The Western diet: A blind spot of eating disorder research? - A narrative review and recommendations for treatment and research

Nutrition Reviews

Volumn 78, Issue 7, 2020, Pages 579-596

  Ayton, Agnes ^a   Ibrahim, Ali ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

anorexia nervosa; binge eating disorder; bulimia nervosa; diet; metabolism; neurobiology

Indexed keywords

CARBOHYDRATE; INSULIN; FOOD ADDITIVE; GLUCOSE;

ANOREXIA NERVOSA; APPETITE; ARTICLE; BINGE EATING DISORDER; BRAIN; BULIMIA; DIABETES MELLITUS; DIETARY PATTERN; EATING DISORDER; EPIDEMIC; FEEDING BEHAVIOR; FOOD INTAKE; HUMAN; MEDICAL RESEARCH; METABOLISM; MINIMALLY PROCESSED FOOD; OBESITY; ULTRA-PROCESSED FOOD; WESTERN DIET; CONCEPTUAL FRAMEWORK; PROCESSED FOOD; PSYCHOLOGICAL MODEL; REVIEW; TREATMENT OUTCOME;

APPETITE; BIOMEDICAL RESEARCH; DIET, WESTERN; FEEDING AND EATING DISORDERS; FEEDING BEHAVIOR; HUMANS; OBESITY;

EID: 85086135375     PISSN: 00296643     EISSN: 17534887     Source Type: Journal    
DOI: 10.1093/nutrit/nuz089     Document Type: Article

References (197)

1. Kask J, Ramklint M, Kolia N. Anorexia nervosa in males: excess mortality and psychiatric co-morbidity in 609 Swedish in-patients. Psychol Med. 2017;47:1-11.
2. Thornton LM, Watson HJ, Jangmo A, et al. Binge-eating disorder in the Swedish national registers: somatic comorbidity. Int J Eat Disord. 2017;50:58-65.
3. Thornton LM, Trace SE, Brownley KA, et al. A comparison of personality, life events, comorbidity, and health in monozygotic twins discordant for anorexia nervosa. Twin Res Hum Genet. 2017;20:310-318.
4. Arcelus J, Mitchell AJ, Wales J, et al. Mortality rates in patients with anorexia nervosa and other eating disorders. A meta-analysis of 36 studies. Arch Gen Psychiatry. 2011;68:724-731.
5. Duncan AE, Ziobrowski HN, Nicol G. The prevalence of past 12-month and lifetime DSM-IV eating disorders by BMI category in US men and women. Eur Eat Disorders Rev. 2017;25:165-171.
6. Keski-Rahkonen A, Mustelin L. Epidemiology of eating disorders in Europe: prevalence, incidence, comorbidity, course, consequences, and risk factors. Curr Opin Psychiatry. 2016;29:340-345.
7. APA. Diagnostic and Statistical Manual of Mental Disorders: DSM-5. 5th ed. Washington, DC: American Psychiatric Association; 2013.
8. Tong J, Miao S, Wang J, et al. A two-stage epidemiologic study on prevalence of eating disorders in female university students in Wuhan, China. Soc Psychiatry Psychiatr Epidemiol. 2014;49:499-505.
9. Hilbert A, Hoek HW, Schmidt R. Evidence-based clinical guidelines for eating disorders: international comparison. Curr Opin Psychiatry. 2017;30:423-437.
10. National Institute of Clinical Health and Excellence. NICE Guidance 69. Eating disorders: recognition and treatment. London; 2017.
11. Lock J. Family therapy for eating disorders in youth: current confusions, advances, and new directions. Curr Opin Psychiatry. 2018;31:431-435.
12. Milos G, Spindler A, Schnyder U, et al. Instability of eating disorder diagnoses: prospective study. Br J Psychiatry. 2005;187:573-578.
13. Fairburn CG, Cooper Z, Shafran R. Cognitive behaviour therapy for eating disorders: a "transdiagnostic" theory and treatment. Behav Res Ther. 2003;41:509-528.
14. Schmidt U, Ryan EG, Bartholdy S, et al. Two-year follow-up of the MOSAIC trial: a multicenter randomized controlled trial comparing two psychological treatments in adult outpatients with broadly defined anorexia nervosa. Int J Eat Disord. 2016;49:793-800.
15. McIntosh VV, Jordan J, Luty SE, et al. Specialist supportive clinical management for anorexia nervosa. Int J Eat Disord. 2006;39:625-632.
16. Zipfel S, Wild B, Groß G, et al. Focal psychodynamic therapy, cognitive behaviour therapy, and optimised treatment as usual in outpatients with anorexia nervosa (ANTOP study): randomised controlled trial. Lancet. 2014;383:127-137.
17. Schaumberg K, Welch E, Breithaupt L, et al. The science behind the academy for eating disorders' nine truths about eating disorders. Eur Eat Disorders Rev. 2017;25:432-450.
18. Breithaupt L, Hubel C, Bulik CM. Updates on genome-wide association findings in eating disorders and future application to precision medicine. Curr Neuropharmacol. 2018;16:1102-1110.
19. Donnelly B, Touyz S, Hay P, et al. Neuroimaging in bulimia nervosa and binge eating disorder: a systematic review. J Eat Disord. 2018;6:3.
20. Tylee DS, Sun J, Hess JL, et al. Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data. Am J Med Genet. 2018;177:641-657.
21. Borgo F, Riva A, Benetti A, et al. Microbiota in anorexia nervosa: the triangle between bacterial species, metabolites and psychological tests. PLoS One. 2017;12:e0179739.
22. Hinney A, Kesselmeier M, Jall S, et al. Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Mol Psychiatry. 2017;22:192-201.
23. Duncan L, Yilmaz Z, Gaspar H, et al. Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa. Am J Psychiatry. 2017;174:850-858.
24. Watson HJ, Yilmaz Z, Thornton LM, et al. Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nat Genet. 2019;51:1207.
25. Slade E, Keeney E, Mavranezouli I, et al. Treatments for bulimia nervosa: a network meta-analysis. Psychol Med. 2018;48:2629-2636.
26. Fisher CA, Skocic S, Rutherford KA, et al. Family therapy approaches for anorexia nervosa. Cochrane Database Syst Rev 2018;10:CD004780.
27. Byrne S, Wade T, Hay P, et al. A randomised controlled trial of three psychological treatments for anorexia nervosa. Psychol Med. 2017;47:2823-2833.
28. van Deth R, Vandereycken W. Food refusal and insanity: sitophobia and anorexia nervosa in Victorian asylums. Int J Eat Disord. 2000;27:390-404.
29. Russell GF. The changing nature of anorexia nervosa: an introduction to the conference. J Psychiatr Res. 1985;19:101-109.
30. Prince R. The concept of culture-bound syndromes: anorexia nervosa and brainfag. Soc Sci Med. 1985;21:197-203.
31. Jones DJ, Fox MM, Babigian HM, et al. Epidemiology of anorexia nervosa in Monroe County, New York: 1960-1976. Psychosom Med. 1980;42:551-558.
32. Micali N, Hagberg KW, Petersen I, et al. The incidence of eating disorders in the UK in 2000-2009: findings from the General Practice Research Database. BMJ Open. 2013;3:e002646.
33. Udo T, Grilo CM. Prevalence and correlates of DSM-5-defined eating disorders in a nationally representative sample of U.S. adults. Biol Psychiatry. 2018;84:345-354.
34. Nakamura K, Yamamoto M, Yamazaki O, et al. Prevalence of anorexia nervosa and bulimia nervosa in a geographically defined area in Japan. Int J Eat Disord. 2000;28:173-180.
35. Tsai MC, Gan ST, Lee CT, et al. National population-based data on the incidence, prevalence, and psychiatric comorbidity of eating disorders in Taiwanese adolescents and young adults. Int J Eat Disord. 2018;51:1277.
36. Pike KM, Dunne PE. The rise of eating disorders in Asia: a review. J Eat Disord. 2015;3:33.
37. Russell G. Bulimia nervosa: an ominous variant of anorexia nervosa. Psychol Med. 1979;9:429-448.
38. Fairburn CG. Overcoming Binge Eating. 2nd ed. New York: Guilford Press; 2013.
39. Thomas JJ, Crosby RD, Wonderlich SA, et al. A latent profile analysis of the typology of bulimic symptoms in an indigenous Pacific population: evidence of crosscultural variation in phenomenology. Psychol Med. 2011;41:195-206.
40. Pike KM, Hoek HW, Dunne PE. Cultural trends and eating disorders. Curr Opin Psychiatry. 2014;27:436-442.
41. Mohler-Kuo M, Schnyder U, Dermota P, et al. The prevalence, correlates, and help-seeking of eating disorders in Switzerland. Psychol Med. 2016;46:2749-2758.
42. Hay P, Girosi F, Mond J. Prevalence and sociodemographic correlates of DSM-5 eating disorders in the Australian population. J Eat Disord. 2015;3:19.
43. Swartz L. Anorexia nervosa as a culture-bound syndrome. Soc Sci Med. 1985;20:725-730.
44. Monteiro CA, Moubarac JC, Cannon G, et al. Ultra-processed products are becoming dominant in the global food system. Obes Rev. 2013;14(suppl 2):21-28.
45. Nghiem S, Vu XB, Barnett A. Trends and determinants of weight gains among OECD countries: an ecological study. Public Health. 2018;159:31-39.
46. Peralta M, Ramos M, Lipert A, et al. Prevalence and trends of overweight and obesity in older adults from 10 European countries from 2005 to 2013. Scand J Public Health. 2018;46:522-529.
47. Rodgers A, Woodward A, Swinburn B, et al. Prevalence trends tell us what did not precipitate the US obesity epidemic. Lancet Public Health. 2018;3:e162-e163.
48. Huse O, Hettiarachchi J, Gearon E, et al. Obesity in Australia. Obes Res Clin Pract. 2018;12:29-39.
49. Rodriguez LA, Madsen KA, Cotterman C, et al. Added sugar intake and metabolic syndrome in US adolescents: cross-sectional analysis of the National Health and Nutrition Examination Survey 2005-2012. Public Health Nutr. 2016;19:2424-2434.
50. Weisman A, Fazli GS, Johns A, et al. Evolving trends in the epidemiology, risk factors, and prevention of type 2 diabetes: a review. Can J Cardiol. 2018;34:552-564.
51. Murray SB, Pila E, Griffiths S, et al. When illness severity and research dollars do not align: are we overlooking eating disorders? World Psychiatry. 2017;16:321.
52. Brandkvist M, Bjorngaard JH, Odegard RA, et al. Quantifying the impact of genes on body mass index during the obesity epidemic: longitudinal findings from the HUNT Study. BMJ 2019;366:14067.
53. da Luz FQ, Sainsbury A, Mannan H, et al. Prevalence of obesity and comorbid eating disorder behaviors in South Australia from 1995 to 2015. Int J Obes. 2017;41:1148-1153.
54. Hedman A, Breithaupt L, Hubel C, et al. Bidirectional relationship between eating disorders and autoimmune diseases. J Child Psychol Psychiatr. 2019;60:803-812.
55. Garcia-Mayor RV, Garcia-Soidan FJ. Eating disoders in type 2 diabetic people: brief review. Diabetes Metab Syndr 2017;11:221-224.
56. Nieto-Martinez R, Gonzalez-Rivas JP, Medina-Inojosa JR, et al. Are eating disorders risk factors for type 2 diabetes? A systematic review and meta-analysis. Curr Diab Rep. 2017;17:138.
57. Astley CM, Todd JN, Salem RM, et al. Genetic evidence that carbohydratestimulated insulin secretion leads to obesity. Clin Chem. 2018;64:192-200.
58. Micali N, Martini MG, Thomas JJ, et al. Lifetime and 12-month prevalence of eating disorders amongst women in mid-life: a population-based study of diagnoses and risk factors. BMC Med. 2017;15:12.
59. von Soest T, Wichstrom L. Secular trends in eating problems among Norwegian adolescents from 1992 to 2010. Int J Eat Disord. 2014;47:448-457.
60. Eik-Nes T, Romild U, Guzey I, et al. Women's weight and disordered eating in a large Norwegian community sample: the Nord-Trøndelag Health Study (HUNT). BMJ Open. 2015;5:e008125.
61. Slof-Op 't Landt MCT, van Furth EF, van Beijsterveldt CEM, et al. Prevalence of dieting and fear of weight gain across ages: a community sample from adolescents to the elderly. Int J Public Health. 2017;62:911-919.
62. Abed RT. The sexual competition hypothesis for eating disorders. Br J Med Psychol. 1998;71(Pt 4):525-547.
63. Bajos N, Wellings K, Laborde C, et al. Sexuality and obesity, a gender perspective: results from French national random probability survey of sexual behaviours. BMJ. 2010;340:c2573.
64. Bovet J, Lao J, Bartholomee O, et al. Mapping female bodily features of attractiveness. Sci Rep. 2016;6:18551.
65. Mangweth-Matzek B, Hoek HW. Epidemiology and treatment of eating disorders in men and women of middle and older age. Curr Opin Psychiatry. 2017;30:446-451.
66. Calzo JP, Horton NJ, Sonneville KR, et al. Male eating disorder symptom patterns and health correlates from 13 to 26 years of age. J Am Acad Child Adolesc Psychiatry. 2016;55:693-700.e2.
67. USDA. Dietary Guidelines Advisory Committee Report. Appendix 5: History of the Dietary Guidelines for Americans. 2005. https://health.gov/dietaryguidelines/ dga2005/report/PDF/G5_History.pdf.
68. Johnson RJ, Sanchez-Lozada LG, Andrews P, et al. Perspective: a historical and scientific perspective of sugar and its relation with obesity and diabetes. Adv Nutr. 2017;8:412-422.
69. Rippe JM, Angelopoulos TJ. Sucrose, high-fructose corn syrup, and fructose, their metabolism and potential health effects: what do we really know? Adv Nutr. 2013;4:236-245.
70. Moodie R, Stuckler D, Monteiro C, et al. Profits and pandemics: prevention of harmful effects of tobacco, alcohol, and ultra-processed food and drink industries. Lancet. 2013;381:670-679.
71. Monteiro CA, Cannon G, Levy RB, et al. Ultra-processed foods: what they are and how to identify them. Public Health Nutr. 2019;22:1-6.
72. Gibney MJ, Forde CG, Mullally D, et al. Ultra-processed foods in human health: a critical appraisal. Am J Clin Nutr. 2017;106:717-724.
73. Monteiro CA, Cannon G, Moubarac JC, et al. The UN decade of nutrition, the NOVA food classification and the trouble with ultra-processing. Public Health Nutr. 2018;21:5-17.
74. Martinez Steele E, Popkin BM, Swinburn B, Monteiro CA. The share of ultraprocessed foods and the overall nutritional quality of diets in the US: evidence from a nationally representative cross-sectional study. Popul Health Metr. 2017;15:6.
75. Nardocci M, Leclerc BS, Louzada ML, et al. Consumption of ultra-processed foods and obesity in Canada. Can J Public Health. 2019;110:4-14.
76. Juul F, Martinez-Steele E, Parekh N, et al. Ultra-processed food consumption and excess weight among US adults. Br J Nutr. 2018;120:90-100.
77. Bielemann RM, Santos LP, Costa CDS, et al. Early feeding practices and consumption of ultraprocessed foods at 6 y of age: findings from the 2004 Pelotas (Brazil) Birth Cohort Study. Nutrition. 2018;47:27-32.
78. Rauber F, da Costa Louzada ML, Steele EM, et al. Ultra-processed food consumption and chronic non-communicable diseases-related dietary nutrient profile in the UK (2008-2014). Nutrients. 2018;10:587.
79. Lustig RH. Processed food-an experiment that failed. JAMA Pediatr. 2017;171:212-214.
80. Ravuvu A, Friel S, Thow AM, et al. Monitoring the impact of trade agreements on national food environments: trade imports and population nutrition risks in Fiji. Global Health. 2017;13:33.
81. Loria A, Arroyo P, Fernandez V, et al. Prevalence of obesity and diabetes in the socioeconomic transition of rural Mayas of Yucatan from 1962 to 2000. Ethn Health. 2018;23:1-7.
82. Baraldi LG, Martinez Steele E, Canella DS, et al. Consumption of ultra-processed foods and associated sociodemographic factors in the USA between 2007 and 2012: evidence from a nationally representative cross-sectional study. BMJ Open. 2018;8:e020574.
83. Martinez Steele E, Raubenheimer D, Simpson SJ, et al. Ultra-processed foods, protein leverage and energy intake in the USA. Public Health Nutr. 2018;21:114-124.
84. Martinez Steele E, Baraldi LG, Louzada ML, et al. Ultra-processed foods and added sugars in the US diet: evidence from a nationally representative crosssectional study. BMJ Open. 2016;6:e009892.
85. Conway BN, Han X, Munro HM, et al. The obesity epidemic and rising diabetes incidence in a low-income racially diverse southern US cohort. PLoS One. 2018;13: e0190993.
86. Nagata JM, Garber AK, Tabler JL, et al. Prevalence and correlates of disordered eating behaviors among young adults with overweight or obesity. J Gen Intern Med. 2018;33:1337-1343.
87. Becker AE. Television, disordered eating, and young women in Fiji: negotiating body image and identity during rapid social change. Cult Med Psychiatry. 2004;28:533-559.
88. Becker AE, Burwell RA, Gilman SE, et al. Eating behaviours and attitudes following prolonged exposure to television among ethnic Fijian adolescent girls. Br J Psychiatry. 2002;180:509-514.
89. Snowdon W, Raj A, Reeve E, et al. Processed foods available in the Pacific Islands. Global Health. 2013;9:53.
90. Wate JT, Snowdon W, Millar L, et al. Adolescent dietary patterns in Fiji and their relationships with standardized body mass index. Int J Behav Nutr Phys Act. 2013;10:45.
91. Murphy R, Gamble GD, House M, et al. Greater insulin response to acute fructose ingestion among Maori and Pacific people compared to European people living in Aotearoa New Zealand. Intern Med J. 2018;49:196-202.
92. Russell SC, Croker H, Viner RM. The effect of screen advertising on children's dietary intake: a systematic review and meta-analysis. Obes Rev. 2018;20:1-15.
93. Leone A, Martinez-Gonzalez MA, Lahortiga-Ramos F, et al. Adherence to the Mediterranean dietary pattern and incidence of anorexia and bulimia nervosa in women: the SUN cohort. Nutrition. 2018;54:19-25.
94. Brown TA, Keel PK. What contributes to excessive diet soda intake in eating disorders: appetitive drive, weight concerns, or both? Eat Disord. 2013;21:265-274.
95. Afshin A, Micha R, Webb M, et al. Effectiveness of dietary policies to reduce noncommunicable diseases. In: Prabhakaran D, Anand S, Watkins DA, et al., eds. Cardiovascular, Respiratory, and Related Disorders. Washington, DC: World Bank Group; 2017.
96. Eikey EV, Reddy MC, Booth KM, et al. Desire to be underweight: exploratory study on a weight loss app community and user perceptions of the impact on disordered eating behaviors. JMIR Mhealth Uhealth. 2017;5:e150.
97. Schmidt U, Magill N, Renwick B, et al. The Maudsley Outpatient Study of Treatments for Anorexia Nervosa and Related Conditions (MOSAIC): comparison of the Maudsley Model of Anorexia Nervosa Treatment for Adults (MANTRA) with specialist supportive clinical management (SSCM) in outpatients with broadly defined anorexia nervosa: a randomized controlled trial. J Consult Clin Psychol. 2015;83:796-807.
98. Treasure J, Leslie M, Chami R, et al. Are trans diagnostic models of eating disorders fit for purpose? A consideration of the evidence for food addiction. Eur Eat Disorders Rev. 2018;26:83-91.
99. Hart S, Marnane C, McMaster C, et al. Development of the "Recovery from Eating Disorders for Life" Food Guide (REAL Food Guide)-a food pyramid for adults with an eating disorder. J Eat Disord. 2018;6:6.
100. Ludwig DS, Ebbeling CB. The carbohydrate-insulin model of obesity: beyond "calories in, calories out." JAMA Intern Med. 2018;178:1098.
101. Hall KD. A review of the carbohydrate-insulin model of obesity. Eur J Clin Nutr. 2017;71:323-326.
102. Kroemer G, Lopez-Otin C, Madeo F, et al. Carbotoxicity-noxious effects of carbohydrates. Cell. 2018;175:605-614.
103. Hancock ML, Meyer RC, Mistry M, et al. Insulin receptor associates with promoters genome-wide and regulates gene expression. Cell. 2019;177:722-736.e722.
104. Berner LA, Brown TA, Lavender JM, et al. Neuroendocrinology of reward in anorexia nervosa and bulimia nervosa: beyond leptin and ghrelin. Mol Cell Endocrinol. 2018;497:110320.
105. Peterson CM, Young-Hyman D, Fischer S, et al. Examination of psychosocial and physiological risk for bulimic symptoms in youth with type 1 diabetes transitioning to an insulin pump: a pilot study. J Pediatr Psychol. 2018;43:83-93.
106. Johnson RJ, Nakagawa T, Sanchez-Lozada LG, et al. Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes. 2013;62:3307-3315.
107. Cordain L, Miller JB, Eaton SB, et al. Plant-animal subsistence ratios and macronutrient energy estimations in worldwide hunter-gatherer diets. Am J Clin Nutr. 2000;71:682-692.
108. Chow KF. A review of excessive sugar metabolism on oral and general health. Chin J Dent Res. 2017;20:193-198.
109. Muller A, Hussein K. Meta-analysis of teeth from European populations before and after the 18th century reveals a shift towards increased prevalence of caries and tooth loss. Arch Oral Biol. 2017;73:7-15.
110. Jang C, Hui S, Lu W, et al. The small intestine converts dietary fructose into glucose and organic acids. Cell Metab. 2018; 27:351-361.e353.
111. van Opstal AM, Kaal I, van den Berg-Huysmans AA, et al. Dietary sugars and noncaloric sweeteners elicit different homeostatic and hedonic responses in the brain. Nutrition. 2019;60:80-86.
112. Luo S, Monterosso JR, Sarpelleh K, et al. Differential effects of fructose versus glucose on brain and appetitive responses to food cues and decisions for food rewards. Proc Natl Acad Sci USA. 2015;112:6509-6514.
113. Johnson RJ, Andrews P, Benner SA, et al. The evolution of obesity: insights from the mid-Miocene. Trans Am Clin Climatol Assoc. 2010;121:295-305. discussion 305-298.
114. Welch E, Jangmo A, Thornton LM, et al. Treatment-seeking patients with bingeeating disorder in the Swedish national registers: clinical course and psychiatric comorbidity. BMC Psychiatry. 2016;16:163.
115. Hall H, Perelman D, Breschi A, et al. Glucotypes reveal new patterns of glucose dysregulation. PLoS Biol. 2018;16:e2005143.
116. Zeevi D, Korem T, Zmora N, et al. Personalized nutrition by prediction of glycemic responses. Cell. 2015;163:1079-1094.
117. Rothschild D, Weissbrod O, Barkan E, et al. Environment dominates over host genetics in shaping human gut microbiota. Nature. 2018;555:210-215.
118. Ilyas A, Hubel C, Stahl D, et al. The metabolic underpinning of eating disorders: a systematic review and meta-analysis of insulin sensitivity. Mol Cell Endocrinol. 2018;497:110307.
119. Milano W, Capasso A. Neuroendocrine and metabolic disorders in bulimia nervosa. Endocr Metab Immune Disord Drug Targets. 2018;18:297-305.
120. Zhang J, Abbasi O, Malevanchik L, et al. Pilot study of the prevalence of binge eating disorder in non-alcoholic fatty liver disease patients. Ann Gastroenterol. 2017;30:664-669.
121. DiNicolantonio JJ, O'Keefe JH. Good fats versus bad fats: a comparison of fatty acids in the promotion of insulin resistance, inflammation, and obesity. Mo Med. 2017;114:303-307.
122. Naughton SS, Mathai ML, Hryciw DH, et al. Linoleic acid and the pathogenesis of obesity. Prostaglandins Other Lipid Mediat. 2016;125:90-99.
123. Naughton SS, Mathai ML, Hryciw DH, et al. Australia's nutrition transition 1961-2009: a focus on fats. Br J Nutr. 2015;114:337-346.
124. Saini RK, Keum YS. Omega-3 and omega-6 polyunsaturated fatty acids: dietary sources, metabolism, and significance-a review. Life Sci. 2018;203:255-267.
125. Simopoulos AP. An increase in the omega-6/omega-3 fatty acid ratio increases the risk for obesity. Nutrients. 2016;8:128.
126. Di Rienzi SC, Jacobson J, Kennedy EA, et al. Resilience of small intestinal beneficial bacteria to the toxicity of soybean oil fatty acids. Elife. 2018;7:e32581.
127. Ayton AK. Dietary polyunsaturated fatty acids and anorexia nervosa: is there a link? Nutr Neurosci. 2004;7:1-12.
128. Torres-Castillo N, Silva-Gomez JA, Campos-Perez W, et al. High dietary x-6:x-3 PUFA ratio is positively associated with excessive adiposity and waist circumference. Obes Facts. 2018;11:344-353.
129. Zhang YY, Liu W, Zhao TY, et al. Efficacy of omega-3 polyunsaturated fatty acids supplementation in managing overweight and obesity: a meta-analysis of randomized clinical trials. J Nutr Health Aging. 2017;21:187-192.
130. Ayton AK, Azaz A, Horrobin DF. A pilot open case series of ethyl-EPA supplementation in the treatment of anorexia nervosa. Prostaglandins Leukot Essent Fatty Acids. 2004;71:205-209.
131. Tirosh A, Calay ES, Tuncman G, et al. The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans. Sci Transl Med. 2019;11:aav0120.
132. Chassaing B, Koren O, Goodrich JK, et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 2015;519:92-96.
133. Cani PD. Metabolism: dietary emulsifiers-sweepers of the gut lining? Nat Rev Endocrinol. 2015;11:319-320.
134. Viennois E, Chassaing B. First victim, later aggressor: how the intestinal microbiota drives the pro-inflammatory effects of dietary emulsifiers? Gut Microbes. 2018;1-4:288-291.
135. Chassaing B, Van de Wiele T, De Bodt J, et al. Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation. Gut. 2017;66:1414-1427.
136. Halmos EP, Mack A, Gibson PR. Review article: emulsifiers in the food supply and implications for gastrointestinal disease. Aliment Pharmacol Ther. 2019;49:41-50.
137. Lerner A, Matthias T. Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease. Autoimmun Rev. 2015;14:479-489.
138. Zerwas S, Larsen JT, Petersen L, et al. Eating disorders, autoimmune, and autoinflammatory disease. Pediatrics. 2017;140:e20162089.
139. Gardner C, Wylie-Rosett J, Gidding SS, et al. Nonnutritive sweeteners: current use and health perspectives: a scientific statement from the American Heart Association and the American Diabetes Association. Circulation. 2012;126:509-519.
140. de la Pena C. Artificial sweetener as a historical window to culturally situated health. Ann N Y Acad Sci. 2010;1190:159-165.
141. Sylvetsky AC, Jin Y, Clark EJ, et al. Consumption of low-calorie sweeteners among children and adults in the United States. J Acad Nutr Diet. 2017;117:441-448.e442.
142. Pearlman M, Obert J, Casey L. The association between artificial sweeteners and obesity. Curr Gastroenterol Rep. 2017;19:64.
143. Suez J, Korem T, Zeevi D, et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014;514:181-186.
144. Suez J, Korem T, Zilberman-Schapira G, et al. Non-caloric artificial sweeteners and the microbiome: findings and challenges. Gut Microbes. 2015;6:149-155.
145. Fowler S. Low-calorie sweetener use and energy balance: results from experimental studies in animals, and large-scale prospective studies in humans. Physiol Behav. 2016;164(pt B):517-523.
146. Klein DA, Boudreau GS, Devlin MJ, et al. Artificial sweetener use among individuals with eating disorders. Int J Eat Disord. 2006;39:341-345.
147. Schebendach J, Klein DA, Mayer LES, et al. Assessment of the motivation to use artificial sweetener among individuals with an eating disorder. Appetite. 2017;109:131-136.
148. Siega-Riz AM, Haugen M, Meltzer HM, et al. Nutrient and food group intakes of women with and without bulimia nervosa and binge eating disorder during pregnancy. Am J Clin Nutr. 2008;87:1346-1355.
149. Sampey BP, Vanhoose AM, Winfield HM, et al. Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet. Obesity (Silver Spring). 2011;19:1109-1117.
150. Buyukdere Y, Gulec A, Akyol A. Cafeteria diet increased adiposity in comparison to high fat diet in young male rats. PeerJ. 2019;7:e6656.
151. Del Bas JM, Guirro M, Boque N, et al. Alterations in gut microbiota associated with a cafeteria diet and the physiological consequences in the host. Int J Obes. 2018;42:746-754.
152. Mack I, Penders J, Cook J, et al. Is the impact of starvation on the gut microbiota specific or unspecific to anorexia nervosa? A narrative review based on a systematic literature search. Curr Neuropharmacol. 2018;16:1131-1149.
153. Mack I, Cuntz U, Gramer C, et al. Weight gain in anorexia nervosa does not ameliorate the faecal microbiota, branched chain fatty acid profiles, and gastrointestinal complaints. Sci Rep. 2016;6:26752.
154. Succurro E, Segura-Garcia C, Ruffo M, et al. Obese patients with a binge eating disorder have an unfavorable metabolic and inflammatory profile. Medicine (Baltimore). 2015;94:e2098.
155. Hall KD, Ayuketah A, Brychta R, et al. Ultra-processed diets cause excess calorie intake and weight gain: an inpatient randomized controlled trial of ad libitum food intake. Cell Metab. 2019;30:67-77.e63.
156. Steward T, Menchon JM, Jimenez-Murcia S, et al. Neural network alterations across eating disorders: a narrative review of fMRI studies. Curr Neuropharmacol. 2018;16:1150-1163.
157. Johnson PM, Kenny PJ. Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nat Neurosci. 2010;13:635-641.
158. Fernandez-Aranda F, Karwautz A, Treasure J. Food addiction: a transdiagnostic construct of increasing interest. Eur Eat Disord Rev. 2018;26:536-540.
159. DiNicolantonio JJ, O'Keefe JH, Wilson WL. Sugar addiction: is it real? A narrative review. Br J Sports Med. 2018;52:910-913.
160. Garber AK, Lustig RH. Is fast food addictive? Curr Drug Abuse Rev. 2011;4:146-162.
161. Small DM, DiFeliceantonio AG. Processed foods and food reward. Science. 2019;363:346-347.
162. de Araujo IE, Lin T, Veldhuizen MG, et al. Metabolic regulation of brain response to food cues. Curr Biol. 2013;23:878-883.
163. DiFeliceantonio AG, Coppin G, Rigoux L. Supra-additive effects of combining fat and carbohydrate on food reward. Cell Metab. 2018;28:33-44.e33.
164. Rudenga KJ, Sinha R, Small DM. Acute stress potentiates brain response to milkshake as a function of body weight and chronic stress. Int J Obes. 2013;37:309-316.
165. Lindqvist A, Baelemans A, Erlanson-Albertsson C. Effects of sucrose, glucose and fructose on peripheral and central appetite signals. Regul Pept. 2008;150:26-32.
166. Cooper JA. Factors affecting circulating levels of peptide YY in humans: a comprehensive review. Nutr Res Rev. 2014;27:186-197.
167. Hannon-Engel S. Regulating satiety in bulimia nervosa: the role of cholecystokinin. Perspect Psychiatr Care. 2012;48:34-40.
168. Gosby AK, Conigrave AD, Raubenheimer D, et al. Protein leverage and energy intake. Obes Rev. 2014;15:183-191.
169. Kaviani S, Cooper JA. Appetite responses to high-fat meals or diets of varying fatty acid composition: a comprehensive review. Eur J Clin Nutr. 2017;71:1154-1165.
170. Segura-Garcia C, De Fazio P, Sinopoli F, et al. Food choice in disorders of eating behavior: correlations with the psychopathological aspects of the diseases. Compr Psychiatry. 2014;55:1203-1211.
171. Kashyap PC, Chia N, Nelson H, et al. Microbiome at the frontier of personalized medicine. Mayo Clin Proc. 2017;92:1855-1864.
172. Valdes AM, Walter J, Segal E, et al. Role of the gut microbiota in nutrition and health. BMJ. 2018;361:k2179.
173. Brietzke E, Mansur RB, Subramaniapillai M, et al. Ketogenic diet as a metabolic therapy for mood disorders: evidence and developments. Neurosci Biobehav Rev. 2018;94:11-16.
174. Arab A, Mehrabani S, Moradi S, et al. The association between diet and mood: a systematic review of current literature. Psychiatry Res. 2019;271:428-437.
175. Walton K, Kleinman KP, Rifas-Shiman SL, et al. Secular trends in family dinner frequency among adolescents. BMC Res Notes. 2016;9:35.
176. Monteiro CA, Cannon G, Moubarac JC, et al. We should eat freshly cooked meals. BMJ. 2018;362:k3099.
177. Saslow LR, Daubenmier JJ, Moskowitz JT, et al. Twelve-month outcomes of a randomized trial of a moderate-carbohydrate versus very low-carbohydrate diet in overweight adults with type 2 diabetes mellitus or prediabetes. Nutr Diabetes. 2017;7:304.
178. Wisting L, Reas DL, Bang L, et al. Eating patterns in adolescents with type 1 diabetes: associations with metabolic control, insulin omission, and eating disorder pathology. Appetite. 2017;114:226-231.
179. Treasure J, Kan C, Stephenson L, et al. Developing a theoretical maintenance model for disordered eating in type 1 diabetes. Diabet Med. 2015;32:1541-1545.
180. Peterson CM, Fischer S, Young-Hyman D. Topical review: a comprehensive risk model for disordered eating in youth with type 1 diabetes. J Pediatr Psychol. 2015;40:385-390.
181. Raevuori A, Suokas J, Haukka J, et al. Highly increased risk of type 2 diabetes in patients with binge eating disorder and bulimia nervosa. Int J Eat Disord. 2015;48:555-562.
182. Landry MJ, Asigbee FM, Vandyousefi S, et al. Diet quality is an indicator of disease risk factors in Hispanic college freshmen. J Acad Nutr Diet 2019;119:760-768.
183. Lennerz BS, Barton A, Bernstein RK, et al. Management of type 1 diabetes with a very low-carbohydrate diet. Pediatrics. 2018;141:e20173349.
184. Barazzoni R, Deutz NEP, Biolo G, et al. Carbohydrates and insulin resistance in clinical nutrition: recommendations from the ESPEN expert group. Clin Nutr. 2017;36:355-363.
185. Evert AB, Dennison M, Gardner CD, et al. Nutrition therapy for adults with diabetes or prediabetes: a consensus report. Diabetes Care. 2019;42:731-754.
186. Saslow LR, Summers C, Aikens JE, et al. Outcomes of a digitally delivered lowcarbohydrate type 2 diabetes self-management program: 1-year results of a single-arm longitudinal study. JMIR Diabetes. 2018;3:e12.
187. Schmidt S, Christensen MB, Serifovski N, et al. Low versus high carbohydrate diet in type 1 diabetes: a 12-week randomized open-label crossover study. Diabetes Obes Metab. 2019;21:1680.
188. Mohorko N, Cernelic-Bizjak M, Poklar-Vatovec T, et al. Weight loss, improved physical performance, cognitive function, eating behavior, and metabolic profile in a 12-week ketogenic diet in obese adults. Nutr Res. 2019;62:64-77.
189. Castro AI, Gomez-Arbelaez D, Crujeiras AB, et al. Effect of a very low-calorie ketogenic diet on food and alcohol cravings, physical and sexual activity, sleep disturbances, and quality of life in obese patients. Nutrients. 2018;10:1348.
190. Mathisen TF, Rosenvinge JH, Pettersen G, et al. The PED-t trial protocol: the effect of physical exercise-and dietary therapy compared with cognitive behavior therapy in treatment of bulimia nervosa and binge eating disorder. BMC Psychiatry. 2017;17:180.
191. Scolnick B. Ketogenic diet and anorexia nervosa. Med Hypotheses. 2017;109:150-152.
192. Cotter DG, Schugar RC, Crawford PA. Ketone body metabolism and cardiovascular disease. Am J Physiol Heart Circ Physiol. 2013;304:H1060-H1076.
193. Gross EC, Klement RJ, Schoenen J, et al. Potential protective mechanisms of ketone bodies in migraine prevention. Nutrients. 2019;11:811.
194. Yamanashi T, Iwata M, Kamiya N, et al. Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses. Sci Rep. 2017;7:7677.
195. Kovacs Z, D'Agostino DP, Diamond D, et al. Therapeutic potential of exogenous ketone supplement induced ketosis in the treatment of psychiatric disorders: review of current literature. Front Psychiatry. 2019;10:363.
196. Cai QY, Zhou ZJ, Luo R, et al. Safety and tolerability of the ketogenic diet used for the treatment of refractory childhood epilepsy: a systematic review of published prospective studies. World J Pediatr. 2017;13:528-536.
197. Khalsa SS, Portnoff LC, McCurdy-McKinnon D, et al. What happens after treatment? A systematic review of relapse, remission, and recovery in anorexia nervosa. J Eat Disord. 2017;5:20.