Scientific Opinion on Flavouring Group Evaluation 13Rev1: Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14

EFSA Journal

Volumn 8, Issue 4, 2010, Pages

[No Author Info available]

Author keywords

disulphide; flavourings; furan; furfuryl; safety; sulphur substituted; thioester; trisulphide

Indexed keywords

EID: 85006704539     PISSN: None     EISSN: 18314732     Source Type: Journal    
DOI: 10.2903/j.efsa.2010.1403     Document Type: Article

References (199)

1. Adams, T.B., Lake, B.G., Beamad, J.A., Price, R.J., Ford, R.A., Goodman, J.I., 1998b. An investigation of the effect of furfural on the unscheduled DNA synthesis in cultured human liver slices. Toxicologist 42 (1–S), 79.
2. Aeschbacher, H.U., Chappus, C., Manganel, M., Aeschbach, R., 1981. Investigation of maillard products in bacterial mutagenicity test systems. Prog. Food Nutr. Sci. 5, 279–294.
3. Aeschbacher, H.U., Wolleb, U., Loliger, J., Spadone, J.C., Liardon, R., 1989. Contribution of coffee aroma constituents to the mutagenicity of coffee. Food Chem. Toxicol. 27 (4), 227–232.
4. Archer, M.C., Bruce, W.R., Chan, C.C., Corpet, D.E., Medline, A., Roncucci, L., Stamp, D., Zhang, X.-M., 1992. Aberrant crypt foci and microadenoma as markers for colon cancer. Environ. Health Perspect. 98 (0), 195–197.
5. Asquith, J.C., 1989a. Bacterial reverse mutation assay ST 15C 89. Firmenich SA. Toxicol study no. M/AMES/18216. September 1989. Unpublished report submitted by EFFA to FLAVIS Secretariat.
6. Bio-Research Laboratory, 1980. Ethyl-beta-furfural-alpha-thiopropionate (EFTP). Unpublished report submitted by EFFA to FLAVIS Secretariat.
7. Boopathy, R., Bokang, H., Daniels, L., 1993. Biotransformation of furfural and 5-hydroxymethyl furfural by enteric bacteria. J. Ind. Microbiol. 11 (3), 147–150.
8. Brigelius, R., 1985. Mixed disulfides: Biological function and increase in oxidative stress. In: Sies, H. (ed.). Oxidative Stress. Academic Press, New York, 243–272.
9. Brown, J.M., 1982. Initial submission: Acute oral toxicity study with furfural in various vehicles in the rats with cover letter dated 073192. Quaker Oats Company. Report no. 1. EPA Doc 88–920005444, microfiche no. OTS0544698. August, 1982. Unpublished report submitted by EFFA to FLAVIS Secretariat.
10. Bruce, W.R., Archer, M.C., Corpet, D.E., Medline, A., Minkin, S., Stamp, D., Yin, Y., Zhang, X.M., 1993. Diet, aberrant crypt foci and colorectal cancer. Mutat. Res. 290, 111–118.
11. Chatterji, T., Keerthi, K., Gates, K.S., 2005. Generation of reactive oxygen species by a persulfide (BnSSH). Bioorg. Med. Chem. Lett. 15, 3921–3924.
12. CIVO-TNO, 2003. In vivo gene mutation by use of lambdaZ-transgenic mice with furfural. Steenwinkel, M.-J.S.T. Project no. 01044074. 1 May 2003. Unpublished report submitted to EFSA.
13. CoE, 1992. Flavouring substances and natural sources of flavourings. 4th Ed. vol. I. Chemically defined flavouring substances. Council of Europe, partial agreement in the social and public health field. Strasbourg.
14. Costa, M., Zhitkovich, A., Harris, M., Paustenbach, D., Gargas, M., 1997. DNA-protein cross-links produced by various chemicals in cultured human lymphoma cells. J. Toxicol. Environ. Health 50 (5), 433–449.
15. Cotgreave, I.A., Atzori, L., Moldéus, P., 1989. Thiol-disulphide exchange: Physiological and toxicological aspects. In: Damani, L.A. (ed.). Sulphur-containing drugs and related organic compounds. Ellis Horwood Series in Biochem. Pharmacol. John Wiley & Sons, New York. pp. 101–119.
16. Cramer, G.M., Ford, R.A., Hall, R.L., 1978. Estimation of toxic hazard - a decision tree approach. Food Cosmet. Toxicol. 16 (3), 255–276.
17. Czok, G., 1970. [Tolerance to 5-hydroxymethylfurfural (HMF). 2. Pharmacological properties]. Z. Ernährungswissenschaft 10 (2), 103–110. (In German)
18. Damani, L.A., 1987. Metabolism of sulphur-containing drugs. In: Benford, D.J., Bridges, J.W., Gibson, G.G. (Eds.). Drug metabolism - from molecules to man. Taylor & Francis, London, New York, Philadelphia, pp. 581–603.
19. De Vries, J.X., Walter-Sack, Voss, A., Forster, W., Ilisisteguipons, P., Stoetzer, F., Sprauls, M., Ackermanns, M., Moyna, G. (1993). Metabolism of benzbromarone in man: structures of new oxidative metabolites, 6-hydroxy- and 1 '-oxo-benzbromarone, and the enantioselective formation and elimination of 1 ‘-hydroxybenzbromarone. Xenobiotica, 23 (12), 1435–1450
20. Dillon, D., Combes, R., Zeiger, E., 1998. The effectiveness of Salmonella strains TA100, TA102 and TA104 for detecting mutagenicity of some aldehydes and peroxides. Mutagenesis 13 (1), 19–26.
21. Doull, J., Plzak, V., Brois, S.J., 1962. A survey of compounds for radiation protection. Armed Services Technical Information Agency, 1-124. Unpublished report submitted by EFFA to FLAVIS Secretariat.
22. Duerksen-Hughes, P.J., Yang, J., Ozcan, O., 1999. p53 induction as a genotoxic test for twenty-five chemicals undergoing in vivo carcinogenicity testing. Environ. Health Perspect. 107 (10), 805–812.
23. Durward, R., 2007a. Furyl methyl ketone: unscheduled DNA synthesis (UDS) assay liver in vitro. Safepharm Laboratories Ltd. Project no. 1834/0005. Unpublished report submitted by EFFA to FLAVIS Secretariat.
24. Durward, R., 2007b. Furyl methyl ketone: in vivo liver unscheduled DNA synthesis (UDS) assay. Safepharm Laboratories Ltd. Project no. 1834/0004. Unpublished report submitted by EFFA to FLAVIS Secretariat.
25. Dutton, G.J., Illing, H.P.A. 1972. Mechanism of biosynthesis of thio-beta-D-glucuronides. Biochem. J., 129, 539–550.
26. EC, 1996. Regulation No 2232/96 of the European Parliament and of the Council of 28 October 1996. Official Journal of the European Communities 23.11.1996, L 299, 1–4.
27. EC, 1999a. Commission Decision 1999/217/EC of 23 February 1999 adopting a register of flavouring substances used in or on foodstuffs. Official Journal of the European Communities 27.3.1999, L 84, 1–137.
28. EC, 2000a. Commission Regulation No 1565/2000 of 18 July 2000 laying down the measures necessary for the adoption of an evaluation programme in application of Regulation (EC) No 2232/96. Official Journal of the European Communities 19.7.2000, L 180, 8–16.
29. EC, 2002b. Commission Regulation No 622/2002 of 11 April 2002 establishing deadlines for the submission of information for the evaluation of chemically defined flavouring substances used in or on foodstuffs. Official Journal of the European Communities 12.4.2002, L 95, 10–11.
30. EC, 2009a. Commission Decision 2009/163/EC of 26 February 2009 amending Decision 1999/217/EC as regards the register of flavouring substances used in or on foodstuffs. Official Journal of the European Union 27.2.2009, L 27.2.2009,, 41.
31. Eder, E., Scheckenbach, S., Deininger, C., Hoffman, C., 1993. The possible role of alpha, beta-unsaturated carbonyl compounds in mutagenesis and carcinogenesis. Toxicol. Lett. 67, 87–103.
32. Edwards, A., 1999. Draft report. An in vivo unscheduled DNA synthesis assay in the mouse with furfural. Report no. 3389/1/1/99. BIBRA International, Carshalton.
33. EFFA, 2002i. Letter from EFFA to Dr. Joern Gry, Danish Veterinary and Food Administration. Dated 31 October 2002. Re.: Second group of questions. FLAVIS/8.26.
34. EFFA, 2003g. Submission 2003–3. Flavoring group evaluation of 19 flavoring substances (candidate chemicals) of the chemical group 14 (Annex I of 1565/2000/EC) structurally related to furfuryl alcohol and related substances [JECFA/WHO FAS 46/55] and sulfursubstituted furan derivates [JECFA/WHO FAS 50/59] used as flavoring substances. 31 January, 2003. Unpublished report submitted by EFFA to FLAVIS Secretariat. FLAVIS/8.21.
35. EFFA, 2004e. Intake - Collection and collation of usage data for flavouring substances. Letter from Dan Dils, EFFA to Torben Hallas-M⊘ller, EFSA. May 31, 2004.
36. EFFA, 2004y. Submission 2003–3 Addendum. Supplement of eight flavouring substances (candidate chemicals) to the flavouring group evaluation of chemical group 14 (Annex I of 1565/2000/EC) structurally related to furfuryl alcohol and related substances [JECFA/WHO FAS 46/55] and sulfursubstituted furan derivatives [JECFA/WHO FAS 50/59] used as flavouring substances 3 June 2004. Unpublished report submitted by EFFA to FLAVIS Secretariat. FLAVIS/8.68.
37. EFFA, 2007a. E-mail from Jan Demyttenaere, EFFA to Flavis Secretariat, National Foodinstitute, Technical University of Denmark. Dated 8 February 2007. RE: FLAVIS submissions - use levels for Category 14.2 - Alcoholic beverages FLAVIS/8.70.
38. th Plenary meeting of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food, Held in Brussels on 12–13 July 2004. Brussels, 28 September 2004. [Online]. Available: www.efsa.europa.eu/cs/BlobServer/Event_Meeting/afc_minutes_07_en1.pdf?ssbinary=yrue
39. EFSA, 2004c. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to furfural and furfural diethylacetal. Question number EFSA-Q-2003-236. Adopted by written procedure on 2 June 2004. The EFSA Journal 67, 1–27.
40. th meeting). Adopted on 26 November 2009. EFSA-Q-2008-032Q.
41. th meeting). Adopted on 26 November 2009. EFSA-Q-2008-032S.
42. th meeting). Adopted 9 July 2008. EFSA-Q-2008-032R
43. EFSA, 2009z. Opinion of the Scientific Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids on a request from the Commission related to Flavouring Group Evaluation 08, Revision 1, (FGE.08Rev1): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical group 20 (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Adopted on 26 March 2009. EFSA-Q-2009-00479.
44. Esterbauer, H., Zollner, H., Scholz, N., 1975. Reaction of glutathione with conjugated carbonyls. Z. Naturforsch. 30c, 466–473.
45. Esterbauer, H., Ertl, A., Scholz, N., 1976. The reaction of cysteine with alpha, beta-unsaturated aldehydes. Tetrahedron 32, 285–289.
46. EU-RAR (European Union Risk Assessment Report), 2004b. EU-RAR on furfural (CAS no: 98–01-1; EINECS no: 202–627-7). Draft human health section. October, 2004. European Chemicals Bureau, Institute for Health and Consumer Protection, Ispra, Italy.
47. Eurostat, 1998. Total population. Cited in Eurostat, 2004. The EU population, Total population. [Online]. Available: epp.eurostat.ec.europa.eu/portal/page?_pageid=1090,30070682,1090_33076576&_dad=dortal&_schema=aORTAL, Population and social conditions, Population, Demography, Main demographic indicators, Total population. December 2008.
48. Feron, V.J., 1972. Respiratory tract tumors in hamsters after intratracheal instillations of benzo[a]pyrene alone and with furfural. Cancer Res. 32, 28–36.
49. Flavour Industry, 2009b. Unpublished information submitted by Flavour Industry to FLAVIS Secretariat. A-13Rev1 [FL-no: 13.199]
50. Flek, J., Sedivec, V., 1978. The absorption, metabolism and excretion of furfural in man. Int. Arch. Occup. Environ. Health 41, 159–168.
51. Florin, I., Rutberg, L., Curvall, M., Enzell, C.R., 1980. Screening of tobacco smoke constituents for mutagenicity using the Ames' test. Toxicology. 18, 219–232.
52. Fogleman, R.W., Suppers, L., 1973a. Acute oral toxicity in mice with 15129 (2,5-dimethyl-3-thiofuroylfuran). Affiliated Medical Research, Inc. Contract no. 121–2079-93. October 23, 1973. Unpublished report submitted by EFFA to FLAVIS Secretariat.
53. Fogleman, R.W., Suppers, L., 1973b. Acute oral toxicity in mice with 15124 (2,5-dimethyl-3-thiosovalerate). Affiliated Medical Research, Inc. Contract no. 121–2079-93. October 23, 1973. Unpublished report submitted by EFFA to FLAVIS Secretariat.
54. Fogleman, R.W., Suppers, L., 1974a. Acute oral toxicity in mice with 15124 (2,5-dimethyl-3-thioisovalerate). Affiliated Medical Research, Inc. Contract no. 121–2079-93. February 11, 1974. Unpublished report submitted by EFFA to FLAVIS Secretariat.
55. Fogleman, R.W., Suppers, L., 1974b. Acute oral toxicity in mice with 15129 (2,5-dimethyl-3-thiofuroylfuran). Affiliated Medical Research, Inc. Contract no. 121–2079-93. February 11, 1974. Unpublished report submitted by EFFA to FLAVIS Secretariat.
56. Friedmann, E., 1911. Verhalten der furfuracrylsäure und der furoylessigsäure im tierkörper. Biochem. Z. 35, 40–48. (In German)
57. Gallo, M.A., Cox, G.E., Babish, J.G., 1976b. 90-Day feeding study in rats with compound 75–15963 (3-[(2-methyl-3-furyl)-thio]-4-heptanone). Food and Drug Research Laboratories, Inc. Lab. no. 2689d. Decembero 30, 1976. Unpublished report submitted by EFFA to FLAVIS Secretariat.
58. Gammal, L.M., Wiley, R.A., Traiger, G., Haschek, W.M., Baraban, S., 1984. Toxicity-distribution relationships among 3-alkylfurans in the mouse lung. Toxicology 30, 177–184.
59. Germond, J.-E., Philippossian, G., Richli, U., Bracco, I., Arnaud, M.J., 1987. Rapid and complete urinary elimination of [14C]-5-hydroxymethyl-2-furaldehyde administered orally or intravenously to rats. J. Toxicol. Environ. Health 22, 79–89.
60. Gill, M.W., Van Miller, J.P., 1987b. Fourteen-day dietary minimum toxicity screen (MTS) in albino rats. 3-acetyl-2, 5-dimethylthiophene, carvacryl ethyl ether, 2,2'-(thiodimethylene) difuran, 5-methyl-5-hexen-2-one, 5-methyl-2-thiophene carboxaldehyde. Bushy Run Research Center. Project report 50-527. August 31, 1987. Unpublished data submitted by EFFA to FLAVIS Secretariat.
61. Godfrey, V.B., Chen, L.-J., Griffin, R.J., Lebetkin, E.H., Burka, L.T., 1999. Distribution and metabolism of (5-hydroxymethyl)furfural in male F344 rats and B6C3F1 mice after oral administration. J. Toxicol. Environ. Health, Part A 57, 199–210.
62. Gomez-Arroyo, S., Souza, V.S., 1985. In vitro and occupational induction of sister-chromatid exchanges in human lymphocytes with furfuryl alcohol and furfural. Mutat. Res. 156, 233–238.
63. Great Lakes Chemical Corp., 1998. Initial submission: Letter from Lakes Chemical Corp. to USEPA reporting results of acute oral toxicity study in rats with methyl-2-furoate, dated 2/5/1998. Methyl-2-furoate. Wil Research Laboratories, Inc. EPA Doc 88980000095, microfiche no. OTS0559247. February 5, 1998. Unpublished data submitted by EFFA to FLAVIS Secretariat.
64. Greenzaid, P., Jencks, W.P., 1971. Pig liver esterase. Reactions with alcohols, structure-reactivity correlations, and the acyl-enzyme intermediate. Biochem. 10 (7), 1210–1222.
65. Gregus, Z., Fekete, T., Varga, F., Klaassen, C.D., 1993. Dependence of glycine conjugation on availability of glycine: role of the glycine cleavage system. Xenobiotica 23, 141–153.
66. Griffiths, J., Babish, J.G., 1977a. Acute oral toxicity (LD50) of ethyl furfuryl alpha-thiopropionate in mice. Ethyl furfuryl alpha-thiopropionate. Food and Drug Research Laboratories, Inc. Lab. no. 5663a. Octobero 10, 1977. Unpublished report submitted by EFFA to FLAVIS Secretariat.
67. Grundschober, F., 1977. Toxicological assessment of flavouring esters. Toxicology 8, 387–390.
68. Gudi, R., Schadly, E.H., 1996. In vitro mammalian cytogenetic test with an independent repeat assay of furfural, final report, with cover letter dated 11/22/1996 (sanitized). Furfural. Microbiological Associates, Inc. EPA Doc 88970000074S, microfiche no. OTS0559061. November 19, 1996. Unpublished report submitted by EFFA to FLAVIS Secretariat.
69. Hall, I.H., Wong, O.T., Reynolds, D.J., Chang, J.J., 1993. The hypolipidemic effects of 2-furoic acid in Sprague-Dawley rats. Arch. Pharm. (Weinheim) 326 (1), 15–23.
70. Hammond, A.H., Fry, J.R., 1991. The use of hepatocytes cultured from inducer-treated rats in the detection of cytochrome p-450-mediated cytotoxicity. Toxicol. In Vitro 5 (2), 133–137.
71. Hawksworth, G., Scheline, R.R., 1975. Metabolism in the rat of some pyrazine derivatives having flavour importance in foods. Xenobiotica 5 (7), 389–399.
72. Heymann, E., 1980. Carboxylesterases and amidases. In: Jakoby, W.B. (ed.). Enzymatic basis of detoxication. 2nd Ed. Academic Press, New York, pp. 291–323.
73. Hoodi, A.A., Damani, L.A., 1984. Cytochrome P-450 and non-P-450 sulphoxidations. Indian J. Pharm. Pharmacol. 36, 62P.
74. Ichikawa, M., Yamamoto, K., Tanaka, A., Swaminathan, S., Hatcher, J.F., Erturk, E., Bryan, G.T., 1986b. Mutagenicity of 3,4-diphenyl-5-nitrofuran analogs in Salmonella typhimurium. Carcinogenesis 7 (8), 1339–1344.
75. IOFI, 1995. European inquiry on volume of use. IOFI, International Organization of the Flavor Industry, 1995.
76. Jansson, T., Curvall, M., Hedin, A., Enzell, C., 1986. In vitro studies of biological effects of cigarette smoke condensate. II. Induction of sister-chromatid in human lymphocytes by weakly acidic, semivolatile constituents. Mutat. Res. 169, 129–139.
77. Janzowski, C., Glaab, V., Samimi, E., Schlatter, J., Eisenbrand, G., 2000. 5-Hydroxymethylfurfural: assessment of mutagenicity, DNA-damaging potential and reactivity towards cellular glutathione. Food Chem. Toxicol. 38 (9), 801–809.
78. JECFA, 1995. Evaluation of certain food additives and contaminants. Forty-fourth Meeting of the Joint FAO/WHO Expert Committee on Food Additives. 14–23 February 1995. WHO Technical Report Series, no. 859. Geneva.
79. JECFA, 1996a. Toxicological evaluation of certain food additives. The forty-fourth meeting of the Joint FAO/WHO Expert Committee on Food Additives and contaminants. WHO Food Additives Series: 35. IPCS, WHO, Geneva.
80. JECFA, 1997a. Evaluation of certain food additives and contaminants. Forty-sixth report of the Joint FAO/WHO Expert Committee on Food Additives. Geneva, 6–15 February 1996. WHO Technical Report Series, no. 868. Geneva.
81. JECFA, 1999b. Evaluation of certain food additives and contaminants. Forty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives. Rome, 17–26 June 1997. WHO Technical Report Series, no. 884. Geneva.
82. JECFA, 2000d. Compendium of food additive specifications. Addendum 8. Joint FAO/WHO Expert Committee of Food Additives. 55th meeting. Geneva, 6–15 June 2000. FAO Food and Nutrition paper 52 Add. 8.
83. JECFA, 2001a. Evaluation of certain food addtives and contaminants. Fifty-fifth report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, no. 901. Geneva, 6–15 June 2000.
84. JECFA, 2001b. Safety evaluation of certain food additives and contaminants. Fifty-fifth meeting of the Joint FAO/WHO Expert Committee on Food Additives, WHO Food Additives Series: 46. IPCS, WHO, Geneva.
85. th session. Rome, 5–14 June 2001. FAO Food and Nutrition paper 52 Add. 9.
86. JECFA, 2002c. Evaluation of certain food additives. Fifty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, no. 913. Geneva, 4–13 June 2002.
87. th session. Geneva, 4–13 June 2002. FAO Food and Nutrition paper 52 Add. 10.
88. JECFA, 2003a. Safety evaluation of certain food additives. Fifty-ninth meeting of the Joint FAO/WHO Expert Committee on Food Additives, WHO Food Additives Series: 50. IPCS, WHO, Geneva.
89. JECFA, 2006b. Evaluation of certain food additives. Sixty-fifth report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, no. 934. Geneva, 7–16 June 2005.
90. JECFA, 2009a. Safety evaluation of certain food additives and contaminants. Sixty-ninth meeting of the Joint FAO/WHO Expert Committee on Food Additives, WHO Food Additives Series: 60. IPCS, WHO, Geneva 2009 whqlibdoc.who.int/publications/2009/9789241660600_eng.pdf (May 2009)
91. JECFA, 2009c. Evaluation of certain food additives. Sixty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, no. 952. Rome, 17–26 June 2008. whqlibdoc.who.int/trs/WHO_TRS_952_eng.pdf (May 2009)
92. Jellum, E., Borresen, H.C., Eldjarn, L., 1973. The presence of furen derivates in patients receiving fructose-containing solutions intravenously. Clin. Chim. Acta 47, 191–201.
93. Jodynis-Liebert, J., 1985. Badania metaboliszmu 5-methylfurfuralu u szczura. Cz. I. Isolacja i identyfikacja 5-methylofuroiloglicyny. Bromatologiai Chemia Toksykologiczna XVIII, 219–223. (In Polish)
94. Jodynis-Liebert, J., 1988. Metabolism of 5-methyl-2-furaldehyde in rat. III. Identification and determination of 5-methyl-2-furylmethylketone. Xenobiotica 18 (8), 887–892.
95. Jonker, D., 2000b. Sub-chronic (13-week) oral toxicity study in rats with micro-encapsulated furfural. Report V99.520. May, 1999. TNO, Zeist, The Netherlands.
96. Kerckaert, G.A., Isfort, R.J., Carr, G.J., Aardema, M.J., LeBoeuf, R.A., 1996. A comprehensive protocol for conducting the Syrian hamster embryo cell transformation assay at pH 6.70. Mutat. Res. 356, 64–84.
97. Kim, S.B., Hayase, F., Kato, H., 1987b. Desmutagenic effect of alpha-dicarbonyl and alpha-hydroxycarbonyl compounds against mutagenic heterocyclic amines. Mutat. Res. 177, 9–15.
98. Kitamura, S., Koga, H., Tatsumi, K., Yoshimura, H., Horiuchi, T., 1978. Relationship between biological activities and enzymatic reduction of nitrofuran derivatives. J. Pharm. Dyn. 1, 15–21.
99. Koenig, K., Andreesen, J.R., 1990. Xanthine dehydrogenase and 2-furoyl-coenzyme A dehydrogenase from Pseudomonas putida Fu1; two molybenum-containing dehydrogenases of novel structural composition. J. Bacteriol. 172, 5999–6009.
100. Kowalski, L.A., Assi, K.P., Wee, R.K.-H., Madden, Z., 2001. In vitro prediction of carcinogenicity using a bovine papillomavirus DNA-carrying C3H/10T1/2 cell line (T1). II: Results from the testing of 100 chemicals. Environ. Mol. Mutag. 37 (3), 231–240.
101. Kurooka, S., Hashimoto, M., Tomita, M., Maki, A., Yoshimura, Y., 1976. Relationship between the structures of S-acyl thiol compounds and their rates of hydrolysis by pancreatic lipase and hepatic carboxylic esterase. J. Biochem. 79, 533–541.
102. Lam, L., Zheng, B., 1992. Inhibitory effects of 2-n-heptylfuran and 2-n-butylthiophene on benzo[a]pyrene-induced lung and forestomach tumorigenesis in A/J mice. Nutr. Cancer 17 (1), 19–26.
103. Lang, K., Kieckebusch, W., Bässler, K.H., Griem, W., Czok, G., 1970. [Tolerance of 5-hydroxymethylfurfural (HMF). 1. Chronic administration of HMF and metabolites of the substance]. Z. Ernährungswissenschaft 10 (2), 97–101. (In German)
104. Lee, H., Bian, S.S., Chen, Y.L., 1994. Genotoxicity of 1,3-dithiane and 1,4-dithiane in the CHO/SCE assay and the Salmonella/microsomal test. Mutat. Res. 321, 213–218.
105. Lee, Y.C., Shlyankevich, M., Jeong, H.K., Douglas, J.S., Surh, Y.J., 1995b. Bioactivation of 5-hydroxylmethyl-2-furaldehyde to an electrophilic and mutagenic allylic sulfuric acid ester. Biochem. Biophys. Res. Commun. 209 (3), 996–1002.
106. Loquet, C., Toussaint, G., LeTalaer, J.Y., 1981. Studies on the mutagenic constituents of apple brandy and various alcoholic beverages collected in western France, a high incidence area for oesophageal cancer. Mutat. Res. 88, 155–164.
107. Maiorino, R.M., Bruce, D.C., Aposhian, H.V., 1989. Determination and metabolism of dithiol chelating agents VI. Isolation and identification of the mixed disulfides of meso-2, 3-dimercaptosuccinic acid with L-cysteine in human urine. Toxicol. Appl. Pharmacol. 97, 338–349.
108. Majeska, J.B., McGregor, D.B., 1992. Effects of plate preparation on results in microbial mutation assays. Environ. Molec. Mutagen. 19 (3), 244–252.
109. Marnett, L.J., Hurd, H.K., Hollstein, M.C., Levin, D.E., Esterbauer, H., Ames, B.N., 1985a. Naturally-occurring carbonyl compounds are mutagens in Salmonella tester strain TA104. Mutat. Res. 148, 25–34.
110. Matsui, S., Yamamoto, R., Yamada, H., 1989. The Bacillus Subtilis/Microsome rec-assay for the detection of DNA damaging substances which may occur in chlorinated and ozonated waters. Water Sci. Technol. 21, 875–887.
111. McBain, J.B., Menn, J.J., 1969. S-methylation, oxidation, hydroxylation, and conjugation of thiophenol in the rat. Biochem. Pharmacol. 18 (9), 2282–2285.
112. McGregor, D.B., McConville, M.L., Prentice, R.D.M., Riach, C.G., 1981. Mutagenic activity of 123 compounds with known carcinogenic potential. Presented at 7th International Symposium on Chemical & Toxicological Aspects of Environmental Quality. September 7–10, London. Inveresk Research International Limited, Musselburgh.
113. McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., Caspary, W.J., 1988b. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay II: 18 coded chemicals. Environ. Mol. Mutag. 11, 91–118.
114. McMahon, R.E., Cline, J.C., Thompson, C.Z., 1979. Assay of 855 test chemicals in ten tester strains using a new modification of the ames test for bacterial mutagens. Cancer Res. 39, 682–693.
115. McMurtry, R.J., Mitchell, J.R., 1977. Renal and hepatic necrosis after metabolic activation of 2-substituted furans and thiophenes, including furosemide and cephaloridine. Toxicol. Appl. Pharmacol. 42, 285–300.
116. Moran, E.J., Easterday, D.D., Oser, B.L., 1980. Acute oral toxicity of selected flavor chemicals. Drug Chem. Toxicol. 3 (3), 249–258.
117. Moreno, O.M., 1978g. Acute oral toxicity of 5-methyl furfural in rats. MB Research Laboratories. Project no. MB 77-2207. February 9, 1978. Unpublished report submitted by EFFA to FLAVIS Secretariat.
118. Morgareidge, K., Oser, B.L., 1970e. 90-Day feeding studies in rats with bis-(2-methyl-3-furyl)-disulfide (31001). Food and Drug Research Laboratories, Inc. Lab. no. 0028. August 24, 1970. Report submitted by EFFA to FLAVIS Secretariat.
119. Morgareidge, K., Oser, B.L., 1970f. 90-Day feeding studies in rats with bis-(2-methyl-3-furyl)-tetrasulfide (31058). Food and Drug Research Laboratories, Inc. Lab. no. 0031. August 24, 1970. Report submitted by EFFA to FLAVIS Secretariat.
120. Morgareidge, K., Cox, G.E., Bailey, D.E., 1974a. 90-Day feeding study in rats with compound 15124 (2,5-dimethyl-3-thioisovalerylfuran). Food and Drug Research Laboratories, Inc. Lab. no. 2107g. Decembero 30, 1974. Report submitted by EFFA to FLAVIS Secretariat.
121. Morgareidge, K., Cox, G.E., Bailey, D.E., 1974b. 90-Day feeding study in rats with 2,5-dimethyl-3-thiofuroylfuran. Food and Drug Research Laboratories, Inc. Lab. no. 2107h. Decembero 30, 1974. Report submitted by EFFA to FLAVIS Secretariat.
122. Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., Zeiger, E., 1986. Salmonella mutagenicity tests II. Results from the testing of 270 chemicals. Environ. Mol. Mutag. 8 (Suppl. 7), 1–119.
123. Munday, R., Gellatly, J.B., 1972. Biological evaluation of dusmelline and DUS-5. Part 1. Palatability study in rats. Unilever Research Colworth/ Welwyn. NCW 1387. Project CW 22390. July 11, 1972. Report submitted by EFFA to FLAVIS Secretariat.
124. Munday, R., Gellatly, J.B., 1973a. Biological evaluation of feeding trial with DUS-5. Part 4. 13-week rat. Unilever Research Colworth/ Welwyn. NCW 73 1159. Project CW 22390. July 11, 1972. Report submitted by EFFA to FLAVIS Secretariat.
125. Munday, R., Gellatly, J.B., 1973b. Biological evaluation of DUS-5. Part 5. Reversibility of toxic effects induced by the feeding of DUS-5. Unilever Research Colworth/ Welwyn. NCW 73 1299. Project CW 22390. July 7, 1973. Report submitted by EFFA to SCF.
126. Munday, R., Gellatly, J.B., 1974. Biological evaluation of DUS-5. Part 7. 1-year test with DUS-5 in rats. Private communication to FEMA. Unilever Research Colworth/ Welwyn. NCW 74 1104. Project CW 22390. February 7, 1974. Report submitted by EFFA to FLAVIS Secretariat.
127. Muñoz, E.R., Barnett, M.B., 1999. Meiotic nondisjunction induced by furfural in Drosophila melanogaster females. Environ. Molec. Mutagen. 34 (1), 61–63.
128. Münchberg, U., Anwar, A., Mecklenburg, S., Jacob, C., 2007. Polysulfides as biologically active ingredients of garlic. Org. Biomol. Chem. 5, 1505–1518.
129. Nakamura, S.I., Oda, Y., Shimada, T., Oki, I., Sugimoto, K., 1987. SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: examination with 151 chemicals. Mutat. Res. 192, 239–246.
130. Nemec, M.D., 1997a. Support: A dose range-finding developmental toxicity study of furfural in rats with cover letter dated 08/12/97 (Sanitized). Wil Research Laboratories, Inc. EPA Doc 89970000266S, microfiche no. OTS0573751. August 12, 1997. Unpublished report submitted by EFFA to FLAVIS Secretariat.
131. Nemec, M.D., 1997b. Initial submission: A developmental toxicity study of furfural in rats with cover letter dated 09/18/97 (sanitized). Wil Research Laboratories, Inc. EPA Doc 88970000276S, microfiche no. OTS0573760. September 18, 1997. Unpublished report submitted by EFFA to FLAVIS Secretariat.
132. Nickson, R.M., Mitchell, S.C., 1994. Fate of dipropyl sulphide and dipropyl sulphoxide in rat. Xenobiotica 24 (2), 157–168.
133. Nickson, R.M., Mitchell, S.C., Zhang, A.Q., 1995. Fate of dipropyl sulfone in rat. Xenobiotica 25 (12), 1391–1398.
134. Nishi, Y., Miyakawa, Y., Kato, K., 1989. Chromosome aberrations induced by pyrolysates of carbohydrates in Chinese hamster V79 cells. Mutat. Res. 227, 117–123.
135. Nnane, P., Damani, L.A., 1995. The involvement of rat liver CYP2B1 and CYP2D1 in the microsomal sulphoxidation of 4-chlorophenyl methyl sulphide. ISSX Proceedings 8, 110.
136. Nomeir, A.A., Silvena, D.M., McComish, M.F., Chadwick, M., 1992. Comparative metabolism and disposition of furfural and furfuryl alcohol in rats. Drug Metab. Disposition 20 (2), 198–204.
137. NTP, 1990a. NTP technical report on the toxicology and carcinogenesis studies of furfural (CAS no. 98–01-1) in F344/N rats and B6C3F1 mice (gavage studies). March 1990. NTP-TR 382. NIH Publication no. 90-2837.
138. NTP, 1999a. Toxicology and carcinogenesis studies of furfuryl alcohol (CAS no. 98–00-0) in F344/N rats and B6C3F1 mice (inhalation studies). February 1999. NTP-TR 482. NIH Publication no. 99-3972. NC.
139. Nutley, B.P., Farmer, P., Caldwell, J., 1994. Metabolism of trans-cinnamic acid in the rat and the mouse and its variation with dose. Food Chem. Toxicol. 32 (10), 877–886.
140. Ochi, T., Ohsawa, M., 1985. Participation of active oxygen species in the induction of chromosomal aberrations by cadmium chloride in cultured Chinese hamster cells. Mutat. Res. 143, 137–142.
141. Omura, H., Jahan, N., Shinohara, K., Murakami, H., 1983. Formation of mutagens by the maillard reaction. In: Waller, G.R., Feather, M.S. (Eds.). The Maillard Reaction in Foods and Nutrition. ACS Symposium Series, 215. American Chemical Society, Washington D.C., pp. 537–563.
142. Osawa, T., Namiki, M., 1982. Mutagen formation in the reaction of nitrite with the food components analogous to sorbic acid. Agric. Biol. Chem. 45, 2299–2304.
143. Oser, B.L., 1969a. Approximate acute oral LD50 in mice. 2-Methyl-3-furanthiol. Food and Drug Research Laboratories, Inc. Lab. no. 906. August 4, 1969. Unpublished report submitted by EFFA to FLAVIS Secretariat.
144. Oser, B.L., 1969b. The acute oral toxicity (LD50) to mice of bis-(2-methyl-3-furyl) disulfide. Food and Drug Research Laboratories, Inc. Lab. no. 90606a. Augusto 4, 1969. Unpublished report submitted by EFFA to FLAVIS Secretariat.
145. Oser, B.L., 1970a. 90-Day feeding studies with bis-(2-methyl-3-furyl) disulfide in rats. Food and Drug Research Laboratories, Inc. Lab. no. 90616. January 22, 1970. Unpublished report submitted by EFFA to FLAVIS Secretariat.
146. Oser, B.L., 1970b. 90-Day feeding studies with 2-methyl-3-furanthiol in rats. Food and Drug Research Laboratories, Inc. Lab. no. 90615. January 22, 1970. Unpublished report submitted by EFFA to FLAVIS Secretariat.
147. Oser, B.L., 1970c. The acute oral toxicity to mice of ten compounds. Food and Drug Research Laboratories, Inc. Lab. no. 91115-91124. April 13, 1970. Unpublished report submitted by EFFA to FLAVIS Secretariat.
148. Parkash, M.K., Caldwell, J., 1994. Metabolism and excretion of [14C]-furfural in the rat and the mouse. Food Chem. Toxicol. 32 (10), 887–895.
149. Paul, H.E., Austin, F.L., Paul, M.F., Ells, U.R., 1949. Metabolism of the nitrofurans. I. Ultraviolet absorption studies of urinary end-products after oral administration. J. Biol. Chem. 180, 345–363.
150. Pettersen, J.E., Jellum, E., 1972. The identification and metabolic origin of 2-furoylglycine and 2,5-furandicarboxylic acid in human urine. Clin. Chim. Acta 41, 199–207.
151. Phatak, N.M., Emerson, G.A., 1936. Toxicity and local anesthetic activity of alkyl esters of 2-furoic acid. J. Pharmacol. Exp. Ther. 58, 405–407.
152. Phillips, J.C., Gaunt, I.F., Hardy, J., Kiss, I.S., Gangolli, S.D., Butterworth, K.R., 1977. Short-term toxicity of furfuryl mercaptan in rats. Food Cosmet. Toxicol. 15, 383–387.
153. Phillips, B.J., Jackson, L.I., Tate, B., Price, R.J., Adams, T.B., Ford, R.A., Goodinan, J.I., Lake, B.J., 1997. Furfural does not induce unscheduled DNA synthesis (UDS) in the in vivo rat hepatocyte DNA repair assay. Presented 1997 Society of Toxicol. Annu. Meeting, Cincinnati Ohio.
154. Posternak, N.M., Linder, A., Vodoz, C.A., 1969. Summaries of toxicological data. Toxicological tests on flavouring matters. Food Cosmet. Toxicol. 7, 405–407.
155. Posternak, J.M., Dufour, J.J., Rogg, C., Vodoz, C.A., 1975. Summaries of toxicological data. Toxicological tests on flavouring matters. II. Pyrazines and other compounds. Food Cosmet. Toxicol. 13, 487–490.
156. Ravindranath, V., Boyd, M.R., 1985. Metabolic activation of 2-methylfuran by rat microsomal systems. Toxicol. Appl. Pharmacol. 78, 370–376.
157. Ravindranath, V., Boyd, M.R., 1991. Effect of modulators of glutathione synthesis on the hepatotoxicity of 2-methylfuran. Biochem. Pharmacol. 41 (9), 1311–1318.
158. Ravindranath, V., Burka, L.T., Boyd, M.R., 1984. Isolation and characterization of the reactive metabolites of 2-methylfuran (2-MF) and 3-methylfuran (3-MF). Pharmacologist 25, 171.
159. Ravindranath, V., Burka, L.T., Boyd, M.R., 1984. Reactive metabolites from the bioactivation of toxic methylfurans. Science 224, 884–886.
160. Ravindranath, V., McMenamin, M.G., Dees, J.H., Boyd, M.R., 1986. 2-Methylfuran toxicity in rats - role of metabolic activarion in vivo. Toxicol. Appl. Pharmacol. 85, 78–91.
161. Renwick, A.G., 1989. Sulphoxides and sulphones. In: Damani, L.A. (ed.). Sulphur-containing drugs and related organic compounds. Chemistry, Biochemistry and Toxicology. vol. 1B. Metabolism of sulphur-functional groups. Ellis Horwood Limited. John Wiley & Sons, New York, pp. 133–154.
162. Richardson, K.A., Edward, V.T., Jones, B.C., Hutson, D.H., 1991. Metabolism in the rat of a model xenobiotic plant metabolite S-benzyl-N-malonyl-L-cysteine. Xenobiotica 21 (3), 371–382.
163. Rodriquez-Arnaiz, R., Morales, P.R., Moctezuma, R.V., Salas, R.M.B., 1989. Evidence for the absence of mutagenic activity of furfuryl alcohol in tests of germ cells in Drosophila melanogaster. Mutat. Res. 223, 309–311.
164. Rodriquez-Arnaiz, R., Morales, P.R., Zimmering, S., 1992. Evaluation in Drosophila melanogaster of the mutagenic potential of futtural in the mei-9(a) test for chromosome loss in germ-line cells. Mutat. Res. 280, 75–80.
165. Rush, R.E., 1991. 14-Day dietary toxicity study in rats with 2-methyl-3-tetrahydrofuranthiol (1030). Springborn Laboratories, Inc. Study no. 3141.4. May 7, 1991. Unpublished report submitted by EFFA to FLAVIS Secretariat.
166. Salzer, U., 1991. In vitro hydrolysis-test. 2-Methyl-3-tetrahydrofuranthiol. Unpublished report submitted by EFFA to FLAVIS Secretariat.
167. SCF, 1995. Scientific Committee for Food. First annual report on chemically defined flavouring substances. May 1995, 2nd draft prepared by the SCF Working Group on Flavouring Substances (Submitted by the SCF Secretariat, 17 May 1995). CS/FLAV/FL/140-Rev2. Annex 6 to Document III/5611/95, European Commission, Directorate-General III, Industry.
168. SCF, 1999. Opinion on a programme for the evaluation of flavouring substances (expressed on 2 December 1999). Scientific Committee on Food. SCF/CS/FLAV/TASK/11 Final 6/12/1999. Annex I the minutes of the 119th Plenary meeting. European Commission, Health & Consumer Protection Directorate-General.
169. Shane, B.S., Troxclair, A.M., McMillin, D.J., Henry, C.B., 1988. Comparative mutagenicity of nine brands of coffee to Salmonella typhimurium TA100, TA102, and TA104. Environ. Mol. Mutag. 11, 195–206
170. Shellenberger, T.E., 1971e. Subacute toxicity evaluation of 2-pentyl furan with rats. Gulf South Research Institute. GSRI Project NC-403. January 4, 1971. Unpublished report submittec by EFFA to FLAVIS Secretariat.
171. Shimizu, A., Kanisawa, M., 1986. Experimental studies on hepatic cirrhosis and hepatocarcinogenesis. I. Production of hepatic cirrhosis by furfural administration. Acta Pathol. Jap. 36 (7), 1027–1038.
172. Shimizu, A., Yoshiyasu, N., Harada, M., Ono, T., Sato, K., Inoue, T., Kanisawa, M., 1989. Positive foci of glutathione S-transferase placental form in the liver of rats given furfural by oral administration. Jap. J. Cancer Res. 80, 608–611.
173. Shinohara, K., Kim, E., Omura, H., 1986. Furans as the mutagens formed by amino-carbonyl reactions. In: Fujimaki, M., Namiki, M., Kato, H., (Eds.). Amino-Carbonyl Reactions in Food and Biological Systems. Elsevier, New York.
174. Sies, H., Brigelius, R., Graf, P., 1987. Hormones, glutathione status and protein S-thiolation. Adv. Enzyme Regul. 26, 175–189.
175. Simonyan, T.A., 1969. [Toxico-hygienic characteristics of hydroxymethylfurfural]. Vopr. Pitan. 28 (1), 54–58. (In Russian)
176. Soska, J., Koukalova, B., Ebringer, L., 1981. Mutagenic activities of simple nitrofuran derivatives. I. Comparison of related compounds in the phage inductest, chloroplast-bleaching and bacterial repair and mutagenicity tests. Mutat. Res. 81 (1), 21–26.
177. Spalding, J.W., French, J.E., Stasiewicz, S., Furedi-Machacek, M., Conner, F., Tice, R.R., Tennant, R.W., 2000. Responses of transgenic mouse lines p53(+/-) and Tg.AC to agents tested in conventional carcinogenicity bioassays. Toxicol. Sci. 53 (2), 213–223.
178. Stasenkova, K.P., Shchirskaya, V.A., 1967. [Toxicity of butyl 2-furancarboxylate and butyl 5-chloromethyl-2-furancarboxylate]. Vopr. Pitan. 9, 118–126. (In Russian)
179. Stich, H.F., Rosin, M.P., San, R.H.C., Wu, C.H., Powrie, W.D., 1981a. Intake, formation and release of mutagens by man. Banbury Rep. 7, 247–266.
180. Stich, H.F., Rosin, M.P., Wu, C.H., Powrie, W.D., 1981b. Clastogenicity of furans found in food. Cancer Lett. 13, 89–95.
181. Subramanyam, S., Sailaja, D., Rathnaprabha, D., 1989. Genotoxic assay of two dietary furans by some in vivo cytogenetic parameters. Environ. Mol. Mutag. 14 (15), 239.
182. Sujatha, P.S., Subramanyam, S., 1994. Clastogenicity of furfuryl alcohol in a mouse bone marrow system. Med. Sci. Res. 22 (4), 281–284.
183. Sujatha, P.S., Jayanthi, A., Subramanyam, S., 1993. Evaluation of the clastogenic potential of 2-furyl methyl ketone in an in vivo mouse system. Med. Sci. Res. 21 (18), 675–678.
184. Sujatha, P.S., 2007. Genotoxic evaluation of furfuryl alcohol and 2-furyl methyl ketone by sister chromatid exchange (SCE) analysis. J. Health Sci. 53 (1), 124–127.
185. Surh, Y.-J., Tannenbaum, S.R., 1994. Activation of the Maillard reaction product 5-(hydroxymethyl)furfural to strong mutagens via allylic sulfonation and chlorination. Chem. Res. Toxicol. 7, 313–318.
186. Surh, Y.-J., Liem, A., Miller, J.A., Tannenbaum, S.R., 1994. 5-Sulfooxymethylfurfural as a possible ultimate mutagenic and carcinogenic metabolite of the Maillard reaction product, 5-hydroxymethylfurfural. Carcinogenesis 15 (10), 2375–2377.
187. Thornton-Manning, J.R., Nichols, W.K., Manning, B.W., Skiles, G.L., Yost, G.S., 1993. Metabolism and bioactivation of 3-methylindole by Clara cells, alveolar macrophages and subcellular fractions from rabbit lungs. Toxicol. Appl. Pharmacol. 122, 182–190.
188. TNO, 2000. Volatile Compounds in Food - VCF Database. TNO Nutrition and Food Research Institute. Boelens Aroma Chemical Information Service BACIS, Zeist, The Netherlands.
189. TNO, 2009. Volatile Compounds in Food - VCF Database. TNO Nutrition and Food Research Institute. Boelens Aroma Chemical Information Service BACIS, Zeist, The Netherlands.
190. Warf Institute, 1977. Initial Submission: Acute oral LD50 study with hydroxymethylfurfural in rats with cover letter dated 07/31/92. Quaker Oats Co. Warf Institute no. 7061313. Quaker Control no. 60. EPA Doc 88–920005429, microfiche no. OTS0544683. June 10, 1977. Unpublished report submitted by EFFA to FLAVIS Secretariat.
191. Wiley, R.A., Traiger, G.J., Baraban, S., Gammal, L.M., 1984. Toxicity-distribution relationships among 3-alkylfurans in mouse liver and kidney. Toxicol. Appl. Pharmacol. 74, 1–9.
192. Wnorowski, G., 1997d. 14-Day dietary study in rats: Furfuryl thiopentanone - 4.2. Product Safety Labs. Study no. 5212. July 21, 1997. Unpublished report submitted by EFFA to FLAVIS Secretariat.
193. Wood, S.G., John, B.A., Chasseaud, L.F., Bonn, R., Grote, H., Sandrock, K., Darragh, A., Lambe, R.F., 1987. Metabolic fate of the thrombolytic agent benzarone in man: comparison with the rat and dog. Xenobiotica 17 (7), 881–896.
194. Woodruff, R.C., Mason, J.M., Valencia, R., Zimmering, S., 1985. Chemical mutagenesis testing in Drosophila. V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutag. 7, 677–702.
195. Zaitzev, A.N., Simonyan, T.A., Pozdnyakov, A.L., 1975. [Hygienic standardization of oxymethylfurfurol in food products]. Vopr. Pitan. 1, 52–55. (In Russian)
196. Zang, X.M., Chan, C.C., Stamp, D., Minkin, S., Archer, M.C., Bruce, W.R., 1993. Initiation and promotion of colonic aberrant crypt foci in rats by 5-hydroxymethyl-2-furaldehyde in thermolyzed sucrose. Carcinogenesis 14, 773–775.
197. Zdzienicka, M., Tudek, B., Zielenska, M., Szymczyk, T., 1978. Mutagenic activity of furfural in Salmonella typhimurium TA 100. Mutat. Res. 58, 205–209.
198. Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., 1992. Salmonella mutagenicity tests: V. Results from the testing of 311 chemicals. Environ. Mol. Mutag. 19 (21), 2–141.
199. Aaron, C.S., Harbach, P.R., Wiser, S.K., Grzegorczyk, C.R., Smith, A.L., 1989. The in vitro unscheduled DNA synthesis (UDS) assay in rat primary hepatocytes: Evaluation of 2-furoic acid and 7 drug candidates. Mutat. Res. 223 (2), 163–169.