakha, E.A.8
  • 28
    • 84885632147 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition increases during the progression of in situ to invasive basal-like breast cancer
    • [CrossRef] [PubMed]
    • Choi, Y.; Lee, H.J.; Jang, M.H.; Gwak, J.M.; Lee, K.S.; Kim, E.J.; Kim, H.J.; Lee, H.E.; Park, S.Y. Epithelial-mesenchymal transition increases during the progression of in situ to invasive basal-like breast cancer. Hum. Pathol. 2013, 44, 2581-2589. [CrossRef] [PubMed]
    • (2013) Hum. Pathol , vol.44 , pp. 2581-2589
    • Choi, Y.1    Lee, H.J.2    Jang, M.H.3    Gwak, J.M.4    Lee, K.S.5    Kim, E.J.6    Kim, H.J.7    Lee, H.E.8    Park, S.Y.9
  • 32
    • 84906927974 scopus 로고    scopus 로고
    • Co-expression of putative stemness and epithelial-to-mesenchymal transition markers on single circulating tumour cells from patients with early and metastatic breast cancer
    • [CrossRef] [PubMed]
    • Papadaki, M.A.; Kallergi, G.; Zafeiriou, Z.; Manouras, L.; Theodoropoulos, P.A.; Mavroudis, D.; Georgoulias, V.; Agelaki, S. Co-expression of putative stemness and epithelial-to-mesenchymal transition markers on single circulating tumour cells from patients with early and metastatic breast cancer. BMC Cancer 2014, 14, 651. [CrossRef] [PubMed]
    • (2014) BMC Cancer , vol.14
    • Papadaki, M.A.1    Kallergi, G.2    Zafeiriou, Z.3    Manouras, L.4    Theodoropoulos, P.A.5    Mavroudis, D.6    Georgoulias, V.7    Agelaki, S.8
  • 33
    • 84860397754 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition markers expressed in circulating tumour cells of early and metastatic breast cancer patients
    • [CrossRef] [PubMed]
    • Kallergi, G.; Papadaki, M.A.; Politaki, E.; Mavroudis, D.; Georgoulias, V.; Agelaki, S. Epithelial to mesenchymal transition markers expressed in circulating tumour cells of early and metastatic breast cancer patients. Breast Cancer Res. 2011, 13, R59. [CrossRef] [PubMed]
    • (2011) Breast Cancer Res , vol.13
    • Kallergi, G.1    Papadaki, M.A.2    Politaki, E.3    Mavroudis, D.4    Georgoulias, V.5    Agelaki, S.6
  • 34
    • 44349139461 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and the stem cell phenotype
    • [PubMed]
    • Radisky, D.C.; LaBarge, M.A. Epithelial-mesenchymal transition and the stem cell phenotype. Cell Stem Cell 2008, 2, 511-512. [PubMed]
    • (2008) Cell Stem Cell , vol.2 , pp. 511-512
    • Radisky, D.C.1    LaBarge, M.A.2
  • 35
    • 0037388204 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic breast cancer cells
    • [PubMed]
    • AL-Hajj, M.;Wicha, M.S.; Benito-Hernandez, A.; Morrison, S.J.; Clarke, M.F. Prospective identification of tumorigenic breast cancer cells. PNAS 2003, 100, 3983-3988. [PubMed]
    • (2003) PNAS , vol.100 , pp. 3983-3988
    • AL-Hajj, M.1    Wicha, M.S.2    Benito-Hernandez, A.3    Morrison, S.J.4    Clarke, M.F.5
  • 36
    • 84892619683 scopus 로고    scopus 로고
    • Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts
    • [PubMed]
    • Liu, S.; Cong, Y.; Wang, D.; Sun, Y.; Deng, L.; Liu, Y.; Martin-Trevino, R.; Shang, L.; McDermott, S.P.; Landis, M.D.; et al. Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts. Stem Cell Rep. 2013, 2, 78-91. [PubMed]
    • (2013) Stem Cell Rep , vol.2 , pp. 78-91
    • Liu, S.1    Cong, Y.2    Wang, D.3    Sun, Y.4    Deng, L.5    Liu, Y.6    Martin-Trevino, R.7    Shang, L.8    McDermott, S.P.9    Landis, M.D.10
  • 37
    • 84885980367 scopus 로고    scopus 로고
    • Triple negative breast tumors in African-American and Hispanic/Latina women are high in CD44+, low in CD24+, and have loss of PTEN
    • [CrossRef] [PubMed]
    • Wu, Y.; Sarkissyan, M.; Elshimali, Y.; Vadgama, J.V. Triple negative breast tumors in African-American and Hispanic/Latina women are high in CD44+, low in CD24+, and have loss of PTEN. PLoS ONE 2013, 8, e78259. [CrossRef] [PubMed]
    • (2013) PLoS ONE , vol.8
    • Wu, Y.1    Sarkissyan, M.2    Elshimali, Y.3    Vadgama, J.V.4
  • 39
    • 79955776264 scopus 로고    scopus 로고
    • The CD44+/CD24- phenotype relates to "triple-negative" state and unfavorable prognosis in breast cancer patients
    • [CrossRef] [PubMed]
    • Giatromanolaki, A.; Sivridis, E.; Fiska, A.; Koukourakis, M.I. The CD44+/CD24- phenotype relates to "triple-negative" state and unfavorable prognosis in breast cancer patients. Med. Oncol. 2011, 28, 745-752. [CrossRef] [PubMed]
    • (2011) Med. Oncol , vol.28 , pp. 745-752
    • Giatromanolaki, A.1    Sivridis, E.2    Fiska, A.3    Koukourakis, M.I.4
  • 40
    • 84863201206 scopus 로고    scopus 로고
    • CD44+/CD24- phenotype contributes to malignant relapse following surgical resection and chemotherapy in patients with invasive ductal carcinoma
    • Lin, Y.; Zhong, Y.; Guan, H.; Zhang, X.; Sun, Q. CD44+/CD24- phenotype contributes to malignant relapse following surgical resection and chemotherapy in patients with invasive ductal carcinoma. J. Exp. Clin. Cancer Res. 2012, 31, 31-59.
    • (2012) J. Exp. Clin. Cancer Res , vol.31 , pp. 31-59
    • Lin, Y.1    Zhong, Y.2    Guan, H.3    Zhang, X.4    Sun, Q.5
  • 42
    • 84948429460 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes ro chemoresistance
    • [CrossRef] [PubMed]
    • Fischer, K.R.; Durrans, A.; Lee, S.; Sheng, J.; Li, F.; Wong, S.T.; Choi, H.; El Rayes, T.; Ryu, S.; Troeger, J.; et al. Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes ro chemoresistance. Nature 2015, 527. [CrossRef] [PubMed]
    • (2015) Nature
    • Fischer, K.R.1    Durrans, A.2    Lee, S.3    Sheng, J.4    Li, F.5    Wong, S.T.6    Choi, H.7    El Rayes, T.8    Ryu, S.9    Troeger, J.10
  • 43
    • 65249155400 scopus 로고    scopus 로고
    • Twist1-mediated Adriamycin-induced epithelial-mesenchymal transition relates to multidrug resistance and invasive potential in breast cancer cells
    • [CrossRef] [PubMed]
    • Li, Q.; Xu, J.; Wang, W.; Cao, X.; Chen, Q.; Tang, F.; Chen, Z.Q.; Liu, X.P.; Xu, Z.D. Twist1-mediated Adriamycin-induced epithelial-mesenchymal transition relates to multidrug resistance and invasive potential in breast cancer cells. Clin. Cancer Res. 2009, 15, 2657-2665. [CrossRef] [PubMed]
    • (2009) Clin. Cancer Res , vol.15 , pp. 2657-2665
    • Li, Q.1    Xu, J.2    Wang, W.3    Cao, X.4    Chen, Q.5    Tang, F.6    Chen, Z.Q.7    Liu, X.P.8    Xu, Z.D.9
  • 44
    • 84901832596 scopus 로고    scopus 로고
    • Acquisition of epithelial-mesenchymal transition is associated with Skp2 expression in paclitaxel-resistant breast cancer cells
    • [CrossRef] [PubMed]
    • Yang, Q.; Huang, J.; Wu, Q.; Cai, Y.; Zhu, L.; Lu, X.; Chen, S.; Chen, C.; Wang, Z. Acquisition of epithelial-mesenchymal transition is associated with Skp2 expression in paclitaxel-resistant breast cancer cells. Br. J. Cancer 2014, 110, 1958-1967. [CrossRef] [PubMed]
    • (2014) Br. J. Cancer , vol.110 , pp. 1958-1967
    • Yang, Q.1    Huang, J.2    Wu, Q.3    Cai, Y.4    Zhu, L.5    Lu, X.6    Chen, S.7    Chen, C.8    Wang, Z.9
  • 45
    • 84855833376 scopus 로고    scopus 로고
    • Chemoresistance to 5-fluorouracil induces epithelial-mesenchymal transition via up-regulation of Snail in MCF7 human breast cancer cells
    • [CrossRef] [PubMed]
    • Zhang, W.; Feng, M.; Zheng, G.; Chen, Y.; Wang, X.; Pen, B.; Yin, J.; Yu, Y.; He, Z. Chemoresistance to 5-fluorouracil induces epithelial-mesenchymal transition via up-regulation of Snail in MCF7 human breast cancer cells. Biochem. Biophys. Res. Commun. 2012, 417, 679-685. [CrossRef] [PubMed]
    • (2012) Biochem. Biophys. Res. Commun , vol.417 , pp. 679-685
    • Zhang, W.1    Feng, M.2    Zheng, G.3    Chen, Y.4    Wang, X.5    Pen, B.6    Yin, J.7    Yu, Y.8    He, Z.9
  • 46
    • 79951681780 scopus 로고    scopus 로고
    • Drug resistant MCF-7 cells exhibit epithelial-mesenchymal transition gene expression pattern
    • [CrossRef] [PubMed]
    • Iseri, Ö.D.; Kars, M.D.; Arpaci, F.; Atalay, C.; Pak, I.; Gündüz, U. Drug resistant MCF-7 cells exhibit epithelial-mesenchymal transition gene expression pattern. Biomed. Phamacother. 2011, 65, 40-45. [CrossRef] [PubMed]
    • (2011) Biomed. Phamacother , vol.65 , pp. 40-45
    • Iseri, Ö.D.1    Kars, M.D.2    Arpaci, F.3    Atalay, C.4    Pak, I.5    Gündüz, U.6
  • 47
    • 28844494352 scopus 로고    scopus 로고
    • Tamoxifen resistance in MCF7 cells promotes EMT-like behavior and involves modulation of β-catenin phosphorylation
    • [CrossRef] [PubMed]
    • Hiscox, S.; Jiang,W.G.; Obermeier, K.; Taylor, K.; Morgan, L.; Burmi, R.; Barrow, D.; Nicholson, R.I. Tamoxifen resistance in MCF7 cells promotes EMT-like behavior and involves modulation of β-catenin phosphorylation. Int. J. Cancer 2006, 118, 290-301. [CrossRef] [PubMed]
    • (2006) Int. J. Cancer , vol.118 , pp. 290-301
    • Hiscox, S.1    Jiang, W.G.2    Obermeier, K.3    Taylor, K.4    Morgan, L.5    Burmi, R.6    Barrow, D.7    Nicholson, R.I.8
  • 48
    • 84882265082 scopus 로고    scopus 로고
    • Tamoxifen-resistant breast cancer cells possess cancer stem-like cell properties
    • [PubMed]
    • Liu, H.; Zhang, H.W.; Sun, X.F.; Guo, X.H.; He, Y.N.; Cui, S.D.; Fan, Q.X. Tamoxifen-resistant breast cancer cells possess cancer stem-like cell properties. Chin. Med. J. 2013, 126, 3030-3034. [PubMed]
    • (2013) Chin. Med. J , vol.126 , pp. 3030-3034
    • Liu, H.1    Zhang, H.W.2    Sun, X.F.3    Guo, X.H.4    He, Y.N.5    Cui, S.D.6    Fan, Q.X.7
  • 50
    • 84871392766 scopus 로고    scopus 로고
    • Expression of Wnt3 activates Wnt/β-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells
    • [CrossRef] [PubMed]
    • Wu, Y.; Ginther, C.; Kim, J.; Mosher, N.; Chung, S.; Slamon, D.; Vadgama, J.V. Expression of Wnt3 activates Wnt/β-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells. Mol. Cancer Res. 2012, 10, 1597-1606. [CrossRef] [PubMed]
    • (2012) Mol. Cancer Res , vol.10 , pp. 1597-1606
    • Wu, Y.1    Ginther, C.2    Kim, J.3    Mosher, N.4    Chung, S.5    Slamon, D.6    Vadgama, J.V.7
  • 51
    • 83955165959 scopus 로고    scopus 로고
    • Expression of epithelial-mesenchymal transition-inducing transcription factors in primary breast cancer: The effect of neoadjuvant therapy
    • [CrossRef] [PubMed]
    • Mego, M.; Mani, S.A.; Lee, B.N.; Li, C.; Evans, K.W.; Cohen, E.N.; Gao, H.; Jackson, S.A.; Giordano, A.; Hortobagyi, G.N.; et al. Expression of epithelial-mesenchymal transition-inducing transcription factors in primary breast cancer: The effect of neoadjuvant therapy. Int. J. Cancer 2012, 130, 808-816. [CrossRef] [PubMed]
    • (2012) Int. J. Cancer , vol.130 , pp. 808-816
    • Mego, M.1    Mani, S.A.2    Lee, B.N.3    Li, C.4    Evans, K.W.5    Cohen, E.N.6    Gao, H.7    Jackson, S.A.8    Giordano, A.9    Hortobagyi, G.N.10
  • 52
    • 23044466047 scopus 로고    scopus 로고
    • Specificity and versatility in TGF-β signaling though Smads
    • [CrossRef] [PubMed]
    • Feng, X.; Derynck, R. Specificity and versatility in TGF-β signaling though Smads. Annu. Rev. Cell Dev. Biol. 2005, 21, 659-693. [CrossRef] [PubMed]
    • (2005) Annu. Rev. Cell Dev. Biol , vol.21 , pp. 659-693
    • Feng, X.1    Derynck, R.2
  • 53
    • 84866742560 scopus 로고    scopus 로고
    • TGFβ signaling in context
    • [CrossRef] [PubMed]
    • Massagué, J. TGFβ signaling in context. Nat. Rev. Mol. Cell Biol. 2012, 13, 616-630. [CrossRef] [PubMed]
    • (2012) Nat. Rev. Mol. Cell Biol , vol.13 , pp. 616-630
    • Massagué, J.1
  • 54
    • 84859437880 scopus 로고    scopus 로고
    • Role of Smads in TGFβ signaling
    • [CrossRef] [PubMed]
    • Heldin, C.; Moustakas, A. Role of Smads in TGFβ signaling. Cell Tissue Res. 2012, 347, 21-36. [CrossRef] [PubMed]
    • (2012) Cell Tissue Res , vol.347 , pp. 21-36
    • Heldin, C.1    Moustakas, A.2
  • 55
    • 84893835907 scopus 로고    scopus 로고
    • Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis
    • [CrossRef] [PubMed]
    • Xue, J.; Lin, X.; Chiu,W.T.; Chen, Y.H.; Yu, G.; Liu, M.; Feng, X.H.; Sawaya, R.; Medema, R.H.; Hung, M.C.; et al. Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis. J. Clin. Invest. 2014, 124, 564-579. [CrossRef] [PubMed]
    • (2014) J. Clin. Invest , vol.124 , pp. 564-579
    • Xue, J.1    Lin, X.2    Chiu, W.T.3    Chen, Y.H.4    Yu, G.5    Liu, M.6    Feng, X.H.7    Sawaya, R.8    Medema, R.H.9    Hung, M.C.10
  • 56
    • 0038369998 scopus 로고    scopus 로고
    • A self-enabling TGFβ response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells
    • [CrossRef]
    • Kang, Y.; Chen, C.R.; Massagué, J. A self-enabling TGFβ response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol. Cell 2003, 11, 915-926. [CrossRef]
    • (2003) Mol. Cell , vol.11 , pp. 915-926
    • Kang, Y.1    Chen, C.R.2    Massagué, J.3
  • 57
    • 84916928394 scopus 로고    scopus 로고
    • Oct-4 and Nanog promote the epithelial-mesenchymal transition of breast cancer stem cells and are associated with poor prognosis in breast cancer patients
    • [CrossRef] [PubMed]
    • Wang, D.; Lu, P.; Zhang, H.; Luo, M.; Zhang, X.; Wei, X.; Gao, J.; Zhao, Z.; Liu, C. Oct-4 and Nanog promote the epithelial-mesenchymal transition of breast cancer stem cells and are associated with poor prognosis in breast cancer patients. Oncotarget 2014, 5, 10803-10815. [CrossRef] [PubMed]
    • (2014) Oncotarget , vol.5 , pp. 10803-10815
    • Wang, D.1    Lu, P.2    Zhang, H.3    Luo, M.4    Zhang, X.5    Wei, X.6    Gao, J.7    Zhao, Z.8    Liu, C.9
  • 58
    • 33751514601 scopus 로고    scopus 로고
    • A Wnt-Axin2-GSK3β cascade regulates Snail1 activity in breast cancer cells
    • [CrossRef] [PubMed]
    • Yook, J.I.; Li, X.Y.; Ota, I.; Hu, C.; Kim, H.S.; Kim, N.H.; Cha, S.Y.; Ryu, J.K.; Choi, Y.J.; Kim, J.; et al. A Wnt-Axin2-GSK3β cascade regulates Snail1 activity in breast cancer cells. Nat. Cell Biol. 2006, 8, 1398-1406. [CrossRef] [PubMed]
    • (2006) Nat. Cell Biol , vol.8 , pp. 1398-1406
    • Yook, J.I.1    Li, X.Y.2    Ota, I.3    Hu, C.4    Kim, H.S.5    Kim, N.H.6    Cha, S.Y.7    Ryu, J.K.8    Choi, Y.J.9    Kim, J.10
  • 60
    • 84923068587 scopus 로고    scopus 로고
    • Effect of nitric oxide synthase on multiple drug resistance is related to Wnt signaling in non-small cell lung cancer
    • [CrossRef] [PubMed]
    • Li, Y.; Ma, C.; Shi, X.; Wen, Z.; Li, D.; Sun, M.; Ding, H. Effect of nitric oxide synthase on multiple drug resistance is related to Wnt signaling in non-small cell lung cancer. Oncol. Rep. 2014, 32, 1703-1708. [CrossRef] [PubMed]
    • (2014) Oncol. Rep , vol.32 , pp. 1703-1708
    • Li, Y.1    Ma, C.2    Shi, X.3    Wen, Z.4    Li, D.5    Sun, M.6    Ding, H.7
  • 61
    • 84905489532 scopus 로고    scopus 로고
    • TCF4 silencing sensitizes the colon cancer cell line to oxaliplatin as a common chemotherapeutic drug
    • [CrossRef] [PubMed]
    • Gheidari, F.; Bakhshandeh, B.; Teimoori-Toolabi, L.; Mehrtash, A.; Ghadir, M.; Zeinali, S. TCF4 silencing sensitizes the colon cancer cell line to oxaliplatin as a common chemotherapeutic drug. Anticancer Drugs 2014, 25, 908-916. [CrossRef] [PubMed]
    • (2014) Anticancer Drugs , vol.25 , pp. 908-916
    • Gheidari, F.1    Bakhshandeh, B.2    Teimoori-Toolabi, L.3    Mehrtash, A.4    Ghadir, M.5    Zeinali, S.6
  • 62
    • 84875505291 scopus 로고    scopus 로고
    • The Wnt signaling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer
    • Loh, Y.N.; Hedditch, E.L.; Baker, L.A.; Jary, E.; Ward, R.L.; Ford, C.E. The Wnt signaling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer. BMC Cancer 2013, 13, 1471-2407.
    • (2013) BMC Cancer , vol.13 , pp. 1471-2407
    • Loh, Y.N.1    Hedditch, E.L.2    Baker, L.A.3    Jary, E.4    Ward, R.L.5    Ford, C.E.6
  • 63
    • 24944506696 scopus 로고    scopus 로고
    • High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
    • [CrossRef] [PubMed]
    • Reedijk, M.; Odorcic, S.; Chang, L.; Zhang, H.; Miller, N.; McCready, D.R.; Lockwood, G.; Egan, S.E. High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res. 2005, 65, 8530-8537. [CrossRef] [PubMed]
    • (2005) Cancer Res , vol.65 , pp. 8530-8537
    • Reedijk, M.1    Odorcic, S.2    Chang, L.3    Zhang, H.4    Miller, N.5    McCready, D.R.6    Lockwood, G.7    Egan, S.E.8
  • 64
    • 77953523118 scopus 로고    scopus 로고
    • The Role of Notch signaling pathway in epithelial-mesenchymal transition (EMT) during development and tumor aggressiveness
    • [CrossRef] [PubMed]
    • Wang, Z.; Li, Y.; Kong, D.; Sarkar, F.H. The Role of Notch signaling pathway in epithelial-mesenchymal transition (EMT) during development and tumor aggressiveness. Curr. Drug Targets 2010, 11, 745-751. [CrossRef] [PubMed]
    • (2010) Curr. Drug Targets , vol.11 , pp. 745-751
    • Wang, Z.1    Li, Y.2    Kong, D.3    Sarkar, F.H.4
  • 65
    • 36549010842 scopus 로고    scopus 로고
    • Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin
    • [CrossRef] [PubMed]
    • Leong, K.G.; Niessen, K.; Kulic, I.; Raouf, A.; Eaves, C.; Pollet, I.; Karsan, A. Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. J. Exp. Med. 2007, 204, 2935-2948. [CrossRef] [PubMed]
    • (2007) J. Exp. Med , vol.204 , pp. 2935-2948
    • Leong, K.G.1    Niessen, K.2    Kulic, I.3    Raouf, A.4    Eaves, C.5    Pollet, I.6    Karsan, A.7
  • 66
    • 84924239129 scopus 로고    scopus 로고
    • Notch1 signaling regulates the epithelial-mesenchymal transition and invasion of breast cancer in a Slug-dependent manner
    • [CrossRef] [PubMed]
    • Shao, S.; Zhao, X.; Zhang, X.; Luo, M.; Zuo, X.; Huang, S.; Wang, Y.; Gu, S.; Zhao, X. Notch1 signaling regulates the epithelial-mesenchymal transition and invasion of breast cancer in a Slug-dependent manner. Mol. Cancer 2015, 14, 28. [CrossRef] [PubMed]
    • (2015) Mol. Cancer , vol.14
    • Shao, S.1    Zhao, X.2    Zhang, X.3    Luo, M.4    Zuo, X.5    Huang, S.6    Wang, Y.7    Gu, S.8    Zhao, X.9
  • 67
    • 84887849044 scopus 로고    scopus 로고
    • Silencing NOTCH signaling causes growth arrest in both breast cancer stem cells and breast cancer cells
    • [CrossRef] [PubMed]
    • Suman, S.; Das, T.P.; Damodaran, C. Silencing NOTCH signaling causes growth arrest in both breast cancer stem cells and breast cancer cells. Br. J. Cancer 2013, 109, 2587-2596. [CrossRef] [PubMed]
    • (2013) Br. J. Cancer , vol.109 , pp. 2587-2596
    • Suman, S.1    Das, T.P.2    Damodaran, C.3
  • 68
    • 84894593599 scopus 로고    scopus 로고
    • Molecular mechanisms of epithelial-mesenchymal transition
    • [CrossRef] [PubMed]
    • Lamouille, S.; Xu, J.; Derynck, R. Molecular mechanisms of epithelial-mesenchymal transition. Nat. Rev. 2014, 15, 178-196. [CrossRef] [PubMed]
    • (2014) Nat. Rev , vol.15 , pp. 178-196
    • Lamouille, S.1    Xu, J.2    Derynck, R.3
  • 69
    • 0034711307 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase function is required for transforming growth factor β-mediated epithelial to mesenchymal transition and cell migration
    • [CrossRef] [PubMed]
    • Bakin, A.V.; Tomlinson, A.K.; Bhowmick, N.A.; Moses, H.L.; Arteaga, C.L. Phosphatidylinositol 3-kinase function is required for transforming growth factor β-mediated epithelial to mesenchymal transition and cell migration. J. Bio. Chem. 2000, 275, 36803-36810. [CrossRef] [PubMed]
    • (2000) J. Bio. Chem , vol.275 , pp. 36803-36810
    • Bakin, A.V.1    Tomlinson, A.K.2    Bhowmick, N.A.3    Moses, H.L.4    Arteaga, C.L.5
  • 70
    • 78650510746 scopus 로고    scopus 로고
    • Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-β-induced epithelial-mesenchymal transition
    • [CrossRef] [PubMed]
    • Lamouille, S.; Derynck, R. Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-β-induced epithelial-mesenchymal transition. Cells Tissues Organs 2011, 193, 8-22. [CrossRef] [PubMed]
    • (2011) Cells Tissues Organs , vol.193 , pp. 8-22
    • Lamouille, S.1    Derynck, R.2
  • 71
    • 34547587877 scopus 로고    scopus 로고
    • Cell size and invasion in TGF-β-Induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
    • [CrossRef] [PubMed]
    • Lamouille, S.; Derynck, R. Cell size and invasion in TGF-β-Induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J. Cell Biol. 2007, 178, 437-451. [CrossRef] [PubMed]
    • (2007) J. Cell Biol , vol.178 , pp. 437-451
    • Lamouille, S.1    Derynck, R.2
  • 72
    • 84861448736 scopus 로고    scopus 로고
    • TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion
    • [CrossRef] [PubMed]
    • Lamouille1, S.; Connolly, E.; Smyth, J.W.; Akhurst, R.J.; Derynck, R. TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. J. Cell Sci. 2012, 125, 1259-1273. [CrossRef] [PubMed]
    • (2012) J. Cell Sci , vol.125 , pp. 1259-1273
    • Lamouille, S.1    Connolly, E.2    Smyth, J.W.3    Akhurst, R.J.4    Derynck, R.5
  • 73
    • 6944248910 scopus 로고    scopus 로고
    • Activation of the Erk pathway is required for TGF-β-induced EMT in vitro
    • [CrossRef] [PubMed]
    • Xie, L.; Law, B.K.; Chytil, A.M.; Brown, K.A.; Aakre, M.E.; Moses, H.L. Activation of the Erk pathway is required for TGF-β-induced EMT in vitro. Neoplasia 2004, 6, 603-610. [CrossRef] [PubMed]
    • (2004) Neoplasia , vol.6 , pp. 603-610
    • Xie, L.1    Law, B.K.2    Chytil, A.M.3    Brown, K.A.4    Aakre, M.E.5    Moses, H.L.6
  • 74
    • 52049111663 scopus 로고    scopus 로고
    • TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-β
    • [CrossRef] [PubMed]
    • Yamashita, M.; Fatyol, K.; Jin, C.; Wang, X.; Liu, Z.; Zhang, Y.E. TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-β. Mol. Cell 2008, 31, 918-924. [CrossRef] [PubMed]
    • (2008) Mol. Cell , vol.31 , pp. 918-924
    • Yamashita, M.1    Fatyol, K.2    Jin, C.3    Wang, X.4    Liu, Z.5    Zhang, Y.E.6
  • 76
    • 84894432430 scopus 로고    scopus 로고
    • STAT3 activation in HER2-overexpressing breast cancer promotes epithelial-mesenchymal transition and cancer stem cell traits
    • [PubMed]
    • Chung, S.; Giehl, N.;Wu, Y.; Vadgama, J.V. STAT3 activation in HER2-overexpressing breast cancer promotes epithelial-mesenchymal transition and cancer stem cell traits. Int. J. Oncol. 2014, 44, 403-411. [PubMed]
    • (2014) Int. J. Oncol , vol.44 , pp. 403-411
    • Chung, S.1    Giehl, N.2    Wu, Y.3    Vadgama, J.V.4
  • 77
    • 78649987710 scopus 로고    scopus 로고
    • Transforming growth factor-β-induced epithelial-mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression
    • [CrossRef] [PubMed]
    • Wendt, M.K.; Smith, J.A.; Schiemann, W.P. Transforming growth factor-β-induced epithelial-mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression. Oncogene 2010, 29, 6485-6498. [CrossRef] [PubMed]
    • (2010) Oncogene , vol.29 , pp. 6485-6498
    • Wendt, M.K.1    Smith, J.A.2    Schiemann, W.P.3
  • 78
    • 79951813692 scopus 로고    scopus 로고
    • TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition
    • [CrossRef] [PubMed]
    • Shirakihara, T.; Horiguchi, K.; Miyazawa, K.; Ehata, S.; Shibata, T.; Morita, I.; Miyazono, K.; Saitoh, M. TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition. EMBO J. 2011, 30, 783-795. [CrossRef] [PubMed]
    • (2011) EMBO J , vol.30 , pp. 783-795
    • Shirakihara, T.1    Horiguchi, K.2    Miyazawa, K.3    Ehata, S.4    Shibata, T.5    Morita, I.6    Miyazono, K.7    Saitoh, M.8
  • 79
    • 33646596637 scopus 로고    scopus 로고
    • Cooperation between snail and LEF-1 transcription factors is essential for TGF-β1-induced epithelial-mesenchymal transition
    • [CrossRef] [PubMed]
    • Medici, D.; Hay, E.D.; Goodenough, D.A. Cooperation between snail and LEF-1 transcription factors is essential for TGF-β1-induced epithelial-mesenchymal transition. Mol. Biol Cell 2006, 17, 1871-1879. [CrossRef] [PubMed]
    • (2006) Mol. Biol Cell , vol.17 , pp. 1871-1879
    • Medici, D.1    Hay, E.D.2    Goodenough, D.A.3
  • 80
    • 67650996280 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: The importance of changing cell state in development and disease
    • [CrossRef] [PubMed]
    • Acloque, H.; Adams, M.S.; Fishwick, K.; Bronner-Fraser, M.; Nieto, M.A. Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J. Clin. Invest. 2009, 119, 1438-1449. [CrossRef] [PubMed]
    • (2009) J. Clin. Invest , vol.119 , pp. 1438-1449
    • Acloque, H.1    Adams, M.S.2    Fishwick, K.3    Bronner-Fraser, M.4    Nieto, M.A.5
  • 81
    • 84887456252 scopus 로고    scopus 로고
    • The epigenetics of epithelial-mesenchymal plasticity in cancer
    • [CrossRef] [PubMed]
    • Tam, W.L.; Weinberg, R.A. The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat. Med. 2013, 19, 1438-1449. [CrossRef] [PubMed]
    • (2013) Nat. Med , vol.19 , pp. 1438-1449
    • Tam, W.L.1    Weinberg, R.A.2
  • 82
    • 84919868497 scopus 로고    scopus 로고
    • Role of epigenetic mechanisms in epithelial-to-mesenchymal transition of breast cancer cells
    • [CrossRef] [PubMed]
    • Nickel, A.; Stadler, S.C. Role of epigenetic mechanisms in epithelial-to-mesenchymal transition of breast cancer cells. Transl. Res. 2015, 165, 126-142. [CrossRef] [PubMed]
    • (2015) Transl. Res , vol.165 , pp. 126-142
    • Nickel, A.1    Stadler, S.C.2
  • 83
    • 59449097723 scopus 로고    scopus 로고
    • How epigenetics can explain human metastasis: A new role for microRNAs
    • [CrossRef] [PubMed]
    • Lujambio, A.; Esteller, M. How epigenetics can explain human metastasis: A new role for microRNAs. Cell Cycle 2009, 8, 377-382. [CrossRef] [PubMed]
    • (2009) Cell Cycle , vol.8 , pp. 377-382
    • Lujambio, A.1    Esteller, M.2
  • 84
    • 84870745374 scopus 로고    scopus 로고
    • Epigenetic control of epithelial-to-mesenchymal transition and cancer metastasis
    • [CrossRef] [PubMed]
    • Wang, Y.; Shang, Y. Epigenetic control of epithelial-to-mesenchymal transition and cancer metastasis. Exp. Cell Res. 2013, 319, 160-169. [CrossRef] [PubMed]
    • (2013) Exp. Cell Res , vol.319 , pp. 160-169
    • Wang, Y.1    Shang, Y.2
  • 86
    • 0029114538 scopus 로고
    • Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas
    • [CrossRef] [PubMed]
    • Yoshiura, K.; Kanai, Y.; Ochiai, A.; Shimoyama, Y.; Sugimura, T.; Hirohashi, S. Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc. Natl. Acad. Sci. USA 1995, 92, 7416-7419. [CrossRef] [PubMed]
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7416-7419
    • Yoshiura, K.1    Kanai, Y.2    Ochiai, A.3    Shimoyama, Y.4    Sugimura, T.5    Hirohashi, S.6
  • 87
    • 0034723255 scopus 로고    scopus 로고
    • Methylation patterns of the E-cadherin 51-CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression
    • [CrossRef] [PubMed]
    • Graff, J.R.; Gabrielson, E.; Fujii, H.; Baylin, S.B.; Herman, J.G. Methylation patterns of the E-cadherin 51-CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression. J. Biol. Chem. 2000, 275, 2727-2732. [CrossRef] [PubMed]
    • (2000) J. Biol. Chem , vol.275 , pp. 2727-2732
    • Graff, J.R.1    Gabrielson, E.2    Fujii, H.3    Baylin, S.B.4    Herman, J.G.5
  • 89
    • 84952875140 scopus 로고    scopus 로고
    • The H3K9 Methyltransferase G9a Represses E-cadherin and is Associated with Myometrial Invasion in Endometrial Cancer
    • [CrossRef] [PubMed]
    • Hsiao, S.M.; Chen, M.W.; Chen, C.A.; Chien, M.H.; Hua, K.T.; Hsiao, M.; Kuo, M.L.; Wei, L.H. The H3K9 Methyltransferase G9a Represses E-cadherin and is Associated with Myometrial Invasion in Endometrial Cancer. Ann. Surg. Oncol. 2015, 3, 1556-1565. [CrossRef] [PubMed]
    • (2015) Ann. Surg. Oncol , vol.3 , pp. 1556-1565
    • Hsiao, S.M.1    Chen, M.W.2    Chen, C.A.3    Chien, M.H.4    Hua, K.T.5    Hsiao, M.6    Kuo, M.L.7    Wei, L.H.8
  • 90
    • 84859731270 scopus 로고    scopus 로고
    • G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer
    • [CrossRef] [PubMed]
    • Dong, C.;Wu, Y.; Yao, J.;Wang, Y.; Yu, Y.; Rychahou, P.G.; Evers, B.M.; Zhou, B.P. G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. J. Clin. Invest. 2012, 122, 1469-1486. [CrossRef] [PubMed]
    • (2012) J. Clin. Invest , vol.122 , pp. 1469-1486
    • Dong, C.1    Wu, Y.2    Yao, J.3    Wang, Y.4    Yu, Y.5    Rychahou, P.G.6    Evers, B.M.7    Zhou, B.P.8
  • 91
    • 77956338683 scopus 로고    scopus 로고
    • Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition
    • [CrossRef]
    • Lin, T.; Ponn, A.; Hu, X.; Law, B.K.; Lu, J. Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition. Oncogene 2010, 29, 4896-4904. [CrossRef]
    • (2010) Oncogene , vol.29 , pp. 4896-4904
    • Lin, T.1    Ponn, A.2    Hu, X.3    Law, B.K.4    Lu, J.5
  • 92
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • [CrossRef] [PubMed]
    • Peinado, H.; Olmeda, D.; Cano, A. Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype? Nat. Rev. Cancer 2007, 7, 415-428. [CrossRef] [PubMed]
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 93
    • 0037326569 scopus 로고    scopus 로고
    • The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: A comparison with Snail and E47 repressors
    • [CrossRef] [PubMed]
    • Bolós, V.; Peinado, H.; Pérez-Moreno, M.A.; Fraga, M.F.; Esteller, M.; Cano, A. The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: A comparison with Snail and E47 repressors. J. Cell Sci. 2003, 116, 499-511. [CrossRef] [PubMed]
    • (2003) J. Cell Sci , vol.116 , pp. 499-511
    • Bolós, V.1    Peinado, H.2    Pérez-Moreno, M.A.3    Fraga, M.F.4    Esteller, M.5    Cano, A.6
  • 94
    • 0037086277 scopus 로고    scopus 로고
    • The SLUG zinc-finger protein represses E-cadherin in breast cancer
    • [PubMed]
    • Hajra, K.M.; Chen, D.Y.; Fearon, E.R. The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res. 2002, 62, 1613-1618. [PubMed]
    • (2002) Cancer Res , vol.62 , pp. 1613-1618
    • Hajra, K.M.1    Chen, D.Y.2    Fearon, E.R.3
  • 95
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target Recognition and Regulatory Functions
    • [CrossRef] [PubMed]
    • Bartel, D.P. MicroRNAs: Target Recognition and Regulatory Functions. Cell 2009, 136, 215-233. [CrossRef] [PubMed]
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 96
    • 84861802693 scopus 로고    scopus 로고
    • MicroRNAs: Critical regulators of epithelial to mesenchymal (EMT) and mesenchymal to epithelial transition (MET) in cancer progression
    • [CrossRef] [PubMed]
    • Bullock, M.D.; Sayan, A.E.; Packham, G.K.; Mirnezami, A.H. MicroRNAs: Critical regulators of epithelial to mesenchymal (EMT) and mesenchymal to epithelial transition (MET) in cancer progression. Biol. Cell 2012, 104, 3-12. [CrossRef] [PubMed]
    • (2012) Biol. Cell , vol.104 , pp. 3-12
    • Bullock, M.D.1    Sayan, A.E.2    Packham, G.K.3    Mirnezami, A.H.4
  • 99
    • 35148886434 scopus 로고    scopus 로고
    • Tumor invasion and metastasis initiated by microRNA-10b in breast cancer
    • [CrossRef] [PubMed]
    • Ma, L.; Teruya-Feldstein, J.;Weinberg, R.A. Tumor invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 2007, 449, 682-688. [CrossRef] [PubMed]
    • (2007) Nature , vol.449 , pp. 682-688
    • Ma, L.1    Teruya-Feldstein, J.2    Weinberg, R.A.3
  • 100
    • 79952458197 scopus 로고    scopus 로고
    • MicroRNA-137 targets carboxyl-terminal binding protein 1 in melanoma cell lines
    • [CrossRef] [PubMed]
    • Deng, Y.; Deng, H.; Bi, F.; Liu, J.; Bemis, L.T.; Norris, D.; Wang, X.J.; Zhang, Q. MicroRNA-137 targets carboxyl-terminal binding protein 1 in melanoma cell lines. Int. J. Biol. Sci. 2011, 7, 133-137. [CrossRef] [PubMed]
    • (2011) Int. J. Biol. Sci , vol.7 , pp. 133-137
    • Deng, Y.1    Deng, H.2    Bi, F.3    Liu, J.4    Bemis, L.T.5    Norris, D.6    Wang, X.J.7    Zhang, Q.8
  • 101
    • 77956230322 scopus 로고    scopus 로고
    • The ZEB/miR-200 feedback loop-A motor of cellular plasticity in development and cancer?
    • [CrossRef] [PubMed]
    • Brabletz, S.; Brabletz, T. The ZEB/miR-200 feedback loop-A motor of cellular plasticity in development and cancer? EMBO Rep. 2010, 11, 670-677. [CrossRef] [PubMed]
    • (2010) EMBO Rep , vol.11 , pp. 670-677
    • Brabletz, S.1    Brabletz, T.2
  • 105
    • 55849123946 scopus 로고    scopus 로고
    • MicroRNA-155 is regulated by the transforming growth factor β/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA
    • [CrossRef] [PubMed]
    • Kong,W.; Yang, H.; He, L.; Zhao, J.J.; Coppola, D.; Dalton,W.S.; Cheng, J.Q. MicroRNA-155 is regulated by the transforming growth factor β/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol. Cell Biol. 2008, 28, 6773-6784. [CrossRef] [PubMed]
    • (2008) Mol. Cell Biol , vol.28 , pp. 6773-6784
    • Kong, W.1    Yang, H.2    He, L.3    Zhao, J.J.4    Coppola, D.5    Dalton, W.S.6    Cheng, J.Q.7
  • 106
    • 84890572219 scopus 로고    scopus 로고
    • MiR-155-mediated loss of C/EBPβ shifts the TGF-β response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer
    • [CrossRef] [PubMed]
    • Johansson, J.; Berg, T.; Kurzejamska, E.; Pang, M.F.; Tabor, V.; Jansson, M.; Roswall, P.; Pietras, K.; Sund, M.; Religa, P. MiR-155-mediated loss of C/EBPβ shifts the TGF-β response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer. Oncogene 2013, 32, 5614-5624. [CrossRef] [PubMed]
    • (2013) Oncogene , vol.32 , pp. 5614-5624
    • Johansson, J.1    Berg, T.2    Kurzejamska, E.3    Pang, M.F.4    Tabor, V.5    Jansson, M.6    Roswall, P.7    Pietras, K.8    Sund, M.9    Religa, P.10
  • 107
    • 79960391940 scopus 로고    scopus 로고
    • miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells
    • [CrossRef] [PubMed]
    • Eades, G.; Yao, Y.; Yang, M.; Zhang, Y.; Chumsri, S.; Zhou, Q. miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells. J. Biol. Chem. 2011, 286, 25992-26002. [CrossRef] [PubMed]
    • (2011) J. Biol. Chem , vol.286 , pp. 25992-26002
    • Eades, G.1    Yao, Y.2    Yang, M.3    Zhang, Y.4    Chumsri, S.5    Zhou, Q.6
  • 108
    • 79952283482 scopus 로고    scopus 로고
    • p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs
    • [CrossRef] [PubMed]
    • Chang, C.J.; Chao, C.H.; Xia, W.; Yang, J.Y.; Xiong, Y.; Li, C.W.; Yu,W.H.; Rehman, S.K.; Hsu, J.L.; Lee, H.H.; et al. p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat. Cell Biol. 2011, 13, 317-323. [CrossRef] [PubMed]
    • (2011) Nat. Cell Biol , vol.13 , pp. 317-323
    • Chang, C.J.1    Chao, C.H.2    Xia, W.3    Yang, J.Y.4    Xiong, Y.5    Li, C.W.6    Yu, W.H.7    Rehman, S.K.8    Hsu, J.L.9    Lee, H.H.10
  • 110
    • 33847185603 scopus 로고    scopus 로고
    • A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains
    • [CrossRef] [PubMed]
    • Hutchinson, J.N.; Ensminger, A.W.; Clemson, C.M.; Lynch, C.R.; Lawrence, J.B.; Chess, A. A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains. BMC Genomics 2007, 8, 39. [CrossRef] [PubMed]
    • (2007) BMC Genomics , vol.8
    • Hutchinson, J.N.1    Ensminger, A.W.2    Clemson, C.M.3    Lynch, C.R.4    Lawrence, J.B.5    Chess, A.6
  • 111
    • 0344429906 scopus 로고    scopus 로고
    • MALAT1, a novel noncoding RNA, and thymosin β4 predict metastasis and survival in early-stage non-small cell lung cancer
    • [CrossRef] [PubMed]
    • Ji, P.; Diederichs, S.; Wang, W.; Böing, S.; Metzger, R.; Schneider, P.M.; Tidow, N.; Brandt, B.; Buerger, H.; Bulk, E. MALAT1, a novel noncoding RNA, and thymosin β4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene 2003, 22, 8031-8041. [CrossRef] [PubMed]
    • (2003) Oncogene , vol.22 , pp. 8031-8041
    • Ji, P.1    Diederichs, S.2    Wang, W.3    Böing, S.4    Metzger, R.5    Schneider, P.M.6    Tidow, N.7    Brandt, B.8    Buerger, H.9    Bulk, E.10
  • 112
    • 81755161347 scopus 로고    scopus 로고
    • The long noncoding MALAT1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth
    • [CrossRef] [PubMed]
    • Schmidt, L.H.; Spieker, T.; Koschmieder, S.; Schäffers, S.; Humberg, J.; Jungen, D.; Bulk, E.; Hascher, A.; Wittmer, D.; Marra, A.; et al. The long noncoding MALAT1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth. J. Thorac. Oncol. 2011, 6, 1984-1992. [CrossRef] [PubMed]
    • (2011) J. Thorac. Oncol , vol.6 , pp. 1984-1992
    • Schmidt, L.H.1    Spieker, T.2    Koschmieder, S.3    Schäffers, S.4    Humberg, J.5    Jungen, D.6    Bulk, E.7    Hascher, A.8    Wittmer, D.9    Marra, A.10
  • 113
    • 84873451950 scopus 로고    scopus 로고
    • The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells
    • [CrossRef] [PubMed]
    • Gutschner, T.; Hammerle, M.; Eissmann, M.; Hsu, J.; Kim, Y.; Hung, G.; Revenko, A.; Arun, G.; Stentrup, M.; Gross, M. The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res. 2013, 73, 1180-1189. [CrossRef] [PubMed]
    • (2013) Cancer Res , vol.73 , pp. 1180-1189
    • Gutschner, T.1    Hammerle, M.2    Eissmann, M.3    Hsu, J.4    Kim, Y.5    Hung, G.6    Revenko, A.7    Arun, G.8    Stentrup, M.9    Gross, M.10
  • 114
    • 84871973062 scopus 로고    scopus 로고
    • Inducing cell proliferation inhibition, apoptosis, and motility reduction by silencing long noncoding ribonucleic acid metastasis-associated lung adenocarcinoma transcript 1 in urothelial carcinoma of the bladder
    • [CrossRef] [PubMed]
    • Han, Y.; Liu, Y.; Nie, L.; Gui, Y.; Cai, Z. Inducing cell proliferation inhibition, apoptosis, and motility reduction by silencing long noncoding ribonucleic acid metastasis-associated lung adenocarcinoma transcript 1 in urothelial carcinoma of the bladder. Urology 2013, 81, e201-e207. [CrossRef] [PubMed]
    • (2013) Urology , vol.81 , pp. e201-e207
    • Han, Y.1    Liu, Y.2    Nie, L.3    Gui, Y.4    Cai, Z.5
  • 115
    • 84864691867 scopus 로고    scopus 로고
    • Upregulated MALAT1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition
    • [CrossRef] [PubMed]
    • Ying, L.; Chen, Q.;Wang, Y.; Zhou, Z.; Huang, Y.; Qiu, F. Upregulated MALAT1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition. Mol. Biosyst. 2012, 8, 2289-2294. [CrossRef] [PubMed]
    • (2012) Mol. Biosyst , vol.8 , pp. 2289-2294
    • Ying, L.1    Chen, Q.2    Wang, Y.3    Zhou, Z.4    Huang, Y.5    Qiu, F.6
  • 116
    • 79955996135 scopus 로고    scopus 로고
    • MALAT1: A long non-coding RNA and its important 31 end functional motif in colorectal cancer metastasis
    • [PubMed]
    • Xu, C.; Yang, M.; Tian, J.; Wang, X.; Li, Z. MALAT1: A long non-coding RNA and its important 31 end functional motif in colorectal cancer metastasis. Int. J. Oncol. 2011, 39, 169-175. [PubMed]
    • (2011) Int. J. Oncol , vol.39 , pp. 169-175
    • Xu, C.1    Yang, M.2    Tian, J.3    Wang, X.4    Li, Z.5
  • 117
    • 84879837310 scopus 로고    scopus 로고
    • MALAT1-A paradigm for long noncoding RNA function in cancer
    • [CrossRef] [PubMed]
    • Gutschner, T.; Hämmerle, M.; Diederichs, S. MALAT1-A paradigm for long noncoding RNA function in cancer. J. Mol. Med. 2013, 91, 791-801. [CrossRef] [PubMed]
    • (2013) J. Mol. Med , vol.91 , pp. 791-801
    • Gutschner, T.1    Hämmerle, M.2    Diederichs, S.3
  • 119
    • 1642289104 scopus 로고    scopus 로고
    • 5-aza-21-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis
    • [CrossRef] [PubMed]
    • Nam, J.S.; Ino, Y.; Kanai, Y.; Sakamoto, M.; Hirohashi, S. 5-aza-21-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis. Clin. Exp. Metastasis. 2004, 21, 49-56. [CrossRef] [PubMed]
    • (2004) Clin. Exp. Metastasis , vol.21 , pp. 49-56
    • Nam, J.S.1    Ino, Y.2    Kanai, Y.3    Sakamoto, M.4    Hirohashi, S.5
  • 120
    • 67449147110 scopus 로고    scopus 로고
    • Targeting DNA methylation
    • [CrossRef] [PubMed]
    • Issa, J.P.; Kantarjian, H.M. Targeting DNA methylation. Clin. Cancer Res. 2009, 15, 3938-3946. [CrossRef] [PubMed]
    • (2009) Clin. Cancer Res , vol.15 , pp. 3938-3946
    • Issa, J.P.1    Kantarjian, H.M.2
  • 121
    • 73949128107 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in cancer therapy
    • Lane, A.A.; Chabner, B.A. Histone deacetylase inhibitors in cancer therapy. J. Clin. Oncol. 2009, 27, 5459-5468.
    • (2009) J. Clin. Oncol , vol.27 , pp. 5459-5468
    • Lane, A.A.1    Chabner, B.A.2
  • 122
    • 77957937450 scopus 로고    scopus 로고
    • Epigenetic modifications as therapeutic targets
    • [CrossRef] [PubMed]
    • Kelly, T.K.; de Carvalho, D.D.; Jones, P.A. Epigenetic modifications as therapeutic targets. Nat. Biotechnol. 2010, 28, 1069-1078. [CrossRef] [PubMed]
    • (2010) Nat. Biotechnol , vol.28 , pp. 1069-1078
    • Kelly, T.K.1    de Carvalho, D.D.2    Jones, P.A.3
  • 124
    • 70349665197 scopus 로고    scopus 로고
    • A phase I dose-finding study of 5-azacytidine in combination with sodium phenylbutyrate in patients with refractory solid tumors
    • [CrossRef] [PubMed]
    • Lin, J.; Gilbert, J.; Rudek, M.A.; Zwiebel, J.A.; Gore, S.; Jiemjit, A.; Zhao, M.; Baker, S.D.; Ambinder, R.F.; Herman, J.G.; et al. A phase I dose-finding study of 5-azacytidine in combination with sodium phenylbutyrate in patients with refractory solid tumors. Clin. Cancer Res. 2009, 15, 6241-6249. [CrossRef] [PubMed]
    • (2009) Clin. Cancer Res , vol.15 , pp. 6241-6249
    • Lin, J.1    Gilbert, J.2    Rudek, M.A.3    Zwiebel, J.A.4    Gore, S.5    Jiemjit, A.6    Zhao, M.7    Baker, S.D.8    Ambinder, R.F.9    Herman, J.G.10
  • 125
    • 70349682188 scopus 로고    scopus 로고
    • Phase I trial of vorinostat and doxorubicin in solid tumours: Histone deacetylase 2 expression as a predictive marker
    • [CrossRef] [PubMed]
    • Munster, P.N.; Marchion, D.; Thomas, S.; Egorin, M.; Minton, S. Phase I trial of vorinostat and doxorubicin in solid tumours: Histone deacetylase 2 expression as a predictive marker. Br. J. Cancer. 2009, 10, 1044-1050. [CrossRef] [PubMed]
    • (2009) Br. J. Cancer , vol.10 , pp. 1044-1050
    • Munster, P.N.1    Marchion, D.2    Thomas, S.3    Egorin, M.4    Minton, S.5
  • 127
    • 33750367989 scopus 로고    scopus 로고
    • E-cadherin immunohistochemical expression as a prognostic factor in infiltrating ductal carcinoma of the breast: A systematic review and meta-analysis
    • Bonnie, E.; Rothberg, G.; Bracken, M.B. E-cadherin immunohistochemical expression as a prognostic factor in infiltrating ductal carcinoma of the breast: A systematic review and meta-analysis. Breast Cancer Res. Treat. 2006, 100, 139-148.
    • (2006) Breast Cancer Res. Treat , vol.100 , pp. 139-148
    • Bonnie, E.1    Rothberg, G.2    Bracken, M.B.3
  • 128
    • 77953183234 scopus 로고    scopus 로고
    • Wnt/β-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome
    • [CrossRef] [PubMed]
    • Khramtsov, A.I.; Khramtsova, G.F.; Tretiakova, M.; Huo, D.; Olopade, O.I.; Goss, K.H. Wnt/β-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome. Am. J. Pathol. 2010, 176, 2911-2920. [CrossRef] [PubMed]
    • (2010) Am. J. Pathol , vol.176 , pp. 2911-2920
    • Khramtsov, A.I.1    Khramtsova, G.F.2    Tretiakova, M.3    Huo, D.4    Olopade, O.I.5    Goss, K.H.6
  • 129
    • 21244437500 scopus 로고    scopus 로고
    • Expression of the transcription factors Snail, Slug, and Twist and their clinical significance in human breast cancer
    • [CrossRef] [PubMed]
    • Martin, T.A.; Goyalm, A.; ChB, M.B.; Watkins, G.; Kiang, W.G. Expression of the transcription factors Snail, Slug, and Twist and their clinical significance in human breast cancer. Ann. Surg. Oncol. 2005, 12, 488-496. [CrossRef] [PubMed]
    • (2005) Ann. Surg. Oncol , vol.12 , pp. 488-496
    • Martin, T.A.1    Goyalm, A.2    ChB, M.B.3    Watkins, G.4    Kiang, W.G.5
  • 130
    • 45049086574 scopus 로고    scopus 로고
    • The clinicopathologic and prognostic significance of CD44+/CD24β-/low and CD44-/CD24+ tumor cells in invasive breast carcinomas
    • [CrossRef] [PubMed]
    • Mylona, E.; Giannopoulou, I.; Fasomytakis, E.; Nomikos, A.; Magkou, C.; Bakarakos, P.; Nakopoulou, L. The clinicopathologic and prognostic significance of CD44+/CD24β-/low and CD44-/CD24+ tumor cells in invasive breast carcinomas. Hum. Pathol. 2008, 39, 1096-1102. [CrossRef] [PubMed]
    • (2008) Hum. Pathol , vol.39 , pp. 1096-1102
    • Mylona, E.1    Giannopoulou, I.2    Fasomytakis, E.3    Nomikos, A.4    Magkou, C.5    Bakarakos, P.6    Nakopoulou, L.7
  • 131
    • 84906062671 scopus 로고    scopus 로고
    • MicroRNA-9 is associated with epithelial-mesenchymal transition, breast cancer stem cell phenotype, and tumor progression in breast cancer
    • [CrossRef] [PubMed]
    • Gwak, J.M.; Kim, H.J.; Kim, E.J.; Chung, Y.R.; Yun, S.; Seo, A.N.; Lee, H.J.; Park, S.Y. MicroRNA-9 is associated with epithelial-mesenchymal transition, breast cancer stem cell phenotype, and tumor progression in breast cancer. Breast Cancer Res. Treat. 2014, 147, 39-49. [CrossRef] [PubMed]
    • (2014) Breast Cancer Res. Treat , vol.147 , pp. 39-49
    • Gwak, J.M.1    Kim, H.J.2    Kim, E.J.3    Chung, Y.R.4    Yun, S.5    Seo, A.N.6    Lee, H.J.7    Park, S.Y.8


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