Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3

Emerging Microbes and Infections

Volumn 5, Issue 1, 2016, Pages 1-9

  Lui, Pak Yin ^a,b   Wong, Lok Yin Roy ^a,b   Fung, Cheuk Lai ^a   Siu, Kam Leung ^a   Yeung, Man Lung ^a   Yuen, Kit San ^a   Chan, Chi Ping ^a   Woo, Patrick Chiu Yat ^a   Yuen, Kwok Yung ^a   Jin, Dong Yan ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b The University of Hong Kong ^*

Author keywords

innate antiviral response; IRF3 activation; MERS coronavirus; RIG I like receptors; type I interferons

Indexed keywords

INTERFERON; INTERFERON REGULATORY FACTOR 3; M PROTEIN, CORONAVIRUS; MATRIX PROTEIN; PHOSPHOTRANSFERASE; PROTEIN SERINE THREONINE KINASE; RETINOIC ACID INDUCIBLE PROTEIN I; TBK1 PROTEIN, HUMAN; TRAF3 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3;

ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CASE REPORT; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNE EVASION; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; PATHOGENICITY; PHOSPHORYLATION; PHYSIOLOGY; SARS CORONAVIRUS; SAUDI ARABIA; SENDAI VIRUS; SEQUENCE ALIGNMENT;

DEAD BOX PROTEIN 58; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; IMMUNE EVASION; IMMUNITY, INNATE; INTERFERON REGULATORY FACTOR-3; INTERFERON TYPE I; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; PHOSPHORYLATION; PHOSPHOTRANSFERASES; PROTEIN-SERINE-THREONINE KINASES; SARS VIRUS; SAUDI ARABIA; SENDAI VIRUS; SEQUENCE ALIGNMENT; TNF RECEPTOR-ASSOCIATED FACTOR 3; VIRAL MATRIX PROTEINS;

EID: 85003938202     PISSN: None     EISSN: 22221751     Source Type: Journal    
DOI: 10.1038/emi.2016.33     Document Type: Article

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