Quantitative characterization of therapeutic index: Application of mixed-effects modeling to evaluate oxybutynin dose-efficacy and dose-side effect relationships

Clinical Pharmacology and Therapeutics

Volumn 65, Issue 6, 1999, Pages 672-684

  Gupta, Suneel K ^a,b,c,d   Sathyan, Gayatri ^a,b,c   Lindemulder, Elizabeth A ^a,b,c   Ho, Pai Ling ^a,b,c   Sheiner, Lewis B ^a,b,c   Aarons, Leon ^a,b,c  

^a ALZA CORPORATION   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXYBUTYNIN;

ADULT; AGED; ANTICHOLINERGIC EFFECT; ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG SAFETY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NONLINEAR SYSTEM; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; STATISTICAL ANALYSIS; URINE INCONTINENCE; XEROSTOMIA;

ADULT; AGED; AGED, 80 AND OVER; CHOLINERGIC ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MANDELIC ACIDS; MIDDLE AGED; PARASYMPATHOLYTICS; SALIVATION; TREATMENT OUTCOME; URINARY INCONTINENCE;

EID: 0032977094     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-9236(99)90089-9     Document Type: Article

References (12)

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