Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 33, 2006, Pages 12540-12545

  Lu, Wei ^a,b,c   Zheng, Bo Jian ^d   Xu, Ke ^a,b   Schwarz, Wolfgang ^c,e   Du, Lanying ^d   Wong, Charlotte K L ^d   Chen, Jiadong ^c   Duan, Shuming ^c   Deubel, Vincent ^a   Sun, Bing ^a,b  

^a INSTITUTE PASTEUR OF SHANGHAI   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^c Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

^e MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

Author keywords

Channel activity; ORF 3a; Tetramer; Two electrode voltage clamp

Indexed keywords

BARIUM; COMPLEMENTARY DNA; COMPLEMENTARY RNA; CYSTEINE; DISULFIDE; ION CHANNEL; MEMBRANE PROTEIN; MESSENGER RNA; POTASSIUM; RECOMBINANT PROTEIN; SMALL INTERFERING RNA; TETRAMER; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS PROTEIN 3A;

AMINO ACID SEQUENCE; ARTICLE; CELL MEMBRANE; CELL NUCLEUS; CELL STRAIN HEK293; CELL SURFACE; CONTROLLED STUDY; CYTOPLASM; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; OPEN READING FRAME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VIRUS GENOME; VOLTAGE CLAMP; WESTERN BLOTTING; XENOPUS;

ANIMALS; CELL LINE; HUMANS; ION CHANNELS; OOCYTES; OPEN READING FRAMES; PATCH-CLAMP TECHNIQUES; POTASSIUM; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; SARS VIRUS; VIRAL PROTEINS; VIRUS REPLICATION; XENOPUS LAEVIS;

CORONAVIRUS; SARS CORONAVIRUS;

EID: 33747617366     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0605402103     Document Type: Article

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