Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa

American Journal of Psychiatry

Volumn 174, Issue 9, 2017, Pages 850-858

  Duncan, Laramie ^a,b,c,d,e,f   Yilmaz, Zeynep ^a,b,c,d,e,f   Gaspar, Helena ^a,b,c,d,e   Walters, Raymond ^a,b,c,d,e,f   Goldstein, Jackie ^a,b,c,d,e,f   Anttila, Verneri ^a,b,c,d,e,f   Bulik Sullivan, Brendan ^a,b,c,d,e,f   Ripke, Stephan ^a,b,c,d,e,f   Thornton, Laura ^a,b,c,d,e,f   Hinney, Anke ^a,b,c,d,e,f   Daly, Mark J ^a,b,c,d,e,f   Sullivan, Patrick F ^a,b,c,d,e,f   Zeggini, Eleftheria ^a,b,c,d,e,f   Breen, Gerome ^a,b,c,d,e,f   Bulik, Cynthia M ^a,b,c,d,e,f   Gaspar, Héléna ^f   Adan, Roger ^f   Alfredsson, Lars ^f   Ando, Tetsuya ^f   Andreassen, Ole ^f   Aschauer, Harald ^f   Baker, Jessica ^f   Barrett, Jeffrey ^f   Bencko, Vladimir ^f   Bergen, Andrew ^f   Berrettini, Wade ^f   Birgegård, Andreas ^f   Boni, Claudette ^f   Perica, Vesna Boraska ^f   Brandt, Harry ^f   Burghardt, Roland ^f   Carlberg, Laura ^f   Cassina, Matteo ^f   Cesta, Carolyn ^f   Cichon, Sven ^f   Clementi, Maurizio ^f   Cohen Woods, Sarah ^f   Coleman, Joni ^f   Cone, Roger ^f   Courtet, Philippe ^f   Crawford, Steven ^f   Crow, Scott ^f   Crowley, Jim ^f   Danner, Unna ^f   Davis, Oliver ^f   de Zwaan, Martina ^f   Dedoussis, George ^f   Degortes, Daniela ^f   DeSocio, Janiece ^f   Danielle, Dick ^f   Dikeos, Dimitris ^f   Dina, Christian ^f   Ding, Bo ^f   Dmitrzak Weglarz, Monika ^f   Docampo, Elisa ^f   Egberts, Karin ^f   Ehrlich, Stefan ^f   Escaramís, Geòrgia ^f   Esko, Tõnu ^f   Espeseth, Thomas ^f   Estivill, Xavier ^f   Favaro, Angela ^f   Fernández Aranda, Fernando ^f   Fichter, Manfred ^f   Finan, Chris ^f   Fischer, Krista ^f   Floyd, James ^f   Föcker, Manuel ^f   Foretova, Lenka ^f   Forzan, Monica ^f   Fox, Caroline ^f   Franklin, Christopher ^f   Gaborieau, Valerie ^f   Gallinger, Steven ^f   Gambaro, Giovanni ^f   Giegling, Ina ^f   Gonidakis, Fragiskos ^f   Gorwood, Philip ^f   Gratacos, Monica ^f   Guillaume, Sébastien ^f   Guo, Yiran ^f   Hakonarson, Hakon ^f   Halmi, Katherine ^f   Harrison, Rebecca ^f   Hatzikotoulas, Konstantinos ^f   Hauser, Joanna ^f   Hebebrand, Johannes ^f   Helder, Sietske ^f   Hendriks, Judith ^f   Herms, Stefan ^f   Herpertz Dahlmann, Beate ^f   Herzog, Wolfgang ^f   Hilliard, Christopher ^f   Huckins, Laura ^f   Hudson, James ^f   Huemer, Julia ^f   Imgart, Hartmut ^f   Inoko, Hidetoshi ^f   Jall, Sigrid ^f   Jamain, Stephane ^f   Janout, Vladimir ^f   Jiménez Murcia, Susana ^f   Johnson, Craig ^f   Jordan, Jenny ^f   Julià, Antonio ^f   Juréus, Anders ^f   Kalsi, Gursharan ^f   Kaplan, Allan ^f   Kaprio, Jaakko ^f   Karhunen, Leila ^f   Karwautz, Andreas ^f   Kas, Martien ^f   Kaye, Walter ^f   Kennedy, Martin ^f   Kennedy, James ^f   Keski Rahkonen, Anna ^f   Kiezebrink, Kirsty ^f   Kim, Youl Ri ^f   Klareskog, Lars ^f   Klump, Kelly ^f   Knudsen, Gun Peggy ^f   Koeleman, Bobby ^f   Koubek, Doris ^f   La Via , Maria ^f   Landén, Mikael ^f   Le Hellard, Stephanie ^f   Leboyer, Marion ^f   Levitan, Robert ^f   Li, Dong ^f   Lichtenstein, Paul ^f   Lilenfeld, Lisa ^f   Lissowska, Jolanta ^f   Lundervold, Astri ^f   Magistretti, Pierre ^f   Maj, Mario ^f   Mannik, Katrin ^f   Marsal, Sara ^f   Kaminska, Debora ^f   Martin, Nicholas ^f   Mattingsdal, Morten ^f   McDevitt, Sara ^f   McGuffin, Peter ^f   Merl, Elisabeth ^f   Metspalu, Andres ^f   Meulenbelt, Ingrid ^f   Micali, Nadia ^f   Mitchell, James ^f   Mitchell, Karen ^f   Monteleone, Palmiero ^f   Monteleone, Alessio Maria ^f   Montgomery, Grant ^f   Mortensen, Preben ^f   Munn Chernoff, Melissa ^f   Müller, Timo ^f   Nacmias, Benedetta ^f   Navratilova, Marie ^f   Nilsson, Ida ^f   Norring, Claes ^f   Ntalla, Ioanna ^f   Ophoff, Roel ^f   O’Toole, Julie ^f   Palotie, Aarno ^f   Pantel, Jacques ^f   Papezova, Hana ^f   Parker, Richard ^f   Pinto, Dalila ^f   Rabionet, Raquel ^f   Raevuori, Anu ^f   Rajewski, Andrzej ^f   Ramoz, Nicolas ^f   William Rayner, N ^f   Reichborn Kjennerud, Ted ^f   Ricca, Valdo ^f   Ripatti, Samuli ^f   Ritschel, Franziska ^f   Roberts, Marion ^f   Rotondo, Alessandro ^f   Rujescu, Dan ^f   Rybakowski, Filip ^f   Santonastaso, Paolo ^f   Scherag, André ^f   Scherer, Stephen ^f   Schmidt, Ulrike ^f   Schork, Nicholas ^f   Schosser, Alexandra ^f   Scott, Laura ^f   Seitz, Jochen ^f   Slachtova, Lenka ^f   Sladek, Robert ^f   Eline Slagboom, P ^f   Slof Op ’t Landt, Margarita ^f   Slopien, Agnieszka ^f   Smith, Tosha ^f   Soranzo, Nicole ^f   Sorbi, Sandro ^f   Southam, Lorraine ^f   Steen, Vidar ^f   Strengman, Eric ^f   Strober, Michael ^f   Szatkiewicz, Jin ^f   Szeszenia Dabrowska, Neonila ^f   Tachmazidou, Ioanna ^f   Tenconi, Elena ^f   Tortorella, Alfonso ^f   Tozzi, Federica ^f   Treasure, Janet ^f   Tschöp, Matthias ^f   Tsitsika, Artemis ^f   Tziouvas, Konstantinos ^f   van Elburg, Annemarie ^f   van Furth, Eric ^f   Wade, Tracey ^f   Wagner, Gudrun ^f   Walton, Esther ^f   Watson, Hunna ^f   Wichmann, H Erich ^f   Widen, Elisabeth ^f   Woodside, Blake ^f   Yanovski, Jack ^f   Yao, Shuyang ^f   Zerwas, Stephanie ^f   Zipfel, Stephan ^f   more..

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^f NONE

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN;

ANOREXIA NERVOSA; ARTICLE; AUTOIMMUNE DISEASE; BODY MASS; CASE CONTROL STUDY; CHROMOSOME 12; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATIONAL STUDY; EDUCATION; EDUCATIONAL STATUS; GENE EXPRESSION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC CORRELATION; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; HERITABILITY; HUMAN; INDEL MUTATION; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; METABOLISM; NEUROSIS; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; META ANALYSIS; PHENOTYPE;

ANOREXIA NERVOSA; CASE-CONTROL STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LINKAGE DISEQUILIBRIUM; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 85028720725     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2017.16121402     Document Type: Article

References (40)

1. Bulik C, Sullivan P, Tozzi F, et al: Prevalence, heritability, and prospective risk factors for anorexia nervosa. Arch Gen Psychiatry 2006; 63:305-312
2. Hudson JI, Hiripi E, Pope HG Jr, et al: The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication. Biol Psychiatry 2007; 61:348-358
3. Watson HJ, Bulik CM: Update on the treatment of anorexia nervosa: review of clinical trials, practice guidelines, and emerging interventions. Psychol Med 2013; 43:2477-2500
4. SteinhausenH, Jakobsen H, Helenius D, et al:Anation-wide study of the family aggregation and risk factors in anorexia nervosa over three generations. Int J Eat Disord 2015; 48:1-8
5. Yilmaz Z, Hardaway JA, Bulik CM: Genetics and epigenetics of eating disorders. Adv Genom Genet 2015; 5:131-150
6. Boraska V, Franklin CS, Floyd JA, et al: A genome-wide association study of anorexia nervosa. Mol Psychiatry 2014; 19:1085-1094
7. Wang K, Zhang H, Bloss CS, et al: A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa. Mol Psychiatry 2011; 16:949-959
8. Bulik-Sullivan BK, Loh PR, Finucane HK, et al: LD score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet 2015; 47:291-295
9. Tozzi F, Thornton L, Klump K, et al: Symptom fluctuation in eating disorders: correlates of diagnostic crossover. AmJ Psychiatry 2005; 162:732-740
10. Pinheiro A, Thornton L, Plotonicov K, et al: Patterns of menstrual disturbance in eating disorders. Int J Eat Disord 2007; 40:424-434
11. American Psychiatric Association: Diagnostic and StatisticalManual of Mental Disorders, 5th ed. Washington, DC, American Psychiatric Association, 2013
12. Sysko R, Roberto CA, Barnes RD, et al: Test-retest reliability of the proposed DSM-5 eating disorder diagnostic criteria. Psychiatry Res 2012; 196:302-308
13. Psychiatric GWAS Consortium Steering Committee: A framework for interpreting genome-wide association studies of psychiatric disorders. Mol Psychiatry 2009; 14:10-17
14. Schizophrenia Working Group of the Psychiatric Genomics Consortium: Biological insights from 108 schizophrenia-associated genetic loci. Nature 2014; 511:421-427
15. Novembre J, Johnson T, Bryc K, et al: Genes mirror geography within Europe. Nature 2008; 456:98-101
16. Clarke L, Fairley S, Zheng-Bradley X, et al: The International Genome Sample Resource (IGSR): a worldwide collection of genome variation incorporating the 1000 Genomes Project data. Nucleic Acids Res 2016; 45(D1):D854-D859
17. Willer C, Li Y, Abecasis G: METAL: fastand efficient meta-analysis of genomewide association scans. Bioinformatics 2010; 26:2190-2191
18. Ihaka R, Gentleman RR: A language for data analysis and graphics. J Comput Graph Stat 1996; 5:299-314
19. Pruim RJ, Welch RP, Sanna S, et al: LocusZoom: regional visualization ofgenome-wide association scan results. Bioinformatics 2010; 26:2336-2337
20. Barrett J, Clayton D, Concannon P, et al: Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 2009; 41:703-707
21. Okada Y, Wu D, Trynka G, et al: Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 2014; 506: 376-381
22. Genotype-Tissue Expression Consortium: Human genomics: the Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science 2015; 348:648-660
23. Bulik-Sullivan B, Finucane H, Anttila V, et al: An atlas of genetic correlations across human diseases and traits. Nat Genet 2015; 47: 1236-1241
24. Anttila V, Bulik-Sullivan B, Finucane HK, et al: Analysis of shared heritability in common disorders of the brain [Internet]. bioRxiv 2016. http://biorxiv.org/content/early/2016/04/16/048991. article-info
25. Sullivan P, Daly M, O'Donovan M: Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nat Rev Genet 2012; 13:537-551
26. Visscher PM, Brown MA, McCarthy MI, et al: Five years of GWAS discovery. Am J Hum Genet 2012; 90:7-24
27. Cederlöf M, Thornton L, Lichtenstein P, et al: Etiological overlap between obsessive-compulsive disorder and anorexia nervosa: a longitudinal cohort, family and twin study. World Psychiatry 2015; 14:333-338
28. Kaye W, Bulik C, Thornton L, et al: Comorbidity of anxiety disorders with anorexia and bulimia nervosa. Am J Psychiatry 2004; 161: 2215-2221
29. Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee SH, Ripke S, et al: Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 2013; 45: 984-994
30. Goodman A, Heshmati A, Koupil I: Family history of education predicts eating disorders across multiple generations among 2 million Swedish males and females. PLoS One 2014; 9:e106475
31. Müller M, Geisler C: From the past to future: from energy expenditure to energy intake to energy expenditure. Eur J Clin Nutr 2017; 71:358-364
32. Yu YH, Vasselli J, Zhang Y, et al: Metabolic vs hedonic obesity: a conceptual distinction and its clinical implications. Obes Rev 2015; 16:234-247
33. Hinney A, Kesselmeier M, Jall S, et al: Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Mol Psychiatry 2017; 22:192-201
34. LockeAE, Kahali B, Berndt SI, et al:Genetic studiesof bodymass index yield new insights for obesity biology. Nature 2015; 518:197-206
35. Stelzer G, RosenN, Plaschkes I, et al:TheGeneCards suite:from gene data mining to disease genome sequence analyses. Curr Protoc Bioinformatics 2016; 54:1.30.1-1.30.33
36. Schauder C, Wu X, Saheki Y, et al: Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer. Nature 2014; 510:552-555
37. Föcking M, Lopez LM, English JA, et al: Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia. Mol Psychiatry 2015; 20:424-432
38. Sommer I, van Westrhenen R, Begemann M, et al: Efficacy of antiinflammatory agents to improve symptoms in patients with schizophrenia: an update. Schizophr Bull 2014; 40:181-191
39. Wang Q, Yang C, Gelernter J, et al: Pervasive pleiotropy between psychiatric disorders and immune disorders revealed by integrative analysis of multiple GWAS. Hum Genet 2015; 134:1195-1209
40. Pickrell JK, Berisa T, Liu JZ, et al: Detection and interpretation of shared genetic influences on 42 human traits. Nat Genet 2016; 48: 709-717