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Volumn 13, Issue 5, 2015, Pages

Scientific Opinion on the re-evaluation of ascorbic acid (E 300), sodium ascorbate (E 301) and calcium ascorbate (E 302) as food additives
[No Author Info available]

Author keywords

ascorbic acid (E 300); calcium ascorbate (E 302); Food additives; sodium ascorbate (E 301); vitamin C

Indexed keywords


EID: 85078101347     PISSN: None     EISSN: 18314732     Source Type: Journal    
DOI: 10.2903/j.efsa.2015.4087     Document Type: Article
Times cited : (32)

References (189)
  • 1
    • 0017260220 scopus 로고
    • Effect of large daily doses of ascorbic-acid on pregnancy in guinea pigs, rats, and hamsters
    • Alleva FR, Alleva JJ and Balazs T, 1976. Effect of large daily doses of ascorbic-acid on pregnancy in guinea pigs, rats, and hamsters. Toxicology and Applied Pharmacology, 35, 393–395.
    • (1976) Toxicology and Applied Pharmacology , vol.35 , pp. 393-395
    • Alleva, F.R.1    Alleva, J.J.2    Balazs, T.3
  • 3
    • 0023929821 scopus 로고
    • Loss of penicillinase plasmids of Staphylococcus aureus after treatment with L-ascorbic acid
    • Amabile-Cuevas CH, 1988. Loss of penicillinase plasmids of Staphylococcus aureus after treatment with L-ascorbic acid. Mutation Research, 207, 107–109.
    • (1988) Mutation Research , vol.207 , pp. 107-109
    • Amabile-Cuevas, C.H.1
  • 4
    • 0019819468 scopus 로고
    • Ascorbate is not detectably mutagenic in the L5178Y TK±cell mutation assay
    • Amacher DE and Paillet SC, 1981. Ascorbate is not detectably mutagenic in the L5178Y TK±cell mutation assay. Cancer Letters, 14, 151–158.
    • (1981) Cancer Letters , vol.14 , pp. 151-158
    • Amacher, D.E.1    Paillet, S.C.2
  • 5
    • 0033789887 scopus 로고    scopus 로고
    • Ellagic acid, vitamin C, and total phenolic contents and radical scavenging capacity affected by freezing and frozen storage in raspberry fruit
    • Ancos B, Gonzalez EM and Cano MP, 2000. Ellagic acid, vitamin C, and total phenolic contents and radical scavenging capacity affected by freezing and frozen storage in raspberry fruit. Journal of Agricultural and Food Chemistry, 48, 4565–4570.
    • (2000) Journal of Agricultural and Food Chemistry , vol.48 , pp. 4565-4570
    • Ancos, B.1    Gonzalez, E.M.2    Cano, M.P.3
  • 6
    • 0029025436 scopus 로고
    • The effect of antioxidants on bleomycin treatment in in vitro and in vivo genotoxicity assays
    • Anderson D, Basaran N, Blowers SD and Edwards AJ, 1995. The effect of antioxidants on bleomycin treatment in in vitro and in vivo genotoxicity assays. Mutation Research, 329, 37–47.
    • (1995) Mutation Research , vol.329 , pp. 37-47
    • Anderson, D.1    Basaran, N.2    Blowers, S.D.3    Edwards, A.J.4
  • 7
    • 0017387547 scopus 로고
    • Long term toxicity study with orthotoluene-sulfonamide and saccharin
    • (as referred to by JECFA, 1993)
    • Arnold, DL et al., 1977. Long term toxicity study with orthotoluene-sulfonamide and saccharin.Toxicology and Applied Pharmacology, 41, 164, abstract No 78 (as referred to by JECFA, 1993).
    • (1977) Toxicology and Applied Pharmacology , vol.41 , Issue.164
    • Arnold, D.L.1
  • 9
    • 0031954563 scopus 로고    scopus 로고
    • The effect of ascorbic acid ingestion on the biochemical and physicochemical risk factors associated with calcium oxalate kidney stone formation
    • Auer BL, Auer D and Rodgers AL, 1998. The effect of ascorbic acid ingestion on the biochemical and physicochemical risk factors associated with calcium oxalate kidney stone formation. Clinical Chemistry and Laboratory Medicine, 36, 143–147.
    • (1998) Clinical Chemistry and Laboratory Medicine , vol.36 , pp. 143-147
    • Auer, B.L.1    Auer, D.2    Rodgers, A.L.3
  • 11
    • 85078384722 scopus 로고
    • Calcium ascorbat, ascorbinsäure, Natrium ascorbat. Interne mitteilung No 4670. Unpublished study report submitted by DSM, July 2010
    • Bächtold, 1973. Prüfung im 5-tage-toxizitätsversuch an mäusen und ratten. Calcium ascorbat, ascorbinsäure, Natrium ascorbat. Interne mitteilung No 4670. Unpublished study report submitted by DSM, July 2010.
    • (1973) Prüfung im 5-tage-toxizitätsversuch an mäusen und ratten
    • Bächtold1
  • 13
    • 0016586472 scopus 로고
    • Safety considerations with high ascorbic-acid dosage
    • Barness LA, 1975. Safety considerations with high ascorbic-acid dosage. Annals of the New York Academy of Sciences, 258, 523–528.
    • (1975) Annals of the New York Academy of Sciences , vol.258 , pp. 523-528
    • Barness, L.A.1
  • 15
    • 84896545166 scopus 로고    scopus 로고
    • BfR Expert Opinion No 013/2006, 1 December 2005. Available online
    • BfR (Bundesinstitut für Risikobewertung [Federal Institute for Risk Assessment]), 2005. Indications of the possible formation of benzene from benzoic acid in foods. BfR Expert Opinion No 013/2006, 1 December 2005. Available online: http://www.bfr.bund.de/cm/349/indications_of_the_possible_formation_of_benzene_from_benzoic_acid_in_foods.pdf.
    • (2005) Indications of the possible formation of benzene from benzoic acid in foods
  • 16
    • 85078366898 scopus 로고    scopus 로고
    • Aktualisierte FAQ des BfR vom 16. December 2013. Available online
    • BfR (Bundesinstitut für Risikobewertung [Federal Institute for Risk Assessment]), 2013. Fragen und Antworten zu Benzol in Erfrischungsgetränken und Karottensäften. Aktualisierte FAQ des BfR vom 16. December 2013. Available online: http://www.bfr.bund.de/cm/343/fragen-und-antworten-zu-benzol-in-erfrischungsgetraenken-und-karottensaeften.pdf.
    • (2013) Fragen und Antworten zu Benzol in Erfrischungsgetränken und Karottensäften
  • 19
    • 0025066396 scopus 로고
    • Spontaneous decay of oxidised ascorbic acid (dehydro-L-ascorbic acid) evaluated by high-pressure liquid chromatography
    • Bode AM, Cunningham L and Rose RC, 1990. Spontaneous decay of oxidised ascorbic acid (dehydro-L-ascorbic acid) evaluated by high-pressure liquid chromatography. Clinical Chemistry, 36, 1807–1809.
    • (1990) Clinical Chemistry , vol.36 , pp. 1807-1809
    • Bode, A.M.1    Cunningham, L.2    Rose, R.C.3
  • 20
    • 0034174839 scopus 로고    scopus 로고
    • Simple in-line postcolumn oxidation and derivatization for the simultaneous analysis of ascorbic and dehydroascorbic acids in Foods
    • Bognár A and Daood HG, 2000. Simple in-line postcolumn oxidation and derivatization for the simultaneous analysis of ascorbic and dehydroascorbic acids in Foods. Journal of Chromatographic Science, 38, 162–168.
    • (2000) Journal of Chromatographic Science , vol.38 , pp. 162-168
    • Bognár, A.1    Daood, H.G.2
  • 22
    • 0017250825 scopus 로고
    • Vitamin-C-induced hyperoxaluria
    • Briggs M, 1976. Vitamin-C-induced hyperoxaluria. Lancet, 1, 154–154.
    • (1976) Lancet , vol.1 , pp. 154
    • Briggs, M.1
  • 23
    • 0018643050 scopus 로고
    • The mutagenic activity of 61 agents as determined by the micronucleus, Salmonella, and sperm abnormality assays
    • Bruce R and Heddle JA, 1979. The mutagenic activity of 61 agents as determined by the micronucleus, Salmonella, and sperm abnormality assays. Canadian Journal of Genetics and Cytology, 21, 319–334.
    • (1979) Canadian Journal of Genetics and Cytology , vol.21 , pp. 319-334
    • Bruce, R.1    Heddle, J.A.2
  • 24
    • 28044455458 scopus 로고    scopus 로고
    • Degradation of vitamin C in citrus juice concentrates during storage
    • Burdurlu HS, Koca N and Karadeniz F, 2006. Degradation of vitamin C in citrus juice concentrates during storage. Journal of Food Engineering, 74, 211–216.
    • (2006) Journal of Food Engineering , vol.74 , pp. 211-216
    • Burdurlu, H.S.1    Koca, N.2    Karadeniz, F.3
  • 25
    • 0016275402 scopus 로고
    • Orthomolecular treatment of cancer.2. Clinical trial of high-dose ascorbic-acid supplements in advanced human cancer
    • Cameron E and Campbell A, 1974. Orthomolecular treatment of cancer.2. Clinical trial of high-dose ascorbic-acid supplements in advanced human cancer. Chemico-Biological Interactions, 9, 285–315.
    • (1974) Chemico-Biological Interactions , vol.9 , pp. 285-315
    • Cameron, E.1    Campbell, A.2
  • 26
    • 0033040739 scopus 로고    scopus 로고
    • Does vitamin C act as a pro-oxidant under physiological conditions?
    • (as referred to by EFSA NDA Panel, 2013)
    • Carr A and Frei B, 1999. Does vitamin C act as a pro-oxidant under physiological conditions? FASEB Journal, 13, 1007–1024 (as referred to by EFSA NDA Panel, 2013).
    • (1999) FASEB Journal , vol.13 , pp. 1007-1024
    • Carr, A.1    Frei, B.2
  • 27
    • 35948947103 scopus 로고
    • Studies on benzene formation in beverages
    • Chang P and Ku K, 1993. Studies on benzene formation in beverages. Journal of Food and Drug Analysis, 1, 385–393.
    • (1993) Journal of Food and Drug Analysis , vol.1 , pp. 385-393
    • Chang, P.1    Ku, K.2
  • 28
    • 22344441619 scopus 로고    scopus 로고
    • Final report of the safety assessment of L-ascorbic acid, calcium ascorbate, magnesium ascorbate, magnesium ascorbyl phosphate, sodium ascorbate, and sodium ascorbyl phosphate as used in cosmetics. Report prepared by Elmore AR
    • CIR (Cosmetic Ingredient Review), 2005. Final report of the safety assessment of L-ascorbic acid, calcium ascorbate, magnesium ascorbate, magnesium ascorbyl phosphate, sodium ascorbate, and sodium ascorbyl phosphate as used in cosmetics. Report prepared by Elmore AR. International Journal of Toxicology, 24, 51–111.
    • (2005) International Journal of Toxicology , vol.24 , pp. 51-111
  • 29
    • 85078369339 scopus 로고    scopus 로고
    • Steenwinkel M-JST. Project no 01044074. 1 May 2003. Unpublished report (as referred to by EFSA CEF Panel, 2011)
    • Central Institute for Food and Nutrition Research (CIVO-TNO), 2003. In vivo gene mutation by use of lambda Z-transgenic mice with furfural. Steenwinkel M-JST. Project no 01044074. 1 May 2003. Unpublished report (as referred to by EFSA CEF Panel, 2011).
    • (2003) vivo gene mutation by use of lambda Z-transgenic mice with furfural
  • 32
    • 0029961619 scopus 로고    scopus 로고
    • A prospective study of the intake of vitamins C and B6, and the risk of kidney stones in men
    • Curhan GC, Willett WC, Rimm EB and Stampfer MJ, 1996. A prospective study of the intake of vitamins C and B6, and the risk of kidney stones in men. Journal of Urology, 155, 1847–1851.
    • (1996) Journal of Urology , vol.155 , pp. 1847-1851
    • Curhan, G.C.1    Willett, W.C.2    Rimm, E.B.3    Stampfer, M.J.4
  • 34
    • 33947628181 scopus 로고    scopus 로고
    • Investigation of the role of extracellular H2O2 and transition metal ions in the genotoxic action of ascorbic acid in cell culture models
    • Duarte TL, Almeida GM and Jones GDD, 2007. Investigation of the role of extracellular H2O2 and transition metal ions in the genotoxic action of ascorbic acid in cell culture models. Toxicology Letters, 170, 57–65.
    • (2007) Toxicology Letters , vol.170 , pp. 57-65
    • Duarte, T.L.1    Almeida, G.M.2    Jones, G.D.D.3
  • 35
    • 0029998738 scopus 로고    scopus 로고
    • Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes
    • Duthie SJ, Ma AG, Ross MA and Collins AR, 1996. Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Research, 56, 1291–1295.
    • (1996) Cancer Research , vol.56 , pp. 1291-1295
    • Duthie, S.J.1    Ma, A.G.2    Ross, M.A.3    Collins, A.R.4
  • 36
    • 85078373103 scopus 로고    scopus 로고
    • Held in Brussels on 20 July 2007. SANCO – D1D/411718. Available online
    • EC (European Commission), 2007a. Summary record of the Standing Committee on the Food Chain and Animal Health. Held in Brussels on 20 July 2007. SANCO – D1(2007)D/411718. Available online: http://ec.europa.eu/food/committees/regulatory/scfcah/toxic/summary20072007_en.pdf.
    • (2007) Summary record of the Standing Committee on the Food Chain and Animal Health , Issue.2007
  • 37
    • 85078388776 scopus 로고    scopus 로고
    • Held in Brussels on 14 December 2007. SANCO – D1D/412774. Available online
    • EC (European Commission), 2007b. Summary record of the Standing Committee on the Food Chain and Animal Health. Held in Brussels on 14 December 2007. SANCO – D1(2007)D/412774. Available online: http://ec.europa.eu/food/committees/regulatory/scfcah/toxic/summary14122007_en.pdf.
    • (2007) Summary record of the Standing Committee on the Food Chain and Animal Health , Issue.2007
  • 39
    • 33645157558 scopus 로고    scopus 로고
    • Scientific opinion of the Panel on Dietetic Products, Nutrition and Allergies (NDA) on a request from the Commission related to the Tolerable Upper Intake Level of Vitamin C (L-Ascorbic acid, its calcium, potassium and sodium salts and L-ascorbyl-6-palmitate)
    • 2004
    • EFSA (European Food Safety Authority), 2004. Scientific opinion of the Panel on Dietetic Products, Nutrition and Allergies (NDA) on a request from the Commission related to the Tolerable Upper Intake Level of Vitamin C (L-Ascorbic acid, its calcium, potassium and sodium salts and L-ascorbyl-6-palmitate). The EFSA Journal 2004, 59, 1–21.
    • (2004) The EFSA Journal , vol.59 , pp. 1-21
  • 40
    • 85066609204 scopus 로고    scopus 로고
    • Opinion of the Scientific Panel on Dietetic products, nutrition and allergies (NDA) related to the Tolerable Upper Intake Level of Sodium
    • 2005
    • EFSA (European Food Safety Authority), 2005. Opinion of the Scientific Panel on Dietetic products, nutrition and allergies (NDA) related to the Tolerable Upper Intake Level of Sodium. The EFSA Journal 2005, 209, 1–26.
    • (2005) The EFSA Journal , vol.209 , pp. 1-26
  • 41
    • 44749086017 scopus 로고    scopus 로고
    • Scientific opinion of the Scientific Committee related to uncertainties in dietary exposure assessment
    • 2007
    • EFSA (European Food Safety Authority), 2007. Scientific opinion of the Scientific Committee related to uncertainties in dietary exposure assessment. The EFSA Journal 2007, 438, 1–54.
    • (2007) The EFSA Journal , vol.438 , pp. 1-54
  • 42
    • 85078377374 scopus 로고    scopus 로고
    • Scientific opinion of the Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to calcium ascorbate with a content of threonate for use as a source of vitamin C in food supplements
    • 2006
    • EFSA (European Food Safety Authority), 2006. Scientific opinion of the Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to calcium ascorbate with a content of threonate for use as a source of vitamin C in food supplements. The EFSA Journal 2006, 491, 1–10.
    • (2006) The EFSA Journal , vol.491 , pp. 1-10
  • 43
    • 85078386009 scopus 로고    scopus 로고
    • Scientific opinion of the Panel on Food Additives and Nutrient Sources added to food (ANS) on calcium L-threonate for use as a source of calcium in food supplements
    • 2008
    • EFSA (European Food Safety Authority), 2008. Scientific opinion of the Panel on Food Additives and Nutrient Sources added to food (ANS) on calcium L-threonate for use as a source of calcium in food supplements. The EFSA Journal 2008, 866, 1–20.
    • (2008) The EFSA Journal , vol.866 , pp. 1-20
  • 44
    • 85078390215 scopus 로고    scopus 로고
    • Scientific opinion of the Panel on Food Additives and Nutrient Sources added to food (ANS) on calcium ascorbate, magnesium ascorbate and zinc ascorbate added for nutritional purposes in food supplements
    • 2009
    • EFSA (European Food Safety Authority), 2009. Scientific opinion of the Panel on Food Additives and Nutrient Sources added to food (ANS) on calcium ascorbate, magnesium ascorbate and zinc ascorbate added for nutritional purposes in food supplements. The EFSA Journal 2009, 994, 1–22.
    • (2009) The EFSA Journal , vol.994 , pp. 1-22
  • 45
    • 84983059607 scopus 로고    scopus 로고
    • Management of left-censored data in dietary exposure assessment of chemical substances
    • 2010
    • EFSA (European Food Safety Authority), 2010. Management of left-censored data in dietary exposure assessment of chemical substances. EFSA Journal 2010;8(3):1557, 96 pp. doi:10.2903/j.efsa.2010.1557.
    • (2010) EFSA Journal , vol.8 , Issue.3 , pp. 1557-1596
  • 46
    • 85078396885 scopus 로고    scopus 로고
    • Statement of EFSA on the safety of calcium L-ascorbate with a content of threonate produced by a new manufacturing process as a source of vitamin C in food supplements
    • 2011
    • EFSA (European Food Safety Authority), 2011a. Statement of EFSA on the safety of calcium L-ascorbate with a content of threonate produced by a new manufacturing process as a source of vitamin C in food supplements. EFSA Journal 2011;9(9):2395, 17pp. doi:10.2903/j.efsa.2010.2395.
    • (2011) EFSA Journal , vol.9 , Issue.9 , pp. 2395
  • 47
    • 85077752327 scopus 로고    scopus 로고
    • Use of the EFSA Comprehensive European Food Consumption Database in Exposure Assessment
    • 2011
    • EFSA (European Food Safety Authority), 2011b. Use of the EFSA Comprehensive European Food Consumption Database in Exposure Assessment. EFSA Journal 2011;9(3):2097, 34 pp. doi:10.2903/j.efsa.2011.2097.
    • (2011) EFSA Journal , vol.9 , Issue.3 , pp. 2097-2034
  • 48
    • 84888442809 scopus 로고    scopus 로고
    • Evaluation of the FoodEx, the food classification system applied to the development of the EFSA Comprehensive European Food Consumption Database
    • 2011
    • EFSA (European Food Safety Authority), 2011c. Evaluation of the FoodEx, the food classification system applied to the development of the EFSA Comprehensive European Food Consumption Database. EFSA Journal 2011;9(3):1970, 27 pp. doi:10.2903/j.efsa.2011.1970.
    • (2011) EFSA Journal , vol.9 , Issue.3 , pp. 1970-1927
  • 49
    • 84930384468 scopus 로고    scopus 로고
    • Scientific Opinion on the use of sodium ascorbate as a food additive in vitamin D preparations intended to be used in formulae and weaning food for infants and young children
    • 2010
    • EFSA Panel on Food Additives and Nutrient Sources (ANS), 2010. Scientific Opinion on the use of sodium ascorbate as a food additive in vitamin D preparations intended to be used in formulae and weaning food for infants and young children. EFSA Journal 2010;8(12):1942, 13 pp. doi:10.2903/j.efsa.2010.1942.
    • (2010) EFSA Journal , vol.8 , Issue.12 , pp. 1942-1913
  • 50
    • 85078397281 scopus 로고    scopus 로고
    • Scientific Opinion on re-evaluation of calcium carbonate (E 170) as a food additive
    • 2011
    • EFSA Panel on Food Additives and Nutrient Sources (ANS), 2011a. Scientific Opinion on re-evaluation of calcium carbonate (E 170) as a food additive. EFSA Journal 2011;9(7):2318, 73 pp. doi:10.2903/j.efsa.2011.2318.
    • (2011) EFSA Journal , vol.9 , Issue.7 , pp. 2318-2373
  • 51
    • 84992716905 scopus 로고    scopus 로고
    • Scientific Opinion on the re-evaluation of caramel colours (E 150 a,b,c,d) as food additives
    • 2011
    • EFSA Panel on Food Additives and Nutrient Sources (ANS), 2011b. Scientific Opinion on the re-evaluation of caramel colours (E 150 a,b,c,d) as food additives. EFSA Journal 2011;9(3):2004, 103 pp. doi:10.2903/j.efsa.2011.2004.
    • (2011) EFSA Journal , vol.9 , Issue.3 , pp. 2004-2103
  • 52
    • 85043702652 scopus 로고    scopus 로고
    • Statement on a conceptual framework for the risk assessment of certain food additives re-evaluated under Commission Regulation (EU) No 257/2010
    • 2014
    • EFSA ANS Panel (EFSA Panel on Food Additives and Nutrient Sources Added to Food), 2014. Statement on a conceptual framework for the risk assessment of certain food additives re-evaluated under Commission Regulation (EU) No 257/2010. EFSA Journal 2014;12(6):3697, 11 pp. doi:10.2903/j.efsa.2014.3697.
    • (2014) EFSA Journal , vol.12 , Issue.6 , pp. 3697-3611
  • 53
    • 85006704539 scopus 로고    scopus 로고
    • Scientific opinion on Flavouring Group Evaluation 13 Revision 1 (FGE.13.Rev1): Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14
    • EFSA Panel on Food Contact Materials, Enzymes, Flavouring and Processing Aids (CEF), 2010. Scientific opinion on Flavouring Group Evaluation 13 Revision 1 (FGE.13.Rev1): Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14. The EFSA Journal 2010;8(4):1403, 112 pp. doi:10.2903/j.efsa.2010.1403.
    • (2010) The EFSA Journal 2010 , vol.8 , Issue.4 , pp. 1403-1112
  • 54
    • 85033200202 scopus 로고    scopus 로고
    • Scientific opinion on Flavouring Group Evaluation 218, Revision 1 (FGE.218.Rev1): alpha, beta-Unsaturated aldehydes and precursors from subgroup 4.2 of FGE.19: Furfural derivatives
    • EFSA Panel on Food Contact Materials, Enzymes, Flavouring and Processing Aids (CEF), 2011. Scientific opinion on Flavouring Group Evaluation 218, Revision 1 (FGE.218.Rev1): alpha, beta-Unsaturated aldehydes and precursors from subgroup 4.2 of FGE.19: Furfural derivatives. The EFSA Journal 2011;9(3):1840, 112 pp. doi:10.2903/j.efsa.2011.1840.
    • (2011) The EFSA Journal 2011 , vol.9 , Issue.3 , pp. 1840-1112
  • 55
    • 85039905172 scopus 로고    scopus 로고
    • Scientific Opinion on arsenic in food
    • EFSA Panel on Contaminants in Food Chain (CONTAM), 2009. Scientific Opinion on arsenic in food. The EFSA Journal 2009;7(10):1351, 199 pp. doi:10.2903/j.efsa.2009.1351.
    • (2009) The EFSA Journal 2009 , vol.7 , Issue.10 , pp. 1351-1199
  • 56
    • 85029722363 scopus 로고    scopus 로고
    • Scientific Opinion on lead in food
    • EFSA Panel on Contaminants in Food Chain (CONTAM), 2010. Scientific Opinion on lead in food. The EFSA Journal 2010;8(4):1570, 151 pp. doi:10.2903/j.efsa.2010.1570.
    • (2010) The EFSA Journal 2010 , vol.8 , Issue.4 , pp. 1570-1151
  • 57
    • 84962197569 scopus 로고    scopus 로고
    • Scientific Opinion on the risk for public health related to the presence of mercury and methylmercury in food
    • EFSA Panel on Contaminants in Food Chain (CONTAM), 2012. Scientific Opinion on the risk for public health related to the presence of mercury and methylmercury in food. The EFSA Journal 2012;10(12):2985, 241 pp. doi:10.2903/j.efsa.2012.2985.
    • (2012) The EFSA Journal 2012 , vol.10 , Issue.12 , pp. 2985-2241
  • 58
    • 84936163642 scopus 로고    scopus 로고
    • Scientific Opinion on the safety and efficacy of vitamin C (ascorbic acid and sodium calcium ascorbyl phosphate) as a feed additive for all animal species based on a dossier submitted by VITAC EEIG
    • 2013
    • EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), 2013a. Scientific Opinion on the safety and efficacy of vitamin C (ascorbic acid and sodium calcium ascorbyl phosphate) as a feed additive for all animal species based on a dossier submitted by VITAC EEIG. EFSA Journal 2013;11(2):3103, 25 pp. doi:10.2903/j.efsa.2013.3103.
    • (2013) EFSA Journal , vol.11 , Issue.2 , pp. 3103-3125
  • 59
    • 85053357349 scopus 로고    scopus 로고
    • Scientific Opinion on the safety and efficacy of vitamin C (ascorbic acid, sodium ascorbate, calcium ascorbate, ascorbyl palmitate, sodium calcium ascorbyl phosphate and sodium ascorbyl phosphate) as a feed additive for all animal species based on a dossier submitted by DSM Nutritional Products Ltd
    • 2013
    • EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), 2013b. Scientific Opinion on the safety and efficacy of vitamin C (ascorbic acid, sodium ascorbate, calcium ascorbate, ascorbyl palmitate, sodium calcium ascorbyl phosphate and sodium ascorbyl phosphate) as a feed additive for all animal species based on a dossier submitted by DSM Nutritional Products Ltd. EFSA Journal 2013;11(2):3104, 36 pp. doi:10.2903/j.efsa.2013.3104.
    • (2013) EFSA Journal , vol.11 , Issue.2 , pp. 3104-3136
  • 60
    • 85078378412 scopus 로고    scopus 로고
    • Scientific opinion on the substantiation of health claims related to vitamin C and protection of DNA, proteins and lipids from oxidative damage (ID 129, 138, 143, 148), antioxidant function of lutein (ID 146), maintenance of vision (ID 141, 142), collagen formation (ID 130, 131, 136, 137, 149), function of the nervous system (ID 133), function of the immune system (ID 134), function of the immune system during and after extreme physical exercise (ID 144), non-haem iron absorption (ID 132, 147), energy-yielding metabolism (ID 135), and relief in case of irritation in the upper respiratory tract (ID 1714, 1715) pursuant to Article 13(1) of Regulation (EC) No 1924/2006
    • 2009
    • EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), 2009. Scientific opinion on the substantiation of health claims related to vitamin C and protection of DNA, proteins and lipids from oxidative damage (ID 129, 138, 143, 148), antioxidant function of lutein (ID 146), maintenance of vision (ID 141, 142), collagen formation (ID 130, 131, 136, 137, 149), function of the nervous system (ID 133), function of the immune system (ID 134), function of the immune system during and after extreme physical exercise (ID 144), non-haem iron absorption (ID 132, 147), energy-yielding metabolism (ID 135), and relief in case of irritation in the upper respiratory tract (ID 1714, 1715) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 2009;7(9):1226, 28 pp. doi:10.2903/j.efsa.2009.1226.
    • (2009) EFSA Journal , vol.7 , Issue.9 , pp. 1226-1228
  • 61
    • 85078378496 scopus 로고    scopus 로고
    • Scientific Opinion on the substantiation of a health claim related to a combination of blackcurrant seed oil, fish oil, lycopene, vitamin C, and vitamin E and helps to improve dry skin conditions pursuant to Article 13(5) of Regulation (EC) No 1924/2006
    • 2010
    • E EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), 2010a. Scientific Opinion on the substantiation of a health claim related to a combination of blackcurrant seed oil, fish oil, lycopene, vitamin C, and vitamin E and helps to improve dry skin conditions pursuant to Article 13(5) of Regulation (EC) No 1924/2006. EFSA Journal 2010;8(5):1608, 13 pp. doi:10.2903/j.efsa.2010.1608.
    • (2010) EFSA Journal , vol.8 , Issue.5 , pp. 1608-1613
  • 62
    • 85078385895 scopus 로고    scopus 로고
    • Scientific Opinion on the substantiation of health claims related to vitamin C and reduction of tiredness and fatigue (ID 139, 2622), contribution to normal psychological functions (ID 140), regeneration of the reduced form of vitamin E (ID 202), contribution to normal energy-yielding metabolism (ID 2334, 3196), maintenance of the normal function of the immune system (ID 4321) and protection of DNA, proteins and lipids from oxidative damage (ID 3331) pursuant to Article 13(1) of Regulation (EC) No 1924/2006
    • 2010
    • EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), 2010b. Scientific Opinion on the substantiation of health claims related to vitamin C and reduction of tiredness and fatigue (ID 139, 2622), contribution to normal psychological functions (ID 140), regeneration of the reduced form of vitamin E (ID 202), contribution to normal energy-yielding metabolism (ID 2334, 3196), maintenance of the normal function of the immune system (ID 4321) and protection of DNA, proteins and lipids from oxidative damage (ID 3331) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 2010;8(10):1815, 20 pp. doi:10.2903/j.efsa.2010.1815.
    • (2010) EFSA Journal , vol.8 , Issue.10 , pp. 1815-1820
  • 63
    • 84943740210 scopus 로고    scopus 로고
    • Scientific Opinion on dietary reference values for vitamin C
    • 2013
    • EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2013. Scientific Opinion on dietary reference values for vitamin C. EFSA Journal 2013;11(11):3418, 68 pp. doi:10.2903/j.efsa.2013.3418.
    • (2013) EFSA Journal , vol.11 , Issue.11 , pp. 3418-3468
  • 64
    • 84996465324 scopus 로고    scopus 로고
    • Guidance on selected default values to be used by the EFSA Scientific Committee, Scientific Panels and Units in the absence of actual measured data
    • 2012
    • EFSA Scientific Committee, 2012. Guidance on selected default values to be used by the EFSA Scientific Committee, Scientific Panels and Units in the absence of actual measured data. EFSA Journal 2012;10(3):2579, 32 pp. doi:10.2903/j.efsa.2012.2579.
    • (2012) EFSA Journal , vol.10 , Issue.3 , pp. 2579-2532
  • 65
    • 64049105397 scopus 로고    scopus 로고
    • 8th edition, Band 2
    • European Pharmacopoeia, 2014. 8th edition, Band 2. pp. 2157–2159.
    • (2014) European Pharmacopoeia , pp. 2157-2159
  • 66
    • 33751517170 scopus 로고    scopus 로고
    • Effects of high intensity pulsed electric field processing conditions on vitamin C and antioxidant capacity of orange juice and gazpacho, a cold vegetable soup
    • Elez-Martínez P and Martín-Belloso O, 2007. Effects of high intensity pulsed electric field processing conditions on vitamin C and antioxidant capacity of orange juice and gazpacho, a cold vegetable soup. Food Chemistry, 102, 201–209.
    • (2007) Food Chemistry , vol.102 , pp. 201-209
    • Elez-Martínez, P.1    Martín-Belloso, O.2
  • 67
    • 84856315814 scopus 로고    scopus 로고
    • EVM/99/21.REVISEDAUGUST2002. Available online
    • EVM (Expert Group on Vitamins and Minerals), 2002. Expert Group on vitamins and minerals: revised review of vitamin C. EVM/99/21.REVISEDAUGUST2002. Available online: http://www.food.gov.uk/multimedia/pdfs/vitaminc.pdf.
    • (2002) Expert Group on vitamins and minerals: revised review of vitamin C
  • 68
    • 0042088455 scopus 로고    scopus 로고
    • Available online
    • EVM (Expert Group on Vitamins and Minerals), 2003. Safe upper levels for vitamins and minerals. Available online: www.food.gov.uk/multimedia/pdfs/vitmin2003.pdf.
    • (2003) Safe upper levels for vitamins and minerals
  • 69
    • 18544371788 scopus 로고    scopus 로고
    • Second Edition, Chapter 7, Vitamin C. 130-139. Available online
    • FAO/WHO (Food and Agriculture Organization of the United Nations/World Health Organization), 2004. Vitamin and Mineral Requirements in Human Nutrition. Second Edition. Chapter 7, Vitamin C. 130-139. Available online: http://whqlibdoc.who.int/publications/2004/9241546123.pdf.
    • (2004) Vitamin and Mineral Requirements in Human Nutrition
  • 71
    • 18544384019 scopus 로고
    • LXXIII – Oxidation of tartaric acid in presence of iron
    • Fenton HJH, 1894. LXXIII – Oxidation of tartaric acid in presence of iron. Journal of the Chemical Society Transactions, 65, 899–910.
    • (1894) Journal of the Chemical Society Transactions , vol.65 , pp. 899-910
    • Fenton, H.J.H.1
  • 72
    • 0003844788 scopus 로고    scopus 로고
    • National Academy of Sciences. Institute of Medicine. Food and Nutrition Board, Available online
    • FNB (Food and Nutrition Board), 2000. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. National Academy of Sciences. Institute of Medicine. Food and Nutrition Board. Available online: http://fnic.nal.usda.gov/nal_display/index.php?info_center=4&tax_level=4&tax_subject=256&topic_id=1342&level1343_id=5141&level1344_id=10591.
    • (2000) Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids
  • 73
    • 24044499330 scopus 로고    scopus 로고
    • HPLC-UV determination of total vitamin C in a wide range of fortified food products
    • Fontannaz P, Kilinc T and Heudi O, 2006. HPLC-UV determination of total vitamin C in a wide range of fortified food products. Food Chemistry, 94, 626–231.
    • (2006) Food Chemistry , vol.94 , pp. 626-231
    • Fontannaz, P.1    Kilinc, T.2    Heudi, O.3
  • 74
    • 0034632252 scopus 로고    scopus 로고
    • Validation of single cell gel assay in human leucocytes with 18 reference compounds
    • Frenzilli G, Bosco E and Barale R, 2000. Validation of single cell gel assay in human leucocytes with 18 reference compounds. Mutation Research, 468, 93–108.
    • (2000) Mutation Research , vol.468 , pp. 93-108
    • Frenzilli, G.1    Bosco, E.2    Barale, R.3
  • 75
    • 78049248591 scopus 로고    scopus 로고
    • Influence of drying by convective air dryer or power ultrasoind on the vitamin C and beta-carotene content of carrots
    • Frias J, Penas E, Ullat M and Vidal-Valverde C, 2010. Influence of drying by convective air dryer or power ultrasoind on the vitamin C and beta-carotene content of carrots. Journal of Agricultural and Food Chemistry, 58, 10539–10544.
    • (2010) Journal of Agricultural and Food Chemistry , vol.58 , pp. 10539-10544
    • Frias, J.1    Penas, E.2    Ullat, M.3    Vidal-Valverde, C.4
  • 76
    • 0015884590 scopus 로고
    • Reproduktionstoxikologische studien mit ascorbinsaure an mausen and ratten [Reproduction-toxicologic studies on ascorbic-acid in mice and rats]
    • Frohberg H, Gleich J and Kieser H, 1973. Reproduktionstoxikologische studien mit ascorbinsaure an mausen and ratten [Reproduction-toxicologic studies on ascorbic-acid in mice and rats]. Arzneimittel-Forschung [Drug Research], 23, 1081–1082.
    • (1973) Arzneimittel-Forschung [Drug Research] , vol.23 , pp. 1081-1082
    • Frohberg, H.1    Gleich, J.2    Kieser, H.3
  • 77
    • 0018393389 scopus 로고
    • Vitamin C is positive in the DNA synthesis inhibition and sister-chromatic exchange test
    • Galloway SM and Painter RB, 1979. Vitamin C is positive in the DNA synthesis inhibition and sister-chromatic exchange test. Mutation Research, 60, 321–327.
    • (1979) Mutation Research , vol.60 , pp. 321-327
    • Galloway, S.M.1    Painter, R.B.2
  • 78
    • 0034055475 scopus 로고    scopus 로고
    • Meta-analysis of studies on breast cancer risk and diet: the role of fruit and vegetable consumption and the intake of associated micronutrients
    • Gandini S, Merzenich H, Robertson C and Boyle P, 2000. Meta-analysis of studies on breast cancer risk and diet: the role of fruit and vegetable consumption and the intake of associated micronutrients. European Journal of Cancer, 36, 636–646.
    • (2000) European Journal of Cancer , vol.36 , pp. 636-646
    • Gandini, S.1    Merzenich, H.2    Robertson, C.3    Boyle, P.4
  • 79
    • 33751385022 scopus 로고
    • Benzene production from decarboxylation of benzoic acid in the presence of ascorbic acid and a transition-metal catalyst
    • Gardner LK and Lawrence GD, 1993. Benzene production from decarboxylation of benzoic acid in the presence of ascorbic acid and a transition-metal catalyst. Journal of Agricultural and Food Chemistry, 41, 693–695.
    • (1993) Journal of Agricultural and Food Chemistry , vol.41 , pp. 693-695
    • Gardner, L.K.1    Lawrence, G.D.2
  • 81
    • 61849120253 scopus 로고    scopus 로고
    • Biochemical and colour changes of watercress (Nasturtium officinale R. Br.) during freezing and frozen storage
    • Gonçalves EM, Cruz RMS, Abreu M, Branda, TRS and Silva CLM, 2009. Biochemical and colour changes of watercress (Nasturtium officinale R. Br.) during freezing and frozen storage. Journal of Food Engineering, 93, 32–39.
    • (2009) Journal of Food Engineering , vol.93 , pp. 32-39
    • Gonçalves, E.M.1    Cruz, R.M.S.2    Abreu, M.3    Branda, T.R.S.4    Silva, C.L.M.5
  • 83
  • 84
    • 0002687692 scopus 로고    scopus 로고
    • Vitamins
    • 3rd Edition, Eds, O R Fennema, Marcel Dekker Inc, NewYork, USA
    • Gregory JF, 1996. Vitamins. In:Food chemistry, 3rd Edition. Eds O R Fennema; Marcel Dekker Inc; NewYork, USA, pp. 559–568.
    • (1996) Food chemistry , pp. 559-568
    • Gregory, J.F.1
  • 85
    • 0024401672 scopus 로고
    • Chromosome aberration and sister chromatid exchange test in Chinese hamster ovarycells in vitro III: results of 27 chemicals
    • Gulati DK, Witt K, Anderson B, Zeiger E and Shelby M, 1989. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovarycells in vitro III: results of 27 chemicals. Environmental and Molecular Mutagenesis, 13, 133–193.
    • (1989) Environmental and Molecular Mutagenesis , vol.13 , pp. 133-193
    • Gulati, D.K.1    Witt, K.2    Anderson, B.3    Zeiger, E.4    Shelby, M.5
  • 88
    • 0008577867 scopus 로고
    • The safety of high vitamin C intakes in man
    • Eds, Counsell JN, Hornig DH., Applied Science Publishers, London
    • Hornig DH and Moser U, 1981. The safety of high vitamin C intakes in man. In: Vitamin C (ascorbic acid). Eds Counsell JN and Hornig DH. Applied Science Publishers, London, pp. 225–248.
    • (1981) Vitamin C (ascorbic acid) , pp. 225-248
    • Hornig, D.H.1    Moser, U.2
  • 90
    • 85078372226 scopus 로고    scopus 로고
    • World Health Organization
    • Volume, F. A review of human carcinogens. Available online
    • IARC (International Agency for Research on Cancer), 2012. World Health Organization. Chemical Agents and related Occupations. Volume 100F. A review of human carcinogens. Available online: http://monographs.iarc.fr/ENG/Monographs/vol100F/mono100F.pdf.
    • (2012) Chemical Agents and related Occupations , vol.100
  • 93
    • 0023855146 scopus 로고
    • A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell culture
    • Ishidate M Jr, Harnois MC and Soduni T, 1988. A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell culture. Mutation Research, 195, 151–213.
    • (1988) Mutation Research , vol.195 , pp. 151-213
    • Ishidate, M.1    Harnois, M.C.2    Soduni, T.3
  • 94
    • 0043065970 scopus 로고
    • Sixth Report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series No 228; FAO Nutrition Meetings Report Series No 31
    • JECFA (Joint FAO/WHO Expert Committee on Food Additives), 1962. Evaluation of the toxicity of a number of antimicrobials and antioxidants. Sixth Report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series No 228; FAO Nutrition Meetings Report Series No 31.
    • (1962) Evaluation of the toxicity of a number of antimicrobials and antioxidants
  • 95
    • 0003520230 scopus 로고
    • Seventeenth Report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series 539. Available online
    • JECFA (Joint FAO/WHO Expert Committee on Food Additives), 1974a. Toxicological evaluation of certain food additieves with a review of general principles and of specifications. Seventeenth Report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series 539. Available online: http://whqlibdoc.who.int/trs/WHO_TRS_539.pdf.
    • (1974) Toxicological evaluation of certain food additieves with a review of general principles and of specifications
  • 97
    • 0003550147 scopus 로고
    • Twenty-fifth meeting of the Joint FAO/WHO Expert Committee on Food Additives. Technical Report Series No 669. Available online
    • JECFA (Joint FAO/WHO Expert Committee on Food Additives), 1981a. Evaluation of certain food additives. Twenty-fifth meeting of the Joint FAO/WHO Expert Committee on Food Additives. Technical Report Series No 669. Available online: http://whqlibdoc.who.int/trs/WHO_TRS_669.pdf.
    • (1981) Evaluation of certain food additives
  • 98
    • 0003520236 scopus 로고
    • Twenty-fifth meeting of the Joint FAO/WHO Expert Committee on Food Additives. Food Additive Series No 16. Available online
    • JECFA (Joint FAO/WHO Expert Committee on Food Additives), 1981b. Toxicological evaluation of certain food additives. Twenty-fifth meeting of the Joint FAO/WHO Expert Committee on Food Additives. Food Additive Series No 16. Available online: http://www.inchem.org/documents/jecfa/jecmono/v16je06.htm.
    • (1981) Toxicological evaluation of certain food additives
  • 99
    • 85078392913 scopus 로고
    • JECFA Monograph. 545., WHO Food Additives Series 17. Available online
    • JECFA (Joint FAO/WHO Expert Committee on Food Additives), 1993. JECFA Monograph. 545. Saccharin. WHO Food Additives Series 17. Available online: http://www.inchem.org/documents/jecfa/jecmono/v17je25.htm.
    • (1993) Saccharin
  • 100
    • 79952856038 scopus 로고    scopus 로고
    • Monograph 1., Available online
    • JECFA (Joint FAO/WHO Expert Committee on Food Additives), 2006. Monograph 1. Combined compendium of food additive specifications. Available online: http://www.fao.org/ag/agn/jecfa-additives/search.html.
    • (2006) Combined compendium of food additive specifications
  • 101
    • 0032890707 scopus 로고    scopus 로고
    • Biomarkers for establishing a tolerable upper intake level for vitamin C
    • (as referred to EFSA NDA Panel, 2013)
    • Johnston CS, 1999. Biomarkers for establishing a tolerable upper intake level for vitamin C. Nutrition Reviews, 57, 71–77 (as referred to EFSA NDA Panel, 2013).
    • (1999) Nutrition Reviews , vol.57 , pp. 71-77
    • Johnston, C.S.1
  • 102
    • 0033000491 scopus 로고    scopus 로고
    • Improved method for simultaneous determination of ascorbic acid and dehydroascorbic acid, isoascorbic acid and dehydroisoascorbic acid in food and biological samples
    • Kall MA and Andersen C, 1999. Improved method for simultaneous determination of ascorbic acid and dehydroascorbic acid, isoascorbic acid and dehydroisoascorbic acid in food and biological samples. Journal of Chromatography B, 730, 101–111.
    • (1999) Journal of Chromatography B , vol.730 , pp. 101-111
    • Kall, M.A.1    Andersen, C.2
  • 106
    • 43949107893 scopus 로고    scopus 로고
    • Antimutagenic profile of antioxidant vitamins in drosophila mulation test
    • Khan PK and Sinha SP. Antimutagenic profile of antioxidant vitamins in drosophila mulation test. Diodemidal and Environmental Sciences, 21, 163–166.
    • Diodemidal and Environmental Sciences , vol.21 , pp. 163-166
    • Khan, P.K.1    Sinha, S.P.2
  • 107
    • 0036045443 scopus 로고    scopus 로고
    • Mutagenicity and DNA-damaging activity caused by decomposed products of potassium sorbate reacting with ascorbic acid in the presence of Fe salt
    • Kitano K, Fukukawa T, Ohtsuji Y, Masuda T and Yamaguchi H, 2002. Mutagenicity and DNA-damaging activity caused by decomposed products of potassium sorbate reacting with ascorbic acid in the presence of Fe salt. Food and Chemical Toxicology, 40, 1589–1594.
    • (2002) Food and Chemical Toxicology , vol.40 , pp. 1589-1594
    • Kitano, K.1    Fukukawa, T.2    Ohtsuji, Y.3    Masuda, T.4    Yamaguchi, H.5
  • 109
    • 0022529472 scopus 로고
    • Inhibition of cyclophosphamide and mitocycin C-induced sister chromatid exchanges in mice
    • Krishna G, Nath J and Ong T, 1986. Inhibition of cyclophosphamide and mitocycin C-induced sister chromatid exchanges in mice. Cancer Research, 46, 2670–2674.
    • (1986) Cancer Research , vol.46 , pp. 2670-2674
    • Krishna, G.1    Nath, J.2    Ong, T.3
  • 113
    • 0024445711 scopus 로고
    • Interplay of urinary sodium and potassium concentration with urinary pH in urinary bladder carcinogenesis in rats
    • Lina BAR and Woutersen RA, 1989. Interplay of urinary sodium and potassium concentration with urinary pH in urinary bladder carcinogenesis in rats. Carcinogenesis, 10, 1733–1736.
    • (1989) Carcinogenesis , vol.10 , pp. 1733-1736
    • Lina, B.A.R.1    Woutersen, R.A.2
  • 115
    • 32744470088 scopus 로고
    • Submitted by FDA in response to an FOI request in 1999,, (as referred to by CIR, 2005)
    • Litton Bionetics, 1975. Mutagenicity evaluation of compound FDA71-65 ascorbic acid. Report No 223-74-2104. Submitted by FDA in response to an FOI request in 1999, 46 pp. (as referred to by CIR, 2005).
    • (1975) Mutagenicity evaluation of compound FDA71-65 ascorbic acid , pp. 46
    • Litton, B.1
  • 116
    • 32744455033 scopus 로고
    • Submitted by FDA in response to an FOI request in 1999., (as referred to by CIR, 2005)
    • Litton Bionetics, 1976. Mutagenicity evaluation of sodium ascorbate USP, FCC, FDA 75–64 final report. Report No 223-76-2101. Submitted by FDA in response to an FOI request in 1999. 32 pp. (as referred to by CIR, 2005).
    • (1976) Mutagenicity evaluation of sodium ascorbate USP, FCC, FDA 75–64 final report , pp. 32
  • 117
    • 0017835850 scopus 로고
    • The use of short-term tests to measure the preventive action of reducing agents on formation and activation of carcinogenic nitroso compounds
    • Lo LW and Stich HF, 1978. The use of short-term tests to measure the preventive action of reducing agents on formation and activation of carcinogenic nitroso compounds. Mutation Research, 57, 57–67.
    • (1978) Mutation Research , vol.57 , pp. 57-67
    • Lo, L.W.1    Stich, H.F.2
  • 118
    • 84865641910 scopus 로고    scopus 로고
    • Evaluation of ascorbic acid and sugar degradation products during fruit dessert processing under conventional or ohmic heating treatment
    • Louarme L and Billaud C, 2012. Evaluation of ascorbic acid and sugar degradation products during fruit dessert processing under conventional or ohmic heating treatment. LWT Food Science and Technology, 49, 184–187.
    • (2012) LWT Food Science and Technology , vol.49 , pp. 184-187
    • Louarme, L.1    Billaud, C.2
  • 119
    • 0027691673 scopus 로고
    • Survey of benzene in foods by using headspace concentration techniques and capillary gas chromatography
    • McNeal TP, Nyman PJ, Diachenko GW and Hollifield HC, 1993. Survey of benzene in foods by using headspace concentration techniques and capillary gas chromatography. Journal of AOAC International, 76, 1213–1219.
    • (1993) Journal of AOAC International , vol.76 , pp. 1213-1219
    • McNeal, T.P.1    Nyman, P.J.2    Diachenko, G.W.3    Hollifield, H.C.4
  • 120
    • 0018736629 scopus 로고
    • Induction of sister chromatid exchanges in Chinese hamster cells by the reducing agents bisulfite and ascorbic acid
    • Macrae WD and Stich HF, 1979. Induction of sister chromatid exchanges in Chinese hamster cells by the reducing agents bisulfite and ascorbic acid. Toxicology, 13, 167–174.
    • (1979) Toxicology , vol.13 , pp. 167-174
    • Macrae, W.D.1    Stich, H.F.2
  • 121
    • 22144484168 scopus 로고    scopus 로고
    • Ascorbate increases human oxaluria and kidney stone risk
    • Massey LK, Liebman M and Kynast-Gales SA, 2005. Ascorbate increases human oxaluria and kidney stone risk. Journal of Nutrition, 135, 1673–1677.
    • (2005) Journal of Nutrition , vol.135 , pp. 1673-1677
    • Massey, L.K.1    Liebman, M.2    Kynast-Gales, S.A.3
  • 122
    • 0028863401 scopus 로고
    • Evaluation of the micronucleus test in vivo using Chinese hamster cells
    • Miller B, Pujadas E and Gocke E, 1995. Evaluation of the micronucleus test in vivo using Chinese hamster cells. Environmental and Molecular Mutagenesis, 26, 240–247.
    • (1995) Environmental and Molecular Mutagenesis , vol.26 , pp. 240-247
    • Miller, B.1    Pujadas, E.2    Gocke, E.3
  • 123
    • 0029012935 scopus 로고
    • The in vitro-in vivo replicative DNA synthesis (RDS) test with hepatocytes prepared from male B6C3F1 mice as an early prediction assay for putative nongenotoxic (Ames-negative) mouse hepatocytes
    • Miyagawa M, Takasawa H, Sugiyama A, Inoue Y, Murata T, Uno Y and Yoshikawa K, 1995. The in vitro-in vivo replicative DNA synthesis (RDS) test with hepatocytes prepared from male B6C3F1 mice as an early prediction assay for putative nongenotoxic (Ames-negative) mouse hepatocytes. Mutation Research, 343, 157–183.
    • (1995) Mutation Research , vol.343 , pp. 157-183
    • Miyagawa, M.1    Takasawa, H.2    Sugiyama, A.3    Inoue, Y.4    Murata, T.5    Uno, Y.6    Yoshikawa, K.7
  • 124
    • 0025744675 scopus 로고
    • Chemical mutagenesis at the thymidine kinase locus in L5178Y mouse lymphoma cells: results for 31 coded compounds in the National Toxicology Program
    • Myhr BC and Caspary WJ, 1991. Chemical mutagenesis at the thymidine kinase locus in L5178Y mouse lymphoma cells: results for 31 coded compounds in the National Toxicology Program. Environmental and Molecular Mutagenesis, 18, 51–83.
    • (1991) Environmental and Molecular Mutagenesis , vol.18 , pp. 51-83
    • Myhr, B.C.1    Caspary, W.J.2
  • 127
    • 80054796926 scopus 로고    scopus 로고
    • Vitamin C degradation products and pathways in the human lens
    • Nemet I and Monnier VM, 2011. Vitamin C degradation products and pathways in the human lens. The Journal of Biological Chemistry, 286, 37128–37136.
    • (2011) The Journal of Biological Chemistry , vol.286 , pp. 37128-37136
    • Nemet, I.1    Monnier, V.M.2
  • 129
    • 0021934384 scopus 로고
    • Inhibition of DNA synthesis by chemical carcinogens in cultures of initiated and normal proliferating rat hepatocytes
    • Novicki DL, Rosenberg MR and Michalopoulos G, 1985. Inhibition of DNA synthesis by chemical carcinogens in cultures of initiated and normal proliferating rat hepatocytes. Cancer Research, 45, 337–344.
    • (1985) Cancer Research , vol.45 , pp. 337-344
    • Novicki, D.L.1    Rosenberg, M.R.2    Michalopoulos, G.3
  • 133
    • 84938311733 scopus 로고    scopus 로고
    • Vitamins, 7. Vitamin C (L-Ascorbic Acid)
    • Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany
    • Oster B and Fechtel U, 2012. Vitamins, 7. Vitamin C (L-Ascorbic Acid). Ullmann's Encyclopedia of Industrial Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany.
    • (2012) Ullmann's Encyclopedia of Industrial Chemistry
    • Oster, B.1    Fechtel, U.2
  • 137
    • 0030977245 scopus 로고    scopus 로고
    • No effect of supplementation with vitamin E, ascorbic acid, or coenzyme Q10 on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2′-deoxyguanosine excretion in smokers
    • Prieme H, Loft S, Nyyssonen K, Salonen JT and Poulsen HE, 1997. No effect of supplementation with vitamin E, ascorbic acid, or coenzyme Q10 on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2′-deoxyguanosine excretion in smokers. American Journal of Clinical Nutrition, 65, 503–507.
    • (1997) American Journal of Clinical Nutrition , vol.65 , pp. 503-507
    • Prieme, H.1    Loft, S.2    Nyyssonen, K.3    Salonen, J.T.4    Poulsen, H.E.5
  • 140
    • 84982339804 scopus 로고
    • A productive synthesis of L-arcorbic acid (C-vitamin)
    • Reichstein T and Grussner A, 1934. A productive synthesis of L-arcorbic acid (C-vitamin). Helvetica Chimica Acta, 17, 311–328.
    • (1934) Helvetica Chimica Acta , vol.17 , pp. 311-328
    • Reichstein, T.1    Grussner, A.2
  • 141
    • 2442484935 scopus 로고    scopus 로고
    • DNA lesions and cytogenetic changes induced by N-nitrosomorpholine in HepG2, V79 and VH10 cells: the protective effects of Vitamins A, C and E
    • Robichová S, Slamenová D, Chalupa I and L$ivia Šebová L, 2004. DNA lesions and cytogenetic changes induced by N-nitrosomorpholine in HepG2, V79 and VH10 cells: the protective effects of Vitamins A, C and E. Mutation Research, 560, 91–99.
    • (2004) Mutation Research , vol.560 , pp. 91-99
    • Robichová, S.1    Slamenová, D.2    Chalupa, I.3    L$ivia Šebová, L.4
  • 142
    • 0018872455 scopus 로고
    • Mutagenic activity of ascorbate in mammalian cell cultures
    • Rosin MP, San RHC and Stich HF. 1980. Mutagenic activity of ascorbate in mammalian cell cultures. Cancer Letters, 8, 299–305.
    • (1980) Cancer Letters , vol.8 , pp. 299-305
    • Rosin, M.P.1    San, R.H.C.2    Stich, H.F.3
  • 143
    • 85078389541 scopus 로고    scopus 로고
    • Water soluble vitamins
    • 3rd Edition, Eds, Nolet LMI, Toldrà F., CRC Press Taylor and Francis Group
    • Russell LF, 2013. Water soluble vitamins. In: Food analysis by HPLC. 3rd Edition. Eds Nolet LMI and Toldrà F. CRC Press Taylor and Francis Group, 331.
    • (2013) Food analysis by HPLC , pp. 331
    • Russell, L.F.1
  • 146
    • 85078389027 scopus 로고
    • Reports of the Scientific Committee for Food (twenty-second series). Available online
    • SCF (Scientific Committee on Food), 1989b. Report on antioxidants (opinion expressed 11 December 1987). Reports of the Scientific Committee for Food (twenty-second series). Available online: http://ec.europa.eu/food/fs/sc/scf/reports/scf_reports_22.pdf.
    • (1989) Report on antioxidants (opinion expressed 11 December 1987)
  • 148
    • 79952367639 scopus 로고
    • Nutrient and energy intakes for the European Community
    • Reports of the Scientific Committee for Food, 31st Series., European Commission, Luxembourg, Available online
    • SCF (Scientific Committee on Food), 1993. Nutrient and energy intakes for the European Community. Reports of the Scientific Committee for Food, 31st Series. Food–Science and Technique. European Commission, Luxembourg, 248 pp. Available online: http://ec.europa.eu/food/fs/sc/scf/reports/scf_reports_31.pdf.
    • (1993) Food–Science and Technique , pp. 248
  • 155
    • 0027526525 scopus 로고
    • Evaluation of a three-exposure mouse bone marrow micronucleus protocol: results with 49 chemicals
    • Shelby MD, Erexon GL, Hook GJ and Tice RR, 1993. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: results with 49 chemicals. Environmental and Molecular Mutagenesis, 21, 160–179.
    • (1993) Environmental and Molecular Mutagenesis , vol.21 , pp. 160-179
    • Shelby, M.D.1    Erexon, G.L.2    Hook, G.J.3    Tice, R.R.4
  • 156
    • 0025071557 scopus 로고
    • The degradation of L-ascorbic acid in neutral solutions containing oxygen
    • Shin DB and Feather MS, 1990. The degradation of L-ascorbic acid in neutral solutions containing oxygen. Journal of Carbohydrate Chemistry, 9, 461–469.
    • (1990) Journal of Carbohydrate Chemistry , vol.9 , pp. 461-469
    • Shin, D.B.1    Feather, M.S.2
  • 157
    • 0031452090 scopus 로고    scopus 로고
    • Vitamin C supplementation of the maternal diet reduces the rate of malformation in the offspring of diabetic rats
    • Simán CM and Eriksson UJ, 1997. Vitamin C supplementation of the maternal diet reduces the rate of malformation in the offspring of diabetic rats. Diabetologia, 40, 1416–1424.
    • (1997) Diabetologia , vol.40 , pp. 1416-1424
    • Simán, C.M.1    Eriksson, U.J.2
  • 158
    • 0033594181 scopus 로고    scopus 로고
    • Relation of serum ascorbic acid to serum vitamin B-12, serum ferritin, and kidney stones in US adults
    • Simon JA and Hudes ES, 1999. Relation of serum ascorbic acid to serum vitamin B-12, serum ferritin, and kidney stones in US adults. Archives of Internal Medicine, 159, 619–624.
    • (1999) Archives of Internal Medicine , vol.159 , pp. 619-624
    • Simon, J.A.1    Hudes, E.S.2
  • 159
    • 0034655826 scopus 로고    scopus 로고
    • The non-oxidative degradation of ascorbic acid at physiological conditions
    • Simpson GLW and Ortwerth BJ, 2000. The non-oxidative degradation of ascorbic acid at physiological conditions. Biochimica et Biophysica Acta, 1501, 12–24.
    • (2000) Biochimica et Biophysica Acta , vol.1501 , pp. 12-24
    • Simpson, G.L.W.1    Ortwerth, B.J.2
  • 160
    • 0027656142 scopus 로고
    • Ascorbic-acid is an abettor in calcium urolithiasis - an experimental-study
    • Singh PP, Kiran R, Pendse AK, Ghosh R and Surana SS, 1993. Ascorbic-acid is an abettor in calcium urolithiasis - an experimental-study. Scanning Microscopy, 7, 1041–1048.
    • (1993) Scanning Microscopy , vol.7 , pp. 1041-1048
    • Singh, P.P.1    Kiran, R.2    Pendse, A.K.3    Ghosh, R.4    Surana, S.S.5
  • 161
    • 79955996082 scopus 로고    scopus 로고
    • Effect of freezing and canning on the content of vitamin C in immature seeds of five cultivars of common bean (Phaseolus vulgaris, L.)
    • Slupski J, 2011. Effect of freezing and canning on the content of vitamin C in immature seeds of five cultivars of common bean (Phaseolus vulgaris, L.), Technologia Alimentaria, Acta Scientiarum Polonorum, 10, 199–208.
    • (2011) Technologia Alimentaria, Acta Scientiarum Polonorum , vol.10 , pp. 199-208
    • Slupski, J.1
  • 162
    • 0025833781 scopus 로고
    • Ascorbic acid and oxidative inactivation of proteins
    • Stadtman ER, 1991. Ascorbic acid and oxidative inactivation of proteins. American Journal of Clinical Nutrition, 54, 1125S–1128S.
    • (1991) American Journal of Clinical Nutrition , vol.54 , pp. 1125S-1128S
    • Stadtman, E.R.1
  • 163
    • 0018885770 scopus 로고
    • The SCE-inducing capacity of vitamin C: investigations in vitro and in vivo
    • Speit G, Wolf M and Vogel W, 1980. The SCE-inducing capacity of vitamin C: investigations in vitro and in vivo. Mutation Research, 78, 273–278.
    • (1980) Mutation Research , vol.78 , pp. 273-278
    • Speit, G.1    Wolf, M.2    Vogel, W.3
  • 164
    • 0017255777 scopus 로고
    • Ascorbic acid-induced uricosuria–consequence of megavitamin therapy
    • Stein HB, Hasan A and Fox IH, 1976. Ascorbic acid-induced uricosuria–consequence of megavitamin therapy. Annals of Internal Medicine, 84, 385–388.
    • (1976) Annals of Internal Medicine , vol.84 , pp. 385-388
    • Stein, H.B.1    Hasan, A.2    Fox, I.H.3
  • 166
  • 167
    • 0019218213 scopus 로고
    • Chromosome aberrations in mammalian cells exposed to vitamin C and multiple vitamin pills
    • Stich HG, Wei L and Whitting RF, 1980. Chromosome aberrations in mammalian cells exposed to vitamin C and multiple vitamin pills. Food and Cosmetics Toxicology, 18, 497–501.
    • (1980) Food and Cosmetics Toxicology , vol.18 , pp. 497-501
    • Stich, H.G.1    Wei, L.2    Whitting, R.F.3
  • 170
    • 0028837060 scopus 로고
    • Hemorrhagic toxicity of a large dose of alpha-tocopherol, beta-tocopherol, gamma-tocopherol and delta-tocopherol, ubiquinone, beta-carotene, retinol acetate and l-ascorbic-acid in the rat
    • Takahashi O, 1995. Hemorrhagic toxicity of a large dose of alpha-tocopherol, beta-tocopherol, gamma-tocopherol and delta-tocopherol, ubiquinone, beta-carotene, retinol acetate and l-ascorbic-acid in the rat. Food and Chemical Toxicology, 33, 121–128.
    • (1995) Food and Chemical Toxicology , vol.33 , pp. 121-128
    • Takahashi, O.1
  • 171
    • 0016277121 scopus 로고
    • Combined chronic feeding and three-generation reproduction study of sodium saccharin in the rat
    • ((as referred to by JECFA, 1993)
    • Taylor JM and Friedman L, 1974. Combined chronic feeding and three-generation reproduction study of sodium saccharin in the rat. Toxicology and Applied Pharmacology, 29, 154 (abstract No 200) (as referred to by JECFA, 1993).
    • (1974) Toxicology and Applied Pharmacology , vol.29 , Issue.154
    • Taylor, J.M.1    Friedman, L.2
  • 172
    • 9644273945 scopus 로고    scopus 로고
    • Dietary factors and the risk of incident kidney stones in men: new insights after 14 years of follow-up
    • Taylor EN, Stampfer MJ and Curhan GC, 2004. Dietary factors and the risk of incident kidney stones in men: new insights after 14 years of follow-up. Journal of the American Society of Nephrology, 15, 3225–3232.
    • (2004) Journal of the American Society of Nephrology , vol.15 , pp. 3225-3232
    • Taylor, E.N.1    Stampfer, M.J.2    Curhan, G.C.3
  • 174
    • 85078395231 scopus 로고    scopus 로고
    • Assessment provided for DSM Nutritional products, BASF and DuPont Nutrition Biosciences. 9 January, 104. Unpublished study report
    • Tennant D, 2004. Usage of tocopherols and ascorbates in food and non-alcoholic beverages. Assessment provided for DSM Nutritional products, BASF and DuPont Nutrition Biosciences. 9 January, 104. Unpublished study report.
    • (2004) Usage of tocopherols and ascorbates in food and non-alcoholic beverages
    • Tennant, D.1
  • 176
    • 0011870739 scopus 로고
    • Long-term feeding of saccharin in rats
    • symposium. Ed., Inglett GE., AVI Publishing Co., Westport, Connecticut, (as referred to by JECFA, 1993)
    • Tisdel MO et al., 1974. Long-term feeding of saccharin in rats. In: Sweetness, symposium. Ed. Inglett GE. AVI Publishing Co., Westport, Connecticut, 145 pp. (as referred to by JECFA, 1993).
    • (1974) Sweetness , pp. 145
    • Tisdel, M.O.1
  • 177
    • 0024990610 scopus 로고
    • Genetic toxicity of 6 carcinogens and 6 noncarcinogens in the drosophila wing spot-test
    • Tripathy NK, Wurgler FE and Frei H, 1990. Genetic toxicity of 6 carcinogens and 6 noncarcinogens in the drosophila wing spot-test. Mutation Research, 242, 169–180.
    • (1990) Mutation Research , vol.242 , pp. 169-180
    • Tripathy, N.K.1    Wurgler, F.E.2    Frei, H.3
  • 178
    • 85004434461 scopus 로고
    • Selective oxidation of tryptophan and histidine residues in protein through the copper-catalyzed autoxidation of L-ascorbic acid
    • Uchida K and Kawakishi S, 1988. Selective oxidation of tryptophan and histidine residues in protein through the copper-catalyzed autoxidation of L-ascorbic acid. Agricultural and Biological Chemistry, 52, 1529–1535.
    • (1988) Agricultural and Biological Chemistry , vol.52 , pp. 1529-1535
    • Uchida, K.1    Kawakishi, S.2
  • 179
    • 0005473070 scopus 로고
    • The hydroxyl radical generated by an iron(II)/EDTA/ascorbate system preferentially attacks tryptophan residues of the protein
    • Uchida K, Enomoto N, Itakura K and Kawakishi S, 1989. The hydroxyl radical generated by an iron(II)/EDTA/ascorbate system preferentially attacks tryptophan residues of the protein. Agricultural and Biological Chemistry, 53, 3285–3292.
    • (1989) Agricultural and Biological Chemistry , vol.53 , pp. 3285-3292
    • Uchida, K.1    Enomoto, N.2    Itakura, K.3    Kawakishi, S.4
  • 181
    • 0035178377 scopus 로고    scopus 로고
    • Pharmacokinetics in dogs after oral administration of two different forms of ascorbic acid
    • Wang S, Berge GE, Hoem NO and Sund RB, 2001. Pharmacokinetics in dogs after oral administration of two different forms of ascorbic acid. Research in Veterinary Science, 71, 27–32.
    • (2001) Research in Veterinary Science , vol.71 , pp. 27-32
    • Wang, S.1    Berge, G.E.2    Hoem, N.O.3    Sund, R.B.4
  • 183
    • 0023257956 scopus 로고
    • Antioxidants inhibit the effect of vitamin C on oxygen radical-induced sister chromatid exchange
    • Weitberg AB, 1987. Antioxidants inhibit the effect of vitamin C on oxygen radical-induced sister chromatid exchange. Mutation Research, 191, 53–56.
    • (1987) Mutation Research , vol.191 , pp. 53-56
    • Weitberg, A.B.1
  • 184
    • 0020080933 scopus 로고
    • Effects of oxygen radical scavengers and antioxidants on phagocyte-induced mutagenesis
    • Weitzman SA and Stossel TP, 1982. Effects of oxygen radical scavengers and antioxidants on phagocyte-induced mutagenesis. Journal of Immunology, 128, 2770–2772.
    • (1982) Journal of Immunology , vol.128 , pp. 2770-2772
    • Weitzman, S.A.1    Stossel, T.P.2
  • 187
    • 0003771862 scopus 로고    scopus 로고
    • Fourth Edition, Benzene, p., Available online
    • WHO (World Health Organization), 2011. Guidelines for Drinking-water Quality. Fourth Edition. Benzene, p. 322. Available online: http://www.who.int/water_sanitation_health/dwq/guidelines/en/.
    • (2011) Guidelines for Drinking-water Quality , pp. 322
  • 188
    • 0023620331 scopus 로고
    • Dependence of intestinal iron absorption on the valency state of iron
    • (as referred to by EFSA NDA Panel, 2013)
    • Wollenberg P and Rummel W, 1987. Dependence of intestinal iron absorption on the valency state of iron. Naunyn-Schmiedeberg's Archives of Pharmacology, 336, 578–582 (as referred to by EFSA NDA Panel, 2013).
    • (1987) Naunyn-Schmiedeberg's Archives of Pharmacology , vol.336 , pp. 578-582
    • Wollenberg, P.1    Rummel, W.2


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