The SARS coronavirus 3a protein causes endoplasmic reticulum stress and induces ligand-independent downregulation of the Type 1 interferon receptor

PLoS ONE

Volumn 4, Issue 12, 2009, Pages

  Minakshi, Rinki ^a,b   Padhan, Kartika ^a,c   Rani, Manjusha ^a   Khan, Nabab ^a   Ahmad, Faizan ^b   Jameel, Shahid ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^b JAMIA MILLIA ISLAMIA CENTRAL UNIVERSITY   (India)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; ALPHA INTERFERON RECEPTOR; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; INTERFERON RECEPTOR; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN IFNAR1; PROTEIN IRE 1; PROTEIN KINASE R; PROTEIN PERK; SARS CORONAVIRUS 3A PROTEIN; SERINE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INNATE IMMUNITY; LYSOSOME; NONHUMAN; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; RNA TRANSLATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; DOWN-REGULATION; EIF-2 KINASE; ENDOPLASMIC RETICULUM; ENDORIBONUCLEASES; EUKARYOTIC INITIATION FACTOR-2; HUMANS; LIGANDS; LYSOSOMES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTOR, INTERFERON ALPHA-BETA; UBIQUITINATION; UNFOLDED PROTEIN RESPONSE; VIRAL PROTEINS;

EUKARYOTA; SARS CORONAVIRUS;

EID: 77949519531     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0008342     Document Type: Article

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