-
1
-
-
0037844361
-
Pharmacodynamics of NN2211, a novel long acting GLP-1 derivative
-
Agerso H, Vicini P (2003) Pharmacodynamics of NN2211, a novel long acting GLP-1 derivative. Eur J Pharm Sci 19(2–3):141–150.
-
(2003)
Eur J Pharm Sci
, vol.19
, Issue.2-3
, pp. 141-150
-
-
Agerso, H.1
Vicini, P.2
-
2
-
-
33748748732
-
Development and evaluation of a population pharmacokinetic-pharmacodynamic model of darbepoetin alfa in patients with nonmyeloid malignancies undergoing multicycle chemotherapy
-
Agoram B, Heatherington AC, Gastonguay MR (2006) Development and evaluation of a population pharmacokinetic-pharmacodynamic model of darbepoetin alfa in patients with nonmyeloid malignancies undergoing multicycle chemotherapy. AAPS J 8(3):E552–E563.
-
(2006)
AAPS J
, vol.8
, Issue.3
, pp. E552-E563
-
-
Agoram, B.1
Heatherington, A.C.2
Gastonguay, M.R.3
-
3
-
-
0033619117
-
Modelling ordered categorical data: Recent advances and future challenges
-
Agresti A (1999) Modelling ordered categorical data: recent advances and future challenges. Stat Med 18(17–18):2191–2207.
-
(1999)
Stat Med
, vol.18
, Issue.17-18
, pp. 2191-2207
-
-
Agresti, A.1
-
4
-
-
0021272976
-
Inhalation pharmacokinetics: Evaluating systemic extraction, total in vivo metabolism, and the time course of enzyme induction for inhaled styrene in rats based on arterial blood:Inhaled air concentration ratios
-
Andersen ME, Gargas ML, Ramsey JC (1984) Inhalation pharmacokinetics: evaluating systemic extraction, total in vivo metabolism, and the time course of enzyme induction for inhaled styrene in rats based on arterial blood:inhaled air concentration ratios. Toxicol Appl Pharmacol 73(1):176–187.
-
(1984)
Toxicol Appl Pharmacol
, vol.73
, Issue.1
, pp. 176-187
-
-
Andersen, M.E.1
Gargas, M.L.2
Ramsey, J.C.3
-
5
-
-
0023158895
-
Physiologically based pharmacokinetics and the risk assessment process for methylene chloride
-
Andersen ME, Clewell HJ III, Gargas ML, Smith FA, Reitz RH (1987) Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. Toxicol Appl Pharmacol 87(2):185–205.
-
(1987)
Toxicol Appl Pharmacol
, vol.87
, Issue.2
, pp. 185-205
-
-
Andersen, M.E.1
Clewell, H.J.2
Gargas, M.L.3
Smith, F.A.4
Reitz, R.H.5
-
6
-
-
0029961207
-
Calcium channel blockers versus other antihypertensive therapies on progression of NIDDM associated nephropathy
-
Bakris GL, Copley JB, Vicknair N, Sadler R, Leurgans S (1996) Calcium channel blockers versus other antihypertensive therapies on progression of NIDDM associated nephropathy. Kidney Int 50(5):1641–1650.
-
(1996)
Kidney Int
, vol.50
, Issue.5
, pp. 1641-1650
-
-
Bakris, G.L.1
Copley, J.B.2
Vicknair, N.3
Sadler, R.4
Leurgans, S.5
-
7
-
-
80051684814
-
-
edn. Cambridge University Press, Cambridge
-
Bass RF (2011) Stochastic processes, edn. Cambridge University Press, Cambridge
-
(2011)
Stochastic Processes
-
-
Bass, R.F.1
-
8
-
-
0028268634
-
Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice
-
Baxter LT, Zhu H, Mackensen DG, Jain RK (1994) Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice. Cancer Res 54(6):1517–1528.
-
(1994)
Cancer Res
, vol.54
, Issue.6
, pp. 1517-1528
-
-
Baxter, L.T.1
Zhu, H.2
Mackensen, D.G.3
Jain, R.K.4
-
9
-
-
84918720320
-
-
Rand Corporation, Santa Monica, California
-
Bellman RE, Jacquez JA, Kalaba RE, Kotkin B (1963) A mathematical model of drug distribution in the body: implications for cancer chemotherapy. Rand Corporation, Santa Monica, California.
-
(1963)
A Mathematical Model of Drug Distribution in the Body: Implications for Cancer Chemotherapy
-
-
Bellman, R.E.1
Jacquez, J.A.2
Kalaba, R.E.3
Kotkin, B.4
-
10
-
-
79951770481
-
Clearance (nee Rowland) concepts: A downdate and an update
-
Benet LZ (2010) Clearance (nee Rowland) concepts: a downdate and an update. J Pharmacokinet Pharmacodyn 37(6):529–539.
-
(2010)
J Pharmacokinet Pharmacodyn
, vol.37
, Issue.6
, pp. 529-539
-
-
Benet, L.Z.1
-
11
-
-
0018606615
-
Noncompartmental determination of the steady-state volume of distribution
-
Benet LZ, Galeazzi RL (1979) Noncompartmental determination of the steady-state volume of distribution. J Pharm Sci 68(8):1071–1074.
-
(1979)
J Pharm Sci
, vol.68
, Issue.8
, pp. 1071-1074
-
-
Benet, L.Z.1
Galeazzi, R.L.2
-
12
-
-
57449117844
-
-
World Intellectual Property Organization, Geneva, Publ. no. W0/2000/027341
-
Benincosa L, Jusko W (1999) Novel method of treatment. World Intellectual Property Organization, Geneva, Publ. no. W0/2000/027341.
-
(1999)
Novel Method of Treatment
-
-
Benincosa, L.1
Jusko, W.2
-
13
-
-
0018487598
-
Quantitative estimation of insulin sensitivity
-
Bergman RN, Ider YZ, Bowden CR, Cobelli C (1979) Quantitative estimation of insulin sensitivity. Am J Physiol 236(6):E667–E677.
-
(1979)
Am J Physiol
, vol.236
, Issue.6
, pp. E667-E677
-
-
Bergman, R.N.1
Ider, Y.Z.2
Bowden, C.R.3
Cobelli, C.4
-
15
-
-
33646649531
-
Impact of pharmacometrics on drug approval and labeling decisions: A survey of 42 new drug applications
-
Bhattaram VA, Booth BP, Ramchandani RP, Beasley BN, Wang Y, Tandon V et al (2005) Impact of pharmacometrics on drug approval and labeling decisions: a survey of 42 new drug applications. AAPS J 7(3):E503–512.
-
(2005)
AAPS J
, vol.7
, Issue.3
, pp. E503-E512
-
-
Bhattaram, V.A.1
Booth, B.P.2
Ramchandani, R.P.3
Beasley, B.N.4
Wang, Y.5
Tandon, V.6
-
16
-
-
0002958299
-
Drug distribution in mammals
-
Bischoff KB (1966) Drug distribution in mammals. Chem Eng Med Biol 62(66): 33–45.
-
(1966)
Chem Eng Med Biol
, vol.62
, Issue.66
, pp. 33-45
-
-
Bischoff, K.B.1
-
17
-
-
0016723180
-
Some fundamental considerations of the applications of pharmacokinetics to cancer chemotherapy
-
Bischoff KB (1975) Some fundamental considerations of the applications of pharmacokinetics to cancer chemotherapy. Cancer Chemother Rep Part 1 59(4):777–793.
-
(1975)
Cancer Chemother Rep
, vol.59
, Issue.4
, pp. 777-793
-
-
Bischoff, K.B.1
-
18
-
-
0343095702
-
-
edn, Drinking Water and Health, Pharmacokinetics in Risk Assessment. National Academy Press, Washington, DC
-
Bischoff KB (1987) Physiologically based pharmacokinetic modeling, edn, Drinking Water and Health, Volume 8: Pharmacokinetics in Risk Assessment. National Academy Press, Washington, DC.
-
(1987)
Physiologically Based Pharmacokinetic Modeling
, vol.8
-
-
Bischoff, K.B.1
-
19
-
-
85081149730
-
-
Presentation at the Chemical Industry Institute of Toxicology Founders Award
-
Bischoff KB (1992) PBPK models: what are we really assuming? Presentation at the Chemical Industry Institute of Toxicology Founders Award
-
(1992)
PBPK Models: What are We Really Assuming
-
-
Bischoff, K.B.1
-
20
-
-
0014315369
-
Thiopental pharmacokinetics
-
Bischoff KB, Dedrick RL (1968) Thiopental pharmacokinetics. J Pharm Sci 57(8):1346–1351.
-
(1968)
J Pharm Sci
, vol.57
, Issue.8
, pp. 1346-1351
-
-
Bischoff, K.B.1
Dedrick, R.L.2
-
21
-
-
0014732778
-
Preliminary model for methotrexate pharmacokinetics
-
Bischoff KB, Dedrick RL, Zaharko DS (1970) Preliminary model for methotrexate pharmacokinetics. J Pharm Sci 59(2):149–154.
-
(1970)
J Pharm Sci
, vol.59
, Issue.2
, pp. 149-154
-
-
Bischoff, K.B.1
Dedrick, R.L.2
Zaharko, D.S.3
-
22
-
-
77953539848
-
Multinomial logistic estimation of Markov-chain models for modeling sleep architecture in primary insomnia patients
-
Bizzotto R, Zamuner S, De Nicolao G, Karlsson MO, Gomeni R (2010) Multinomial logistic estimation of Markov-chain models for modeling sleep architecture in primary insomnia patients. J Pharmacokinet Pharmacodyn 37(2):137–155.
-
(2010)
J Pharmacokinet Pharmacodyn
, vol.37
, Issue.2
, pp. 137-155
-
-
Bizzotto, R.1
Zamuner, S.2
De Nicolao, G.3
Karlsson, M.O.4
Gomeni, R.5
-
23
-
-
80052582027
-
Multinomial logistic functions in markov chain models of sleep architecture: Internal and external validation and covariate analysis
-
Bizzotto R, Zamuner S, Mezzalana E, De Nicolao G, Gomeni R, Hooker AC et al (2011) Multinomial logistic functions in markov chain models of sleep architecture: internal and external validation and covariate analysis. AAPS J 13(3):445–463.
-
(2011)
AAPS J
, vol.13
, Issue.3
, pp. 445-463
-
-
Bizzotto, R.1
Zamuner, S.2
Mezzalana, E.3
De Nicolao, G.4
Gomeni, R.5
Hooker, A.C.6
-
24
-
-
0026594942
-
Renal protective effect of enalapril in diabetic nephropathy
-
Bjorck S, Mulec H, Johnsen SA, Norden G, Aurell M (1992) Renal protective effect of enalapril in diabetic nephropathy. BMJ 304(6823):339–343.
-
(1992)
BMJ
, vol.304
, Issue.6823
, pp. 339-343
-
-
Bjorck, S.1
Mulec, H.2
Johnsen, S.A.3
Norden, G.4
Aurell, M.5
-
25
-
-
0019974098
-
Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics
-
Boxenbaum H (1982) Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics. J Pharmacokinet Biopharm 10(2):201–227.
-
(1982)
J Pharmacokinet Biopharm
, vol.10
, Issue.2
, pp. 201-227
-
-
Boxenbaum, H.1
-
26
-
-
0021010984
-
Interspecies pharmacokinetic scaling and the Dedrick plots
-
Boxenbaum H, Ronfeld R (1983) Interspecies pharmacokinetic scaling and the Dedrick plots. Am J Physiol 245(6):R768–R775.
-
(1983)
Am J Physiol
, vol.245
, Issue.6
-
-
Boxenbaum, H.1
Ronfeld, R.2
-
28
-
-
67349241925
-
Simulation for clinical research trials: A theoretical outline
-
Brindley PG, Dunn WF (2009) Simulation for clinical research trials: a theoretical outline. J Crit Care 24(2):164–167.
-
(2009)
J Crit Care
, vol.24
, Issue.2
, pp. 164-167
-
-
Brindley, P.G.1
Dunn, W.F.2
-
29
-
-
0030806348
-
Physiological parameter values for physiologically based pharmacokinetic models
-
Brown R, Delp M, Lindstedt S, Rhomberg L, Beliles R (1997) Physiological parameter values for physiologically based pharmacokinetic models. Toxicol Ind Health 13407:484.
-
(1997)
Toxicol Ind Health
, vol.13407
-
-
Brown, R.1
Delp, M.2
Lindstedt, S.3
Rhomberg, L.4
Beliles, R.5
-
31
-
-
0018745142
-
Physiologically based pharmacokinetic models for anticancer drugs
-
Chen HS, Gross JF (1979) Physiologically based pharmacokinetic models for anticancer drugs. Cancer Chemother Pharmacol 2(2):85–94.
-
(1979)
Cancer Chemother Pharmacol
, vol.2
, Issue.2
, pp. 85-94
-
-
Chen, H.S.1
Gross, J.F.2
-
33
-
-
0020826160
-
Distributed model for drug delivery to CSF and brain tissue
-
Collins JM, Dedrick RL (1983) Distributed model for drug delivery to CSF and brain tissue. Am J Physiol 245(3):R303–R310.
-
(1983)
Am J Physiol
, vol.245
, Issue.3
-
-
Collins, J.M.1
Dedrick, R.L.2
-
34
-
-
0023362517
-
Lumping strategy. 1. Introductory techniques and applications of cluster analysis
-
Coxson PG, Bischoff KB (1987a) Lumping strategy. 1. Introductory techniques and applications of cluster analysis. Ind Eng Chem Res 26(6):1239–1248.
-
(1987)
Ind Eng Chem Res
, vol.26
, Issue.6
, pp. 1239-1248
-
-
Coxson, P.G.1
Bischoff, K.B.2
-
35
-
-
0023436571
-
Lumping strategy. 2. System theoretic approach
-
Coxson PG, Bischoff KB (1987b) Lumping strategy. 2. System theoretic approach. Ind Eng Chem Res 26(10):2151–2157.
-
(1987)
Ind Eng Chem Res
, vol.26
, Issue.10
, pp. 2151-2157
-
-
Coxson, P.G.1
Bischoff, K.B.2
-
36
-
-
6844249427
-
Effects of lisinopril and nifedipine on the progression to overt albuminuria in IDDM patients with incipient nephropathy and normal blood pressure. The Italian Microalbuminuria Study Group in IDDM
-
Crepaldi G, Carta Q, Deferrari G, Mangili R, Navalesi R, Santeusanio F et al (1998) Effects of lisinopril and nifedipine on the progression to overt albuminuria in IDDM patients with incipient nephropathy and normal blood pressure. The Italian Microalbuminuria Study Group in IDDM. Diabetes Care 21(1):104–110.
-
(1998)
Diabetes Care
, vol.21
, Issue.1
, pp. 104-110
-
-
Crepaldi, G.1
Carta, Q.2
Deferrari, G.3
Mangili, R.4
Navalesi, R.5
Santeusanio, F.6
-
37
-
-
16344364224
-
Pharmacokinetics of ximelagatran and relationship to clinical response in acute deep vein thrombosis
-
Cullberg M, Eriksson UG, Wahlander K, Eriksson H, Schulman S, Karlsson MO (2005) Pharmacokinetics of ximelagatran and relationship to clinical response in acute deep vein thrombosis. Clin Pharmacol Ther 77(4):279–290.
-
(2005)
Clin Pharmacol Ther
, vol.77
, Issue.4
, pp. 279-290
-
-
Cullberg, M.1
Eriksson, U.G.2
Wahlander, K.3
Eriksson, H.4
Schulman, S.5
Karlsson, M.O.6
-
38
-
-
0027769745
-
Comparison of four basic models of indirect pharmacodynamic responses
-
Dayneka NL, Garg V, Jusko WJ (1993) Comparison of four basic models of indirect pharmacodynamic responses. J Pharmacokinet Biopharma 21(4):457–478.
-
(1993)
J Pharmacokinet Biopharma
, vol.21
, Issue.4
, pp. 457-478
-
-
Dayneka, N.L.1
Garg, V.2
Jusko, W.J.3
-
39
-
-
0034137637
-
Mathematical modelling of the intravenous glucose tolerance test
-
De Gaetano A, Arino O (2000) Mathematical modelling of the intravenous glucose tolerance test. J Math Biol 40(2):136–168
-
(2000)
J Math Biol
, vol.40
, Issue.2
, pp. 136-168
-
-
De Gaetano, A.1
Arino, O.2
-
40
-
-
33745779941
-
A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying Type 2. Diabetes Mellitus
-
de Winter W, DeJongh, Moules I et al (2006) A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying Type 2. Diabetes Mellitus. J Pharmacokinet Pharmacodyn 33(3):313–343.
-
(2006)
J Pharmacokinet Pharmacodyn
, vol.33
, Issue.3
, pp. 313-343
-
-
De Winter, W.1
Dejongh, M.I.2
-
42
-
-
0018840165
-
Species similarities in pharmacokinetics
-
Dedrick RL, Bischoff KB (1980) Species similarities in pharmacokinetics. Fed Proc 39(1):54–59.
-
(1980)
Fed Proc
, vol.39
, Issue.1
, pp. 54-59
-
-
Dedrick, R.L.1
Bischoff, K.B.2
-
44
-
-
0033730929
-
Pharmacokinetic/pharmacodynamic modeling in drug research and development
-
Derendorf H, Lesko LJ, Chaikin P, Colburn WA, Lee P, Miller R et al (2000) Pharmacokinetic/pharmacodynamic modeling in drug research and development. J Clin Pharmacol 40(12. Pt 2):1399–1418.
-
(2000)
J Clin Pharmacol
, vol.40
, Issue.12
, pp. 1399-1418
-
-
Derendorf, H.1
Lesko, L.J.2
Chaikin, P.3
Colburn, W.A.4
Lee, P.5
Miller, R.6
-
45
-
-
0015375105
-
Pharmacokinetics of highly ionized drugs. 3. Methylene blue– blood levels in the dog and tissue levels in the rat following intravenous administration
-
DiSanto AR, Wagner JG (1972) Pharmacokinetics of highly ionized drugs. 3. Methylene blue– blood levels in the dog and tissue levels in the rat following intravenous administration. J Pharm Sci 61(7):1090–1094.
-
(1972)
J Pharm Sci
, vol.61
, Issue.7
, pp. 1090-1094
-
-
Disanto, A.R.1
Wagner, J.G.2
-
46
-
-
0027380235
-
Statistical moments in pharmacokinetics: Models and assumptions
-
Dunne A (1993) Statistical moments in pharmacokinetics: models and assumptions. J Pharm Pharmacol 45(10):871–875.
-
(1993)
J Pharm Pharmacol
, vol.45
, Issue.10
, pp. 871-875
-
-
Dunne, A.1
-
47
-
-
44649089045
-
-
European agency for the evaluation of medicinal products, CHMP/EWP/185990/06
-
European agency for the evaluation of medicinal products (2007) Guideline on reporting the results of population pharmacokinetic analyses. CHMP/EWP/185990/06 (available at http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003067.pdf)
-
(2007)
Guideline on Reporting the Results of Population Pharmacokinetic Analyses
-
-
-
48
-
-
0031976933
-
Balanced designs in longitudinal population pharmacokinetic studies
-
Ette EI, Sun H, Ludden TM (1998) Balanced designs in longitudinal population pharmacokinetic studies. J Clin Pharmacol 38(5):417–423.
-
(1998)
J Clin Pharmacol
, vol.38
, Issue.5
, pp. 417-423
-
-
Ette, E.I.1
Sun, H.2
Ludden, T.M.3
-
50
-
-
0018644778
-
Cardiac output differences in males and females during mild cycle ergometer exercise
-
Freedson P, Katch VL, Sady S, Weltman A (1979) Cardiac output differences in males and females during mild cycle ergometer exercise. Med Sci Sports 11(1):16–19.
-
(1979)
Med Sci Sports
, vol.11
, Issue.1
, pp. 16-19
-
-
Freedson, P.1
Katch, V.L.2
Sady, S.3
Weltman, A.4
-
51
-
-
0037327319
-
Population PKPD modelling of the long-term hypoglycaemic effect of gliclazide given as a once-a-day modified release (MR) formulation
-
Frey N, Laveille C, Paraire M, Francillard M, Holford NH, Jochemsen R (2003) Population PKPD modelling of the long-term hypoglycaemic effect of gliclazide given as a once-a-day modified release (MR) formulation. Br J Clin Pharmacol 55(2):147–157.
-
(2003)
Br J Clin Pharmacol
, vol.55
, Issue.2
, pp. 147-157
-
-
Frey, N.1
Laveille, C.2
Paraire, M.3
Francillard, M.4
Holford, N.H.5
Jochemsen, R.6
-
52
-
-
0016713468
-
The natural history of non- Hodgkin’s lymphomata stages I and II
-
Fuller LM, Banker FL, Butler JJ, Gamble JF, Sullivan MP (1975) The natural history of non- Hodgkin’s lymphomata stages I and II. Br J Cancer Suppl 2:270–285.
-
(1975)
Br J Cancer Suppl
, vol.2
, pp. 270-285
-
-
Fuller, L.M.1
Banker, F.L.2
Butler, J.J.3
Gamble, J.F.4
Sullivan, M.P.5
-
54
-
-
0027493971
-
The course of kidney function in type 2 (noninsulin- dependent) diabetic patients with diabetic nephropathy
-
Gall MA, Nielsen FS, Smidt UM, Parving HH (1993) The course of kidney function in type 2 (noninsulin- dependent) diabetic patients with diabetic nephropathy. Diabetologia 36(10):1071–1078.
-
(1993)
Diabetologia
, vol.36
, Issue.10
, pp. 1071-1078
-
-
Gall, M.A.1
Nielsen, F.S.2
Smidt, U.M.3
Parving, H.H.4
-
55
-
-
0020963903
-
Physiologically based pharmacokinetic modeling: Principles and applications
-
Gerlowski LE, Jain RK (1983) Physiologically based pharmacokinetic modeling: principles and applications. J Pharm Sci 72(10):1103–1127.
-
(1983)
J Pharm Sci
, vol.72
, Issue.10
, pp. 1103-1127
-
-
Gerlowski, L.E.1
Jain, R.K.2
-
56
-
-
85081147516
-
Pharmacokinetics: Revised and expanded
-
Gibaldi M, Perrier D (1999) Pharmacokinetics: revised and expanded. Drugs Pharma Sci 92:15–15.
-
(1999)
Drugs Pharma Sci
, vol.92
-
-
Gibaldi, M.1
Perrier, D.2
-
57
-
-
0034960482
-
Population pharmacokinetic-pharmacodynamic model of craving in an enforced smoking cessation population: Indirect response and probabilistic modeling
-
Gomeni R, Teneggi V, Iavarone L, Squassante L, Bye A (2001) Population pharmacokinetic-pharmacodynamic model of craving in an enforced smoking cessation population: indirect response and probabilistic modeling. Pharma Res 18(4):537–543.
-
(2001)
Pharma Res
, vol.18
, Issue.4
, pp. 537-543
-
-
Gomeni, R.1
Teneggi, V.2
Iavarone, L.3
Squassante, L.4
Bye, A.5
-
58
-
-
37249043883
-
Determinants of renal volume in autosomal-dominant polycystic kidney disease
-
Grantham JJ, Cook LT, Torres VE, Bost JE, Chapman AB, Harris PC et al (2008) Determinants of renal volume in autosomal-dominant polycystic kidney disease. Kidney Int 73(1):108–116.
-
(2008)
Kidney Int
, vol.73
, Issue.1
, pp. 108-116
-
-
Grantham, J.J.1
Cook, L.T.2
Torres, V.E.3
Bost, J.E.4
Chapman, A.B.5
Harris, P.C.6
-
59
-
-
85081149542
-
Mesure de l’activite physio-logique des reins par le dosage de l’ure’e dans le sang et dans l’urine
-
Grehant N (1904a) Mesure de l’activite physio-logique des reins par le dosage de l’ure’e dans le sang et dans l’urine. J Physiol et Path Gen 7:1.
-
(1904)
J Physiol Et Path Gen
, vol.7
-
-
Grehant, N.1
-
60
-
-
15144356777
-
Physiologique des reins par le dosage de l’uree dans le sang et daus l’urine
-
Grehant N (1904b) Physiologique des reins par le dosage de l’uree dans le sang et daus l’urine. J physiol (Paris) 6:1–8.
-
(1904)
J Physiol (Paris)
, vol.6
, pp. 1-8
-
-
Grehant, N.1
-
61
-
-
0032977094
-
Quantitative characterization of therapeutic index: Application of mixed-effects modeling to evaluate oxybutynin dose-efficacy and dose-side effect relationships
-
Gupta SK, Sathyan G, Lindemulder EA, Ho PL, Sheiner LB, Aarons L (1999) Quantitative characterization of therapeutic index: application of mixed-effects modeling to evaluate oxybutynin dose-efficacy and dose-side effect relationships. Clin Pharmacol Ther 65(6):672–684.
-
(1999)
Clin Pharmacol Ther
, vol.65
, Issue.6
, pp. 672-684
-
-
Gupta, S.K.1
Sathyan, G.2
Lindemulder, E.A.3
Ho, P.L.4
Sheiner, L.B.5
Aarons, L.6
-
64
-
-
45549094640
-
Models for plasma glucose, HbA1c, and hemoglobin interrelationships in patients with type 2 diabetes following tesaglitazar treatment
-
Hamren B, Bjork E, Sunzel M, Karlsson M (2008) Models for plasma glucose, HbA1c, and hemoglobin interrelationships in patients with type 2 diabetes following tesaglitazar treatment. Clin Pharmacol Ther 84(2):228–235.
-
(2008)
Clin Pharmacol Ther
, vol.84
, Issue.2
, pp. 228-235
-
-
Hamren, B.1
Bjork, E.2
Sunzel, M.3
Karlsson, M.4
-
66
-
-
85081146831
-
Statistical analysis and data display: An intermediate course with examples in S-plus, R, and SAS, edn. Springer Herman WH (2003) Diabetes modeling
-
Heiberger RM, Holland B (2004) Statistical analysis and data display: an intermediate course with examples in S-plus, R, and SAS, edn. Springer Herman WH (2003) Diabetes modeling. Diabetes Care 26(11):3182–3183.
-
(2004)
Diabetes Care
, vol.26
, Issue.11
, pp. 3182-3183
-
-
Heiberger, R.M.1
Holland, B.2
-
67
-
-
84881128055
-
A time to event tutorial for pharmacometricians
-
Holford N (2013) A time to event tutorial for pharmacometricians. CPT Pharmacometrics Syst Pharmacol 2:e43.
-
(2013)
CPT Pharmacometrics Syst Pharmacol
, vol.2
-
-
Holford, N.1
-
68
-
-
0026452038
-
Methodologic aspects of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine
-
Holford NH, Peace KE (1992a) Methodologic aspects of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine. Proc Natl Acad Sci U S A 89(23):11466–11470.
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, Issue.23
, pp. 11466-11470
-
-
Holford, N.H.1
Peace, K.E.2
-
69
-
-
0026471544
-
Results and validation of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine
-
Holford NH, Peace KE (1992b) Results and validation of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine. Proc Natl Acad Sci U S A 89(23):11471–11475.
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, Issue.23
, pp. 11471-11475
-
-
Holford, N.H.1
Peace, K.E.2
-
71
-
-
0029420405
-
Frailty models for survival data
-
Hougaard P (1995) Frailty models for survival data. Lifetime Data Anal 1(3):255–273.
-
(1995)
Lifetime Data Anal
, vol.1
, Issue.3
, pp. 255-273
-
-
Hougaard, P.1
-
72
-
-
85046914133
-
Allometric scaling of xenobiotic clearance: Uncertainty versus universality
-
Hu TM, Hayton WL (2001) Allometric scaling of xenobiotic clearance: uncertainty versus universality. AAPS PharmSci 3(4):E29.
-
(2001)
AAPS Pharmsci
, vol.3
, Issue.4
, pp. E29
-
-
Hu, T.M.1
Hayton, W.L.2
-
73
-
-
84863344719
-
PBPK as a tool in regulatory review
-
Huang SM (2012) PBPK as a tool in regulatory review. Biopharm Drug Dispos 33(2):51–52.
-
(2012)
Biopharm Drug Dispos
, vol.33
, Issue.2
, pp. 51-52
-
-
Huang, S.M.1
-
74
-
-
84862777920
-
The role of physiologically based pharmacokinetic modeling in regulatory review
-
Huang SM, Rowland M (2012) The role of physiologically based pharmacokinetic modeling in regulatory review. Clin Pharmacol Ther 91(3):542–549.
-
(2012)
Clin Pharmacol Ther
, vol.91
, Issue.3
, pp. 542-549
-
-
Huang, S.M.1
Rowland, M.2
-
75
-
-
0032900556
-
Physiologically based pharmacokinetic model for fluorocarbon elimination after the administration of an octafluoropropanealbumin microsphere sonographic contrast agent
-
Hutter JC, Luu HM, Mehlhaff PM, Killam AL, Dittrich HC (1999) Physiologically based pharmacokinetic model for fluorocarbon elimination after the administration of an octafluoropropanealbumin microsphere sonographic contrast agent. J Ultrasound Med 18(1):1–11.
-
(1999)
J Ultrasound Med
, vol.18
, Issue.1
, pp. 1-11
-
-
Hutter, J.C.1
Luu, H.M.2
Mehlhaff, P.M.3
Killam, A.L.4
Dittrich, H.C.5
-
76
-
-
0038352147
-
Phase II study of the efficacy and tolerability of two dosing regimens of the farnesyl transferase inhibitor, R115777, in advanced breast cancer
-
Johnston SR, Hickish T, Ellis P, Houston S, Kelland L, Dowsett M et al (2003) Phase II study of the efficacy and tolerability of two dosing regimens of the farnesyl transferase inhibitor, R115777, in advanced breast cancer. J Clin Oncol 21(13):2492–2499.
-
(2003)
J Clin Oncol
, vol.21
, Issue.13
, pp. 2492-2499
-
-
Johnston, S.R.1
Hickish, T.2
Ellis, P.3
Houston, S.4
Kelland, L.5
Dowsett, M.6
-
77
-
-
0027943266
-
Physiologic indirect response models characterize diverse types of pharmacodynamic effects
-
Jusko WJ, Ko HC (1994) Physiologic indirect response models characterize diverse types of pharmacodynamic effects. Clin Pharmacol Ther 56(4):406–419.
-
(1994)
Clin Pharmacol Ther
, vol.56
, Issue.4
, pp. 406-419
-
-
Jusko, W.J.1
Ko, H.C.2
-
78
-
-
0033846594
-
A pharmacodynamic Markov mixed-effects model for the effect of temazepam on sleep
-
Karlsson MO, Schoemaker RC, Kemp B, Cohen AF, van Gerven JM, Tuk B et al (2000) A pharmacodynamic Markov mixed-effects model for the effect of temazepam on sleep. Clin Pharmacol Ther 68(2):175–188.
-
(2000)
Clin Pharmacol Ther
, vol.68
, Issue.2
, pp. 175-188
-
-
Karlsson, M.O.1
Schoemaker, R.C.2
Kemp, B.3
Cohen, A.F.4
Van Gerven, J.M.5
Tuk, B.6
-
79
-
-
0022952529
-
Simulation of human hypnograms using a Markov chain model
-
Kemp B, Kamphuisen HA (1986) Simulation of human hypnograms using a Markov chain model. Sleep 9(3):405–414.
-
(1986)
Sleep
, vol.9
, Issue.3
, pp. 405-414
-
-
Kemp, B.1
Kamphuisen, H.A.2
-
81
-
-
0033697667
-
Prediction of the outcome of a phase 3 clinical trial of an antischizophrenic agent (quetiapine fumarate) by simulation with a population pharmacokinetic and pharmacodynamic model
-
Kimko HC, Reele SS, Holford NH, Peck CC (2000) Prediction of the outcome of a phase 3 clinical trial of an antischizophrenic agent (quetiapine fumarate) by simulation with a population pharmacokinetic and pharmacodynamic model. Clin Pharmacol Ther 68(5):568–577.
-
(2000)
Clin Pharmacol Ther
, vol.68
, Issue.5
, pp. 568-577
-
-
Kimko, H.C.1
Reele, S.S.2
Holford, N.H.3
Peck, C.C.4
-
82
-
-
57749084500
-
Comparison of proportional and differential odds models for mixed-effects analysis of categorical data
-
Kjellsson MC, Zingmark PH, Jonsson EN, Karlsson MO (2008) Comparison of proportional and differential odds models for mixed-effects analysis of categorical data. J Pharmacokinet Pharmacodyn 35(5):483–501.
-
(2008)
J Pharmacokinet Pharmacodyn
, vol.35
, Issue.5
, pp. 483-501
-
-
Kjellsson, M.C.1
Zingmark, P.H.2
Jonsson, E.N.3
Karlsson, M.O.4
-
83
-
-
0036917793
-
Population pharmacokinetic and pharmacodynamic modeling of propofol for long-term sedation in critically ill patients: A comparison between propofol 6 % and propofol 1 %
-
Knibbe CA, Zuideveld KP, DeJongh J, Kuks PF, Aarts LP, Danhof M (2002) Population pharmacokinetic and pharmacodynamic modeling of propofol for long-term sedation in critically ill patients: a comparison between propofol 6 % and propofol 1 %. Clin Pharmacol Ther 72(6):670–684.
-
(2002)
Clin Pharmacol Ther
, vol.72
, Issue.6
, pp. 670-684
-
-
Knibbe, C.A.1
Zuideveld, K.P.2
Dejongh, J.3
Kuks, P.F.4
Aarts, L.P.5
Danhof, M.6
-
84
-
-
0035863226
-
Design evaluation for a population pharmacokinetic study using clinical trial simulations: A case study
-
Kowalski KG, Hutmacher MM (2001) Design evaluation for a population pharmacokinetic study using clinical trial simulations: a case study. Stat Med 20(1):75–91.
-
(2001)
Stat Med
, vol.20
, Issue.1
, pp. 75-91
-
-
Kowalski, K.G.1
Hutmacher, M.M.2
-
85
-
-
0347932020
-
A two-part mixture model for longitudinal adverse event severity data
-
Kowalski KG, McFadyen L, Hutmacher MM, Frame B, Miller R (2003) A two-part mixture model for longitudinal adverse event severity data. J Pharmacokinet Pharmacodyn 30(5):315–336.
-
(2003)
J Pharmacokinet Pharmacodyn
, vol.30
, Issue.5
, pp. 315-336
-
-
Kowalski, K.G.1
McFadyen, L.2
Hutmacher, M.M.3
Frame, B.4
Miller, R.5
-
86
-
-
70349439118
-
A pharmacodynamic Markov mixed-effects model for determining the effect of exposure to certolizumab pegol on the ACR20 score in patients with rheumatoid arthritis
-
Lacroix BD, Lovern MR, Stockis A, Sargentini-Maier ML, Karlsson MO, Friberg LE (2009) A pharmacodynamic Markov mixed-effects model for determining the effect of exposure to certolizumab pegol on the ACR20 score in patients with rheumatoid arthritis. Clin Pharmacol Ther 86(4):387–395.
-
(2009)
Clin Pharmacol Ther
, vol.86
, Issue.4
, pp. 387-395
-
-
Lacroix, B.D.1
Lovern, M.R.2
Stockis, A.3
Sargentini-Maier, M.L.4
Karlsson, M.O.5
Friberg, L.E.6
-
87
-
-
45549108317
-
Pharmacokinetic/pharmacodynamic modelling in diabetes mellitus
-
Landersdorfer CB, Jusko WJ (2008) Pharmacokinetic/pharmacodynamic modelling in diabetes mellitus. Clin Pharmacokinet 47(7):417–448.
-
(2008)
Clin Pharmacokinet
, vol.47
, Issue.7
, pp. 417-448
-
-
Landersdorfer, C.B.1
Jusko, W.J.2
-
88
-
-
0035045467
-
Design and power of a population pharmacokinetic study
-
Lee PI (2001) Design and power of a population pharmacokinetic study. Pharma Res 18(1):75–82.
-
(2001)
Pharma Res
, vol.18
, Issue.1
, pp. 75-82
-
-
Lee, P.I.1
-
89
-
-
84859994663
-
Regulatory experience with physiologically based pharmacokinetic modeling for pediatric drug trials
-
Leong R, Vieira ML, Zhao P, Mulugeta Y, Lee CS, Huang SM et al (2012) Regulatory experience with physiologically based pharmacokinetic modeling for pediatric drug trials. Clin Pharmacol Ther 91(5):926–931.
-
(2012)
Clin Pharmacol Ther
, vol.91
, Issue.5
, pp. 926-931
-
-
Leong, R.1
Vieira, M.L.2
Zhao, P.3
Mulugeta, Y.4
Lee, C.S.5
Huang, S.M.6
-
90
-
-
15044366389
-
The concept of hepatic clearance
-
Lewis AE (1948) The concept of hepatic clearance. Am J Clin Pathol 18(10):789–795.
-
(1948)
Am J Clin Pathol
, vol.18
, Issue.10
, pp. 789-795
-
-
Lewis, A.E.1
-
91
-
-
0027517659
-
The effect of angiotensin-convertingenzyme inhibition on diabetic nephropathy. The Collaborative Study Group
-
Lewis EJ, Hunsicker LG, Bain RP, Rohde RD (1993) The effect of angiotensin-convertingenzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N Engl J Med 329(20):1456–1462.
-
(1993)
N Engl J Med
, vol.329
, Issue.20
, pp. 1456-1462
-
-
Lewis, E.J.1
Hunsicker, L.G.2
Bain, R.P.3
Rohde, R.D.4
-
92
-
-
21144451475
-
Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: An experimental analysis of the role of blood-brain barrier permeability, plasma protein binding, and brain tissue binding
-
Liu X, Smith BJ, Chen C, Callegari E, Becker SL, Chen X et al (2005) Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood-brain barrier permeability, plasma protein binding, and brain tissue binding. J Pharmacol Exp Ther 313(3):1254–1262.
-
(2005)
J Pharmacol Exp Ther
, vol.313
, Issue.3
, pp. 1254-1262
-
-
Liu, X.1
Smith, B.J.2
Chen, C.3
Callegari, E.4
Becker, S.L.5
Chen, X.6
-
93
-
-
0035882273
-
Cumulative logit models for ordinal data: A case study involving allergic rhinitis severity scores
-
Lunn DJ, Wakefield J, Racine-Poon A (2001) Cumulative logit models for ordinal data: a case study involving allergic rhinitis severity scores. Stat Med 20(15):2261–2285.
-
(2001)
Stat Med
, vol.20
, Issue.15
, pp. 2261-2285
-
-
Lunn, D.J.1
Wakefield, J.2
Racine-Poon, A.3
-
94
-
-
6244309282
-
Exendin-4 pharmacodynamics: Insights from the hyperglycemic clamp technique
-
Mager DE, Abernethy DR, Egan JM, Elahi D (2004) Exendin-4 pharmacodynamics: insights from the hyperglycemic clamp technique. J Pharmacol Exp Ther 311(2):830–835.
-
(2004)
J Pharmacol Exp Ther
, vol.311
, Issue.2
, pp. 830-835
-
-
Mager, D.E.1
Abernethy, D.R.2
Egan, J.M.3
Elahi, D.4
-
95
-
-
51749122228
-
Dynamical modeling and multi-experiment fitting with Potters- Wheel
-
Maiwald T, Timmer J (2008) Dynamical modeling and multi-experiment fitting with Potters- Wheel. Bioinformatics 24(18):2037–2043.
-
(2008)
Bioinformatics
, vol.24
, Issue.18
, pp. 2037-2043
-
-
Maiwald, T.1
Timmer, J.2
-
96
-
-
0030471388
-
Population pharmacodynamic model for ketorolac analgesia
-
Mandema JW, Stanski DR (1996) Population pharmacodynamic model for ketorolac analgesia. Clin Pharmacol Ther 60(6):619–635.
-
(1996)
Clin Pharmacol Ther
, vol.60
, Issue.6
, pp. 619-635
-
-
Mandema, J.W.1
Stanski, D.R.2
-
97
-
-
0001306637
-
Regression models for ordinal data
-
McCullagh P (1980) Regression models for ordinal data. J R Stat Soc B 42(2): 109–142.
-
(1980)
J R Stat Soc B
, vol.42
, Issue.2
, pp. 109-142
-
-
McCullagh, P.1
-
98
-
-
84859409756
-
Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3
-
McDonagh CF, Huhalov A, Harms BD, Adams S, Paragas V, Oyama S et al (2012) Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3. Mol Cancer Ther 11(3):582–593.
-
(2012)
Mol Cancer Ther
, vol.11
, Issue.3
, pp. 582-593
-
-
McDonagh, C.F.1
Huhalov, A.2
Harms, B.D.3
Adams, S.4
Paragas, V.5
Oyama, S.6
-
99
-
-
30444448534
-
Population pharmacokinetic studies in pediatrics: Issues in design and analysis
-
Meibohm B, Laer S, Panetta JC, Barrett JS (2005) Population pharmacokinetic studies in pediatrics: issues in design and analysis. AAPS J 7(2):E475–E487.
-
(2005)
AAPS J
, vol.7
, Issue.2
, pp. E475-E487
-
-
Meibohm, B.1
Laer, S.2
Panetta, J.C.3
Barrett, J.S.4
-
100
-
-
34247521874
-
Wei, Lin and Weissfeld’s marginal analysis of multivariate failure time data: Should it be applied to a recurrent events outcome?
-
Metcalfe C, Thompson SG (2007) Wei, Lin and Weissfeld’s marginal analysis of multivariate failure time data: should it be applied to a recurrent events outcome? Stat Methods Med Res 16(2):103–122.
-
(2007)
Stat Methods Med Res
, vol.16
, Issue.2
, pp. 103-122
-
-
Metcalfe, C.1
Thompson, S.G.2
-
101
-
-
0002209037
-
The use of interspecies scaling in toxicokinetics
-
Yacobi A, Skelly JP, Batra V (eds), edn. Pergamon, New York
-
Mordenti J, Chappell W (1989) The use of interspecies scaling in toxicokinetics. In: Yacobi A, Skelly JP, Batra V (eds) Toxicokinetics and new drug development, edn. Pergamon, New York, pp 42–96.
-
(1989)
Toxicokinetics and New Drug Development
, pp. 42-96
-
-
Mordenti, J.1
Chappell, W.2
-
102
-
-
0035035790
-
A population pharmacokinetic- pharmacodynamic and logistic regression analysis of lotrafiban in patients
-
Mould D, Chapelsky M, Aluri J, Swagzdis J, Samuels R, Granett J (2001) A population pharmacokinetic- pharmacodynamic and logistic regression analysis of lotrafiban in patients. Clin Pharmacol Ther 69(4):210–222.
-
(2001)
Clin Pharmacol Ther
, vol.69
, Issue.4
, pp. 210-222
-
-
Mould, D.1
Chapelsky, M.2
Aluri, J.3
Swagzdis, J.4
Samuels, R.5
Granett, J.6
-
103
-
-
84889369132
-
Developing models of disease progression
-
Ette EI, Williams PJ (eds), Wiley, Hoboken
-
Mould DR (2007) Developing models of disease progression. In: Ette EI, Williams PJ (eds) Pharmacometrics: the science of quantitative pharmacology, edn. Wiley, Hoboken, pp 547–581.
-
(2007)
Pharmacometrics: The Science of Quantitative Pharmacology, Edn
, pp. 547-581
-
-
Mould, D.R.1
-
104
-
-
18344394148
-
Population pharmacokinetic and adverse event analysis of topotecan in patients with solid tumors
-
Mould DR, Holford NH, Schellens JH, Beijnen JH, Hutson PR, Rosing H et al (2002) Population pharmacokinetic and adverse event analysis of topotecan in patients with solid tumors. Clin Pharmacol Ther 71(5):334–348.
-
(2002)
Clin Pharmacol Ther
, vol.71
, Issue.5
, pp. 334-348
-
-
Mould, D.R.1
Holford, N.H.2
Schellens, J.H.3
Beijnen, J.H.4
Hutson, P.R.5
Rosing, H.6
-
105
-
-
34250675992
-
Using disease progression models as a tool to detect drug effect
-
Mould DR, Denman NG, Duffull S (2007) Using disease progression models as a tool to detect drug effect. Clin Pharmacol Ther 82(1):81–86.
-
(2007)
Clin Pharmacol Ther
, vol.82
, Issue.1
, pp. 81-86
-
-
Mould, D.R.1
Denman, N.G.2
Duffull, S.3
-
106
-
-
0031661419
-
Lumping of whole-body physiologically based pharmacokinetic models
-
Nestorov IA, Aarons LJ, Arundel PA, Rowland M (1998) Lumping of whole-body physiologically based pharmacokinetic models. J Pharmacokinet Biopharma 26(1):21–46.
-
(1998)
J Pharmacokinet Biopharma
, vol.26
, Issue.1
, pp. 21-46
-
-
Nestorov, I.A.1
Aarons, L.J.2
Arundel, P.A.3
Rowland, M.4
-
107
-
-
84881185263
-
Pharmacokinetic-pharmacodynamic modeling of antibacterial drugs
-
Nielsen EI, Friberg LE (2013) Pharmacokinetic-pharmacodynamic modeling of antibacterial drugs. Pharmacol Rev 65(3):1053–1090.
-
(2013)
Pharmacol Rev
, vol.65
, Issue.3
, pp. 1053-1090
-
-
Nielsen, E.I.1
Friberg, L.E.2
-
108
-
-
44449106066
-
How many subjects are necessary for population pharmacokinetic experiments? Confidence interval approach
-
Ogungbenro K, Aarons L (2008) How many subjects are necessary for population pharmacokinetic experiments? Confidence interval approach. Eur J Clin Pharmacol 64(7):705–713.
-
(2008)
Eur J Clin Pharmacol
, vol.64
, Issue.7
, pp. 705-713
-
-
Ogungbenro, K.1
Aarons, L.2
-
109
-
-
0034982023
-
A whole-body physiologically based pharmacokinetic model incorporating dispersion concepts: Short and long time characteristics
-
Oliver RE, Jones AF, Rowland M (2001) A whole-body physiologically based pharmacokinetic model incorporating dispersion concepts: short and long time characteristics. J Pharmacokinet Pharmacodyn 28(1):27–55.
-
(2001)
J Pharmacokinet Pharmacodyn
, vol.28
, Issue.1
, pp. 27-55
-
-
Oliver, R.E.1
Jones, A.F.2
Rowland, M.3
-
110
-
-
21744446440
-
Alfentanil and placebo analgesia: No sex differences detected in models of experimental pain
-
Olofsen E, Romberg R, Bijl H, Mooren R, Engbers F, Kest B et al (2005) Alfentanil and placebo analgesia: no sex differences detected in models of experimental pain. Anesthesiology 103(1):130–139.
-
(2005)
Anesthesiology
, vol.103
, Issue.1
, pp. 130-139
-
-
Olofsen, E.1
Romberg, R.2
Bijl, H.3
Mooren, R.4
Engbers, F.5
Kest, B.6
-
111
-
-
80052965562
-
First-time-in-human study with GSK1018921, a selective GlyT1 inhibitor: Relationship between exposure and dizziness
-
Ouellet D, Sutherland S, Wang T, Griffini P, Murthy V (2011) First-time-in-human study with GSK1018921, a selective GlyT1 inhibitor: relationship between exposure and dizziness. Clin Pharmacol Ther 90(4):597–604.
-
(2011)
Clin Pharmacol Ther
, vol.90
, Issue.4
, pp. 597-604
-
-
Ouellet, D.1
Sutherland, S.2
Wang, T.3
Griffini, P.4
Murthy, V.5
-
112
-
-
0022797049
-
MINMOD: A computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test
-
Pacini G, Bergman RN (1986) MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test. Compute Methods Programs Biomed 23(2):113–122.
-
(1986)
Compute Methods Programs Biomed
, vol.23
, Issue.2
, pp. 113-122
-
-
Pacini, G.1
Bergman, R.N.2
-
113
-
-
79951774366
-
Physiologically-based pharmacokinetic modeling for absorption, transport, metabolism and excretion
-
Pang KS, Durk MR (2010) Physiologically-based pharmacokinetic modeling for absorption, transport, metabolism and excretion. J Pharmacokinet Pharmacodyn 37(6):591–615.
-
(2010)
J Pharmacokinet Pharmacodyn
, vol.37
, Issue.6
, pp. 591-615
-
-
Pang, K.S.1
Durk, M.R.2
-
114
-
-
0029003679
-
Angiotensin-converting enzyme inhibition in diabetic nephropathy: Ten years’ experience
-
Parving HH, Rossing P, Hommel E, Smidt UM (1995) Angiotensin-converting enzyme inhibition in diabetic nephropathy: ten years’ experience. Am J Kidney Dis 26(1):99–107.
-
(1995)
Am J Kidney Dis
, vol.26
, Issue.1
, pp. 99-107
-
-
Parving, H.H.1
Rossing, P.2
Hommel, E.3
Smidt, U.M.4
-
116
-
-
40549113994
-
Evaluation of a generic physiologically based pharmacokinetic model for lineshape analysis
-
Peters SA (2008) Evaluation of a generic physiologically based pharmacokinetic model for lineshape analysis. Clin Pharmacokinet 47(4):261–275.
-
(2008)
Clin Pharmacokinet
, vol.47
, Issue.4
, pp. 261-275
-
-
Peters, S.A.1
-
118
-
-
41049104351
-
Early identification of drug-induced impairment of gastric emptying through physiologically based pharmacokinetic (PBPK) simulation of plasma concentrationtime profiles in rat
-
Peters SA, Hultin L (2008) Early identification of drug-induced impairment of gastric emptying through physiologically based pharmacokinetic (PBPK) simulation of plasma concentrationtime profiles in rat. J Pharmacokinet Pharmacodyn 35(1):1–30.
-
(2008)
J Pharmacokinet Pharmacodyn
, vol.35
, Issue.1
, pp. 1-30
-
-
Peters, S.A.1
Hultin, L.2
-
119
-
-
0001395585
-
Partial proportional odds models for ordinal response variables
-
Peterson B, Harrell Jr FE (1990) Partial proportional odds models for ordinal response variables. Appl Stat 39(2): 205–217.
-
(1990)
Appl Stat
, vol.39
, Issue.2
, pp. 205-217
-
-
Peterson, B.1
Harrell, F.E.2
-
120
-
-
10844265575
-
A semimechanistic and mechanistic population PK-PD model for biomarker response to ibandronate, a new bisphosphonate for the treatment of osteoporosis
-
Pillai G, Gieschke R, Goggin T, Jacqmin P, Schimmer RC, Steimer JL (2004) A semimechanistic and mechanistic population PK-PD model for biomarker response to ibandronate, a new bisphosphonate for the treatment of osteoporosis. Br J Clin Pharmacol 58(6):618–631.
-
(2004)
Br J Clin Pharmacol
, vol.58
, Issue.6
, pp. 618-631
-
-
Pillai, G.1
Gieschke, R.2
Goggin, T.3
Jacqmin, P.4
Schimmer, R.C.5
Steimer, J.L.6
-
121
-
-
0028363006
-
Magnitude and pattern of skeletal response to long term continuous and cyclic sequential oestrogen/progestin treatment
-
Pors Nielsen S, Barenholdt O, Hermansen F, Munk-Jensen N (1994) Magnitude and pattern of skeletal response to long term continuous and cyclic sequential oestrogen/progestin treatment. Br J Obstet Gynaecol 101(4):319–324.
-
(1994)
Br J Obstet Gynaecol
, vol.101
, Issue.4
, pp. 319-324
-
-
Pors Nielsen, S.1
Barenholdt, O.2
Hermansen, F.3
Munk-Jensen, N.4
-
122
-
-
0033966128
-
A priori prediction of tissue:Plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery
-
Poulin P, Theil FP (2000) A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery. J Pharm Sci 89(1):16–35.
-
(2000)
J Pharm Sci
, vol.89
, Issue.1
, pp. 16-35
-
-
Poulin, P.1
Theil, F.P.2
-
123
-
-
0036144815
-
Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanismbased prediction of volume of distribution
-
Poulin P, Theil FP (2002a) Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanismbased prediction of volume of distribution. J Pharm Sci 91(1):129–156.
-
(2002)
J Pharm Sci
, vol.91
, Issue.1
, pp. 129-156
-
-
Poulin, P.1
Theil, F.P.2
-
124
-
-
0036075799
-
Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition
-
Poulin P, Theil FP (2002b) Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition. J Pharm Sci 91(5):1358–1370.
-
(2002)
J Pharm Sci
, vol.91
, Issue.5
, pp. 1358-1370
-
-
Poulin, P.1
Theil, F.P.2
-
125
-
-
0035044107
-
Prediction of adipose tissue: Plasma partition coefficients for structurally unrelated drugs
-
Poulin P, Schoenlein K, Theil FP (2001) Prediction of adipose tissue: plasma partition coefficients for structurally unrelated drugs. J Pharm Sci 90(4):436–447.
-
(2001)
J Pharm Sci
, vol.90
, Issue.4
, pp. 436-447
-
-
Poulin, P.1
Schoenlein, K.2
Theil, F.P.3
-
126
-
-
0021279862
-
A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans
-
Ramsey JC, Andersen ME (1984) A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol Appl Pharmacol 73(1):159–175.
-
(1984)
Toxicol Appl Pharmacol
, vol.73
, Issue.1
, pp. 159-175
-
-
Ramsey, J.C.1
Ersen, M.E.2
-
127
-
-
70449368218
-
Population pharmacokinetic analysis of varenicline in adult smokers
-
Ravva P, Gastonguay MR, Tensfeldt TG, Faessel HM (2009) Population pharmacokinetic analysis of varenicline in adult smokers. Br J Clin Pharmacol 68(5):669–681.
-
(2009)
Br J Clin Pharmacol
, vol.68
, Issue.5
, pp. 669-681
-
-
Ravva, P.1
Gastonguay, M.R.2
Tensfeldt, T.G.3
Faessel, H.M.4
-
129
-
-
0017117483
-
The natural history of coronary artery stenosis. A longitudinal angiographic assessment
-
Rosch J, Antonovic R, Trenouth RS, Rahimtoola SH, Sim DN, Dotter CT (1976) The natural history of coronary artery stenosis. A longitudinal angiographic assessment. Radiology 119(3):513–520.
-
(1976)
Radiology
, vol.119
, Issue.3
, pp. 513-520
-
-
Rosch, J.1
Antonovic, R.2
Trenouth, R.S.3
Rahimtoola, S.H.4
Sim, D.N.5
Dotter, C.T.6
-
131
-
-
0015309190
-
Application of clearance concepts to some literature data on drug metabolism in the isolated perfused liver preparation and in vivo
-
Rowland M (1972) Application of clearance concepts to some literature data on drug metabolism in the isolated perfused liver preparation and in vivo. Eur J Pharmacol 17(3):352–356.
-
(1972)
Eur J Pharmacol
, vol.17
, Issue.3
, pp. 352-356
-
-
Rowland, M.1
-
134
-
-
79951765993
-
Physiologically-based pharmacokinetics in drug development and regulatory science
-
Rowland M, Peck C, Tucker G (2011) Physiologically-based pharmacokinetics in drug development and regulatory science. Annu Rev Pharmacol and Toxicol 51:45–73.
-
(2011)
Annu Rev Pharmacol and Toxicol
, vol.51
, pp. 45-73
-
-
Rowland, M.1
Peck, C.2
Tucker, G.3
-
135
-
-
0032816085
-
Likelihood-based diagnostics for influential individuals in non-linear mixed effects model selection
-
Sadray S, Jonsson EN, Karlsson MO (1999) Likelihood-based diagnostics for influential individuals in non-linear mixed effects model selection. Pharm Res 16(8):1260–1265.
-
(1999)
Pharm Res
, vol.16
, Issue.8
, pp. 1260-1265
-
-
Sadray, S.1
Jonsson, E.N.2
Karlsson, M.O.3
-
136
-
-
1642368948
-
The predominance of quarter-power scaling in biology
-
Savage VM, Gillooly J, Woodruff W, West G, Allen A, Enquist B et al (2004) The predominance of quarter-power scaling in biology. Funct Ecol 18(2):257–282.
-
(2004)
Funct Ecol
, vol.18
, Issue.2
, pp. 257-282
-
-
Savage, V.M.1
Gillooly, J.2
Woodruff, W.3
West, G.4
Allen, A.5
Enquist, B.6
-
137
-
-
73349104384
-
Importance of shrinkage in empirical bayes estimates for diagnostics: Problems and solutions
-
Savic RM, Karlsson MO (2009) Importance of shrinkage in empirical bayes estimates for diagnostics: problems and solutions. AAPS J 11(3):558–569.
-
(2009)
AAPS J
, vol.11
, Issue.3
, pp. 558-569
-
-
Savic, R.M.1
Karlsson, M.O.2
-
138
-
-
84928333187
-
Disease progression analysis: Towards mechanism-based models
-
Kimko HC, Peck CC (eds), edn. Springer, New York
-
Schmidt S, Post TM, Boroujerdi MA, van Kesteren C, Ploeger BA, Della Pasqua OE et al (2011) Disease progression analysis: towards mechanism-based models. In: Kimko HC, Peck CC (eds) Clinical trial simulations, edn. Springer, New York, pp 433–455.
-
(2011)
Clinical Trial Simulations
, pp. 433-455
-
-
Schmidt, S.1
Post, T.M.2
Boroujerdi, M.A.3
Van Kesteren, C.4
Ploeger, B.A.5
Della Pasqua, O.E.6
-
139
-
-
69849115198
-
Therapeutically targeting ErbB3: A key node in ligand-induced activation of the ErbB receptor-PI3K axis
-
Schoeberl B, Pace EA, Fitzgerald JB, Harms BD, Xu L, Nie L et al (2009) Therapeutically targeting ErbB3: a key node in ligand-induced activation of the ErbB receptor-PI3K axis. Sci Signal 2(77):ra31.
-
(2009)
Sci Signal
, vol.2
, Issue.77
-
-
Schoeberl, B.1
Pace, E.A.2
Fitzgerald, J.B.3
Harms, B.D.4
Xu, L.5
Nie, L.6
-
141
-
-
0017688679
-
Estimation of population characteristics of pharmacokinetic parameters from routine clinical data
-
Sheiner LB, Rosenberg B, Marathe VV (1977) Estimation of population characteristics of pharmacokinetic parameters from routine clinical data. J Pharmacokinet Biopharma 5(5):445–479.
-
(1977)
J Pharmacokinet Biopharma
, vol.5
, Issue.5
, pp. 445-479
-
-
Sheiner, L.B.1
Rosenberg, B.2
Marathe, V.V.3
-
142
-
-
0018394195
-
Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine
-
Sheiner LB, Stanski DR, Vozeh S, Miller RD, Ham J (1979) Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine. Clin Pharmacol Ther 25(3):358–371.
-
(1979)
Clin Pharmacol Ther
, vol.25
, Issue.3
, pp. 358-371
-
-
Sheiner, L.B.1
Stanski, D.R.2
Vozeh, S.3
Miller, R.D.4
Ham, J.5
-
143
-
-
84888012931
-
A Markov Chain model to evaluate the effect of CYP3A5 and ABCB1 polymorphisms on adverse events associated with tacrolimus in pediatric renal transplantation
-
Sy SK, Heuberger J, Shilbayeh S, Conrado DJ, Derendorf H (2013a) A Markov Chain model to evaluate the effect of CYP3A5 and ABCB1 polymorphisms on adverse events associated with tacrolimus in pediatric renal transplantation. AAPS J 15(4):1189–99.
-
(2013)
AAPS J
, vol.15
, Issue.4
, pp. 1189-1199
-
-
Sy, S.K.1
Heuberger, J.2
Shilbayeh, S.3
Conrado, D.J.4
Derendorf, H.5
-
144
-
-
84892039735
-
Influence of CYP3A5 6986A > G and ABCB1 3435C > T Polymorphisms on Adverse Events Associated With Tacrolimus in Jordanian Pediatric Renal Transplant Patients
-
Sy SK, Singh RP, Shilbayeh S, Zmeili R, Conrado D, Derendorf H (2013b) Influence of CYP3A5 6986A > G and ABCB1 3435C > T Polymorphisms on Adverse Events Associated With Tacrolimus in Jordanian Pediatric Renal Transplant Patients. Clin Pharmacol Drug Dev 2(1):67–78.
-
(2013)
Clin Pharmacol Drug Dev
, vol.2
, Issue.1
, pp. 67-78
-
-
Sy, S.K.1
Singh, R.P.2
Shilbayeh, S.3
Zmeili, R.4
Conrado, D.5
Derendorf, H.6
-
145
-
-
0001146538
-
Kinetics of distribution of substances administered to the body, I: The extravascular modes of administration
-
Teorell T (1937a) Kinetics of distribution of substances administered to the body, I: the extravascular modes of administration. Arch Int pharmacodyn Ther 57:205–225.
-
(1937)
Arch Int Pharmacodyn Ther
, vol.57
, pp. 205-225
-
-
Teorell, T.1
-
146
-
-
0001146538
-
Kinetics of distribution of substances administered to the body, II: The intravascular modes of administration
-
Teorell T (1937b) Kinetics of distribution of substances administered to the body, II: the intravascular modes of administration. Arch Int Pharmacodyn Ther 57:226–240.
-
(1937)
Arch Int Pharmacodyn Ther
, vol.57
, pp. 226-240
-
-
Teorell, T.1
-
147
-
-
0037452445
-
Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection
-
Theil FP, Guentert TW, Haddad S, Poulin P (2003) Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection. Toxicol Lett 138(1–2):29–49.
-
(2003)
Toxicol Lett
, vol.138
, Issue.1-2
, pp. 29-49
-
-
Theil, F.P.1
Guentert, T.W.2
Haddad, S.3
Poulin, P.4
-
148
-
-
0031833482
-
Estimation of occupational exposure to 2,3,7,8-tetrachlorodibenzop- dioxin using a minimal physiologic toxicokinetic model
-
Thomaseth K, Salvan A (1998) Estimation of occupational exposure to 2,3,7,8-tetrachlorodibenzop- dioxin using a minimal physiologic toxicokinetic model. Environ Health Perspect 106(Suppl 2):743–753.
-
(1998)
Environ Health Perspect
, vol.106
, pp. 743-753
-
-
Thomaseth, K.1
Salvan, A.2
-
149
-
-
70350573523
-
Modelling overdispersion and Markovian features in count data
-
Troconiz IF, Plan EL, Miller R, Karlsson MO (2009) Modelling overdispersion and Markovian features in count data. J Pharmacokinet Pharmacodyn 36(5):461–477.
-
(2009)
J Pharmacokinet Pharmacodyn
, vol.36
, Issue.5
, pp. 461-477
-
-
Troconiz, I.F.1
Plan, E.L.2
Miller, R.3
Karlsson, M.O.4
-
150
-
-
0003556719
-
-
U.S. Department of Health and Human Services, Food and Drug Administration. DA
-
U.S. Department of Health and Human Services, Food and Drug Administration. DA (1999) Guidance for industry: population pharmacokinetics, (available at http://www.fda.gov/downloads/ScienceResearch/SpecialTopics/WomensHealthResearch/UCM133184.pdf)
-
(1999)
Guidance for Industry: Population Pharmacokinetics
-
-
-
151
-
-
26844471001
-
A generic toxicokinetic model for persistent lipophilic compounds in humans: An application to TCDD
-
van der Molen GW, Kooijman SA, Slob W (1996) A generic toxicokinetic model for persistent lipophilic compounds in humans: an application to TCDD. Fundam Appl Toxicol 31(1):83–94.
-
(1996)
Fundam Appl Toxicol
, vol.31
, Issue.1
, pp. 83-94
-
-
Van Der Molen, G.W.1
Kooijman, S.A.2
Slob, W.3
-
152
-
-
0003895851
-
-
edn, Springer, New York
-
Venables WN, Ripley BD, Venables W (1994) Modern applied statistics with S-PLUS, edn, vol. 250. Springer, New York
-
(1994)
Modern Applied Statistics with S-PLUS
, vol.250
-
-
Venables, W.N.1
Ripley, B.D.2
Venables, W.3
-
153
-
-
84860739324
-
Rapid sample size calculations for a defined likelihood ratio test-based power in mixed-effects models
-
Vong C, Bergstrand M, Nyberg J, Karlsson MO (2012) Rapid sample size calculations for a defined likelihood ratio test-based power in mixed-effects models. AAPS J 14(2):176–186.
-
(2012)
AAPS J
, vol.14
, Issue.2
, pp. 176-186
-
-
Vong, C.1
Bergstrand, M.2
Nyberg, J.3
Karlsson, M.O.4
-
154
-
-
0342941156
-
Computer simulation of the effects of alterations in blood flows and body composition on thiopental pharmacokinetics in humans
-
Wada DR, Bjorkman S, Ebling WF, Harashima H, Harapat SR, Stanski DR (1997) Computer simulation of the effects of alterations in blood flows and body composition on thiopental pharmacokinetics in humans. Anesthesiology 87(4):884–899.
-
(1997)
Anesthesiology
, vol.87
, Issue.4
, pp. 884-899
-
-
Wada, D.R.1
Bjorkman, S.2
Ebling, W.F.3
Harashima, H.4
Harapat, S.R.5
Stanski, D.R.6
-
155
-
-
0030725240
-
Determination of parameters responsible for pharmacokinetic behavior of TCDD in female Sprague- Dawley rats
-
Wang X, Santostefano MJ, Evans MV, Richardson VM, Diliberto JJ, Birnbaum LS (1997) Determination of parameters responsible for pharmacokinetic behavior of TCDD in female Sprague- Dawley rats. Toxicol Appl Pharmacol 147(1):151–168.
-
(1997)
Toxicol Appl Pharmacol
, vol.147
, Issue.1
, pp. 151-168
-
-
Wang, X.1
Santostefano, M.J.2
Evans, M.V.3
Richardson, V.M.4
Diliberto, J.J.5
Birnbaum, L.S.6
-
156
-
-
1842293418
-
An overview of statistical methods for multiple failure time data in clinical trials
-
Wei L, Glidden DV (1997) An overview of statistical methods for multiple failure time data in clinical trials. Stat Med 16(8):833–839.
-
(1997)
Stat Med
, vol.16
, Issue.8
, pp. 833-839
-
-
Wei, L.1
Glidden, D.V.2
-
157
-
-
79953752268
-
Regression analysis of multivariate incomplete failure time data by modeling marginal distributions
-
Wei L-J, Lin DY, Weissfeld L (1989) Regression analysis of multivariate incomplete failure time data by modeling marginal distributions. J Am Stat Assoc 84(408):1065–1073.
-
(1989)
J am Stat Assoc
, vol.84
, Issue.408
, pp. 1065-1073
-
-
Wei, L.-J.1
Lin, D.Y.2
Weissfeld, L.3
-
158
-
-
0030932272
-
A general model for the origin of allometric scaling laws in biology
-
West GB, Brown JH, Enquist BJ (1997) A general model for the origin of allometric scaling laws in biology. Science 276(5309):122–126.
-
(1997)
Science
, vol.276
, Issue.5309
, pp. 122-126
-
-
West, G.B.1
Brown, J.H.2
Enquist, B.J.3
-
159
-
-
0033522952
-
The fourth dimension of life: Fractal geometry and allometric scaling of organisms
-
West GB, Brown JH, Enquist BJ (1999) The fourth dimension of life: fractal geometry and allometric scaling of organisms. Science 284(5420):1677–1679.
-
(1999)
Science
, vol.284
, Issue.5420
, pp. 1677-1679
-
-
West, G.B.1
Brown, J.H.2
Enquist, B.J.3
-
160
-
-
0023132476
-
Clearance approaches in pharmacology
-
Wilkinson GR (1987) Clearance approaches in pharmacology. Pharmacol Rev 39(1):1–47.
-
(1987)
Pharmacol Rev
, vol.39
, Issue.1
, pp. 1-47
-
-
Wilkinson, G.R.1
-
161
-
-
0016566218
-
Commentary: A physiological approach to hepatic drug clearance
-
Wilkinson GR, Shand DG (1975) Commentary: a physiological approach to hepatic drug clearance. Clin Pharmacol Ther 18(4):377–390.
-
(1975)
Clin Pharmacol Ther
, vol.18
, Issue.4
, pp. 377-390
-
-
Wilkinson, G.R.1
Shand, D.G.2
-
162
-
-
0036738120
-
Clinical pharmacokinetics of irinotecan and its metabolites in relation with diarrhea
-
Xie R, Mathijssen RH, Sparreboom A, Verweij J, Karlsson MO (2002) Clinical pharmacokinetics of irinotecan and its metabolites in relation with diarrhea. Clin Pharmacol Ther 72(3):265–275.
-
(2002)
Clin Pharmacol Ther
, vol.72
, Issue.3
, pp. 265-275
-
-
Xie, R.1
Mathijssen, R.H.2
Sparreboom, A.3
Verweij, J.4
Karlsson, M.O.5
-
164
-
-
84877865099
-
The combination of exposure-response and case-control analyses in regulatory decision making
-
Yang J, Zhao H, Garnett C, Rahman A, Gobburu JV, Pierce W et al (2012) The combination of exposure-response and case-control analyses in regulatory decision making. J Clin Pharmacol 53(2):160–6.
-
(2012)
J Clin Pharmacol
, vol.53
, Issue.2
, pp. 160-166
-
-
Yang, J.1
Zhao, H.2
Garnett, C.3
Rahman, A.4
Gobburu, J.V.5
Pierce, W.6
-
165
-
-
16844378936
-
Population pharmacokinetic analysis and simulation of the time-concentration profile of etanercept in pediatric patients with juvenile rheumatoid arthritis
-
Yim DS, Zhou H, Buckwalter M, Nestorov I, Peck CC, Lee H (2005) Population pharmacokinetic analysis and simulation of the time-concentration profile of etanercept in pediatric patients with juvenile rheumatoid arthritis. J Clin Pharmacol 45(3):246–256.
-
(2005)
J Clin Pharmacol
, vol.45
, Issue.3
, pp. 246-256
-
-
Yim, D.S.1
Zhou, H.2
Buckwalter, M.3
Nestorov, I.4
Peck, C.C.5
Lee, H.6
-
166
-
-
70450253289
-
Population pharmacokinetics and pharmacogenetics of tacrolimus in de novo pediatric kidney transplant recipients
-
Zhao W, Elie V, Roussey G, Brochard K, Niaudet P, Leroy V et al (2009) Population pharmacokinetics and pharmacogenetics of tacrolimus in de novo pediatric kidney transplant recipients. Clin Pharmacol Ther 86(6):609–618.
-
(2009)
Clin Pharmacol Ther
, vol.86
, Issue.6
, pp. 609-618
-
-
Zhao, W.1
Elie, V.2
Roussey, G.3
Brochard, K.4
Niaudet, P.5
Leroy, V.6
-
167
-
-
78951482203
-
Applications of physiologically based pharmacokinetic (PBPK) modeling and simulation during regulatory review
-
Zhao P, Zhang L, Grillo JA, Liu Q, Bullock JM, Moon YJ et al (2011) Applications of physiologically based pharmacokinetic (PBPK) modeling and simulation during regulatory review. Clin Pharmacol Ther 89(2):259–267.
-
(2011)
Clin Pharmacol Ther
, vol.89
, Issue.2
, pp. 259-267
-
-
Zhao, P.1
Zhang, L.2
Grillo, J.A.3
Liu, Q.4
Bullock, J.M.5
Moon, Y.J.6
-
168
-
-
84862634533
-
Best practice in the use of physiologically based pharmacokinetic modeling and simulation to address clinical pharmacology regulatory questions
-
Zhao P, Rowland M, Huang SM (2012) Best practice in the use of physiologically based pharmacokinetic modeling and simulation to address clinical pharmacology regulatory questions. Clin Pharmacol Ther 92(1):17–20.
-
(2012)
Clin Pharmacol Ther
, vol.92
, Issue.1
, pp. 17-20
-
-
Zhao, P.1
Rowland, M.2
Huang, S.M.3
-
169
-
-
0042530229
-
Population pharmacokinetics of clomethiazole and its effect on the natural course of sedation in acute stroke patients
-
Zingmark PH, Ekblom M, Odergren T, Ashwood T, Lyden P, Karlsson MO et al (2003) Population pharmacokinetics of clomethiazole and its effect on the natural course of sedation in acute stroke patients. Br J Clin Pharmacol 56(2):173–183
-
(2003)
Br J Clin Pharmacol
, vol.56
, Issue.2
, pp. 173-183
-
-
Zingmark, P.H.1
Ekblom, M.2
Odergren, T.3
Ashwood, T.4
Lyden, P.5
Karlsson, M.O.6
|