메뉴 건너뛰기




Volumn 38, Issue 6, 2012, Pages 689-697

Epithelial-mesenchymal transition and breast cancer: Role, molecular mechanisms and clinical impact

Author keywords

Breast cancer; Cancer stem cell; Epidermal mesenchymal transition

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 4 [2 (4 AMINO 1,2,5 OXADIAZOL 3 YL) 1 ETHYL 7 (3 PIPERIDINYLMETHOXY) 1H IMIDAZO[4,5 C]PYRIDIN 4 YL] 2 METHYL 3 BUTYN 2 OL; ANTINEOPLASTIC AGENT; BETA CATENIN; CISPLATIN; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; ESTROGEN RECEPTOR ALPHA; ETOPOSIDE; EVEROLIMUS; FLUOROURACIL; IMD 0354; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; NERVE CELL ADHESION MOLECULE; NOTCH RECEPTOR; OT 304; PACLITAXEL; PERIFOSINE; PIMASERTIB; PLATINUM DERIVATIVE; TAMOXIFEN; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; TUMOR MARKER; UNCLASSIFIED DRUG; UNINDEXED DRUG; UVOMORULIN; VIMENTIN; VINCA ALKALOID; XL 765;

EID: 84861676291     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2011.11.001     Document Type: Review
Times cited : (241)

References (120)
  • 1
    • 12944288172 scopus 로고    scopus 로고
    • Prevalence of CD44+/CD24-/low cells in breast cancer may not be associated with clinical outcome but may favor distant metastasis
    • Abraham B.K., Fritz P., McClellan M., Hauptvogel P., Athelogou M., Brauch H. Prevalence of CD44+/CD24-/low cells in breast cancer may not be associated with clinical outcome but may favor distant metastasis. Clin Cancer Res 2005, 11:1154-1159.
    • (2005) Clin Cancer Res , vol.11 , pp. 1154-1159
    • Abraham, B.K.1    Fritz, P.2    McClellan, M.3    Hauptvogel, P.4    Athelogou, M.5    Brauch, H.6
  • 2
    • 67650996280 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease
    • Acloque H., Adams M.S., Fishwick K., Bronner-Fraser M., Nieto M.A. Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest 2009, 119:1438-1449.
    • (2009) J Clin Invest , vol.119 , pp. 1438-1449
    • Acloque, H.1    Adams, M.S.2    Fishwick, K.3    Bronner-Fraser, M.4    Nieto, M.A.5
  • 3
    • 75449106680 scopus 로고    scopus 로고
    • Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients
    • Aktas B., Tewes M., Fehm T., Hauch S., Kimmig R., Kasimir-Bauer S. Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients. Breast Cancer Res 2009, 11:R46.
    • (2009) Breast Cancer Res , vol.11
    • Aktas, B.1    Tewes, M.2    Fehm, T.3    Hauch, S.4    Kimmig, R.5    Kasimir-Bauer, S.6
  • 6
    • 48549091043 scopus 로고    scopus 로고
    • Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition
    • Arima Y., Inoue Y., Shibata T., Hayashi H., Nagano O., Saya H., et al. Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition. Cancer Res 2008, 68:5104-5112.
    • (2008) Cancer Res , vol.68 , pp. 5104-5112
    • Arima, Y.1    Inoue, Y.2    Shibata, T.3    Hayashi, H.4    Nagano, O.5    Saya, H.6
  • 7
    • 70349134366 scopus 로고    scopus 로고
    • MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets
    • Baffa R., Fassan M., Volinia S., O'Hara B., Liu C.G., Palazzo J.P., et al. MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. J Pathol 2009, 219:214-221.
    • (2009) J Pathol , vol.219 , pp. 214-221
    • Baffa, R.1    Fassan, M.2    Volinia, S.3    O'Hara, B.4    Liu, C.G.5    Palazzo, J.P.6
  • 8
    • 35648995949 scopus 로고    scopus 로고
    • Cancer metastasis facilitated by developmental pathways: sonic hedgehog, notch, and bone morphogenic proteins
    • Bailey J.M., Singh P.K., Hollingsworth M.A. Cancer metastasis facilitated by developmental pathways: sonic hedgehog, notch, and bone morphogenic proteins. J Cell Biochem 2007, 102:829-839.
    • (2007) J Cell Biochem , vol.102 , pp. 829-839
    • Bailey, J.M.1    Singh, P.K.2    Hollingsworth, M.A.3
  • 9
    • 41549162752 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states in development and disease
    • Baum B., Settleman J., Quinlan M.P. Transitions between epithelial and mesenchymal states in development and disease. Semin Cell Dev Biol 2008, 19:294-308.
    • (2008) Semin Cell Dev Biol , vol.19 , pp. 294-308
    • Baum, B.1    Settleman, J.2    Quinlan, M.P.3
  • 10
    • 85047698213 scopus 로고    scopus 로고
    • Correlation of Snail expression with histological grade and lymph node status in breast carcinomas
    • Blanco M.J., Moreno-Bueno G., Sarrio D., Locascio A., Cano A., Palacios J., et al. Correlation of Snail expression with histological grade and lymph node status in breast carcinomas. Oncogene 2002, 21:3241-3246.
    • (2002) Oncogene , vol.21 , pp. 3241-3246
    • Blanco, M.J.1    Moreno-Bueno, G.2    Sarrio, D.3    Locascio, A.4    Cano, A.5    Palacios, J.6
  • 11
    • 77954860302 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer
    • Blick T., Hugo H., Widodo E., Waltham M., Pinto C., Mani S.A., et al. Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer. J Mammary Gland Biol Neoplasia 2010, 15:235-252.
    • (2010) J Mammary Gland Biol Neoplasia , vol.15 , pp. 235-252
    • Blick, T.1    Hugo, H.2    Widodo, E.3    Waltham, M.4    Pinto, C.5    Mani, S.A.6
  • 12
    • 79951813950 scopus 로고    scopus 로고
    • The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells
    • Brabletz S., Bajdak K., Meidhof S., Burk U., Niedermann G., Firat E., et al. The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. EMBO J 2011, 30:770-782.
    • (2011) EMBO J , vol.30 , pp. 770-782
    • Brabletz, S.1    Bajdak, K.2    Meidhof, S.3    Burk, U.4    Niedermann, G.5    Firat, E.6
  • 14
    • 77950901493 scopus 로고    scopus 로고
    • Bone morphogenetic proteins and its receptors; therapeutic targets in cancer progression and bone metastasis?
    • Buijs J.T., Petersen M., van der Horst G., van der Pluijm G. Bone morphogenetic proteins and its receptors; therapeutic targets in cancer progression and bone metastasis?. Curr Pharm Des 2010, 16:1291-1300.
    • (2010) Curr Pharm Des , vol.16 , pp. 1291-1300
    • Buijs, J.T.1    Petersen, M.2    van der Horst, G.3    van der Pluijm, G.4
  • 15
    • 44649163918 scopus 로고    scopus 로고
    • A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    • Burk U., Schubert J., Wellner U., Schmalhofer O., Vincan E., Spaderna S., et al. A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep 2008, 9:582-589.
    • (2008) EMBO Rep , vol.9 , pp. 582-589
    • Burk, U.1    Schubert, J.2    Wellner, U.3    Schmalhofer, O.4    Vincan, E.5    Spaderna, S.6
  • 17
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • Chaffer C.L., Weinberg R.A. A perspective on cancer cell metastasis. Science 2011, 331:1559-1564.
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 18
    • 33947192053 scopus 로고    scopus 로고
    • Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel
    • Cheng G.Z., Chan J., Wang Q., Zhang W., Sun C.D., Wang L.-H. Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel. Cancer Res 2007, 67:1979-1987.
    • (2007) Cancer Res , vol.67 , pp. 1979-1987
    • Cheng, G.Z.1    Chan, J.2    Wang, Q.3    Zhang, W.4    Sun, C.D.5    Wang, L.-H.6
  • 19
    • 79953121435 scopus 로고    scopus 로고
    • Clinical and molecular evidences of epithelial to mesenchymal transition in acquired resistance to EGFR-TKIs
    • Chung J.H., Rho J.K., Xu X., Lee J.S., Yoon H.I., Lee C.T., et al. Clinical and molecular evidences of epithelial to mesenchymal transition in acquired resistance to EGFR-TKIs. Lung Cancer 2010, 73:176-182.
    • (2010) Lung Cancer , vol.73 , pp. 176-182
    • Chung, J.H.1    Rho, J.K.2    Xu, X.3    Lee, J.S.4    Yoon, H.I.5    Lee, C.T.6
  • 20
    • 66849140943 scopus 로고    scopus 로고
    • MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents
    • Cochrane D.R., Spoelstra N.S., Howe E.N., Nordeen S.K., Richer J.K. MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents. Mol Cancer Ther 2009, 8:1055-1066.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1055-1066
    • Cochrane, D.R.1    Spoelstra, N.S.2    Howe, E.N.3    Nordeen, S.K.4    Richer, J.K.5
  • 23
    • 77954861745 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer
    • Creighton C.J., Chang J.C., Rosen J.M. Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer. J Mammary Gland Biol Neoplasia 2010, 15:253-260.
    • (2010) J Mammary Gland Biol Neoplasia , vol.15 , pp. 253-260
    • Creighton, C.J.1    Chang, J.C.2    Rosen, J.M.3
  • 24
    • 69549131213 scopus 로고    scopus 로고
    • Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features
    • Creighton C.J., Li X., Landis M., Dixon J.M., Neumeister V.M., Sjolund A., et al. Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc Natl Acad Sci USA 2009, 106:13820-13825.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 13820-13825
    • Creighton, C.J.1    Li, X.2    Landis, M.3    Dixon, J.M.4    Neumeister, V.M.5    Sjolund, A.6
  • 25
    • 70349869660 scopus 로고    scopus 로고
    • Targeting cancer-initiating cells with oncolytic viruses
    • Cripe T.P., Wang P.Y., Marcato P., Mahller Y.Y., Lee P.W. Targeting cancer-initiating cells with oncolytic viruses. Mol Ther 2009, 17:1677-1682.
    • (2009) Mol Ther , vol.17 , pp. 1677-1682
    • Cripe, T.P.1    Wang, P.Y.2    Marcato, P.3    Mahller, Y.Y.4    Lee, P.W.5
  • 26
    • 4143094988 scopus 로고    scopus 로고
    • Circulating tumor cells, disease progression, and survival in metastatic breast cancer
    • Cristofanilli M., Budd G.T., Ellis M.J., Stopeck A., Matera J., Miller M.C., et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 2004, 351:781-791.
    • (2004) N Engl J Med , vol.351 , pp. 781-791
    • Cristofanilli, M.1    Budd, G.T.2    Ellis, M.J.3    Stopeck, A.4    Matera, J.5    Miller, M.C.6
  • 27
    • 78649872745 scopus 로고    scopus 로고
    • Metformin against TGFbeta-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis
    • Cufi S., Vazquez-Martin A., Oliveras-Ferraros C., Martin-Castillo B., Joven J., Menendez J.A. Metformin against TGFbeta-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis. Cell Cycle 2010, 9:4461-4468.
    • (2010) Cell Cycle , vol.9 , pp. 4461-4468
    • Cufi, S.1    Vazquez-Martin, A.2    Oliveras-Ferraros, C.3    Martin-Castillo, B.4    Joven, J.5    Menendez, J.A.6
  • 29
    • 70249108848 scopus 로고    scopus 로고
    • Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment
    • Dunn L.K., Mohammad K.S., Fournier P.G., McKenna C.R., Davis H.W., Niewolna M., et al. Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment. PLoS One 2009, 4:e6896.
    • (2009) PLoS One , vol.4
    • Dunn, L.K.1    Mohammad, K.S.2    Fournier, P.G.3    McKenna, C.R.4    Davis, H.W.5    Niewolna, M.6
  • 30
    • 77449088191 scopus 로고    scopus 로고
    • Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cells
    • Fehm T., Hoffmann O., Aktas B., Becker S., Solomayer E.F., Wallwiener D., et al. Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cells. Breast Cancer Res 2009, 11:R59.
    • (2009) Breast Cancer Res , vol.11
    • Fehm, T.1    Hoffmann, O.2    Aktas, B.3    Becker, S.4    Solomayer, E.F.5    Wallwiener, D.6
  • 31
    • 48949119473 scopus 로고    scopus 로고
    • Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy
    • Fillmore C.M., Kuperwasser C. Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res 2008, 10:R25.
    • (2008) Breast Cancer Res , vol.10
    • Fillmore, C.M.1    Kuperwasser, C.2
  • 33
    • 39749157093 scopus 로고    scopus 로고
    • Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis
    • Gal A., Sjoblom T., Fedorova L., Imreh S., Beug H., Moustakas A. Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis. Oncogene 2008, 27:1218-1230.
    • (2008) Oncogene , vol.27 , pp. 1218-1230
    • Gal, A.1    Sjoblom, T.2    Fedorova, L.3    Imreh, S.4    Beug, H.5    Moustakas, A.6
  • 34
    • 64049107465 scopus 로고    scopus 로고
    • MiR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis
    • Gebeshuber C.A., Zatloukal K., Martinez J. MiR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis. EMBO Rep 2009, 10:400-405.
    • (2009) EMBO Rep , vol.10 , pp. 400-405
    • Gebeshuber, C.A.1    Zatloukal, K.2    Martinez, J.3
  • 36
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • Ginestier C., Hur M.H., Charafe-Jauffret E., Monville F., Dutcher J., Brown M., et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007, 1:555-567.
    • (2007) Cell Stem Cell , vol.1 , pp. 555-567
    • Ginestier, C.1    Hur, M.H.2    Charafe-Jauffret, E.3    Monville, F.4    Dutcher, J.5    Brown, M.6
  • 37
    • 3242693775 scopus 로고    scopus 로고
    • Antiadhesive antibodies targeting E-cadherin sensitize multicellular tumor spheroids to chemotherapy in vitro
    • Green S.K., Francia G., Isidoro C., Kerbel R.S. Antiadhesive antibodies targeting E-cadherin sensitize multicellular tumor spheroids to chemotherapy in vitro. Mol Cancer Ther 2004, 3:149-159.
    • (2004) Mol Cancer Ther , vol.3 , pp. 149-159
    • Green, S.K.1    Francia, G.2    Isidoro, C.3    Kerbel, R.S.4
  • 38
    • 43049103824 scopus 로고    scopus 로고
    • The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
    • Gregory P.A., Bert A.G., Paterson E.L., Barry S.C., Tsykin A., Farshid G., et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 2008, 10:593-601.
    • (2008) Nat Cell Biol , vol.10 , pp. 593-601
    • Gregory, P.A.1    Bert, A.G.2    Paterson, E.L.3    Barry, S.C.4    Tsykin, A.5    Farshid, G.6
  • 39
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta P.B., Onder T.T., Jiang G., Tao K., Kuperwasser C., Weinberg R.A., et al. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 2009, 138:645-659.
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3    Tao, K.4    Kuperwasser, C.5    Weinberg, R.A.6
  • 41
    • 28844494352 scopus 로고    scopus 로고
    • Tamoxifen resistance in MCF7 cells promotes EMT-like behaviour and involves modulation of β-catenin phosphorylation
    • Hiscox S., Jiang W.G., Obermeier K., Taylor K., Morgan L., Burmi R., et al. Tamoxifen resistance in MCF7 cells promotes EMT-like behaviour and involves modulation of β-catenin phosphorylation. Int J Cancer 2006, 118:290-301.
    • (2006) Int J Cancer , vol.118 , pp. 290-301
    • Hiscox, S.1    Jiang, W.G.2    Obermeier, K.3    Taylor, K.4    Morgan, L.5    Burmi, R.6
  • 42
    • 4344612243 scopus 로고    scopus 로고
    • NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
    • Huber M.A., Azoitei N., Baumann B., Grunert S., Sommer A., Pehamberger H., et al. NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest 2004, 114:569-581.
    • (2004) J Clin Invest , vol.114 , pp. 569-581
    • Huber, M.A.1    Azoitei, N.2    Baumann, B.3    Grunert, S.4    Sommer, A.5    Pehamberger, H.6
  • 43
    • 65649087527 scopus 로고    scopus 로고
    • Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues
    • Hui A.B., Shi W., Boutros P.C., Miller N., Pintilie M., Fyles T., et al. Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues. Lab Invest 2009, 89:597-606.
    • (2009) Lab Invest , vol.89 , pp. 597-606
    • Hui, A.B.1    Shi, W.2    Boutros, P.C.3    Miller, N.4    Pintilie, M.5    Fyles, T.6
  • 44
    • 34248148453 scopus 로고    scopus 로고
    • N-cadherin signaling potentiates mammary tumor metastasis via enhanced extracellular signal-regulated kinase activation
    • Hulit J., Suyama K., Chung S., Keren R., Agiostratidou G., Shan W., et al. N-cadherin signaling potentiates mammary tumor metastasis via enhanced extracellular signal-regulated kinase activation. Cancer Res 2007, 67:3106-3116.
    • (2007) Cancer Res , vol.67 , pp. 3106-3116
    • Hulit, J.1    Suyama, K.2    Chung, S.3    Keren, R.4    Agiostratidou, G.5    Shan, W.6
  • 45
    • 79951681780 scopus 로고    scopus 로고
    • Drug resistant MCF-7 cells exhibit epithelial-mesenchymal transition gene expression pattern
    • Iseri O.D., Kars M.D., Arpaci F., Atalay C., Pak I., Gunduz U. Drug resistant MCF-7 cells exhibit epithelial-mesenchymal transition gene expression pattern. Biomed Pharmacother 2010, 65:40-45.
    • (2010) Biomed Pharmacother , vol.65 , pp. 40-45
    • Iseri, O.D.1    Kars, M.D.2    Arpaci, F.3    Atalay, C.4    Pak, I.5    Gunduz, U.6
  • 46
    • 75649151387 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer development and its clinical significance
    • Iwatsuki M., Mimori K., Yokobori T., Ishi H., Beppu T., Nakamori S., et al. Epithelial-mesenchymal transition in cancer development and its clinical significance. Cancer Sci 2010, 101:293-299.
    • (2010) Cancer Sci , vol.101 , pp. 293-299
    • Iwatsuki, M.1    Mimori, K.2    Yokobori, T.3    Ishi, H.4    Beppu, T.5    Nakamori, S.6
  • 47
    • 0036665171 scopus 로고    scopus 로고
    • Development and diseases of the pancreas
    • Johansson K.A., Grapin-Botton A. Development and diseases of the pancreas. Clin Genet 2002, 62:14-23.
    • (2002) Clin Genet , vol.62 , pp. 14-23
    • Johansson, K.A.1    Grapin-Botton, A.2
  • 48
    • 79953299688 scopus 로고    scopus 로고
    • β-Microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells
    • Josson S., Nomura T., Lin J.-T., Huang W.-C., Wu D., Zhau H.E., et al. β-Microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells. Cancer Res 2011, 71:2600-2610.
    • (2011) Cancer Res , vol.71 , pp. 2600-2610
    • Josson, S.1    Nomura, T.2    Lin, J.-T.3    Huang, W.-C.4    Wu, D.5    Zhau, H.E.6
  • 49
    • 35148825636 scopus 로고    scopus 로고
    • Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells
    • Kajiyama H., Shibata K., Terauchi M., Yamashita M., Ino K., Nawa A., et al. Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells. Int J Oncol 2007, 31:277-283.
    • (2007) Int J Oncol , vol.31 , pp. 277-283
    • Kajiyama, H.1    Shibata, K.2    Terauchi, M.3    Yamashita, M.4    Ino, K.5    Nawa, A.6
  • 50
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R., Weinberg R.A. The basics of epithelial-mesenchymal transition. J Clin Invest 2009, 119:1420-1428.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 51
    • 70349590317 scopus 로고    scopus 로고
    • Involvement of Pin1 induction in epithelial-mesenchymal transition of tamoxifen-resistant breast cancer cells
    • Kim M.R., Choi H.-K., Cho K.B., Kim H.S., Kang K.W. Involvement of Pin1 induction in epithelial-mesenchymal transition of tamoxifen-resistant breast cancer cells. Cancer Science 2009, 100:1834-1841.
    • (2009) Cancer Science , vol.100 , pp. 1834-1841
    • Kim, M.R.1    Choi, H.-K.2    Cho, K.B.3    Kim, H.S.4    Kang, K.W.5
  • 52
    • 40849102700 scopus 로고    scopus 로고
    • Activity of lapatinib a novel HER2 and EGFR dual kinase inhibitor in human endometrial cancer cells
    • Konecny G.E., Venkatesan N., Yang G., Dering J., Ginther C., Finn R., et al. Activity of lapatinib a novel HER2 and EGFR dual kinase inhibitor in human endometrial cancer cells. Br J Cancer 2008, 98:1076-1084.
    • (2008) Br J Cancer , vol.98 , pp. 1076-1084
    • Konecny, G.E.1    Venkatesan, N.2    Yang, G.3    Dering, J.4    Ginther, C.5    Finn, R.6
  • 54
    • 78149462058 scopus 로고    scopus 로고
    • Tissue transglutaminase promotes drug resistance and invasion by inducing mesenchymal transition in mammary epithelial cells
    • Kumar A., Xu J., Brady S., Gao H., Yu D., Reuben J., et al. Tissue transglutaminase promotes drug resistance and invasion by inducing mesenchymal transition in mammary epithelial cells. PLoS One 2010, 5:e13390.
    • (2010) PLoS One , vol.5
    • Kumar, A.1    Xu, J.2    Brady, S.3    Gao, H.4    Yu, D.5    Reuben, J.6
  • 55
    • 34248168819 scopus 로고    scopus 로고
    • Induction of epithelial to mesenchymal transition in PMC42-LA human breast carcinoma cells by carcinoma-associated fibroblast secreted factors
    • Lebret S.C., Newgreen D.F., Thompson E.W., Ackland M.L. Induction of epithelial to mesenchymal transition in PMC42-LA human breast carcinoma cells by carcinoma-associated fibroblast secreted factors. Breast Cancer Res 2007, 9:R19.
    • (2007) Breast Cancer Res , vol.9
    • Lebret, S.C.1    Newgreen, D.F.2    Thompson, E.W.3    Ackland, M.L.4
  • 56
    • 65249155400 scopus 로고    scopus 로고
    • Twist1-mediated adriamycin-induced epithelial-mesenchymal transition relates to multidrug resistance and invasive potential in breast cancer cells
    • Li Q.-Q., Xu J.-D., Wang W.-J., Cao X.-X., Chen Q., Tang F., et al. Twist1-mediated adriamycin-induced epithelial-mesenchymal transition relates to multidrug resistance and invasive potential in breast cancer cells. Clin Cancer Res 2009, 15:2657-2665.
    • (2009) Clin Cancer Res , vol.15 , pp. 2657-2665
    • Li, Q.-Q.1    Xu, J.-D.2    Wang, W.-J.3    Cao, X.-X.4    Chen, Q.5    Tang, F.6
  • 58
    • 77953198124 scopus 로고    scopus 로고
    • Regulation of microRNAs by natural agents: an emerging field in chemoprevention and chemotherapy research
    • Li Y., Kong D., Wang Z., Sarkar F.H. Regulation of microRNAs by natural agents: an emerging field in chemoprevention and chemotherapy research. Pharm Res 2010, 27:1027-1041.
    • (2010) Pharm Res , vol.27 , pp. 1027-1041
    • Li, Y.1    Kong, D.2    Wang, Z.3    Sarkar, F.H.4
  • 59
    • 67849103555 scopus 로고    scopus 로고
    • MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme
    • Li Y., Li W., Yang Y., Lu Y., He C., Hu G., et al. MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme. Brain Res 2009, 1286:13-18.
    • (2009) Brain Res , vol.1286 , pp. 13-18
    • Li, Y.1    Li, W.2    Yang, Y.3    Lu, Y.4    He, C.5    Hu, G.6
  • 60
    • 33846425793 scopus 로고    scopus 로고
    • The prognostic role of a gene signature from tumorigenic breast-cancer cells
    • Liu R., Wang X., Chen G.Y., Dalerba P., Gurney A., Hoey T., et al. The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med 2007, 356:217-226.
    • (2007) N Engl J Med , vol.356 , pp. 217-226
    • Liu, R.1    Wang, X.2    Chen, G.Y.3    Dalerba, P.4    Gurney, A.5    Hoey, T.6
  • 61
    • 33847296106 scopus 로고    scopus 로고
    • Targeted therapy for cancer stem cells: the patched pathway and ABC transporters
    • Lou H., Dean M. Targeted therapy for cancer stem cells: the patched pathway and ABC transporters. Oncogene 2007, 26:1357-1360.
    • (2007) Oncogene , vol.26 , pp. 1357-1360
    • Lou, H.1    Dean, M.2
  • 62
    • 35148886434 scopus 로고    scopus 로고
    • Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    • Ma L., Teruya-Feldstein J., Weinberg R.A. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 2007, 449:682-688.
    • (2007) Nature , vol.449 , pp. 682-688
    • Ma, L.1    Teruya-Feldstein, J.2    Weinberg, R.A.3
  • 63
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani S.A., Guo W., Liao M.J., Eaton E.N., Ayyanan A., Zhou A.Y., et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008, 133:704-715.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6
  • 64
    • 67349247048 scopus 로고    scopus 로고
    • Oncolytic reovirus effectively targets breast cancer stem cells
    • Marcato P., Dean C.A., Giacomantonio C.A., Lee P.W. Oncolytic reovirus effectively targets breast cancer stem cells. Mol Ther 2009, 17:972-979.
    • (2009) Mol Ther , vol.17 , pp. 972-979
    • Marcato, P.1    Dean, C.A.2    Giacomantonio, C.A.3    Lee, P.W.4
  • 66
    • 21244437500 scopus 로고    scopus 로고
    • Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer
    • Martin T.A., Goyal A., Watkins G., Jiang W.G. Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer. Ann Surg Oncol 2005, 12:488-496.
    • (2005) Ann Surg Oncol , vol.12 , pp. 488-496
    • Martin, T.A.1    Goyal, A.2    Watkins, G.3    Jiang, W.G.4
  • 67
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in cancer
    • Massaguè J. TGFbeta in cancer. Cell 2008, 134:215-230.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massaguè, J.1
  • 68
    • 76649134077 scopus 로고    scopus 로고
    • Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer
    • McConkey D.J., Choi W., Marquis L., Martin F., Williams M.B., Shah J., et al. Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer. Cancer Metastasis Rev 2009, 28:335-344.
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 335-344
    • McConkey, D.J.1    Choi, W.2    Marquis, L.3    Martin, F.4    Williams, M.B.5    Shah, J.6
  • 69
    • 78649636965 scopus 로고    scopus 로고
    • Molecular mechanisms of metastasis in breast cancer-clinical applications
    • Mego M., Mani S.A., Cristofanilli M. Molecular mechanisms of metastasis in breast cancer-clinical applications. Nat Rev Clin Oncol 2010, 7:693-701.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 693-701
    • Mego, M.1    Mani, S.A.2    Cristofanilli, M.3
  • 70
    • 77649196575 scopus 로고    scopus 로고
    • Alteration of microRNA expression in vinyl carbamate-induced mouse lung tumors and modulation by the chemopreventive agent indole-3-carbinol
    • Melkamu T., Zhang X., Tan J., Zeng Y., Kassie F. Alteration of microRNA expression in vinyl carbamate-induced mouse lung tumors and modulation by the chemopreventive agent indole-3-carbinol. Carcinogenesis 2010, 31:252-258.
    • (2010) Carcinogenesis , vol.31 , pp. 252-258
    • Melkamu, T.1    Zhang, X.2    Tan, J.3    Zeng, Y.4    Kassie, F.5
  • 71
    • 28344444026 scopus 로고    scopus 로고
    • Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer
    • Mironchik Y., Winnard P.T., Vesuna F., Kato Y., Wildes F., Pathak A.P., et al. Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer. Cancer Res 2005, 65:10801-10809.
    • (2005) Cancer Res , vol.65 , pp. 10801-10809
    • Mironchik, Y.1    Winnard, P.T.2    Vesuna, F.3    Kato, Y.4    Wildes, F.5    Pathak, A.P.6
  • 72
    • 51449085561 scopus 로고    scopus 로고
    • Generation of breast cancer stem cells through epithelial-mesenchymal transition
    • Morel A.P., Lievre M., Thomas C., Hinkal G., Ansieau S., Puisieux A. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One 2008, 3:e2888.
    • (2008) PLoS One , vol.3
    • Morel, A.P.1    Lievre, M.2    Thomas, C.3    Hinkal, G.4    Ansieau, S.5    Puisieux, A.6
  • 73
    • 56749095797 scopus 로고    scopus 로고
    • Transcriptional regulation of cell polarity in EMT and cancer
    • Moreno-Bueno G., Portillo F., Cano A. Transcriptional regulation of cell polarity in EMT and cancer. Oncogene 2008, 27:6958-6969.
    • (2008) Oncogene , vol.27 , pp. 6958-6969
    • Moreno-Bueno, G.1    Portillo, F.2    Cano, A.3
  • 74
    • 14844364701 scopus 로고    scopus 로고
    • Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity
    • Ozdamar B., Bose R., Barrios-Rodiles M., Wang H.R., Zhang Y., Wrana J.L. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science 2005, 307:1603-1609.
    • (2005) Science , vol.307 , pp. 1603-1609
    • Ozdamar, B.1    Bose, R.2    Barrios-Rodiles, M.3    Wang, H.R.4    Zhang, Y.5    Wrana, J.L.6
  • 75
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
    • Peinado H., Olmeda D., Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?. Nat Rev Cancer 2007, 7:415-428.
    • (2007) Nat Rev Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 76
    • 0036830524 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: a mesodermal cell strategy for evolutive innovation in Metazoans
    • Perez-Pomares J.M., Munoz-Chapuli R. Epithelial-mesenchymal transitions: a mesodermal cell strategy for evolutive innovation in Metazoans. Anat Rec 2002, 268:343-351.
    • (2002) Anat Rec , vol.268 , pp. 343-351
    • Perez-Pomares, J.M.1    Munoz-Chapuli, R.2
  • 77
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
    • Polyak K., Weinberg R.A. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 2009, 9:265-273.
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 78
    • 44349139461 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and the stem cell phenotype
    • Radisky D.C., LaBarge M.A. Epithelial-mesenchymal transition and the stem cell phenotype. Cell Stem Cell 2008, 2:511-512.
    • (2008) Cell Stem Cell , vol.2 , pp. 511-512
    • Radisky, D.C.1    LaBarge, M.A.2
  • 79
    • 77954861244 scopus 로고    scopus 로고
    • Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer
    • Radisky E.S., Radisky D.C. Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer. J Mammary Gland Biol Neoplasia 2010, 15:201-212.
    • (2010) J Mammary Gland Biol Neoplasia , vol.15 , pp. 201-212
    • Radisky, E.S.1    Radisky, D.C.2
  • 80
    • 16444368030 scopus 로고    scopus 로고
    • Circumventing multidrug resistance in cancer by beta-galactoside binding protein, an antiproliferative cytokine
    • Ravatn R., Wells V., Nelson L., Vettori D., Mallucci L., Chin K.V. Circumventing multidrug resistance in cancer by beta-galactoside binding protein, an antiproliferative cytokine. Cancer Res 2005, 65:1631-1634.
    • (2005) Cancer Res , vol.65 , pp. 1631-1634
    • Ravatn, R.1    Wells, V.2    Nelson, L.3    Vettori, D.4    Mallucci, L.5    Chin, K.V.6
  • 81
    • 77953581988 scopus 로고    scopus 로고
    • Circulating tumor cells and biomarkers: implications for personalized targeted treatments for metastatic breast cancer
    • Reuben J.M., Lee B.N., Li C., Gao H., Broglio K.R., Valero V., et al. Circulating tumor cells and biomarkers: implications for personalized targeted treatments for metastatic breast cancer. Breast J 2010, 16:327-330.
    • (2010) Breast J , vol.16 , pp. 327-330
    • Reuben, J.M.1    Lee, B.N.2    Li, C.3    Gao, H.4    Broglio, K.R.5    Valero, V.6
  • 83
    • 77957375136 scopus 로고    scopus 로고
    • AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment
    • Roussos E.T., Keckesova Z., Haley J.D., Epstein D.M., Weinberg R.A., Condeelis J.S. AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment. Cancer Res 2010, 70:7360-7364.
    • (2010) Cancer Res , vol.70 , pp. 7360-7364
    • Roussos, E.T.1    Keckesova, Z.2    Haley, J.D.3    Epstein, D.M.4    Weinberg, R.A.5    Condeelis, J.S.6
  • 84
    • 66149131111 scopus 로고    scopus 로고
    • Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells
    • Santisteban M., Reiman J.M., Asiedu M.K., Behrens M.D., Nassar A., Kalli K.R., et al. Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells. Cancer Res 2009, 69:2887-2895.
    • (2009) Cancer Res , vol.69 , pp. 2887-2895
    • Santisteban, M.1    Reiman, J.M.2    Asiedu, M.K.3    Behrens, M.D.4    Nassar, A.5    Kalli, K.R.6
  • 86
    • 33750979574 scopus 로고    scopus 로고
    • Development of oncolytic adenovirus armed with a fusion of soluble transforming growth factor-beta receptor II and human immunoglobulin Fc for breast cancer therapy
    • Seth P., Wang Z.G., Pister A., Zafar M.B., Kim S., Guise T., et al. Development of oncolytic adenovirus armed with a fusion of soluble transforming growth factor-beta receptor II and human immunoglobulin Fc for breast cancer therapy. Hum Gene Ther 2006, 17:1152-1160.
    • (2006) Hum Gene Ther , vol.17 , pp. 1152-1160
    • Seth, P.1    Wang, Z.G.2    Pister, A.3    Zafar, M.B.4    Kim, S.5    Guise, T.6
  • 87
    • 36349006961 scopus 로고    scopus 로고
    • Development and characterization of gemcitabine-resistant pancreatic tumor cells
    • Shah A.N., Summy J.M., Zhang J., Park S.I., Parikh N.U., Gallick G.E. Development and characterization of gemcitabine-resistant pancreatic tumor cells. Ann Surg Oncol 2007, 14:3629-3637.
    • (2007) Ann Surg Oncol , vol.14 , pp. 3629-3637
    • Shah, A.N.1    Summy, J.M.2    Zhang, J.3    Park, S.I.4    Parikh, N.U.5    Gallick, G.E.6
  • 88
    • 68049114782 scopus 로고    scopus 로고
    • Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells
    • Shimono Y., Zabala M., Cho R.W., Lobo N., Dalerba P., Qian D., et al. Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell 2009, 138:592-603.
    • (2009) Cell , vol.138 , pp. 592-603
    • Shimono, Y.1    Zabala, M.2    Cho, R.W.3    Lobo, N.4    Dalerba, P.5    Qian, D.6
  • 90
    • 0242413065 scopus 로고    scopus 로고
    • Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development
    • Shook D., Keller R. Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development. Mech Dev 2003, 120:1351-1383.
    • (2003) Mech Dev , vol.120 , pp. 1351-1383
    • Shook, D.1    Keller, R.2
  • 91
    • 68849124966 scopus 로고    scopus 로고
    • Oncolytic adenoviruses targeted to cancer stem cells
    • Short J.J., Curiel D.T. Oncolytic adenoviruses targeted to cancer stem cells. Mol Cancer Ther 2009, 8:2096-2102.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2096-2102
    • Short, J.J.1    Curiel, D.T.2
  • 92
    • 41649090153 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells
    • Sun M., Estrov Z., Ji Y., Coombes K.R., Harris D.H., Kurzrock R. Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells. Mol Cancer Ther 2008, 7:464-473.
    • (2008) Mol Cancer Ther , vol.7 , pp. 464-473
    • Sun, M.1    Estrov, Z.2    Ji, Y.3    Coombes, K.R.4    Harris, D.H.5    Kurzrock, R.6
  • 93
    • 34047180566 scopus 로고    scopus 로고
    • Molecular mechanism of liver development and regeneration
    • Tanimizu N., Miyajima A. Molecular mechanism of liver development and regeneration. Int Rev Cytol 2007, 259:1-48.
    • (2007) Int Rev Cytol , vol.259 , pp. 1-48
    • Tanimizu, N.1    Miyajima, A.2
  • 94
    • 77957262381 scopus 로고    scopus 로고
    • Core epithelial-to-mesenchymal transition interactive gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
    • Taube J.H., Herschkowitz J.I., Komurov K., Zhou A.Y., Gupta S., Yang J., et al. Core epithelial-to-mesenchymal transition interactive gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci USA 2010, 107:15449-15454.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 15449-15454
    • Taube, J.H.1    Herschkowitz, J.I.2    Komurov, K.3    Zhou, A.Y.4    Gupta, S.5    Yang, J.6
  • 95
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002, 2:442-454.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 96
    • 0344845003 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and pathologies
    • Thiery J.P. Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 2003, 15:740-746.
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 740-746
    • Thiery, J.P.1
  • 97
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery J.P., Acloque H., Huang R.Y., Nieto M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 98
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • Thiery J.P., Sleeman J.P. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 2006, 7:131-142.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 100
    • 38849093994 scopus 로고    scopus 로고
    • Direct evidence for epithelial-mesenchymal transitions in breast cancer
    • Trimboli A.J., Fukino K., de Bruin A., Wei G., Shen L., Tanner S.M., et al. Direct evidence for epithelial-mesenchymal transitions in breast cancer. Cancer Res 2008, 68:937-945.
    • (2008) Cancer Res , vol.68 , pp. 937-945
    • Trimboli, A.J.1    Fukino, K.2    de Bruin, A.3    Wei, G.4    Shen, L.5    Tanner, S.M.6
  • 101
    • 73949133652 scopus 로고    scopus 로고
    • Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells
    • Tsang W.P., Kwok T.T. Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells. J Nutr Biochem 2010, 21:140-146.
    • (2010) J Nutr Biochem , vol.21 , pp. 140-146
    • Tsang, W.P.1    Kwok, T.T.2
  • 102
    • 78650310780 scopus 로고    scopus 로고
    • Epithelial plasticity, cancer stem cells and bone metastasis formation
    • van der Pluijm G. Epithelial plasticity, cancer stem cells and bone metastasis formation. Bone 2011, 48:37-43.
    • (2011) Bone , vol.48 , pp. 37-43
    • van der Pluijm, G.1
  • 103
    • 70349165716 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic
    • Voulgari A., Pintzas A. Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. Biochim Biophys Acta 2009, 1796:75-90.
    • (2009) Biochim Biophys Acta , vol.1796 , pp. 75-90
    • Voulgari, A.1    Pintzas, A.2
  • 104
    • 77249135186 scopus 로고    scopus 로고
    • Sustained c-jun-NH2-kinase activity promotes epithelial-mesenchymal transition, invasion, and survival of breast cancer cells by regulating extracellular signal-regulated kinase activation
    • Wang J., Kuiatse I., Lee A.V., Pan J., Giuliano A., Cui X. Sustained c-jun-NH2-kinase activity promotes epithelial-mesenchymal transition, invasion, and survival of breast cancer cells by regulating extracellular signal-regulated kinase activation. Mol Cancer Res 2010, 8:266-277.
    • (2010) Mol Cancer Res , vol.8 , pp. 266-277
    • Wang, J.1    Kuiatse, I.2    Lee, A.V.3    Pan, J.4    Giuliano, A.5    Cui, X.6
  • 105
    • 33645049305 scopus 로고    scopus 로고
    • Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells
    • Wang Z., Banerjee S., Li Y., Rahman K.M., Zhang Y., Sarkar F.H. Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. Cancer Res 2006, 66:2778-2784.
    • (2006) Cancer Res , vol.66 , pp. 2778-2784
    • Wang, Z.1    Banerjee, S.2    Li, Y.3    Rahman, K.M.4    Zhang, Y.5    Sarkar, F.H.6
  • 106
    • 77957969261 scopus 로고    scopus 로고
    • Targeting miRNAs involved in cancer stem cell and EMT regulation: an emerging concept in overcoming drug resistance
    • Wang Z., Li Y., Ahmad A., Azmi A.S., Kong D., Banerjee S., et al. Targeting miRNAs involved in cancer stem cell and EMT regulation: an emerging concept in overcoming drug resistance. Drug Resist Updat 2010, 13:109-118.
    • (2010) Drug Resist Updat , vol.13 , pp. 109-118
    • Wang, Z.1    Li, Y.2    Ahmad, A.3    Azmi, A.S.4    Kong, D.5    Banerjee, S.6
  • 107
    • 65549141305 scopus 로고    scopus 로고
    • Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway
    • Wang Z., Li Y., Kong D., Banerjee S., Ahmad A., Azmi A.S., et al. Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. Cancer Res 2009, 69:2400-2407.
    • (2009) Cancer Res , vol.69 , pp. 2400-2407
    • Wang, Z.1    Li, Y.2    Kong, D.3    Banerjee, S.4    Ahmad, A.5    Azmi, A.S.6
  • 108
    • 67349260705 scopus 로고    scopus 로고
    • Targeting cancer stem cells for more effective therapies: taking out cancer's locomotive engine
    • Winquist R.J., Boucher D.M., Wood M., Furey B.F. Targeting cancer stem cells for more effective therapies: taking out cancer's locomotive engine. Biochem Pharmacol 2009, 78:326-334.
    • (2009) Biochem Pharmacol , vol.78 , pp. 326-334
    • Winquist, R.J.1    Boucher, D.M.2    Wood, M.3    Furey, B.F.4
  • 110
    • 0038745381 scopus 로고    scopus 로고
    • The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis
    • Xue C., Plieth D., Venkov C., Xu C., Neilson E.G. The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis. Cancer Res 2003, 63:3386-3394.
    • (2003) Cancer Res , vol.63 , pp. 3386-3394
    • Xue, C.1    Plieth, D.2    Venkov, C.3    Xu, C.4    Neilson, E.G.5
  • 111
    • 55549120234 scopus 로고    scopus 로고
    • MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis
    • Yan L.X., Huang X.F., Shao Q., Huang M.Y., Deng L., Wu Q.L., et al. MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. RNA 2008, 14:2348-2360.
    • (2008) RNA , vol.14 , pp. 2348-2360
    • Yan, L.X.1    Huang, X.F.2    Shao, Q.3    Huang, M.Y.4    Deng, L.5    Wu, Q.L.6
  • 112
    • 33847327128 scopus 로고    scopus 로고
    • Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines
    • Yang A.D., Fan F., Camp E.R., van Buren G., Liu W., Somcio R., et al. Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines. Clin Cancer Res 2006, 12:4147-4153.
    • (2006) Clin Cancer Res , vol.12 , pp. 4147-4153
    • Yang, A.D.1    Fan, F.2    Camp, E.R.3    van Buren, G.4    Liu, W.5    Somcio, R.6
  • 113
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • Yang J., Mani S.A., Donaher J.L., Ramaswamy S., Itzykson R.A., Come C., et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004, 117:927-939.
    • (2004) Cell , vol.117 , pp. 927-939
    • Yang, J.1    Mani, S.A.2    Donaher, J.L.3    Ramaswamy, S.4    Itzykson, R.A.5    Come, C.6
  • 114
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis
    • Yang J., Weinberg R.A. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 2008, 14:818-829.
    • (2008) Dev Cell , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 115
    • 36849078711 scopus 로고    scopus 로고
    • Let-7 regulates self renewal and tumorigenicity of breast cancer cells
    • Yu F., Yao H., Zhu P., Zhang X., Pan Q., Gong C., et al. Let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 2007, 131:1109-1123.
    • (2007) Cell , vol.131 , pp. 1109-1123
    • Yu, F.1    Yao, H.2    Zhu, P.3    Zhang, X.4    Pan, Q.5    Gong, C.6
  • 116
    • 63649147784 scopus 로고    scopus 로고
    • Dysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancer
    • Zardawi S.J., O'Toole S.A., Sutherland R.L., Musgrove E.A. Dysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancer. Histol Histopathol 2009, 24:385-398.
    • (2009) Histol Histopathol , vol.24 , pp. 385-398
    • Zardawi, S.J.1    O'Toole, S.A.2    Sutherland, R.L.3    Musgrove, E.A.4
  • 117
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • Zeisberg M., Neilson E.G. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 2009, 119:1429-1437.
    • (2009) J Clin Invest , vol.119 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 118
    • 57649174634 scopus 로고    scopus 로고
    • MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer
    • Zhao J.J., Lin J., Yang H., Kong W., He L., Ma X., et al. MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer. J Biol Chem 2008, 283:31079-31086.
    • (2008) J Biol Chem , vol.283 , pp. 31079-31086
    • Zhao, J.J.1    Lin, J.2    Yang, H.3    Kong, W.4    He, L.5    Ma, X.6
  • 119
    • 52149095811 scopus 로고    scopus 로고
    • Knockdown of Snail, a novel zinc finger transcription factor, via RNA interference increases A549 cell sensitivity to cisplatin via JNK/mitochondrial pathway
    • Zhuo W., Wang Y., Zhuo X., Zhang Y., Ao X., Chen Z. Knockdown of Snail, a novel zinc finger transcription factor, via RNA interference increases A549 cell sensitivity to cisplatin via JNK/mitochondrial pathway. Lung Cancer 2008, 62:8-14.
    • (2008) Lung Cancer , vol.62 , pp. 8-14
    • Zhuo, W.1    Wang, Y.2    Zhuo, X.3    Zhang, Y.4    Ao, X.5    Chen, Z.6
  • 120
    • 41149143022 scopus 로고    scopus 로고
    • Short interfering RNA directed against TWIST, a novel zinc finger transcription factor, increases A549 cell sensitivity to cisplatin via MAPK/mitochondrial pathway
    • Zhuo W.L., Wang Y., Zhuo X.L., Zhang Y.S., Chen Z.T. Short interfering RNA directed against TWIST, a novel zinc finger transcription factor, increases A549 cell sensitivity to cisplatin via MAPK/mitochondrial pathway. Biochem Biophys Res Commun 2008, 369:1098-1102.
    • (2008) Biochem Biophys Res Commun , vol.369 , pp. 1098-1102
    • Zhuo, W.L.1    Wang, Y.2    Zhuo, X.L.3    Zhang, Y.S.4    Chen, Z.T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.