Severe acute respiratory syndrome Coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC

FASEB Journal

Volumn 33, Issue 8, 2019, Pages 8865-8877

  Siu, Kam Leung ^a   Yuen, Kit San ^a   Castano Rodriguez, Carlos ^b   Ye, Zi Wei ^a   Yeung, Man Lung ^a   Fung, Sin Yee ^a   Yuan, Shuofeng ^a   Chan, Chi Ping ^a   Yuen, Kwok Yung ^a   Enjuanes, Luis ^b   Jin, Dong Yan ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

SARS Coronavirus

Indexed keywords

APOPTOSIS-ASSOCIATED SPECK LIKE PROTEIN CONTAINING A CASPASE RECRUITMENT DOMAIN; BETA TUBULIN; CANAKINUMAB; CAVEOLIN; CRISPR ASSOCIATED ENDONUCLEASE CAS9; CRYOPYRIN; DEUBIQUITINASE; GUIDE RNA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; ION CHANNEL; LAMIN A; LAMIN C; MESSENGER RNA; OPEN READING FRAME 3A PROTEIN; PROCASPASE 1; PROTEIN P50; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; UNCLASSIFIED DRUG; VIRAL PROTEIN; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; NLRP3 PROTEIN, HUMAN; ORF3A PROTEIN, SARS CORONAVIRUS; PYCARD PROTEIN, HUMAN; TRAF3 PROTEIN, HUMAN;

A-549 CELL LINE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOPLASM; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEK293 CELL LINE; HUH-7 CELL LINE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROCESSING; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; UBIQUITINATION; VIRUS GENOME; WESTERN BLOTTING; ANIMAL; CHLOROCEBUS AETHIOPS; METABOLISM; VERO CELL LINE;

A549 CELLS; ANIMALS; CARD SIGNALING ADAPTOR PROTEINS; CHLOROCEBUS AETHIOPS; HEK293 CELLS; HUMANS; INFLAMMASOMES; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; SARS VIRUS; TNF RECEPTOR-ASSOCIATED FACTOR 3; UBIQUITINATION; VERO CELLS; VIRAL STRUCTURAL PROTEINS;

EID: 85070788848     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.201802418R     Document Type: Article

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